Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8J4_LEIBR

TriTrypDb:

LbrM.16.0710 , LBRM2903_160013600

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

A4H8J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8J4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.523
CLV_C14_Caspase3-7	223	227	PF00656	0.285
CLV_C14_Caspase3-7	337	341	PF00656	0.231
CLV_C14_Caspase3-7	68	72	PF00656	0.529
CLV_NRD_NRD_1	276	278	PF00675	0.552
CLV_NRD_NRD_1	426	428	PF00675	0.359
CLV_NRD_NRD_1	504	506	PF00675	0.656
CLV_NRD_NRD_1	520	522	PF00675	0.438
CLV_PCSK_KEX2_1	276	278	PF00082	0.594
CLV_PCSK_KEX2_1	426	428	PF00082	0.359
CLV_PCSK_KEX2_1	504	506	PF00082	0.656
CLV_PCSK_KEX2_1	520	522	PF00082	0.438
CLV_PCSK_SKI1_1	450	454	PF00082	0.563
DEG_APCC_DBOX_1	457	465	PF00400	0.589
DEG_Nend_UBRbox_2	1	3	PF02207	0.568
DEG_SPOP_SBC_1	166	170	PF00917	0.435
DEG_SPOP_SBC_1	322	326	PF00917	0.458
DEG_SPOP_SBC_1	493	497	PF00917	0.541
DOC_CDC14_PxL_1	186	194	PF14671	0.506
DOC_CKS1_1	176	181	PF01111	0.498
DOC_CYCLIN_RxL_1	212	223	PF00134	0.443
DOC_MAPK_gen_1	520	528	PF00069	0.440
DOC_MAPK_MEF2A_6	113	121	PF00069	0.495
DOC_MAPK_RevD_3	262	277	PF00069	0.446
DOC_PP1_RVXF_1	448	455	PF00149	0.440
DOC_PP2B_LxvP_1	124	127	PF13499	0.412
DOC_PP2B_LxvP_1	195	198	PF13499	0.648
DOC_USP7_MATH_1	167	171	PF00917	0.529
DOC_USP7_MATH_1	437	441	PF00917	0.535
DOC_USP7_MATH_1	443	447	PF00917	0.472
DOC_USP7_MATH_1	492	496	PF00917	0.657
DOC_USP7_MATH_1	82	86	PF00917	0.606
DOC_USP7_MATH_1	95	99	PF00917	0.521
DOC_WW_Pin1_4	169	174	PF00397	0.450
DOC_WW_Pin1_4	175	180	PF00397	0.522
DOC_WW_Pin1_4	190	195	PF00397	0.679
DOC_WW_Pin1_4	202	207	PF00397	0.486
DOC_WW_Pin1_4	349	354	PF00397	0.439
DOC_WW_Pin1_4	488	493	PF00397	0.628
DOC_WW_Pin1_4	70	75	PF00397	0.583
LIG_14-3-3_CanoR_1	28	34	PF00244	0.545
LIG_14-3-3_CanoR_1	331	337	PF00244	0.370
LIG_14-3-3_CanoR_1	362	368	PF00244	0.497
LIG_14-3-3_CanoR_1	458	462	PF00244	0.571
LIG_14-3-3_CanoR_1	504	514	PF00244	0.665
LIG_14-3-3_CanoR_1	520	528	PF00244	0.512
LIG_14-3-3_CanoR_1	65	74	PF00244	0.572
LIG_Actin_WH2_2	135	152	PF00022	0.402
LIG_Actin_WH2_2	445	460	PF00022	0.510
LIG_BRCT_BRCA1_1	117	121	PF00533	0.473
LIG_BRCT_BRCA1_1	2	6	PF00533	0.490
LIG_CSL_BTD_1	124	127	PF09270	0.412
LIG_FHA_1	166	172	PF00498	0.467
LIG_FHA_1	209	215	PF00498	0.420
LIG_FHA_1	323	329	PF00498	0.434
LIG_FHA_1	439	445	PF00498	0.542
LIG_FHA_1	506	512	PF00498	0.623
LIG_FHA_2	397	403	PF00498	0.549
LIG_FHA_2	476	482	PF00498	0.658
LIG_FHA_2	505	511	PF00498	0.628
LIG_LIR_Apic_2	199	204	PF02991	0.499
LIG_LIR_Gen_1	246	255	PF02991	0.298
LIG_LIR_Gen_1	29	36	PF02991	0.546
LIG_LIR_Nem_3	118	124	PF02991	0.469
LIG_LIR_Nem_3	246	250	PF02991	0.501
LIG_LIR_Nem_3	29	33	PF02991	0.519
LIG_MYND_1	190	194	PF01753	0.497
LIG_PDZ_Class_1	524	529	PF00595	0.585
LIG_Pex14_1	30	34	PF04695	0.548
LIG_Pex14_2	121	125	PF04695	0.472
LIG_SH2_CRK	247	251	PF00017	0.292
LIG_SH2_NCK_1	369	373	PF00017	0.610
LIG_SH2_SRC	417	420	PF00017	0.415
LIG_SH2_STAT5	346	349	PF00017	0.506
LIG_SH2_STAT5	417	420	PF00017	0.415
LIG_SH3_3	16	22	PF00018	0.646
LIG_SH3_3	173	179	PF00018	0.531
LIG_SH3_3	298	304	PF00018	0.454
LIG_SUMO_SIM_anti_2	256	261	PF11976	0.310
LIG_SUMO_SIM_anti_2	269	274	PF11976	0.450
LIG_TYR_ITIM	245	250	PF00017	0.287
MOD_CDK_SPxK_1	175	181	PF00069	0.499
MOD_CK1_1	175	181	PF00069	0.600
MOD_CK1_1	193	199	PF00069	0.543
MOD_CK1_1	332	338	PF00069	0.242
MOD_CK1_1	67	73	PF00069	0.746
MOD_CK2_1	177	183	PF00069	0.672
MOD_CK2_1	217	223	PF00069	0.278
MOD_CK2_1	396	402	PF00069	0.460
MOD_CK2_1	475	481	PF00069	0.664
MOD_CK2_1	504	510	PF00069	0.548
MOD_GlcNHglycan	11	14	PF01048	0.683
MOD_GlcNHglycan	195	198	PF01048	0.511
MOD_GlcNHglycan	211	214	PF01048	0.453
MOD_GlcNHglycan	218	222	PF01048	0.542
MOD_GlcNHglycan	280	283	PF01048	0.581
MOD_GlcNHglycan	314	317	PF01048	0.688
MOD_GlcNHglycan	374	377	PF01048	0.603
MOD_GlcNHglycan	471	474	PF01048	0.616
MOD_GlcNHglycan	496	499	PF01048	0.606
MOD_GlcNHglycan	84	87	PF01048	0.786
MOD_GSK3_1	145	152	PF00069	0.438
MOD_GSK3_1	165	172	PF00069	0.428
MOD_GSK3_1	332	339	PF00069	0.246
MOD_GSK3_1	465	472	PF00069	0.542
MOD_GSK3_1	488	495	PF00069	0.608
MOD_GSK3_1	70	77	PF00069	0.576
MOD_GSK3_1	91	98	PF00069	0.642
MOD_N-GLC_1	145	150	PF02516	0.321
MOD_N-GLC_1	243	248	PF02516	0.433
MOD_N-GLC_1	396	401	PF02516	0.418
MOD_N-GLC_1	469	474	PF02516	0.648
MOD_N-GLC_1	493	498	PF02516	0.572
MOD_NEK2_1	149	154	PF00069	0.365
MOD_NEK2_1	208	213	PF00069	0.515
MOD_NEK2_1	217	222	PF00069	0.351
MOD_NEK2_1	233	238	PF00069	0.337
MOD_NEK2_1	243	248	PF00069	0.367
MOD_NEK2_1	363	368	PF00069	0.498
MOD_NEK2_1	396	401	PF00069	0.380
MOD_NEK2_1	457	462	PF00069	0.497
MOD_NEK2_1	475	480	PF00069	0.532
MOD_NEK2_1	59	64	PF00069	0.538
MOD_NEK2_2	131	136	PF00069	0.395
MOD_NEK2_2	445	450	PF00069	0.581
MOD_PKA_1	426	432	PF00069	0.395
MOD_PKA_1	504	510	PF00069	0.630
MOD_PKA_2	149	155	PF00069	0.410
MOD_PKA_2	425	431	PF00069	0.433
MOD_PKA_2	457	463	PF00069	0.586
MOD_PKA_2	504	510	PF00069	0.679
MOD_PKA_2	64	70	PF00069	0.606
MOD_PKB_1	63	71	PF00069	0.604
MOD_Plk_1	145	151	PF00069	0.305
MOD_Plk_1	243	249	PF00069	0.336
MOD_Plk_1	396	402	PF00069	0.384
MOD_Plk_4	196	202	PF00069	0.501
MOD_Plk_4	29	35	PF00069	0.556
MOD_Plk_4	396	402	PF00069	0.460
MOD_Plk_4	431	437	PF00069	0.462
MOD_ProDKin_1	169	175	PF00069	0.460
MOD_ProDKin_1	190	196	PF00069	0.698
MOD_ProDKin_1	202	208	PF00069	0.480
MOD_ProDKin_1	349	355	PF00069	0.443
MOD_ProDKin_1	488	494	PF00069	0.629
MOD_ProDKin_1	70	76	PF00069	0.584
MOD_SUMO_rev_2	416	422	PF00179	0.412
TRG_DiLeu_BaEn_1	510	515	PF01217	0.504
TRG_ENDOCYTIC_2	247	250	PF00928	0.297
TRG_ENDOCYTIC_2	346	349	PF00928	0.510
TRG_ER_diArg_1	275	277	PF00400	0.599
TRG_ER_diArg_1	284	287	PF00400	0.370
TRG_ER_diArg_1	504	506	PF00400	0.656
TRG_ER_diArg_1	519	521	PF00400	0.442
TRG_ER_diArg_1	63	66	PF00400	0.562
TRG_Pf-PMV_PEXEL_1	160	165	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJG7	Leptomonas seymouri	35%	100%
A0A3S5H6X5	Leishmania donovani	70%	100%
A4HWW9	Leishmania infantum	70%	100%
E9AQN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QEU7	Leishmania major	68%	100%