eIF2A domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor eIF2A, putative

Species:

Leishmania braziliensis

UniProt:

A4H8J1_LEIBR

TriTrypDb:

LbrM.16.0680 , LBRM2903_160013200

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0015935	small ribosomal subunit	4	1
GO:0022627	cytosolic small ribosomal subunit	5	1
GO:0032991	protein-containing complex	1	1
GO:0044391	ribosomal subunit	3	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H8J1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8J1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0000049	tRNA binding	5	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043022	ribosome binding	4	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.344
CLV_NRD_NRD_1	119	121	PF00675	0.463
CLV_NRD_NRD_1	138	140	PF00675	0.410
CLV_NRD_NRD_1	312	314	PF00675	0.272
CLV_NRD_NRD_1	523	525	PF00675	0.610
CLV_NRD_NRD_1	549	551	PF00675	0.739
CLV_PCSK_KEX2_1	119	121	PF00082	0.449
CLV_PCSK_KEX2_1	138	140	PF00082	0.410
CLV_PCSK_KEX2_1	312	314	PF00082	0.182
CLV_PCSK_KEX2_1	523	525	PF00082	0.610
CLV_PCSK_KEX2_1	548	550	PF00082	0.696
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.696
CLV_PCSK_SKI1_1	231	235	PF00082	0.469
CLV_PCSK_SKI1_1	244	248	PF00082	0.177
CLV_PCSK_SKI1_1	312	316	PF00082	0.264
CLV_PCSK_SKI1_1	530	534	PF00082	0.571
CLV_Separin_Metazoa	135	139	PF03568	0.300
DEG_SPOP_SBC_1	174	178	PF00917	0.655
DEG_SPOP_SBC_1	60	64	PF00917	0.474
DOC_ANK_TNKS_1	118	125	PF00023	0.335
DOC_MAPK_gen_1	11	18	PF00069	0.357
DOC_MAPK_gen_1	312	319	PF00069	0.469
DOC_MAPK_gen_1	450	459	PF00069	0.406
DOC_MAPK_MEF2A_6	11	20	PF00069	0.426
DOC_PP4_FxxP_1	275	278	PF00568	0.562
DOC_PP4_FxxP_1	90	93	PF00568	0.468
DOC_USP7_MATH_1	174	178	PF00917	0.651
DOC_USP7_UBL2_3	238	242	PF12436	0.380
DOC_WW_Pin1_4	101	106	PF00397	0.466
DOC_WW_Pin1_4	118	123	PF00397	0.376
DOC_WW_Pin1_4	274	279	PF00397	0.539
DOC_WW_Pin1_4	329	334	PF00397	0.460
DOC_WW_Pin1_4	492	497	PF00397	0.526
LIG_14-3-3_CanoR_1	244	249	PF00244	0.441
LIG_14-3-3_CanoR_1	312	319	PF00244	0.535
LIG_14-3-3_CanoR_1	347	353	PF00244	0.473
LIG_14-3-3_CanoR_1	83	87	PF00244	0.473
LIG_APCC_ABBA_1	18	23	PF00400	0.420
LIG_BIR_II_1	1	5	PF00653	0.558
LIG_BRCT_BRCA1_1	438	442	PF00533	0.367
LIG_BRCT_BRCA1_1	99	103	PF00533	0.519
LIG_CSL_BTD_1	275	278	PF09270	0.562
LIG_FHA_1	1	7	PF00498	0.339
LIG_FHA_1	106	112	PF00498	0.393
LIG_FHA_1	245	251	PF00498	0.344
LIG_FHA_1	269	275	PF00498	0.469
LIG_FHA_1	299	305	PF00498	0.511
LIG_FHA_1	411	417	PF00498	0.667
LIG_FHA_1	539	545	PF00498	0.538
LIG_FHA_1	60	66	PF00498	0.390
LIG_FHA_2	149	155	PF00498	0.401
LIG_FHA_2	323	329	PF00498	0.523
LIG_FHA_2	332	338	PF00498	0.493
LIG_FHA_2	360	366	PF00498	0.498
LIG_FHA_2	496	502	PF00498	0.595
LIG_FHA_2	64	70	PF00498	0.436
LIG_FHA_2	73	79	PF00498	0.488
LIG_LIR_Apic_2	506	512	PF02991	0.492
LIG_LIR_Apic_2	88	93	PF02991	0.474
LIG_LIR_Gen_1	112	117	PF02991	0.440
LIG_LIR_Gen_1	279	287	PF02991	0.539
LIG_LIR_Gen_1	438	448	PF02991	0.409
LIG_LIR_Gen_1	64	74	PF02991	0.500
LIG_LIR_Gen_1	85	94	PF02991	0.476
LIG_LIR_Nem_3	247	251	PF02991	0.487
LIG_LIR_Nem_3	279	285	PF02991	0.539
LIG_LIR_Nem_3	297	302	PF02991	0.459
LIG_LIR_Nem_3	391	395	PF02991	0.459
LIG_LIR_Nem_3	438	443	PF02991	0.396
LIG_LIR_Nem_3	446	451	PF02991	0.394
LIG_LIR_Nem_3	469	475	PF02991	0.405
LIG_LIR_Nem_3	64	70	PF02991	0.462
LIG_LIR_Nem_3	85	89	PF02991	0.503
LIG_LYPXL_yS_3	472	475	PF13949	0.395
LIG_Pex14_2	86	90	PF04695	0.525
LIG_SH2_CRK	251	255	PF00017	0.389
LIG_SH2_CRK	299	303	PF00017	0.459
LIG_SH2_CRK	440	444	PF00017	0.409
LIG_SH2_CRK	509	513	PF00017	0.603
LIG_SH2_NCK_1	223	227	PF00017	0.503
LIG_SH2_PTP2	282	285	PF00017	0.539
LIG_SH2_PTP2	395	398	PF00017	0.537
LIG_SH2_STAP1	67	71	PF00017	0.375
LIG_SH2_STAT5	109	112	PF00017	0.463
LIG_SH2_STAT5	156	159	PF00017	0.359
LIG_SH2_STAT5	282	285	PF00017	0.539
LIG_SH2_STAT5	38	41	PF00017	0.524
LIG_SH2_STAT5	395	398	PF00017	0.582
LIG_SH2_STAT5	67	70	PF00017	0.474
LIG_SH3_3	154	160	PF00018	0.443
LIG_SH3_3	412	418	PF00018	0.473
LIG_SH3_3	48	54	PF00018	0.500
LIG_SH3_3	89	95	PF00018	0.494
LIG_SH3_4	238	245	PF00018	0.391
LIG_SH3_4	503	510	PF00018	0.644
LIG_SUMO_SIM_anti_2	209	215	PF11976	0.537
LIG_SUMO_SIM_anti_2	334	342	PF11976	0.450
LIG_TRAF2_1	499	502	PF00917	0.729
LIG_TYR_ITIM	65	70	PF00017	0.360
LIG_UBA3_1	233	238	PF00899	0.356
LIG_UBA3_1	338	344	PF00899	0.539
LIG_UBA3_1	5	12	PF00899	0.415
LIG_WRPW_2	237	240	PF00400	0.364
MOD_CDK_SPK_2	101	106	PF00069	0.516
MOD_CDK_SPK_2	492	497	PF00069	0.551
MOD_CK1_1	127	133	PF00069	0.295
MOD_CK1_1	173	179	PF00069	0.646
MOD_CK1_1	294	300	PF00069	0.454
MOD_CK1_1	332	338	PF00069	0.413
MOD_CK1_1	495	501	PF00069	0.681
MOD_CK1_1	85	91	PF00069	0.487
MOD_CK2_1	148	154	PF00069	0.401
MOD_CK2_1	24	30	PF00069	0.444
MOD_CK2_1	331	337	PF00069	0.539
MOD_CK2_1	359	365	PF00069	0.432
MOD_CK2_1	495	501	PF00069	0.554
MOD_CK2_1	63	69	PF00069	0.445
MOD_CK2_1	72	78	PF00069	0.486
MOD_DYRK1A_RPxSP_1	492	496	PF00069	0.519
MOD_GlcNHglycan	171	175	PF01048	0.456
MOD_GlcNHglycan	183	188	PF01048	0.590
MOD_GlcNHglycan	278	281	PF01048	0.283
MOD_GlcNHglycan	292	296	PF01048	0.259
MOD_GlcNHglycan	384	387	PF01048	0.334
MOD_GlcNHglycan	418	421	PF01048	0.557
MOD_GlcNHglycan	533	536	PF01048	0.500
MOD_GlcNHglycan	72	75	PF01048	0.555
MOD_GSK3_1	105	112	PF00069	0.332
MOD_GSK3_1	124	131	PF00069	0.479
MOD_GSK3_1	170	177	PF00069	0.575
MOD_GSK3_1	294	301	PF00069	0.459
MOD_GSK3_1	405	412	PF00069	0.653
MOD_GSK3_1	416	423	PF00069	0.527
MOD_GSK3_1	59	66	PF00069	0.464
MOD_GSK3_1	97	104	PF00069	0.384
MOD_N-GLC_1	124	129	PF02516	0.461
MOD_N-GLC_1	204	209	PF02516	0.580
MOD_N-GLC_1	410	415	PF02516	0.679
MOD_N-GLC_2	348	350	PF02516	0.339
MOD_NEK2_1	172	177	PF00069	0.608
MOD_NEK2_1	443	448	PF00069	0.388
MOD_NEK2_2	124	129	PF00069	0.461
MOD_PIKK_1	466	472	PF00454	0.285
MOD_PIKK_1	503	509	PF00454	0.511
MOD_PKA_1	312	318	PF00069	0.382
MOD_PKA_2	105	111	PF00069	0.456
MOD_PKA_2	312	318	PF00069	0.382
MOD_PKA_2	52	58	PF00069	0.385
MOD_PKA_2	82	88	PF00069	0.479
MOD_Plk_1	12	18	PF00069	0.423
MOD_Plk_1	124	130	PF00069	0.461
MOD_Plk_1	410	416	PF00069	0.709
MOD_Plk_2-3	322	328	PF00069	0.539
MOD_Plk_4	105	111	PF00069	0.369
MOD_Plk_4	12	18	PF00069	0.411
MOD_Plk_4	124	130	PF00069	0.450
MOD_Plk_4	176	182	PF00069	0.716
MOD_Plk_4	294	300	PF00069	0.473
MOD_Plk_4	348	354	PF00069	0.459
MOD_Plk_4	443	449	PF00069	0.394
MOD_Plk_4	538	544	PF00069	0.582
MOD_Plk_4	85	91	PF00069	0.508
MOD_ProDKin_1	101	107	PF00069	0.461
MOD_ProDKin_1	118	124	PF00069	0.366
MOD_ProDKin_1	274	280	PF00069	0.539
MOD_ProDKin_1	329	335	PF00069	0.460
MOD_ProDKin_1	492	498	PF00069	0.536
MOD_SUMO_for_1	287	290	PF00179	0.459
MOD_SUMO_for_1	319	322	PF00179	0.539
MOD_SUMO_rev_2	495	504	PF00179	0.619
TRG_ENDOCYTIC_2	113	116	PF00928	0.420
TRG_ENDOCYTIC_2	282	285	PF00928	0.539
TRG_ENDOCYTIC_2	299	302	PF00928	0.459
TRG_ENDOCYTIC_2	440	443	PF00928	0.437
TRG_ENDOCYTIC_2	472	475	PF00928	0.395
TRG_ENDOCYTIC_2	67	70	PF00928	0.365
TRG_ER_diArg_1	137	139	PF00400	0.400
TRG_ER_diArg_1	312	314	PF00400	0.382
TRG_ER_diArg_1	450	453	PF00400	0.433
TRG_ER_diArg_1	522	524	PF00400	0.600
TRG_ER_diLys_1	546	551	PF00400	0.643
TRG_NES_CRM1_1	308	322	PF08389	0.539
TRG_NLS_MonoCore_2	545	550	PF00514	0.639
TRG_NLS_MonoExtC_3	545	550	PF00514	0.639
TRG_NLS_MonoExtN_4	546	551	PF00514	0.736
TRG_Pf-PMV_PEXEL_1	312	316	PF00026	0.273

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCC7	Leptomonas seymouri	74%	100%
A0A1X0NNW1	Trypanosomatidae	50%	99%
A0A3S5H6X4	Leishmania donovani	87%	100%
A0A422N2R4	Trypanosoma rangeli	51%	100%
A4HWW6	Leishmania infantum	87%	100%
C9ZPL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AQM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O74965	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	96%
Q4QEV0	Leishmania major	87%	100%
Q4QRJ7	Danio rerio	26%	95%
Q54PV7	Dictyostelium discoideum	26%	91%
Q5ZKC1	Gallus gallus	23%	94%
Q7ZY11	Xenopus laevis	25%	95%
Q8BJW6	Mus musculus	25%	95%
Q9BY44	Homo sapiens	24%	94%
Q9VNX8	Drosophila melanogaster	26%	86%
V5BCM0	Trypanosoma cruzi	51%	100%