DNA-directed DNA polymerase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8J6_LEIBR

TriTrypDb:

LbrM.16.0730 , LBRM2903_160013800

Length:

748

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8J6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8J6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	298	302	PF00656	0.688
CLV_NRD_NRD_1	115	117	PF00675	0.462
CLV_NRD_NRD_1	170	172	PF00675	0.536
CLV_NRD_NRD_1	180	182	PF00675	0.384
CLV_NRD_NRD_1	31	33	PF00675	0.621
CLV_NRD_NRD_1	624	626	PF00675	0.570
CLV_PCSK_FUR_1	112	116	PF00082	0.585
CLV_PCSK_KEX2_1	114	116	PF00082	0.538
CLV_PCSK_KEX2_1	170	172	PF00082	0.536
CLV_PCSK_KEX2_1	31	33	PF00082	0.621
CLV_PCSK_KEX2_1	387	389	PF00082	0.632
CLV_PCSK_KEX2_1	624	626	PF00082	0.570
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.702
CLV_PCSK_PC7_1	620	626	PF00082	0.560
CLV_PCSK_SKI1_1	338	342	PF00082	0.417
CLV_PCSK_SKI1_1	616	620	PF00082	0.534
CLV_PCSK_SKI1_1	669	673	PF00082	0.601
DEG_APCC_DBOX_1	113	121	PF00400	0.377
DEG_APCC_DBOX_1	337	345	PF00400	0.427
DEG_Nend_Nbox_1	1	3	PF02207	0.681
DEG_SCF_FBW7_1	683	688	PF00400	0.703
DEG_SPOP_SBC_1	160	164	PF00917	0.546
DEG_SPOP_SBC_1	295	299	PF00917	0.551
DEG_SPOP_SBC_1	524	528	PF00917	0.534
DEG_SPOP_SBC_1	578	582	PF00917	0.546
DEG_SPOP_SBC_1	70	74	PF00917	0.606
DOC_ANK_TNKS_1	424	431	PF00023	0.468
DOC_CKS1_1	152	157	PF01111	0.445
DOC_CKS1_1	538	543	PF01111	0.566
DOC_MAPK_DCC_7	89	98	PF00069	0.480
DOC_MAPK_gen_1	14	22	PF00069	0.500
DOC_MAPK_gen_1	252	261	PF00069	0.524
DOC_MAPK_MEF2A_6	255	263	PF00069	0.503
DOC_MAPK_MEF2A_6	652	659	PF00069	0.489
DOC_MAPK_MEF2A_6	89	98	PF00069	0.480
DOC_PP2B_LxvP_1	85	88	PF13499	0.523
DOC_SPAK_OSR1_1	171	175	PF12202	0.445
DOC_USP7_MATH_1	161	165	PF00917	0.580
DOC_USP7_MATH_1	209	213	PF00917	0.667
DOC_USP7_MATH_1	228	232	PF00917	0.711
DOC_USP7_MATH_1	295	299	PF00917	0.732
DOC_USP7_MATH_1	314	318	PF00917	0.621
DOC_USP7_MATH_1	327	331	PF00917	0.643
DOC_USP7_MATH_1	364	368	PF00917	0.605
DOC_USP7_MATH_1	488	492	PF00917	0.596
DOC_USP7_MATH_1	551	555	PF00917	0.615
DOC_USP7_MATH_1	578	582	PF00917	0.758
DOC_USP7_MATH_1	590	594	PF00917	0.620
DOC_USP7_MATH_1	608	612	PF00917	0.371
DOC_USP7_MATH_1	628	632	PF00917	0.736
DOC_USP7_MATH_1	63	67	PF00917	0.629
DOC_USP7_MATH_1	71	75	PF00917	0.570
DOC_USP7_MATH_1	721	725	PF00917	0.644
DOC_WW_Pin1_4	141	146	PF00397	0.451
DOC_WW_Pin1_4	151	156	PF00397	0.544
DOC_WW_Pin1_4	162	167	PF00397	0.527
DOC_WW_Pin1_4	229	234	PF00397	0.745
DOC_WW_Pin1_4	286	291	PF00397	0.504
DOC_WW_Pin1_4	368	373	PF00397	0.585
DOC_WW_Pin1_4	437	442	PF00397	0.558
DOC_WW_Pin1_4	470	475	PF00397	0.454
DOC_WW_Pin1_4	493	498	PF00397	0.641
DOC_WW_Pin1_4	537	542	PF00397	0.578
DOC_WW_Pin1_4	59	64	PF00397	0.764
DOC_WW_Pin1_4	66	71	PF00397	0.675
DOC_WW_Pin1_4	681	686	PF00397	0.699
DOC_WW_Pin1_4	688	693	PF00397	0.561
DOC_WW_Pin1_4	717	722	PF00397	0.740
DOC_WW_Pin1_4	74	79	PF00397	0.626
DOC_WW_Pin1_4	89	94	PF00397	0.483
LIG_14-3-3_CanoR_1	114	120	PF00244	0.458
LIG_14-3-3_CanoR_1	131	135	PF00244	0.517
LIG_14-3-3_CanoR_1	211	219	PF00244	0.572
LIG_14-3-3_CanoR_1	296	305	PF00244	0.592
LIG_14-3-3_CanoR_1	31	38	PF00244	0.583
LIG_14-3-3_CanoR_1	338	348	PF00244	0.444
LIG_14-3-3_CanoR_1	349	354	PF00244	0.559
LIG_14-3-3_CanoR_1	446	456	PF00244	0.606
LIG_14-3-3_CanoR_1	50	60	PF00244	0.572
LIG_14-3-3_CanoR_1	558	567	PF00244	0.721
LIG_14-3-3_CanoR_1	679	684	PF00244	0.571
LIG_14-3-3_CanoR_1	732	738	PF00244	0.441
LIG_BRCT_BRCA1_1	610	614	PF00533	0.371
LIG_eIF4E_1	741	747	PF01652	0.412
LIG_FHA_1	142	148	PF00498	0.593
LIG_FHA_1	21	27	PF00498	0.640
LIG_FHA_1	280	286	PF00498	0.426
LIG_FHA_1	341	347	PF00498	0.457
LIG_FHA_1	355	361	PF00498	0.712
LIG_FHA_1	40	46	PF00498	0.454
LIG_FHA_1	519	525	PF00498	0.658
LIG_FHA_1	52	58	PF00498	0.469
LIG_FHA_1	652	658	PF00498	0.490
LIG_FHA_1	71	77	PF00498	0.515
LIG_FHA_2	131	137	PF00498	0.362
LIG_FHA_2	152	158	PF00498	0.454
LIG_FHA_2	340	346	PF00498	0.448
LIG_FHA_2	353	359	PF00498	0.637
LIG_FHA_2	564	570	PF00498	0.538
LIG_FHA_2	597	603	PF00498	0.696
LIG_Integrin_isoDGR_2	253	255	PF01839	0.556
LIG_LIR_Gen_1	405	416	PF02991	0.537
LIG_LIR_Nem_3	169	175	PF02991	0.464
LIG_LIR_Nem_3	242	248	PF02991	0.440
LIG_LIR_Nem_3	405	411	PF02991	0.542
LIG_LIR_Nem_3	460	465	PF02991	0.484
LIG_LIR_Nem_3	738	744	PF02991	0.424
LIG_LYPXL_yS_3	741	744	PF13949	0.414
LIG_PCNA_yPIPBox_3	734	747	PF02747	0.425
LIG_Pex14_1	666	670	PF04695	0.458
LIG_Pex14_2	431	435	PF04695	0.490
LIG_PTAP_UEV_1	235	240	PF05743	0.511
LIG_Rb_LxCxE_1	169	190	PF01857	0.503
LIG_SH2_CRK	245	249	PF00017	0.409
LIG_SH2_CRK	645	649	PF00017	0.390
LIG_SH2_STAT3	675	678	PF00017	0.592
LIG_SH2_STAT5	175	178	PF00017	0.483
LIG_SH2_STAT5	462	465	PF00017	0.473
LIG_SH2_STAT5	51	54	PF00017	0.529
LIG_SH2_STAT5	645	648	PF00017	0.403
LIG_SH2_STAT5	670	673	PF00017	0.493
LIG_SH3_1	75	81	PF00018	0.685
LIG_SH3_3	198	204	PF00018	0.731
LIG_SH3_3	230	236	PF00018	0.726
LIG_SH3_3	468	474	PF00018	0.445
LIG_SH3_3	495	501	PF00018	0.826
LIG_SH3_3	535	541	PF00018	0.540
LIG_SH3_3	57	63	PF00018	0.575
LIG_SH3_3	647	653	PF00018	0.437
LIG_SH3_3	75	81	PF00018	0.732
LIG_SH3_3	87	93	PF00018	0.527
LIG_SUMO_SIM_anti_2	41	49	PF11976	0.452
LIG_SUMO_SIM_par_1	136	144	PF11976	0.414
LIG_SUMO_SIM_par_1	281	287	PF11976	0.497
LIG_SUMO_SIM_par_1	342	347	PF11976	0.444
LIG_SUMO_SIM_par_1	653	658	PF11976	0.482
LIG_SUMO_SIM_par_1	742	748	PF11976	0.347
LIG_SUMO_SIM_par_1	94	100	PF11976	0.415
LIG_TRAF2_1	442	445	PF00917	0.641
LIG_TRAF2_2	219	224	PF00917	0.566
LIG_UBA3_1	480	484	PF00899	0.506
LIG_WRC_WIRS_1	27	32	PF05994	0.463
LIG_WW_3	293	297	PF00397	0.620
LIG_WW_3	86	90	PF00397	0.578
MOD_CK1_1	106	112	PF00069	0.528
MOD_CK1_1	212	218	PF00069	0.684
MOD_CK1_1	297	303	PF00069	0.658
MOD_CK1_1	309	315	PF00069	0.674
MOD_CK1_1	352	358	PF00069	0.600
MOD_CK1_1	371	377	PF00069	0.587
MOD_CK1_1	381	387	PF00069	0.635
MOD_CK1_1	41	47	PF00069	0.721
MOD_CK1_1	493	499	PF00069	0.583
MOD_CK1_1	518	524	PF00069	0.709
MOD_CK1_1	64	70	PF00069	0.667
MOD_CK1_1	711	717	PF00069	0.828
MOD_CK1_1	74	80	PF00069	0.634
MOD_CK1_1	97	103	PF00069	0.403
MOD_CK2_1	115	121	PF00069	0.515
MOD_CK2_1	140	146	PF00069	0.438
MOD_CK2_1	151	157	PF00069	0.510
MOD_CK2_1	211	217	PF00069	0.590
MOD_CK2_1	305	311	PF00069	0.637
MOD_CK2_1	352	358	PF00069	0.634
MOD_CK2_1	563	569	PF00069	0.538
MOD_CK2_1	579	585	PF00069	0.776
MOD_CK2_1	657	663	PF00069	0.506
MOD_DYRK1A_RPxSP_1	437	441	PF00069	0.548
MOD_DYRK1A_RPxSP_1	89	93	PF00069	0.444
MOD_GlcNHglycan	104	108	PF01048	0.581
MOD_GlcNHglycan	189	192	PF01048	0.664
MOD_GlcNHglycan	195	198	PF01048	0.641
MOD_GlcNHglycan	211	214	PF01048	0.606
MOD_GlcNHglycan	311	314	PF01048	0.684
MOD_GlcNHglycan	317	320	PF01048	0.667
MOD_GlcNHglycan	329	332	PF01048	0.667
MOD_GlcNHglycan	366	369	PF01048	0.675
MOD_GlcNHglycan	383	386	PF01048	0.795
MOD_GlcNHglycan	512	515	PF01048	0.695
MOD_GlcNHglycan	517	520	PF01048	0.558
MOD_GlcNHglycan	560	563	PF01048	0.697
MOD_GlcNHglycan	57	60	PF01048	0.546
MOD_GlcNHglycan	581	584	PF01048	0.698
MOD_GlcNHglycan	591	595	PF01048	0.618
MOD_GlcNHglycan	599	602	PF01048	0.515
MOD_GlcNHglycan	609	613	PF01048	0.372
MOD_GlcNHglycan	630	633	PF01048	0.625
MOD_GlcNHglycan	634	637	PF01048	0.564
MOD_GlcNHglycan	658	662	PF01048	0.542
MOD_GlcNHglycan	685	688	PF01048	0.724
MOD_GlcNHglycan	699	702	PF01048	0.644
MOD_GSK3_1	126	133	PF00069	0.499
MOD_GSK3_1	156	163	PF00069	0.552
MOD_GSK3_1	26	33	PF00069	0.567
MOD_GSK3_1	297	304	PF00069	0.710
MOD_GSK3_1	305	312	PF00069	0.668
MOD_GSK3_1	340	347	PF00069	0.454
MOD_GSK3_1	364	371	PF00069	0.614
MOD_GSK3_1	374	381	PF00069	0.616
MOD_GSK3_1	486	493	PF00069	0.580
MOD_GSK3_1	496	503	PF00069	0.577
MOD_GSK3_1	51	58	PF00069	0.767
MOD_GSK3_1	510	517	PF00069	0.685
MOD_GSK3_1	518	525	PF00069	0.554
MOD_GSK3_1	59	66	PF00069	0.653
MOD_GSK3_1	597	604	PF00069	0.666
MOD_GSK3_1	628	635	PF00069	0.672
MOD_GSK3_1	669	676	PF00069	0.477
MOD_GSK3_1	679	686	PF00069	0.629
MOD_GSK3_1	70	77	PF00069	0.509
MOD_GSK3_1	713	720	PF00069	0.582
MOD_LATS_1	667	673	PF00433	0.432
MOD_N-GLC_1	708	713	PF02516	0.545
MOD_N-GLC_2	449	451	PF02516	0.617
MOD_NEK2_1	140	145	PF00069	0.580
MOD_NEK2_1	195	200	PF00069	0.598
MOD_NEK2_1	26	31	PF00069	0.613
MOD_NEK2_1	305	310	PF00069	0.626
MOD_NEK2_1	38	43	PF00069	0.487
MOD_NEK2_1	557	562	PF00069	0.742
MOD_NEK2_2	239	244	PF00069	0.434
MOD_NEK2_2	81	86	PF00069	0.532
MOD_PIKK_1	217	223	PF00454	0.570
MOD_PIKK_1	374	380	PF00454	0.606
MOD_PIKK_1	496	502	PF00454	0.559
MOD_PIKK_1	708	714	PF00454	0.713
MOD_PIKK_1	76	82	PF00454	0.685
MOD_PK_1	264	270	PF00069	0.485
MOD_PKA_1	115	121	PF00069	0.447
MOD_PKA_2	115	121	PF00069	0.448
MOD_PKA_2	130	136	PF00069	0.423
MOD_PKA_2	295	301	PF00069	0.667
MOD_PKA_2	30	36	PF00069	0.619
MOD_PKA_2	445	451	PF00069	0.624
MOD_PKA_2	465	471	PF00069	0.400
MOD_PKA_2	549	555	PF00069	0.672
MOD_PKA_2	557	563	PF00069	0.671
MOD_PKA_2	651	657	PF00069	0.558
MOD_PKA_2	678	684	PF00069	0.544
MOD_PKA_2	733	739	PF00069	0.373
MOD_Plk_1	264	270	PF00069	0.328
MOD_Plk_1	344	350	PF00069	0.500
MOD_Plk_1	657	663	PF00069	0.426
MOD_Plk_2-3	301	307	PF00069	0.559
MOD_Plk_4	115	121	PF00069	0.355
MOD_Plk_4	264	270	PF00069	0.441
MOD_Plk_4	41	47	PF00069	0.453
MOD_Plk_4	525	531	PF00069	0.608
MOD_Plk_4	563	569	PF00069	0.558
MOD_Plk_4	742	748	PF00069	0.456
MOD_Plk_4	94	100	PF00069	0.415
MOD_ProDKin_1	141	147	PF00069	0.446
MOD_ProDKin_1	151	157	PF00069	0.556
MOD_ProDKin_1	162	168	PF00069	0.516
MOD_ProDKin_1	229	235	PF00069	0.740
MOD_ProDKin_1	286	292	PF00069	0.515
MOD_ProDKin_1	368	374	PF00069	0.586
MOD_ProDKin_1	437	443	PF00069	0.565
MOD_ProDKin_1	470	476	PF00069	0.458
MOD_ProDKin_1	493	499	PF00069	0.643
MOD_ProDKin_1	537	543	PF00069	0.575
MOD_ProDKin_1	59	65	PF00069	0.762
MOD_ProDKin_1	66	72	PF00069	0.675
MOD_ProDKin_1	681	687	PF00069	0.700
MOD_ProDKin_1	688	694	PF00069	0.561
MOD_ProDKin_1	717	723	PF00069	0.738
MOD_ProDKin_1	74	80	PF00069	0.627
MOD_ProDKin_1	89	95	PF00069	0.475
MOD_SUMO_rev_2	695	700	PF00179	0.560
TRG_DiLeu_BaEn_2	257	263	PF01217	0.403
TRG_DiLeu_BaLyEn_6	739	744	PF01217	0.426
TRG_ENDOCYTIC_2	245	248	PF00928	0.411
TRG_ENDOCYTIC_2	408	411	PF00928	0.547
TRG_ENDOCYTIC_2	462	465	PF00928	0.473
TRG_ENDOCYTIC_2	645	648	PF00928	0.403
TRG_ENDOCYTIC_2	741	744	PF00928	0.453
TRG_ER_diArg_1	112	115	PF00400	0.533
TRG_ER_diArg_1	170	172	PF00400	0.536
TRG_ER_diArg_1	30	32	PF00400	0.556
TRG_ER_diArg_1	453	456	PF00400	0.555
TRG_ER_diArg_1	623	625	PF00400	0.572
TRG_NES_CRM1_1	272	284	PF08389	0.465
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4A3	Leptomonas seymouri	48%	100%
A0A3Q8IAD7	Leishmania donovani	74%	100%
A4HWX1	Leishmania infantum	74%	100%
E9AQN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QEU5	Leishmania major	74%	99%