LeishMANIAdb
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Reverse transcriptase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Reverse transcriptase domain-containing protein
Gene product:
hypothetical protein
Species:
Leishmania braziliensis
UniProt:
A4H8K2_LEIBR
TriTrypDb:
LbrM.16.0470 , LBRM2903_160010900
Length:
1049

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8K2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8K2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 195 199 PF00656 0.681
CLV_C14_Caspase3-7 735 739 PF00656 0.493
CLV_NRD_NRD_1 1044 1046 PF00675 0.411
CLV_NRD_NRD_1 143 145 PF00675 0.655
CLV_NRD_NRD_1 147 149 PF00675 0.617
CLV_NRD_NRD_1 212 214 PF00675 0.481
CLV_NRD_NRD_1 293 295 PF00675 0.858
CLV_NRD_NRD_1 312 314 PF00675 0.333
CLV_NRD_NRD_1 315 317 PF00675 0.589
CLV_NRD_NRD_1 563 565 PF00675 0.350
CLV_NRD_NRD_1 794 796 PF00675 0.461
CLV_NRD_NRD_1 966 968 PF00675 0.428
CLV_NRD_NRD_1 99 101 PF00675 0.516
CLV_PCSK_FUR_1 313 317 PF00082 0.470
CLV_PCSK_FUR_1 97 101 PF00082 0.681
CLV_PCSK_KEX2_1 1044 1046 PF00082 0.411
CLV_PCSK_KEX2_1 143 145 PF00082 0.672
CLV_PCSK_KEX2_1 162 164 PF00082 0.444
CLV_PCSK_KEX2_1 293 295 PF00082 0.841
CLV_PCSK_KEX2_1 312 314 PF00082 0.332
CLV_PCSK_KEX2_1 315 317 PF00082 0.467
CLV_PCSK_KEX2_1 385 387 PF00082 0.632
CLV_PCSK_KEX2_1 563 565 PF00082 0.350
CLV_PCSK_KEX2_1 907 909 PF00082 0.434
CLV_PCSK_KEX2_1 966 968 PF00082 0.428
CLV_PCSK_KEX2_1 99 101 PF00082 0.516
CLV_PCSK_PC1ET2_1 162 164 PF00082 0.594
CLV_PCSK_PC1ET2_1 385 387 PF00082 0.632
CLV_PCSK_PC1ET2_1 907 909 PF00082 0.434
CLV_PCSK_PC1ET2_1 966 968 PF00082 0.428
CLV_PCSK_SKI1_1 1013 1017 PF00082 0.354
CLV_PCSK_SKI1_1 1044 1048 PF00082 0.469
CLV_PCSK_SKI1_1 253 257 PF00082 0.514
CLV_PCSK_SKI1_1 315 319 PF00082 0.526
CLV_PCSK_SKI1_1 331 335 PF00082 0.474
CLV_PCSK_SKI1_1 400 404 PF00082 0.389
CLV_PCSK_SKI1_1 454 458 PF00082 0.350
CLV_PCSK_SKI1_1 479 483 PF00082 0.350
CLV_PCSK_SKI1_1 531 535 PF00082 0.382
CLV_PCSK_SKI1_1 815 819 PF00082 0.456
CLV_PCSK_SKI1_1 857 861 PF00082 0.330
CLV_Separin_Metazoa 114 118 PF03568 0.685
CLV_Separin_Metazoa 248 252 PF03568 0.629
CLV_Separin_Metazoa 706 710 PF03568 0.492
DEG_APCC_DBOX_1 314 322 PF00400 0.630
DEG_APCC_DBOX_1 399 407 PF00400 0.387
DEG_APCC_DBOX_1 856 864 PF00400 0.336
DEG_SPOP_SBC_1 919 923 PF00917 0.504
DOC_ANK_TNKS_1 388 395 PF00023 0.435
DOC_CKS1_1 168 173 PF01111 0.667
DOC_CKS1_1 181 186 PF01111 0.681
DOC_CKS1_1 366 371 PF01111 0.699
DOC_CKS1_1 455 460 PF01111 0.350
DOC_CYCLIN_RxL_1 239 248 PF00134 0.623
DOC_CYCLIN_RxL_1 809 820 PF00134 0.453
DOC_CYCLIN_yCln2_LP_2 838 844 PF00134 0.381
DOC_MAPK_DCC_7 575 585 PF00069 0.330
DOC_MAPK_DCC_7 649 658 PF00069 0.318
DOC_MAPK_DCC_7 717 726 PF00069 0.381
DOC_MAPK_gen_1 312 323 PF00069 0.463
DOC_MAPK_gen_1 375 384 PF00069 0.448
DOC_MAPK_gen_1 572 580 PF00069 0.330
DOC_MAPK_gen_1 855 862 PF00069 0.328
DOC_MAPK_MEF2A_6 717 726 PF00069 0.381
DOC_MAPK_MEF2A_6 836 845 PF00069 0.372
DOC_MAPK_MEF2A_6 855 862 PF00069 0.328
DOC_MAPK_NFAT4_5 855 863 PF00069 0.327
DOC_PP1_RVXF_1 721 727 PF00149 0.382
DOC_PP1_RVXF_1 905 912 PF00149 0.424
DOC_PP2B_LxvP_1 402 405 PF13499 0.384
DOC_USP7_MATH_1 341 345 PF00917 0.487
DOC_USP7_MATH_1 505 509 PF00917 0.359
DOC_USP7_MATH_1 641 645 PF00917 0.318
DOC_USP7_MATH_1 664 668 PF00917 0.508
DOC_USP7_MATH_1 789 793 PF00917 0.365
DOC_USP7_MATH_1 917 921 PF00917 0.484
DOC_USP7_UBL2_3 796 800 PF12436 0.491
DOC_WW_Pin1_4 167 172 PF00397 0.658
DOC_WW_Pin1_4 177 182 PF00397 0.684
DOC_WW_Pin1_4 25 30 PF00397 0.741
DOC_WW_Pin1_4 272 277 PF00397 0.880
DOC_WW_Pin1_4 365 370 PF00397 0.699
DOC_WW_Pin1_4 447 452 PF00397 0.507
DOC_WW_Pin1_4 454 459 PF00397 0.350
DOC_WW_Pin1_4 578 583 PF00397 0.454
LIG_14-3-3_CanoR_1 128 137 PF00244 0.543
LIG_14-3-3_CanoR_1 163 171 PF00244 0.782
LIG_14-3-3_CanoR_1 293 302 PF00244 0.676
LIG_14-3-3_CanoR_1 340 350 PF00244 0.483
LIG_14-3-3_CanoR_1 540 544 PF00244 0.525
LIG_14-3-3_CanoR_1 717 724 PF00244 0.376
LIG_14-3-3_CanoR_1 729 736 PF00244 0.382
LIG_14-3-3_CanoR_1 746 752 PF00244 0.268
LIG_14-3-3_CanoR_1 918 927 PF00244 0.495
LIG_14-3-3_CanoR_1 949 958 PF00244 0.525
LIG_14-3-3_CterR_2 1044 1049 PF00244 0.485
LIG_Actin_WH2_2 433 448 PF00022 0.291
LIG_Actin_WH2_2 721 739 PF00022 0.486
LIG_AP2alpha_1 478 482 PF02296 0.525
LIG_BRCT_BRCA1_1 1004 1008 PF00533 0.341
LIG_BRCT_BRCA1_1 428 432 PF00533 0.389
LIG_Clathr_ClatBox_1 512 516 PF01394 0.350
LIG_deltaCOP1_diTrp_1 198 205 PF00928 0.613
LIG_deltaCOP1_diTrp_1 216 220 PF00928 0.319
LIG_deltaCOP1_diTrp_1 685 689 PF00928 0.405
LIG_deltaCOP1_diTrp_1 903 911 PF00928 0.420
LIG_EVH1_1 362 366 PF00568 0.502
LIG_FHA_1 102 108 PF00498 0.639
LIG_FHA_1 153 159 PF00498 0.605
LIG_FHA_1 245 251 PF00498 0.438
LIG_FHA_1 397 403 PF00498 0.390
LIG_FHA_1 414 420 PF00498 0.390
LIG_FHA_1 540 546 PF00498 0.525
LIG_FHA_1 569 575 PF00498 0.380
LIG_FHA_1 604 610 PF00498 0.350
LIG_FHA_1 723 729 PF00498 0.378
LIG_FHA_1 748 754 PF00498 0.451
LIG_FHA_1 80 86 PF00498 0.556
LIG_FHA_1 801 807 PF00498 0.412
LIG_FHA_1 833 839 PF00498 0.367
LIG_FHA_1 938 944 PF00498 0.332
LIG_FHA_1 986 992 PF00498 0.341
LIG_FHA_2 1012 1018 PF00498 0.418
LIG_FHA_2 122 128 PF00498 0.607
LIG_FHA_2 193 199 PF00498 0.522
LIG_FHA_2 273 279 PF00498 0.773
LIG_FHA_2 306 312 PF00498 0.614
LIG_FHA_2 34 40 PF00498 0.707
LIG_FHA_2 49 55 PF00498 0.521
LIG_FHA_2 61 67 PF00498 0.750
LIG_FHA_2 633 639 PF00498 0.420
LIG_FHA_2 920 926 PF00498 0.504
LIG_IRF3_LxIS_1 779 786 PF10401 0.388
LIG_LIR_Gen_1 1014 1023 PF02991 0.224
LIG_LIR_Gen_1 459 470 PF02991 0.525
LIG_LIR_Gen_1 518 529 PF02991 0.350
LIG_LIR_Gen_1 696 707 PF02991 0.402
LIG_LIR_Gen_1 847 858 PF02991 0.323
LIG_LIR_Gen_1 994 1003 PF02991 0.347
LIG_LIR_Nem_3 1014 1019 PF02991 0.225
LIG_LIR_Nem_3 459 465 PF02991 0.493
LIG_LIR_Nem_3 475 481 PF02991 0.238
LIG_LIR_Nem_3 518 524 PF02991 0.525
LIG_LIR_Nem_3 542 546 PF02991 0.525
LIG_LIR_Nem_3 692 698 PF02991 0.389
LIG_LIR_Nem_3 847 853 PF02991 0.387
LIG_LIR_Nem_3 978 983 PF02991 0.360
LIG_LIR_Nem_3 994 999 PF02991 0.347
LIG_NRBOX 723 729 PF00104 0.378
LIG_PCNA_yPIPBox_3 239 250 PF02747 0.444
LIG_PCNA_yPIPBox_3 855 863 PF02747 0.327
LIG_Pex14_1 201 205 PF04695 0.632
LIG_Pex14_2 478 482 PF04695 0.350
LIG_Rb_LxCxE_1 127 139 PF01857 0.607
LIG_SH2_CRK 521 525 PF00017 0.525
LIG_SH2_NCK_1 231 235 PF00017 0.473
LIG_SH2_NCK_1 521 525 PF00017 0.479
LIG_SH2_STAP1 231 235 PF00017 0.648
LIG_SH2_STAP1 695 699 PF00017 0.385
LIG_SH2_STAT3 240 243 PF00017 0.629
LIG_SH2_STAT5 1033 1036 PF00017 0.400
LIG_SH2_STAT5 231 234 PF00017 0.467
LIG_SH2_STAT5 285 288 PF00017 0.869
LIG_SH2_STAT5 608 611 PF00017 0.330
LIG_SH2_STAT5 698 701 PF00017 0.392
LIG_SH3_1 452 458 PF00018 0.350
LIG_SH3_2 184 189 PF14604 0.804
LIG_SH3_2 257 262 PF14604 0.815
LIG_SH3_3 173 179 PF00018 0.708
LIG_SH3_3 181 187 PF00018 0.773
LIG_SH3_3 254 260 PF00018 0.742
LIG_SH3_3 27 33 PF00018 0.764
LIG_SH3_3 360 366 PF00018 0.512
LIG_SH3_3 437 443 PF00018 0.381
LIG_SH3_3 452 458 PF00018 0.350
LIG_SH3_3 471 477 PF00018 0.350
LIG_SH3_3 576 582 PF00018 0.330
LIG_SH3_3 611 617 PF00018 0.330
LIG_SH3_3 658 664 PF00018 0.420
LIG_SH3_3 85 91 PF00018 0.631
LIG_SH3_3 859 865 PF00018 0.555
LIG_SH3_3 881 887 PF00018 0.410
LIG_SH3_3 911 917 PF00018 0.386
LIG_SUMO_SIM_anti_2 610 616 PF11976 0.330
LIG_SUMO_SIM_anti_2 750 755 PF11976 0.453
LIG_SUMO_SIM_par_1 510 516 PF11976 0.350
LIG_SUMO_SIM_par_1 544 549 PF11976 0.525
LIG_SUMO_SIM_par_1 981 988 PF11976 0.347
LIG_TRAF2_1 1015 1018 PF00917 0.401
LIG_TRAF2_1 261 264 PF00917 0.859
LIG_TRAF2_1 267 270 PF00917 0.765
LIG_TRAF2_1 308 311 PF00917 0.600
LIG_TRAF2_1 6 9 PF00917 0.851
LIG_ULM_U2AF65_1 965 970 PF00076 0.410
MOD_CDK_SPK_2 167 172 PF00069 0.803
MOD_CDK_SPK_2 272 277 PF00069 0.880
MOD_CDK_SPK_2 447 452 PF00069 0.507
MOD_CDK_SPxxK_3 447 454 PF00069 0.350
MOD_CK1_1 1011 1017 PF00069 0.364
MOD_CK1_1 1021 1027 PF00069 0.332
MOD_CK1_1 48 54 PF00069 0.756
MOD_CK1_1 508 514 PF00069 0.350
MOD_CK1_1 61 67 PF00069 0.551
MOD_CK1_1 920 926 PF00069 0.512
MOD_CK1_1 984 990 PF00069 0.343
MOD_CK2_1 1011 1017 PF00069 0.422
MOD_CK2_1 128 134 PF00069 0.618
MOD_CK2_1 264 270 PF00069 0.699
MOD_CK2_1 272 278 PF00069 0.699
MOD_CK2_1 305 311 PF00069 0.632
MOD_CK2_1 33 39 PF00069 0.781
MOD_CK2_1 546 552 PF00069 0.444
MOD_CK2_1 60 66 PF00069 0.801
MOD_CK2_1 729 735 PF00069 0.488
MOD_CK2_1 897 903 PF00069 0.446
MOD_CK2_1 919 925 PF00069 0.498
MOD_CMANNOS 217 220 PF00535 0.458
MOD_CMANNOS 969 972 PF00535 0.402
MOD_Cter_Amidation 146 149 PF01082 0.661
MOD_Cter_Amidation 561 564 PF01082 0.350
MOD_Cter_Amidation 793 796 PF01082 0.422
MOD_DYRK1A_RPxSP_1 454 458 PF00069 0.350
MOD_GlcNHglycan 1004 1007 PF01048 0.359
MOD_GlcNHglycan 138 141 PF01048 0.640
MOD_GlcNHglycan 18 21 PF01048 0.691
MOD_GlcNHglycan 428 431 PF01048 0.414
MOD_GlcNHglycan 447 450 PF01048 0.371
MOD_GlcNHglycan 507 510 PF01048 0.359
MOD_GlcNHglycan 649 652 PF01048 0.420
MOD_GlcNHglycan 666 669 PF01048 0.344
MOD_GlcNHglycan 679 682 PF01048 0.380
MOD_GlcNHglycan 718 721 PF01048 0.369
MOD_GlcNHglycan 731 734 PF01048 0.393
MOD_GlcNHglycan 738 741 PF01048 0.247
MOD_GlcNHglycan 899 902 PF01048 0.413
MOD_GlcNHglycan 922 925 PF01048 0.517
MOD_GlcNHglycan 951 954 PF01048 0.571
MOD_GSK3_1 102 109 PF00069 0.645
MOD_GSK3_1 163 170 PF00069 0.778
MOD_GSK3_1 185 192 PF00069 0.725
MOD_GSK3_1 21 28 PF00069 0.742
MOD_GSK3_1 641 648 PF00069 0.318
MOD_GSK3_1 981 988 PF00069 0.347
MOD_N-GLC_1 107 112 PF02516 0.503
MOD_N-GLC_1 426 431 PF02516 0.580
MOD_N-GLC_2 881 883 PF02516 0.378
MOD_NEK2_1 107 112 PF00069 0.653
MOD_NEK2_1 121 126 PF00069 0.390
MOD_NEK2_1 229 234 PF00069 0.468
MOD_NEK2_1 249 254 PF00069 0.285
MOD_NEK2_1 413 418 PF00069 0.568
MOD_NEK2_1 445 450 PF00069 0.383
MOD_NEK2_1 515 520 PF00069 0.350
MOD_NEK2_1 539 544 PF00069 0.525
MOD_NEK2_1 568 573 PF00069 0.350
MOD_NEK2_1 584 589 PF00069 0.350
MOD_NEK2_1 632 637 PF00069 0.454
MOD_NEK2_1 647 652 PF00069 0.245
MOD_NEK2_1 677 682 PF00069 0.533
MOD_NEK2_1 716 721 PF00069 0.370
MOD_NEK2_1 727 732 PF00069 0.372
MOD_NEK2_1 736 741 PF00069 0.247
MOD_NEK2_1 783 788 PF00069 0.406
MOD_NEK2_1 927 932 PF00069 0.536
MOD_NEK2_1 985 990 PF00069 0.343
MOD_NEK2_2 329 334 PF00069 0.443
MOD_PIKK_1 28 34 PF00454 0.831
MOD_PIKK_1 58 64 PF00454 0.819
MOD_PIKK_1 778 784 PF00454 0.331
MOD_PKA_2 192 198 PF00069 0.706
MOD_PKA_2 341 347 PF00069 0.477
MOD_PKA_2 500 506 PF00069 0.525
MOD_PKA_2 522 528 PF00069 0.350
MOD_PKA_2 539 545 PF00069 0.349
MOD_PKA_2 677 683 PF00069 0.534
MOD_PKA_2 716 722 PF00069 0.377
MOD_PKA_2 736 742 PF00069 0.244
MOD_PKA_2 917 923 PF00069 0.494
MOD_Plk_1 414 420 PF00069 0.390
MOD_Plk_1 546 552 PF00069 0.525
MOD_Plk_1 610 616 PF00069 0.330
MOD_Plk_1 927 933 PF00069 0.362
MOD_Plk_4 224 230 PF00069 0.443
MOD_Plk_4 457 463 PF00069 0.525
MOD_Plk_4 508 514 PF00069 0.350
MOD_Plk_4 610 616 PF00069 0.330
MOD_Plk_4 722 728 PF00069 0.381
MOD_Plk_4 749 755 PF00069 0.429
MOD_Plk_4 813 819 PF00069 0.401
MOD_ProDKin_1 167 173 PF00069 0.662
MOD_ProDKin_1 177 183 PF00069 0.683
MOD_ProDKin_1 25 31 PF00069 0.743
MOD_ProDKin_1 272 278 PF00069 0.882
MOD_ProDKin_1 365 371 PF00069 0.694
MOD_ProDKin_1 447 453 PF00069 0.350
MOD_ProDKin_1 454 460 PF00069 0.350
MOD_ProDKin_1 578 584 PF00069 0.454
MOD_SUMO_for_1 374 377 PF00179 0.647
TRG_AP2beta_CARGO_1 847 857 PF09066 0.382
TRG_DiLeu_BaEn_1 408 413 PF01217 0.421
TRG_DiLeu_BaEn_1 415 420 PF01217 0.383
TRG_DiLeu_BaLyEn_6 1042 1047 PF01217 0.449
TRG_DiLeu_BaLyEn_6 579 584 PF01217 0.330
TRG_DiLeu_BaLyEn_6 854 859 PF01217 0.378
TRG_ENDOCYTIC_2 521 524 PF00928 0.350
TRG_ER_diArg_1 1044 1046 PF00400 0.411
TRG_ER_diArg_1 191 194 PF00400 0.742
TRG_ER_diArg_1 250 253 PF00400 0.538
TRG_ER_diArg_1 312 315 PF00400 0.600
TRG_ER_diArg_1 339 342 PF00400 0.494
TRG_ER_diArg_1 434 437 PF00400 0.373
TRG_ER_diArg_1 563 565 PF00400 0.525
TRG_ER_diArg_1 68 71 PF00400 0.835
TRG_ER_diArg_1 854 857 PF00400 0.317
TRG_ER_diArg_1 97 100 PF00400 0.676
TRG_NLS_Bipartite_1 148 166 PF00514 0.709
TRG_NLS_MonoCore_2 964 969 PF00514 0.470
TRG_NLS_MonoExtC_3 161 167 PF00514 0.606
TRG_NLS_MonoExtC_3 965 971 PF00514 0.474
TRG_NLS_MonoExtN_4 159 166 PF00514 0.596
TRG_NLS_MonoExtN_4 965 970 PF00514 0.410
TRG_Pf-PMV_PEXEL_1 1025 1029 PF00026 0.388
TRG_Pf-PMV_PEXEL_1 210 215 PF00026 0.481
TRG_Pf-PMV_PEXEL_1 316 320 PF00026 0.520
TRG_Pf-PMV_PEXEL_1 331 335 PF00026 0.474
TRG_Pf-PMV_PEXEL_1 351 356 PF00026 0.317
TRG_Pf-PMV_PEXEL_1 479 483 PF00026 0.525
TRG_Pf-PMV_PEXEL_1 836 840 PF00026 0.370
TRG_Pf-PMV_PEXEL_1 861 866 PF00026 0.423

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZG3 Leptomonas seymouri 62% 69%
A4H3E8 Leishmania braziliensis 97% 91%
A4H8H1 Leishmania braziliensis 98% 100%
P15594 Trypanosoma brucei gambiense 31% 89%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS