Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8I9_LEIBR

TriTrypDb:

LbrM.16.0660 , LBRM2903_160013000

Length:

661

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8I9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8I9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	429	433	PF00656	0.609
CLV_C14_Caspase3-7	608	612	PF00656	0.570
CLV_NRD_NRD_1	139	141	PF00675	0.596
CLV_NRD_NRD_1	255	257	PF00675	0.513
CLV_NRD_NRD_1	407	409	PF00675	0.622
CLV_NRD_NRD_1	654	656	PF00675	0.566
CLV_PCSK_KEX2_1	139	141	PF00082	0.596
CLV_PCSK_KEX2_1	255	257	PF00082	0.513
CLV_PCSK_KEX2_1	407	409	PF00082	0.549
CLV_PCSK_KEX2_1	523	525	PF00082	0.673
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.673
CLV_PCSK_SKI1_1	17	21	PF00082	0.784
CLV_PCSK_SKI1_1	255	259	PF00082	0.474
CLV_PCSK_SKI1_1	308	312	PF00082	0.544
CLV_PCSK_SKI1_1	503	507	PF00082	0.317
CLV_PCSK_SKI1_1	97	101	PF00082	0.675
DEG_SPOP_SBC_1	480	484	PF00917	0.327
DEG_SPOP_SBC_1	540	544	PF00917	0.547
DEG_SPOP_SBC_1	558	562	PF00917	0.783
DOC_ANK_TNKS_1	49	56	PF00023	0.585
DOC_ANK_TNKS_1	598	605	PF00023	0.541
DOC_CKS1_1	126	131	PF01111	0.593
DOC_CYCLIN_RxL_1	7	18	PF00134	0.680
DOC_MAPK_gen_1	655	661	PF00069	0.463
DOC_PP1_RVXF_1	501	507	PF00149	0.405
DOC_PP4_FxxP_1	257	260	PF00568	0.411
DOC_USP7_MATH_1	219	223	PF00917	0.767
DOC_USP7_MATH_1	247	251	PF00917	0.513
DOC_USP7_MATH_1	344	348	PF00917	0.453
DOC_USP7_MATH_1	409	413	PF00917	0.542
DOC_USP7_MATH_1	426	430	PF00917	0.708
DOC_USP7_MATH_1	540	544	PF00917	0.787
DOC_USP7_MATH_1	95	99	PF00917	0.619
DOC_WW_Pin1_4	125	130	PF00397	0.593
DOC_WW_Pin1_4	256	261	PF00397	0.411
DOC_WW_Pin1_4	356	361	PF00397	0.541
DOC_WW_Pin1_4	366	371	PF00397	0.406
DOC_WW_Pin1_4	498	503	PF00397	0.605
LIG_14-3-3_CanoR_1	104	110	PF00244	0.821
LIG_14-3-3_CanoR_1	270	276	PF00244	0.261
LIG_14-3-3_CanoR_1	308	313	PF00244	0.521
LIG_14-3-3_CanoR_1	408	417	PF00244	0.565
LIG_14-3-3_CanoR_1	478	488	PF00244	0.364
LIG_14-3-3_CanoR_1	524	533	PF00244	0.689
LIG_14-3-3_CanoR_1	572	579	PF00244	0.534
LIG_BIR_II_1	1	5	PF00653	0.539
LIG_BIR_III_4	113	117	PF00653	0.584
LIG_BIR_III_4	601	605	PF00653	0.539
LIG_BRCT_BRCA1_1	253	257	PF00533	0.261
LIG_BRCT_BRCA1_1	358	362	PF00533	0.641
LIG_BRCT_BRCA1_1	473	477	PF00533	0.366
LIG_BRCT_BRCA1_1	547	551	PF00533	0.536
LIG_Clathr_ClatBox_1	295	299	PF01394	0.513
LIG_CtBP_PxDLS_1	340	344	PF00389	0.443
LIG_FHA_1	18	24	PF00498	0.562
LIG_FHA_1	189	195	PF00498	0.683
LIG_FHA_1	272	278	PF00498	0.387
LIG_FHA_1	286	292	PF00498	0.292
LIG_FHA_1	325	331	PF00498	0.628
LIG_FHA_1	351	357	PF00498	0.596
LIG_FHA_1	481	487	PF00498	0.459
LIG_FHA_1	499	505	PF00498	0.628
LIG_FHA_1	530	536	PF00498	0.535
LIG_FHA_1	9	15	PF00498	0.584
LIG_FHA_1	91	97	PF00498	0.528
LIG_FHA_2	264	270	PF00498	0.284
LIG_FHA_2	309	315	PF00498	0.605
LIG_FHA_2	606	612	PF00498	0.695
LIG_Integrin_RGD_1	599	601	PF01839	0.547
LIG_LIR_Apic_2	254	260	PF02991	0.290
LIG_LIR_Apic_2	553	558	PF02991	0.555
LIG_LIR_Gen_1	266	276	PF02991	0.290
LIG_LIR_Gen_1	311	319	PF02991	0.430
LIG_LIR_Gen_1	359	370	PF02991	0.376
LIG_LIR_Gen_1	391	401	PF02991	0.429
LIG_LIR_Gen_1	456	464	PF02991	0.671
LIG_LIR_Gen_1	548	559	PF02991	0.545
LIG_LIR_Gen_1	640	649	PF02991	0.444
LIG_LIR_Nem_3	238	244	PF02991	0.261
LIG_LIR_Nem_3	266	271	PF02991	0.290
LIG_LIR_Nem_3	311	315	PF02991	0.436
LIG_LIR_Nem_3	359	365	PF02991	0.629
LIG_LIR_Nem_3	389	395	PF02991	0.398
LIG_LIR_Nem_3	399	404	PF02991	0.445
LIG_LIR_Nem_3	443	449	PF02991	0.438
LIG_LIR_Nem_3	456	461	PF02991	0.611
LIG_LIR_Nem_3	548	554	PF02991	0.545
LIG_LIR_Nem_3	640	646	PF02991	0.442
LIG_MAD2	518	526	PF02301	0.642
LIG_NRBOX	95	101	PF00104	0.741
LIG_PCNA_yPIPBox_3	635	645	PF02747	0.551
LIG_PDZ_Class_2	656	661	PF00595	0.466
LIG_Pex14_1	657	661	PF04695	0.468
LIG_Pex14_2	257	261	PF04695	0.411
LIG_Pex14_2	551	555	PF04695	0.533
LIG_SH2_CRK	393	397	PF00017	0.395
LIG_SH2_CRK	494	498	PF00017	0.502
LIG_SH2_GRB2like	446	449	PF00017	0.590
LIG_SH2_NCK_1	393	397	PF00017	0.358
LIG_SH2_NCK_1	447	451	PF00017	0.592
LIG_SH2_STAP1	15	19	PF00017	0.684
LIG_SH2_STAT5	393	396	PF00017	0.384
LIG_SH2_STAT5	490	493	PF00017	0.569
LIG_SH3_2	126	131	PF14604	0.593
LIG_SH3_3	123	129	PF00018	0.626
LIG_SH3_3	280	286	PF00018	0.347
LIG_SH3_3	612	618	PF00018	0.635
LIG_SUMO_SIM_anti_2	311	317	PF11976	0.378
LIG_SUMO_SIM_par_1	273	281	PF11976	0.513
LIG_TRAF2_1	403	406	PF00917	0.657
LIG_TRFH_1	393	397	PF08558	0.358
LIG_TYR_ITSM	442	449	PF00017	0.372
MOD_CDK_SPK_2	498	503	PF00069	0.391
MOD_CDK_SPxK_1	125	131	PF00069	0.594
MOD_CK1_1	203	209	PF00069	0.588
MOD_CK1_1	263	269	PF00069	0.261
MOD_CK1_1	328	334	PF00069	0.604
MOD_CK1_1	384	390	PF00069	0.473
MOD_CK1_1	436	442	PF00069	0.758
MOD_CK1_1	481	487	PF00069	0.347
MOD_CK1_1	541	547	PF00069	0.688
MOD_CK2_1	163	169	PF00069	0.711
MOD_CK2_1	225	231	PF00069	0.635
MOD_CK2_1	247	253	PF00069	0.478
MOD_CK2_1	263	269	PF00069	0.290
MOD_CK2_1	308	314	PF00069	0.549
MOD_CK2_1	371	377	PF00069	0.369
MOD_CMANNOS	485	488	PF00535	0.456
MOD_GlcNHglycan	1	4	PF01048	0.775
MOD_GlcNHglycan	107	110	PF01048	0.804
MOD_GlcNHglycan	212	215	PF01048	0.747
MOD_GlcNHglycan	221	224	PF01048	0.811
MOD_GlcNHglycan	227	230	PF01048	0.628
MOD_GlcNHglycan	249	252	PF01048	0.373
MOD_GlcNHglycan	33	36	PF01048	0.654
MOD_GlcNHglycan	398	401	PF01048	0.608
MOD_GlcNHglycan	411	414	PF01048	0.443
MOD_GlcNHglycan	417	420	PF01048	0.498
MOD_GlcNHglycan	428	431	PF01048	0.561
MOD_GlcNHglycan	561	564	PF01048	0.640
MOD_GlcNHglycan	593	596	PF01048	0.653
MOD_GSK3_1	188	195	PF00069	0.808
MOD_GSK3_1	247	254	PF00069	0.443
MOD_GSK3_1	256	263	PF00069	0.333
MOD_GSK3_1	298	305	PF00069	0.308
MOD_GSK3_1	324	331	PF00069	0.580
MOD_GSK3_1	346	353	PF00069	0.569
MOD_GSK3_1	356	363	PF00069	0.485
MOD_GSK3_1	433	440	PF00069	0.529
MOD_GSK3_1	525	532	PF00069	0.691
MOD_GSK3_1	535	542	PF00069	0.691
MOD_GSK3_1	587	594	PF00069	0.750
MOD_LATS_1	102	108	PF00433	0.810
MOD_N-GLC_1	426	431	PF02516	0.524
MOD_N-GLC_1	605	610	PF02516	0.543
MOD_NEK2_1	105	110	PF00069	0.716
MOD_NEK2_1	142	147	PF00069	0.811
MOD_NEK2_1	210	215	PF00069	0.666
MOD_NEK2_1	235	240	PF00069	0.261
MOD_NEK2_1	261	266	PF00069	0.513
MOD_NEK2_1	298	303	PF00069	0.329
MOD_NEK2_1	559	564	PF00069	0.533
MOD_NEK2_2	8	13	PF00069	0.542
MOD_PIKK_1	261	267	PF00454	0.407
MOD_PIKK_1	58	64	PF00454	0.783
MOD_PKA_2	103	109	PF00069	0.732
MOD_PKA_2	132	138	PF00069	0.661
MOD_PKA_2	440	446	PF00069	0.587
MOD_PKA_2	571	577	PF00069	0.536
MOD_Plk_1	203	209	PF00069	0.541
MOD_Plk_1	298	304	PF00069	0.375
MOD_Plk_1	325	331	PF00069	0.498
MOD_Plk_1	426	432	PF00069	0.644
MOD_Plk_4	271	277	PF00069	0.365
MOD_Plk_4	308	314	PF00069	0.398
MOD_Plk_4	391	397	PF00069	0.578
MOD_Plk_4	481	487	PF00069	0.459
MOD_Plk_4	508	514	PF00069	0.424
MOD_Plk_4	78	84	PF00069	0.688
MOD_ProDKin_1	125	131	PF00069	0.594
MOD_ProDKin_1	256	262	PF00069	0.411
MOD_ProDKin_1	356	362	PF00069	0.533
MOD_ProDKin_1	366	372	PF00069	0.398
MOD_ProDKin_1	498	504	PF00069	0.594
MOD_SUMO_for_1	277	280	PF00179	0.261
TRG_DiLeu_BaEn_1	280	285	PF01217	0.513
TRG_DiLeu_BaEn_1	391	396	PF01217	0.359
TRG_DiLeu_BaEn_2	252	258	PF01217	0.513
TRG_ENDOCYTIC_2	393	396	PF00928	0.384
TRG_ENDOCYTIC_2	446	449	PF00928	0.492
TRG_ER_diArg_1	138	140	PF00400	0.597
TRG_ER_diArg_1	255	257	PF00400	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUK6	Leptomonas seymouri	33%	100%
A0A3S7WTX7	Leishmania donovani	61%	98%
E9AGN3	Leishmania infantum	61%	98%
E9AQM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
Q4QEV2	Leishmania major	61%	100%