EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane transport protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8K4_LEIBR

TriTrypDb:

LbrM.16.0810 , LBRM2903_160014600

Length:

753

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4H8K4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8K4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0009914	hormone transport	4	9
GO:0009987	cellular process	1	9
GO:0010817	regulation of hormone levels	3	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0055085	transmembrane transport	2	9
GO:0060918	auxin transport	5	9
GO:0065007	biological regulation	1	9
GO:0065008	regulation of biological quality	2	9
GO:0080162	endoplasmic reticulum to cytosol auxin transport	3	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	334	338	PF00656	0.699
CLV_NRD_NRD_1	106	108	PF00675	0.630
CLV_NRD_NRD_1	382	384	PF00675	0.520
CLV_NRD_NRD_1	491	493	PF00675	0.300
CLV_NRD_NRD_1	641	643	PF00675	0.335
CLV_PCSK_KEX2_1	146	148	PF00082	0.610
CLV_PCSK_KEX2_1	266	268	PF00082	0.375
CLV_PCSK_KEX2_1	491	493	PF00082	0.300
CLV_PCSK_KEX2_1	633	635	PF00082	0.413
CLV_PCSK_KEX2_1	641	643	PF00082	0.317
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.610
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.374
CLV_PCSK_PC1ET2_1	633	635	PF00082	0.370
CLV_PCSK_SKI1_1	250	254	PF00082	0.405
CLV_PCSK_SKI1_1	259	263	PF00082	0.339
CLV_PCSK_SKI1_1	383	387	PF00082	0.442
CLV_PCSK_SKI1_1	444	448	PF00082	0.345
CLV_PCSK_SKI1_1	468	472	PF00082	0.331
CLV_PCSK_SKI1_1	491	495	PF00082	0.238
CLV_PCSK_SKI1_1	726	730	PF00082	0.271
DEG_APCC_DBOX_1	585	593	PF00400	0.583
DEG_Nend_UBRbox_3	1	3	PF02207	0.487
DEG_SPOP_SBC_1	130	134	PF00917	0.444
DEG_SPOP_SBC_1	22	26	PF00917	0.368
DEG_SPOP_SBC_1	526	530	PF00917	0.518
DOC_CKS1_1	370	375	PF01111	0.615
DOC_CKS1_1	402	407	PF01111	0.727
DOC_CYCLIN_yCln2_LP_2	279	285	PF00134	0.616
DOC_MAPK_DCC_7	143	153	PF00069	0.400
DOC_MAPK_gen_1	142	153	PF00069	0.347
DOC_MAPK_gen_1	350	359	PF00069	0.646
DOC_MAPK_HePTP_8	658	670	PF00069	0.371
DOC_MAPK_MEF2A_6	13	22	PF00069	0.291
DOC_MAPK_MEF2A_6	144	153	PF00069	0.351
DOC_MAPK_MEF2A_6	57	65	PF00069	0.606
DOC_MAPK_MEF2A_6	66	73	PF00069	0.458
DOC_MAPK_MEF2A_6	661	670	PF00069	0.344
DOC_MAPK_MEF2A_6	692	700	PF00069	0.264
DOC_PP1_RVXF_1	106	113	PF00149	0.411
DOC_PP2B_LxvP_1	279	282	PF13499	0.688
DOC_PP2B_LxvP_1	702	705	PF13499	0.350
DOC_PP4_FxxP_1	319	322	PF00568	0.636
DOC_PP4_FxxP_1	92	95	PF00568	0.307
DOC_USP7_MATH_1	130	134	PF00917	0.476
DOC_USP7_MATH_1	327	331	PF00917	0.703
DOC_USP7_MATH_1	707	711	PF00917	0.318
DOC_USP7_UBL2_3	142	146	PF12436	0.487
DOC_USP7_UBL2_3	250	254	PF12436	0.527
DOC_USP7_UBL2_3	444	448	PF12436	0.554
DOC_WW_Pin1_4	369	374	PF00397	0.616
DOC_WW_Pin1_4	398	403	PF00397	0.743
DOC_WW_Pin1_4	469	474	PF00397	0.558
DOC_WW_Pin1_4	662	667	PF00397	0.350
LIG_14-3-3_CanoR_1	307	313	PF00244	0.664
LIG_14-3-3_CanoR_1	356	360	PF00244	0.745
LIG_14-3-3_CanoR_1	586	590	PF00244	0.604
LIG_14-3-3_CanoR_1	641	647	PF00244	0.610
LIG_Actin_WH2_2	532	547	PF00022	0.585
LIG_Actin_WH2_2	633	649	PF00022	0.608
LIG_BRCT_BRCA1_1	155	159	PF00533	0.345
LIG_BRCT_BRCA1_1	471	475	PF00533	0.500
LIG_CtBP_PxDLS_1	103	107	PF00389	0.377
LIG_CtBP_PxDLS_1	498	502	PF00389	0.476
LIG_deltaCOP1_diTrp_1	428	434	PF00928	0.527
LIG_EH1_1	39	47	PF00400	0.338
LIG_eIF4E_1	186	192	PF01652	0.242
LIG_FHA_1	199	205	PF00498	0.326
LIG_FHA_1	23	29	PF00498	0.452
LIG_FHA_1	274	280	PF00498	0.633
LIG_FHA_1	315	321	PF00498	0.611
LIG_FHA_1	337	343	PF00498	0.780
LIG_FHA_1	363	369	PF00498	0.685
LIG_FHA_1	42	48	PF00498	0.186
LIG_FHA_1	460	466	PF00498	0.615
LIG_FHA_1	641	647	PF00498	0.599
LIG_FHA_1	742	748	PF00498	0.342
LIG_FHA_2	32	38	PF00498	0.293
LIG_FHA_2	377	383	PF00498	0.639
LIG_FHA_2	404	410	PF00498	0.624
LIG_GBD_Chelix_1	15	23	PF00786	0.245
LIG_LIR_Apic_2	317	322	PF02991	0.621
LIG_LIR_Gen_1	109	120	PF02991	0.365
LIG_LIR_Gen_1	222	233	PF02991	0.321
LIG_LIR_Gen_1	37	46	PF02991	0.245
LIG_LIR_Gen_1	669	677	PF02991	0.320
LIG_LIR_Gen_1	7	16	PF02991	0.352
LIG_LIR_Nem_3	109	115	PF02991	0.290
LIG_LIR_Nem_3	181	186	PF02991	0.344
LIG_LIR_Nem_3	222	228	PF02991	0.338
LIG_LIR_Nem_3	230	236	PF02991	0.298
LIG_LIR_Nem_3	37	41	PF02991	0.213
LIG_LIR_Nem_3	462	466	PF02991	0.669
LIG_LIR_Nem_3	558	563	PF02991	0.611
LIG_LIR_Nem_3	652	658	PF02991	0.462
LIG_LIR_Nem_3	659	663	PF02991	0.294
LIG_LIR_Nem_3	667	673	PF02991	0.332
LIG_LIR_Nem_3	7	11	PF02991	0.352
LIG_LIR_Nem_3	711	717	PF02991	0.394
LIG_LYPXL_L_2	721	730	PF13949	0.430
LIG_PDZ_Class_1	748	753	PF00595	0.365
LIG_Pex14_1	84	88	PF04695	0.229
LIG_Pex14_2	671	675	PF04695	0.466
LIG_Pex14_2	88	92	PF04695	0.254
LIG_PTB_Apo_2	93	100	PF02174	0.273
LIG_PTB_Phospho_1	93	99	PF10480	0.275
LIG_REV1ctd_RIR_1	90	94	PF16727	0.395
LIG_SH2_CRK	116	120	PF00017	0.303
LIG_SH2_CRK	188	192	PF00017	0.291
LIG_SH2_CRK	99	103	PF00017	0.352
LIG_SH2_NCK_1	116	120	PF00017	0.394
LIG_SH2_NCK_1	417	421	PF00017	0.546
LIG_SH2_PTP2	150	153	PF00017	0.328
LIG_SH2_PTP2	225	228	PF00017	0.309
LIG_SH2_SRC	40	43	PF00017	0.218
LIG_SH2_STAP1	116	120	PF00017	0.316
LIG_SH2_STAP1	188	192	PF00017	0.335
LIG_SH2_STAP1	427	431	PF00017	0.624
LIG_SH2_STAP1	439	443	PF00017	0.490
LIG_SH2_STAP1	569	573	PF00017	0.582
LIG_SH2_STAT3	573	576	PF00017	0.636
LIG_SH2_STAT5	150	153	PF00017	0.328
LIG_SH2_STAT5	216	219	PF00017	0.392
LIG_SH2_STAT5	225	228	PF00017	0.293
LIG_SH2_STAT5	233	236	PF00017	0.309
LIG_SH2_STAT5	285	288	PF00017	0.676
LIG_SH2_STAT5	366	369	PF00017	0.622
LIG_SH2_STAT5	40	43	PF00017	0.233
LIG_SH2_STAT5	417	420	PF00017	0.557
LIG_SH2_STAT5	569	572	PF00017	0.529
LIG_SH2_STAT5	732	735	PF00017	0.309
LIG_SH2_STAT5	749	752	PF00017	0.314
LIG_SH3_3	197	203	PF00018	0.305
LIG_SH3_3	367	373	PF00018	0.617
LIG_SH3_3	399	405	PF00018	0.676
LIG_SH3_3	420	426	PF00018	0.692
LIG_SH3_3	551	557	PF00018	0.699
LIG_Sin3_3	516	523	PF02671	0.406
LIG_SUMO_SIM_anti_2	504	511	PF11976	0.445
LIG_SUMO_SIM_anti_2	517	522	PF11976	0.470
LIG_SUMO_SIM_anti_2	60	65	PF11976	0.597
LIG_SUMO_SIM_anti_2	68	74	PF11976	0.305
LIG_SUMO_SIM_anti_2	693	699	PF11976	0.350
LIG_SUMO_SIM_par_1	43	49	PF11976	0.270
LIG_SUMO_SIM_par_1	68	74	PF11976	0.350
LIG_SUMO_SIM_par_1	696	701	PF11976	0.293
LIG_SxIP_EBH_1	21	33	PF03271	0.338
LIG_TRFH_1	366	370	PF08558	0.616
LIG_TRFH_1	553	557	PF08558	0.660
LIG_TYR_ITIM	114	119	PF00017	0.383
LIG_TYR_ITIM	148	153	PF00017	0.344
LIG_UBA3_1	257	266	PF00899	0.523
LIG_UBA3_1	672	678	PF00899	0.404
LIG_WRC_WIRS_1	657	662	PF05994	0.218
MOD_CK1_1	133	139	PF00069	0.512
MOD_CK1_1	31	37	PF00069	0.397
MOD_CK1_1	336	342	PF00069	0.741
MOD_CK1_1	528	534	PF00069	0.491
MOD_CK1_1	537	543	PF00069	0.575
MOD_CK1_1	74	80	PF00069	0.350
MOD_CK2_1	307	313	PF00069	0.712
MOD_CK2_1	337	343	PF00069	0.748
MOD_CK2_1	447	453	PF00069	0.607
MOD_CK2_1	527	533	PF00069	0.426
MOD_GlcNHglycan	133	136	PF01048	0.654
MOD_GlcNHglycan	238	241	PF01048	0.350
MOD_GlcNHglycan	291	295	PF01048	0.463
MOD_GlcNHglycan	30	33	PF01048	0.527
MOD_GlcNHglycan	300	304	PF01048	0.430
MOD_GlcNHglycan	325	328	PF01048	0.425
MOD_GlcNHglycan	329	332	PF01048	0.416
MOD_GlcNHglycan	339	342	PF01048	0.411
MOD_GlcNHglycan	362	365	PF01048	0.579
MOD_GlcNHglycan	420	423	PF01048	0.326
MOD_GlcNHglycan	99	102	PF01048	0.616
MOD_GSK3_1	129	136	PF00069	0.515
MOD_GSK3_1	198	205	PF00069	0.320
MOD_GSK3_1	24	31	PF00069	0.428
MOD_GSK3_1	273	280	PF00069	0.662
MOD_GSK3_1	323	330	PF00069	0.714
MOD_GSK3_1	333	340	PF00069	0.667
MOD_GSK3_1	360	367	PF00069	0.740
MOD_GSK3_1	374	381	PF00069	0.705
MOD_GSK3_1	41	48	PF00069	0.260
MOD_GSK3_1	510	517	PF00069	0.469
MOD_GSK3_1	525	532	PF00069	0.467
MOD_GSK3_1	598	605	PF00069	0.604
MOD_GSK3_1	662	669	PF00069	0.350
MOD_GSK3_1	686	693	PF00069	0.384
MOD_GSK3_1	703	710	PF00069	0.420
MOD_GSK3_1	741	748	PF00069	0.324
MOD_LATS_1	265	271	PF00433	0.514
MOD_N-GLC_1	164	169	PF02516	0.478
MOD_N-GLC_1	337	342	PF02516	0.458
MOD_N-GLC_1	708	713	PF02516	0.309
MOD_NEK2_1	131	136	PF00069	0.480
MOD_NEK2_1	227	232	PF00069	0.317
MOD_NEK2_1	23	28	PF00069	0.599
MOD_NEK2_1	306	311	PF00069	0.624
MOD_NEK2_1	323	328	PF00069	0.593
MOD_NEK2_1	374	379	PF00069	0.738
MOD_NEK2_1	4	9	PF00069	0.295
MOD_NEK2_1	41	46	PF00069	0.383
MOD_NEK2_1	475	480	PF00069	0.565
MOD_NEK2_1	50	55	PF00069	0.339
MOD_NEK2_1	525	530	PF00069	0.486
MOD_NEK2_1	584	589	PF00069	0.642
MOD_NEK2_1	65	70	PF00069	0.437
MOD_NEK2_1	676	681	PF00069	0.310
MOD_NEK2_1	690	695	PF00069	0.385
MOD_NEK2_1	741	746	PF00069	0.319
MOD_NEK2_2	656	661	PF00069	0.273
MOD_NEK2_2	666	671	PF00069	0.306
MOD_PIKK_1	193	199	PF00454	0.329
MOD_PIKK_1	273	279	PF00454	0.615
MOD_PIKK_1	376	382	PF00454	0.718
MOD_PIKK_1	537	543	PF00454	0.590
MOD_PK_1	447	453	PF00069	0.512
MOD_PKA_1	383	389	PF00069	0.641
MOD_PKA_1	447	453	PF00069	0.577
MOD_PKA_1	632	638	PF00069	0.642
MOD_PKA_2	306	312	PF00069	0.679
MOD_PKA_2	352	358	PF00069	0.671
MOD_PKA_2	459	465	PF00069	0.696
MOD_PKA_2	585	591	PF00069	0.582
MOD_PKA_2	640	646	PF00069	0.526
MOD_PKA_2	649	655	PF00069	0.472
MOD_PKA_2	65	71	PF00069	0.467
MOD_PKA_2	686	692	PF00069	0.388
MOD_Plk_1	337	343	PF00069	0.728
MOD_Plk_1	565	571	PF00069	0.608
MOD_Plk_1	584	590	PF00069	0.551
MOD_Plk_1	690	696	PF00069	0.295
MOD_Plk_1	708	714	PF00069	0.259
MOD_Plk_4	187	193	PF00069	0.283
MOD_Plk_4	202	208	PF00069	0.338
MOD_Plk_4	4	10	PF00069	0.285
MOD_Plk_4	41	47	PF00069	0.331
MOD_Plk_4	475	481	PF00069	0.445
MOD_Plk_4	514	520	PF00069	0.491
MOD_Plk_4	649	655	PF00069	0.487
MOD_Plk_4	65	71	PF00069	0.458
MOD_Plk_4	666	672	PF00069	0.349
MOD_Plk_4	690	696	PF00069	0.288
MOD_Plk_4	708	714	PF00069	0.222
MOD_Plk_4	735	741	PF00069	0.305
MOD_Plk_4	745	751	PF00069	0.301
MOD_ProDKin_1	369	375	PF00069	0.616
MOD_ProDKin_1	398	404	PF00069	0.741
MOD_ProDKin_1	469	475	PF00069	0.558
MOD_ProDKin_1	662	668	PF00069	0.350
MOD_SUMO_for_1	437	440	PF00179	0.510
MOD_SUMO_rev_2	377	386	PF00179	0.627
MOD_SUMO_rev_2	440	446	PF00179	0.569
TRG_DiLeu_BaEn_1	558	563	PF01217	0.648
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.573
TRG_DiLeu_LyEn_5	558	563	PF01217	0.554
TRG_ENDOCYTIC_2	116	119	PF00928	0.295
TRG_ENDOCYTIC_2	150	153	PF00928	0.328
TRG_ENDOCYTIC_2	188	191	PF00928	0.294
TRG_ENDOCYTIC_2	225	228	PF00928	0.309
TRG_ENDOCYTIC_2	717	720	PF00928	0.564
TRG_ENDOCYTIC_2	99	102	PF00928	0.350
TRG_ER_diArg_1	490	492	PF00400	0.500
TRG_ER_diArg_1	542	545	PF00400	0.680
TRG_ER_diArg_1	640	642	PF00400	0.542
TRG_NES_CRM1_1	535	548	PF08389	0.589
TRG_NLS_MonoCore_2	141	146	PF00514	0.466
TRG_NLS_MonoCore_2	630	635	PF00514	0.590
TRG_NLS_MonoExtC_3	141	146	PF00514	0.468
TRG_NLS_MonoExtN_4	139	146	PF00514	0.479
TRG_NLS_MonoExtN_4	444	451	PF00514	0.575
TRG_NLS_MonoExtN_4	631	636	PF00514	0.579
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	561	565	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILL2	Leptomonas seymouri	50%	100%
A0A3S5H6X7	Leishmania donovani	69%	100%
A0A422ND25	Trypanosoma rangeli	34%	100%
A4HA33	Leishmania braziliensis	22%	100%
A4HWX7	Leishmania infantum	69%	100%
E9AQN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4QET9	Leishmania major	67%	99%