Glutaredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8J9_LEIBR

TriTrypDb:

LbrM.16.0760 , LBRM2903_160014200

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8J9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8J9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	428	432	PF00656	0.412
CLV_NRD_NRD_1	299	301	PF00675	0.678
CLV_NRD_NRD_1	39	41	PF00675	0.455
CLV_NRD_NRD_1	437	439	PF00675	0.386
CLV_NRD_NRD_1	440	442	PF00675	0.414
CLV_NRD_NRD_1	494	496	PF00675	0.435
CLV_NRD_NRD_1	503	505	PF00675	0.381
CLV_PCSK_FUR_1	438	442	PF00082	0.465
CLV_PCSK_KEX2_1	299	301	PF00082	0.678
CLV_PCSK_KEX2_1	39	41	PF00082	0.452
CLV_PCSK_KEX2_1	437	439	PF00082	0.386
CLV_PCSK_KEX2_1	440	442	PF00082	0.414
CLV_PCSK_KEX2_1	493	495	PF00082	0.466
CLV_PCSK_KEX2_1	502	504	PF00082	0.379
CLV_PCSK_KEX2_1	518	520	PF00082	0.650
CLV_PCSK_PC1ET2_1	518	520	PF00082	0.666
CLV_PCSK_PC7_1	490	496	PF00082	0.419
CLV_PCSK_SKI1_1	352	356	PF00082	0.477
CLV_PCSK_SKI1_1	359	363	PF00082	0.509
CLV_PCSK_SKI1_1	39	43	PF00082	0.443
CLV_PCSK_SKI1_1	494	498	PF00082	0.463
DEG_APCC_DBOX_1	503	511	PF00400	0.481
DEG_SPOP_SBC_1	142	146	PF00917	0.607
DOC_CYCLIN_RxL_1	11	23	PF00134	0.404
DOC_MAPK_gen_1	502	510	PF00069	0.381
DOC_MAPK_gen_1	518	525	PF00069	0.460
DOC_MAPK_MEF2A_6	503	512	PF00069	0.397
DOC_MAPK_MEF2A_6	82	89	PF00069	0.522
DOC_PP2B_LxvP_1	512	515	PF13499	0.536
DOC_USP7_MATH_1	235	239	PF00917	0.594
DOC_USP7_MATH_1	272	276	PF00917	0.738
DOC_USP7_MATH_1	304	308	PF00917	0.668
DOC_USP7_MATH_1	361	365	PF00917	0.559
DOC_USP7_MATH_1	521	525	PF00917	0.627
DOC_USP7_MATH_1	92	96	PF00917	0.597
DOC_WW_Pin1_4	169	174	PF00397	0.613
DOC_WW_Pin1_4	195	200	PF00397	0.617
DOC_WW_Pin1_4	202	207	PF00397	0.660
DOC_WW_Pin1_4	231	236	PF00397	0.531
DOC_WW_Pin1_4	289	294	PF00397	0.723
LIG_14-3-3_CanoR_1	136	142	PF00244	0.567
LIG_14-3-3_CanoR_1	191	199	PF00244	0.629
LIG_14-3-3_CanoR_1	241	251	PF00244	0.563
LIG_14-3-3_CanoR_1	529	535	PF00244	0.563
LIG_14-3-3_CanoR_1	540	546	PF00244	0.554
LIG_14-3-3_CanoR_1	97	105	PF00244	0.538
LIG_BIR_II_1	1	5	PF00653	0.513
LIG_BIR_III_2	232	236	PF00653	0.529
LIG_BIR_III_4	445	449	PF00653	0.377
LIG_BIR_III_4	498	502	PF00653	0.331
LIG_BRCT_BRCA1_1	431	435	PF00533	0.481
LIG_Clathr_ClatBox_1	457	461	PF01394	0.352
LIG_FHA_1	11	17	PF00498	0.436
LIG_FHA_1	151	157	PF00498	0.615
LIG_FHA_1	196	202	PF00498	0.626
LIG_FHA_1	342	348	PF00498	0.507
LIG_FHA_1	424	430	PF00498	0.368
LIG_FHA_1	460	466	PF00498	0.436
LIG_FHA_1	531	537	PF00498	0.580
LIG_FHA_1	82	88	PF00498	0.558
LIG_FHA_2	142	148	PF00498	0.664
LIG_FHA_2	170	176	PF00498	0.551
LIG_FHA_2	353	359	PF00498	0.504
LIG_FHA_2	40	46	PF00498	0.501
LIG_FHA_2	468	474	PF00498	0.376
LIG_LIR_Nem_3	125	131	PF02991	0.633
LIG_LIR_Nem_3	368	374	PF02991	0.504
LIG_MLH1_MIPbox_1	431	435	PF16413	0.481
LIG_PTB_Apo_2	412	419	PF02174	0.370
LIG_REV1ctd_RIR_1	432	442	PF16727	0.412
LIG_SH2_STAT5	34	37	PF00017	0.403
LIG_SH2_STAT5	341	344	PF00017	0.646
LIG_SH2_STAT5	49	52	PF00017	0.442
LIG_SH3_1	104	110	PF00018	0.521
LIG_SH3_3	104	110	PF00018	0.598
LIG_SH3_3	163	169	PF00018	0.534
LIG_SH3_3	194	200	PF00018	0.686
LIG_SH3_3	223	229	PF00018	0.537
LIG_SH3_3	298	304	PF00018	0.682
LIG_SH3_3	450	456	PF00018	0.424
LIG_SH3_3	505	511	PF00018	0.527
LIG_SH3_3	524	530	PF00018	0.574
LIG_SH3_3	535	541	PF00018	0.554
LIG_SH3_3	82	88	PF00018	0.669
LIG_SH3_CIN85_PxpxPR_1	106	111	PF14604	0.545
LIG_SUMO_SIM_par_1	425	433	PF11976	0.389
LIG_SUMO_SIM_par_1	467	473	PF11976	0.298
LIG_TRAF2_1	354	357	PF00917	0.549
LIG_TRAF2_1	470	473	PF00917	0.381
LIG_UBA3_1	347	352	PF00899	0.508
LIG_UBA3_1	412	420	PF00899	0.370
MOD_CDC14_SPxK_1	234	237	PF00782	0.527
MOD_CDK_SPxK_1	231	237	PF00069	0.533
MOD_CK1_1	143	149	PF00069	0.620
MOD_CK1_1	159	165	PF00069	0.560
MOD_CK1_1	193	199	PF00069	0.646
MOD_CK1_1	205	211	PF00069	0.585
MOD_CK1_1	219	225	PF00069	0.543
MOD_CK1_1	292	298	PF00069	0.671
MOD_CK1_1	444	450	PF00069	0.376
MOD_CK1_1	60	66	PF00069	0.553
MOD_CK1_1	95	101	PF00069	0.670
MOD_CK2_1	141	147	PF00069	0.668
MOD_CK2_1	169	175	PF00069	0.545
MOD_CK2_1	242	248	PF00069	0.535
MOD_CK2_1	352	358	PF00069	0.512
MOD_CK2_1	39	45	PF00069	0.515
MOD_CK2_1	467	473	PF00069	0.376
MOD_Cter_Amidation	500	503	PF01082	0.334
MOD_GlcNHglycan	161	164	PF01048	0.651
MOD_GlcNHglycan	178	181	PF01048	0.523
MOD_GlcNHglycan	192	195	PF01048	0.645
MOD_GlcNHglycan	269	272	PF01048	0.727
MOD_GlcNHglycan	3	6	PF01048	0.470
MOD_GlcNHglycan	311	314	PF01048	0.711
MOD_GlcNHglycan	59	62	PF01048	0.513
MOD_GSK3_1	136	143	PF00069	0.620
MOD_GSK3_1	146	153	PF00069	0.616
MOD_GSK3_1	176	183	PF00069	0.698
MOD_GSK3_1	201	208	PF00069	0.642
MOD_GSK3_1	231	238	PF00069	0.596
MOD_GSK3_1	285	292	PF00069	0.779
MOD_GSK3_1	304	311	PF00069	0.684
MOD_GSK3_1	394	401	PF00069	0.351
MOD_GSK3_1	6	13	PF00069	0.478
MOD_GSK3_1	60	67	PF00069	0.576
MOD_GSK3_1	74	81	PF00069	0.666
MOD_GSK3_1	92	99	PF00069	0.515
MOD_N-GLC_1	266	271	PF02516	0.545
MOD_N-GLC_1	541	546	PF02516	0.568
MOD_NEK2_1	1	6	PF00069	0.693
MOD_NEK2_1	309	314	PF00069	0.565
MOD_NEK2_1	394	399	PF00069	0.370
MOD_NEK2_1	459	464	PF00069	0.462
MOD_NEK2_1	64	69	PF00069	0.595
MOD_NEK2_1	96	101	PF00069	0.560
MOD_NEK2_2	92	97	PF00069	0.537
MOD_PIKK_1	137	143	PF00454	0.539
MOD_PIKK_1	34	40	PF00454	0.360
MOD_PIKK_1	361	367	PF00454	0.588
MOD_PK_1	253	259	PF00069	0.532
MOD_PKA_1	39	45	PF00069	0.515
MOD_PKA_2	116	122	PF00069	0.486
MOD_PKA_2	176	182	PF00069	0.797
MOD_PKA_2	190	196	PF00069	0.591
MOD_PKA_2	39	45	PF00069	0.502
MOD_PKA_2	528	534	PF00069	0.532
MOD_PKA_2	73	79	PF00069	0.664
MOD_PKA_2	81	87	PF00069	0.584
MOD_PKA_2	96	102	PF00069	0.547
MOD_PKB_1	72	80	PF00069	0.541
MOD_Plk_1	253	259	PF00069	0.530
MOD_Plk_1	375	381	PF00069	0.441
MOD_Plk_1	460	466	PF00069	0.320
MOD_Plk_1	541	547	PF00069	0.558
MOD_Plk_1	92	98	PF00069	0.537
MOD_Plk_2-3	376	382	PF00069	0.430
MOD_Plk_2-3	467	473	PF00069	0.376
MOD_Plk_4	205	211	PF00069	0.646
MOD_Plk_4	304	310	PF00069	0.574
MOD_Plk_4	376	382	PF00069	0.444
MOD_Plk_4	460	466	PF00069	0.312
MOD_Plk_4	60	66	PF00069	0.537
MOD_ProDKin_1	169	175	PF00069	0.616
MOD_ProDKin_1	195	201	PF00069	0.639
MOD_ProDKin_1	202	208	PF00069	0.659
MOD_ProDKin_1	231	237	PF00069	0.533
MOD_ProDKin_1	289	295	PF00069	0.724
MOD_SUMO_for_1	50	53	PF00179	0.517
MOD_SUMO_rev_2	345	354	PF00179	0.734
MOD_SUMO_rev_2	475	485	PF00179	0.377
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.516
TRG_DiLeu_BaLyEn_6	453	458	PF01217	0.376
TRG_ER_diArg_1	110	113	PF00400	0.611
TRG_ER_diArg_1	299	301	PF00400	0.800
TRG_ER_diArg_1	39	41	PF00400	0.455
TRG_ER_diArg_1	437	440	PF00400	0.399
TRG_ER_diArg_1	492	495	PF00400	0.424
TRG_ER_diArg_1	502	504	PF00400	0.434
TRG_ER_diArg_1	72	75	PF00400	0.549
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	440	445	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS0	Leptomonas seymouri	37%	73%
A0A3Q8IDN2	Leishmania donovani	67%	95%
A4HWX4	Leishmania infantum	67%	95%
E9AQN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	95%
Q4QEU2	Leishmania major	66%	100%