Chitinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Chitinase

Gene product:

chitinase

Species:

Leishmania braziliensis

UniProt:

A4H8K3_LEIBR

TriTrypDb:

LbrM.16.0800 , LBRM2903_160014500

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 4
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8K3

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	8
GO:0008152	metabolic process	1	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	7
GO:0004568	chitinase activity	5	5
GO:0005488	binding	1	8
GO:0008061	chitin binding	3	8
GO:0016787	hydrolase activity	2	8
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	7
GO:0097367	carbohydrate derivative binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.476
CLV_NRD_NRD_1	150	152	PF00675	0.332
CLV_NRD_NRD_1	307	309	PF00675	0.404
CLV_NRD_NRD_1	325	327	PF00675	0.404
CLV_NRD_NRD_1	342	344	PF00675	0.182
CLV_NRD_NRD_1	374	376	PF00675	0.404
CLV_NRD_NRD_1	4	6	PF00675	0.464
CLV_NRD_NRD_1	444	446	PF00675	0.614
CLV_PCSK_FUR_1	116	120	PF00082	0.476
CLV_PCSK_FUR_1	442	446	PF00082	0.537
CLV_PCSK_KEX2_1	118	120	PF00082	0.476
CLV_PCSK_KEX2_1	150	152	PF00082	0.266
CLV_PCSK_KEX2_1	291	293	PF00082	0.407
CLV_PCSK_KEX2_1	307	309	PF00082	0.404
CLV_PCSK_KEX2_1	324	326	PF00082	0.404
CLV_PCSK_KEX2_1	374	376	PF00082	0.404
CLV_PCSK_KEX2_1	4	6	PF00082	0.464
CLV_PCSK_KEX2_1	444	446	PF00082	0.679
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.223
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.404
CLV_PCSK_PC7_1	321	327	PF00082	0.223
CLV_PCSK_SKI1_1	127	131	PF00082	0.395
CLV_PCSK_SKI1_1	188	192	PF00082	0.251
CLV_PCSK_SKI1_1	194	198	PF00082	0.226
CLV_PCSK_SKI1_1	308	312	PF00082	0.422
DEG_Nend_UBRbox_2	1	3	PF02207	0.467
DEG_SCF_TRCP1_1	422	427	PF00400	0.499
DEG_SPOP_SBC_1	25	29	PF00917	0.560
DEG_SPOP_SBC_1	43	47	PF00917	0.432
DOC_CYCLIN_RxL_1	147	157	PF00134	0.223
DOC_CYCLIN_RxL_1	185	195	PF00134	0.223
DOC_MAPK_gen_1	307	316	PF00069	0.404
DOC_MAPK_gen_1	4	11	PF00069	0.564
DOC_MAPK_MEF2A_6	307	316	PF00069	0.355
DOC_MAPK_MEF2A_6	4	13	PF00069	0.536
DOC_MAPK_NFAT4_5	307	315	PF00069	0.404
DOC_MAPK_NFAT4_5	4	12	PF00069	0.464
DOC_PP1_RVXF_1	148	155	PF00149	0.223
DOC_PP2B_LxvP_1	22	25	PF13499	0.558
DOC_PP2B_LxvP_1	312	315	PF13499	0.351
DOC_USP7_MATH_1	232	236	PF00917	0.404
DOC_USP7_MATH_1	265	269	PF00917	0.415
DOC_USP7_MATH_1	32	36	PF00917	0.631
DOC_USP7_MATH_1	42	46	PF00917	0.670
DOC_WW_Pin1_4	399	404	PF00397	0.518
DOC_WW_Pin1_4	53	58	PF00397	0.584
LIG_14-3-3_CanoR_1	150	155	PF00244	0.400
LIG_14-3-3_CanoR_1	244	250	PF00244	0.476
LIG_14-3-3_CanoR_1	292	300	PF00244	0.223
LIG_14-3-3_CanoR_1	307	313	PF00244	0.476
LIG_14-3-3_CanoR_1	44	52	PF00244	0.656
LIG_14-3-3_CanoR_1	70	74	PF00244	0.223
LIG_Actin_WH2_2	87	102	PF00022	0.476
LIG_APCC_ABBA_1	281	286	PF00400	0.437
LIG_BRCT_BRCA1_1	137	141	PF00533	0.351
LIG_deltaCOP1_diTrp_1	182	189	PF00928	0.353
LIG_deltaCOP1_diTrp_1	332	341	PF00928	0.404
LIG_FHA_1	162	168	PF00498	0.449
LIG_FHA_1	179	185	PF00498	0.388
LIG_FHA_1	309	315	PF00498	0.404
LIG_FHA_1	434	440	PF00498	0.540
LIG_FHA_1	83	89	PF00498	0.351
LIG_FHA_1	96	102	PF00498	0.351
LIG_FHA_2	177	183	PF00498	0.472
LIG_FHA_2	294	300	PF00498	0.223
LIG_GBD_Chelix_1	9	17	PF00786	0.537
LIG_LIR_Apic_2	171	177	PF02991	0.351
LIG_LIR_Gen_1	111	121	PF02991	0.463
LIG_LIR_Gen_1	138	149	PF02991	0.404
LIG_LIR_Gen_1	181	191	PF02991	0.369
LIG_LIR_Gen_1	329	338	PF02991	0.404
LIG_LIR_Gen_1	368	377	PF02991	0.439
LIG_LIR_Nem_3	111	117	PF02991	0.405
LIG_LIR_Nem_3	138	144	PF02991	0.404
LIG_LIR_Nem_3	181	186	PF02991	0.357
LIG_LIR_Nem_3	329	334	PF02991	0.353
LIG_LIR_Nem_3	366	370	PF02991	0.362
LIG_LIR_Nem_3	416	420	PF02991	0.596
LIG_LIR_Nem_3	72	76	PF02991	0.371
LIG_REV1ctd_RIR_1	77	85	PF16727	0.437
LIG_SH2_SRC	199	202	PF00017	0.223
LIG_SH2_SRC	257	260	PF00017	0.404
LIG_SH2_STAP1	257	261	PF00017	0.380
LIG_SH2_STAP1	271	275	PF00017	0.290
LIG_SH2_STAP1	331	335	PF00017	0.385
LIG_SH2_STAP1	76	80	PF00017	0.326
LIG_SH2_STAT5	251	254	PF00017	0.404
LIG_SH2_STAT5	446	449	PF00017	0.523
LIG_SH2_STAT5	65	68	PF00017	0.351
LIG_SH3_3	142	148	PF00018	0.285
LIG_SUMO_SIM_par_1	189	195	PF11976	0.223
LIG_TRAF2_1	296	299	PF00917	0.223
LIG_TYR_ITSM	366	373	PF00017	0.476
MOD_CK1_1	139	145	PF00069	0.316
MOD_CK1_1	274	280	PF00069	0.439
MOD_CK1_1	293	299	PF00069	0.162
MOD_CK1_1	402	408	PF00069	0.488
MOD_CK1_1	51	57	PF00069	0.651
MOD_CK1_1	82	88	PF00069	0.223
MOD_CK2_1	107	113	PF00069	0.404
MOD_CK2_1	150	156	PF00069	0.223
MOD_CK2_1	176	182	PF00069	0.355
MOD_CK2_1	264	270	PF00069	0.404
MOD_CK2_1	293	299	PF00069	0.223
MOD_GlcNHglycan	138	141	PF01048	0.405
MOD_GlcNHglycan	194	197	PF01048	0.285
MOD_GlcNHglycan	241	244	PF01048	0.476
MOD_GlcNHglycan	292	295	PF01048	0.364
MOD_GlcNHglycan	34	37	PF01048	0.601
MOD_GlcNHglycan	385	388	PF01048	0.476
MOD_GlcNHglycan	40	43	PF01048	0.583
MOD_GlcNHglycan	422	425	PF01048	0.716
MOD_GlcNHglycan	426	429	PF01048	0.737
MOD_GlcNHglycan	81	84	PF01048	0.362
MOD_GlcNHglycan	90	93	PF01048	0.441
MOD_GSK3_1	135	142	PF00069	0.223
MOD_GSK3_1	260	267	PF00069	0.476
MOD_GSK3_1	38	45	PF00069	0.680
MOD_GSK3_1	398	405	PF00069	0.424
MOD_GSK3_1	420	427	PF00069	0.576
MOD_LATS_1	306	312	PF00433	0.476
MOD_N-GLC_1	383	388	PF02516	0.476
MOD_N-GLC_1	48	53	PF02516	0.626
MOD_NEK2_1	17	22	PF00069	0.598
MOD_NEK2_1	26	31	PF00069	0.613
MOD_NEK2_1	334	339	PF00069	0.223
MOD_NEK2_1	420	425	PF00069	0.654
MOD_NEK2_1	79	84	PF00069	0.450
MOD_PIKK_1	44	50	PF00454	0.723
MOD_PKA_1	150	156	PF00069	0.223
MOD_PKA_1	308	314	PF00069	0.422
MOD_PKA_2	136	142	PF00069	0.294
MOD_PKA_2	150	156	PF00069	0.321
MOD_PKA_2	38	44	PF00069	0.701
MOD_PKA_2	69	75	PF00069	0.297
MOD_Plk_1	285	291	PF00069	0.396
MOD_Plk_1	48	54	PF00069	0.621
MOD_Plk_2-3	299	305	PF00069	0.223
MOD_Plk_4	150	156	PF00069	0.223
MOD_Plk_4	271	277	PF00069	0.404
MOD_Plk_4	402	408	PF00069	0.399
MOD_Plk_4	69	75	PF00069	0.387
MOD_ProDKin_1	399	405	PF00069	0.512
MOD_ProDKin_1	53	59	PF00069	0.570
TRG_ENDOCYTIC_2	257	260	PF00928	0.385
TRG_ENDOCYTIC_2	331	334	PF00928	0.351
TRG_ENDOCYTIC_2	370	373	PF00928	0.369
TRG_ENDOCYTIC_2	76	79	PF00928	0.366
TRG_ER_diArg_1	116	119	PF00400	0.476
TRG_ER_diArg_1	149	151	PF00400	0.271
TRG_ER_diArg_1	218	221	PF00400	0.395
TRG_ER_diArg_1	3	5	PF00400	0.457
TRG_ER_diArg_1	324	326	PF00400	0.476
TRG_ER_diArg_1	442	445	PF00400	0.687
TRG_NLS_Bipartite_1	325	347	PF00514	0.223
TRG_NLS_MonoExtC_3	342	347	PF00514	0.223
TRG_NLS_MonoExtC_3	373	378	PF00514	0.372
TRG_NLS_MonoExtN_4	374	379	PF00514	0.372
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	445	450	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P753	Leptomonas seymouri	56%	93%
A0A0S4J833	Bodo saltans	32%	100%
A4HWX6	Leishmania infantum	78%	100%
E9AQN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E9QRF2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
O60994	Leishmania donovani	78%	100%
Q4QEU0	Leishmania major	78%	100%
Q873X9	Neosartorya fumigata	25%	100%