Flavin-containing monooxygenase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H8J7_LEIBR

TriTrypDb:

LbrM.16.0740 , LBRM2903_160013900

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8J7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	321	325	PF00656	0.460
CLV_C14_Caspase3-7	451	455	PF00656	0.492
CLV_MEL_PAP_1	353	359	PF00089	0.304
CLV_NRD_NRD_1	283	285	PF00675	0.614
CLV_NRD_NRD_1	415	417	PF00675	0.347
CLV_NRD_NRD_1	578	580	PF00675	0.487
CLV_NRD_NRD_1	588	590	PF00675	0.464
CLV_PCSK_FUR_1	575	579	PF00082	0.485
CLV_PCSK_FUR_1	586	590	PF00082	0.441
CLV_PCSK_KEX2_1	283	285	PF00082	0.600
CLV_PCSK_KEX2_1	415	417	PF00082	0.347
CLV_PCSK_KEX2_1	577	579	PF00082	0.496
CLV_PCSK_KEX2_1	586	588	PF00082	0.457
CLV_PCSK_KEX2_1	68	70	PF00082	0.427
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.416
CLV_PCSK_SKI1_1	213	217	PF00082	0.455
CLV_PCSK_SKI1_1	230	234	PF00082	0.342
CLV_PCSK_SKI1_1	25	29	PF00082	0.483
CLV_PCSK_SKI1_1	252	256	PF00082	0.457
CLV_PCSK_SKI1_1	425	429	PF00082	0.422
CLV_PCSK_SKI1_1	51	55	PF00082	0.384
CLV_Separin_Metazoa	583	587	PF03568	0.377
DEG_Nend_Nbox_1	1	3	PF02207	0.401
DEG_SCF_FBW7_1	15	20	PF00400	0.472
DEG_SPOP_SBC_1	487	491	PF00917	0.773
DEG_SPOP_SBC_1	547	551	PF00917	0.585
DOC_ANK_TNKS_1	282	289	PF00023	0.493
DOC_CYCLIN_RxL_1	21	30	PF00134	0.471
DOC_CYCLIN_RxL_1	420	432	PF00134	0.434
DOC_MAPK_DCC_7	44	52	PF00069	0.379
DOC_MAPK_gen_1	165	175	PF00069	0.626
DOC_MAPK_MEF2A_6	44	52	PF00069	0.387
DOC_PP2B_LxvP_1	113	116	PF13499	0.362
DOC_USP7_MATH_1	109	113	PF00917	0.754
DOC_USP7_MATH_1	155	159	PF00917	0.652
DOC_USP7_MATH_1	205	209	PF00917	0.733
DOC_USP7_MATH_1	364	368	PF00917	0.553
DOC_USP7_MATH_1	369	373	PF00917	0.599
DOC_USP7_MATH_1	374	378	PF00917	0.571
DOC_USP7_MATH_1	547	551	PF00917	0.609
DOC_WW_Pin1_4	104	109	PF00397	0.718
DOC_WW_Pin1_4	13	18	PF00397	0.382
DOC_WW_Pin1_4	194	199	PF00397	0.527
DOC_WW_Pin1_4	293	298	PF00397	0.660
DOC_WW_Pin1_4	365	370	PF00397	0.484
DOC_WW_Pin1_4	466	471	PF00397	0.448
LIG_14-3-3_CanoR_1	69	78	PF00244	0.430
LIG_APCC_ABBA_1	50	55	PF00400	0.374
LIG_BIR_III_4	114	118	PF00653	0.464
LIG_BRCT_BRCA1_1	366	370	PF00533	0.476
LIG_EVH1_2	461	465	PF00568	0.451
LIG_FHA_1	116	122	PF00498	0.382
LIG_FHA_1	219	225	PF00498	0.303
LIG_FHA_1	294	300	PF00498	0.598
LIG_FHA_2	336	342	PF00498	0.487
LIG_FHA_2	374	380	PF00498	0.422
LIG_FHA_2	488	494	PF00498	0.720
LIG_LIR_Gen_1	132	142	PF02991	0.453
LIG_LIR_Gen_1	260	271	PF02991	0.421
LIG_LIR_Nem_3	132	138	PF02991	0.450
LIG_LIR_Nem_3	186	191	PF02991	0.463
LIG_LIR_Nem_3	260	266	PF02991	0.433
LIG_LIR_Nem_3	72	78	PF02991	0.430
LIG_LYPXL_S_1	74	78	PF13949	0.419
LIG_LYPXL_yS_3	75	78	PF13949	0.422
LIG_MYND_1	76	80	PF01753	0.421
LIG_NRBOX	270	276	PF00104	0.423
LIG_NRBOX	531	537	PF00104	0.434
LIG_Pex14_1	49	53	PF04695	0.381
LIG_Pex14_1	71	75	PF04695	0.417
LIG_Pex14_2	2	6	PF04695	0.401
LIG_PTAP_UEV_1	151	156	PF05743	0.634
LIG_PTB_Apo_2	356	363	PF02174	0.310
LIG_REV1ctd_RIR_1	315	324	PF16727	0.336
LIG_SH2_CRK	263	267	PF00017	0.363
LIG_SH2_STAT3	191	194	PF00017	0.461
LIG_SH2_STAT5	120	123	PF00017	0.343
LIG_SH2_STAT5	242	245	PF00017	0.323
LIG_SH2_STAT5	26	29	PF00017	0.390
LIG_SH2_STAT5	510	513	PF00017	0.505
LIG_SH3_3	100	106	PF00018	0.755
LIG_SH3_3	149	155	PF00018	0.725
LIG_SH3_3	450	456	PF00018	0.507
LIG_SUMO_SIM_par_1	324	331	PF11976	0.297
LIG_TRAF2_1	184	187	PF00917	0.463
LIG_TYR_ITSM	259	266	PF00017	0.384
MOD_CDK_SPxK_1	15	21	PF00069	0.416
MOD_CK1_1	104	110	PF00069	0.614
MOD_CK1_1	203	209	PF00069	0.754
MOD_CK1_1	373	379	PF00069	0.537
MOD_CK1_1	538	544	PF00069	0.426
MOD_CK1_1	546	552	PF00069	0.480
MOD_CK2_1	488	494	PF00069	0.546
MOD_Cter_Amidation	66	69	PF01082	0.446
MOD_GlcNHglycan	103	106	PF01048	0.539
MOD_GlcNHglycan	152	155	PF01048	0.633
MOD_GlcNHglycan	180	183	PF01048	0.376
MOD_GlcNHglycan	207	210	PF01048	0.669
MOD_GlcNHglycan	289	292	PF01048	0.647
MOD_GlcNHglycan	308	311	PF01048	0.327
MOD_GlcNHglycan	490	493	PF01048	0.754
MOD_GlcNHglycan	507	510	PF01048	0.702
MOD_GlcNHglycan	545	548	PF01048	0.526
MOD_GSK3_1	11	18	PF00069	0.375
MOD_GSK3_1	200	207	PF00069	0.672
MOD_GSK3_1	209	216	PF00069	0.547
MOD_GSK3_1	258	265	PF00069	0.449
MOD_GSK3_1	287	294	PF00069	0.737
MOD_GSK3_1	301	308	PF00069	0.413
MOD_GSK3_1	365	372	PF00069	0.583
MOD_GSK3_1	403	410	PF00069	0.469
MOD_GSK3_1	488	495	PF00069	0.718
MOD_GSK3_1	505	512	PF00069	0.588
MOD_GSK3_1	543	550	PF00069	0.524
MOD_GSK3_1	599	606	PF00069	0.692
MOD_LATS_1	148	154	PF00433	0.580
MOD_LATS_1	23	29	PF00433	0.479
MOD_N-GLC_1	370	375	PF02516	0.477
MOD_N-GLC_2	59	61	PF02516	0.263
MOD_NEK2_1	11	16	PF00069	0.365
MOD_NEK2_1	129	134	PF00069	0.394
MOD_NEK2_1	237	242	PF00069	0.267
MOD_NEK2_1	27	32	PF00069	0.429
MOD_NEK2_1	301	306	PF00069	0.438
MOD_NEK2_1	355	360	PF00069	0.326
MOD_NEK2_1	438	443	PF00069	0.435
MOD_NEK2_1	535	540	PF00069	0.406
MOD_OFUCOSY	39	46	PF10250	0.306
MOD_PIKK_1	200	206	PF00454	0.676
MOD_PIKK_1	403	409	PF00454	0.473
MOD_PIKK_1	438	444	PF00454	0.422
MOD_PIKK_1	69	75	PF00454	0.434
MOD_PK_1	262	268	PF00069	0.366
MOD_PKA_2	319	325	PF00069	0.322
MOD_PKA_2	355	361	PF00069	0.317
MOD_PKA_2	593	599	PF00069	0.648
MOD_Plk_1	237	243	PF00069	0.274
MOD_Plk_1	555	561	PF00069	0.548
MOD_Plk_4	115	121	PF00069	0.441
MOD_Plk_4	238	244	PF00069	0.396
MOD_Plk_4	262	268	PF00069	0.366
MOD_ProDKin_1	104	110	PF00069	0.720
MOD_ProDKin_1	13	19	PF00069	0.391
MOD_ProDKin_1	194	200	PF00069	0.536
MOD_ProDKin_1	293	299	PF00069	0.643
MOD_ProDKin_1	365	371	PF00069	0.489
MOD_ProDKin_1	466	472	PF00069	0.459
MOD_SUMO_rev_2	398	406	PF00179	0.463
TRG_DiLeu_BaEn_1	432	437	PF01217	0.486
TRG_ENDOCYTIC_2	26	29	PF00928	0.390
TRG_ENDOCYTIC_2	263	266	PF00928	0.370
TRG_ENDOCYTIC_2	75	78	PF00928	0.346
TRG_ER_diArg_1	130	133	PF00400	0.440
TRG_ER_diArg_1	394	397	PF00400	0.469
TRG_ER_diArg_1	575	578	PF00400	0.477
TRG_ER_diArg_1	585	588	PF00400	0.519
TRG_ER_diArg_1	83	86	PF00400	0.312
TRG_Pf-PMV_PEXEL_1	425	430	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Z9	Leptomonas seymouri	51%	100%
A0A3S7WTW8	Leishmania donovani	80%	100%
A4HWX2	Leishmania infantum	81%	100%
D0A669	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	98%
E9AQN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QEU4	Leishmania major	81%	100%