Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8I8_LEIBR

TriTrypDb:

LbrM.16.0650 , LBRM2903_160012900

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8I8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.550
CLV_NRD_NRD_1	162	164	PF00675	0.602
CLV_NRD_NRD_1	370	372	PF00675	0.634
CLV_NRD_NRD_1	395	397	PF00675	0.495
CLV_NRD_NRD_1	460	462	PF00675	0.563
CLV_NRD_NRD_1	509	511	PF00675	0.593
CLV_NRD_NRD_1	516	518	PF00675	0.598
CLV_NRD_NRD_1	53	55	PF00675	0.593
CLV_PCSK_FUR_1	51	55	PF00082	0.616
CLV_PCSK_KEX2_1	148	150	PF00082	0.597
CLV_PCSK_KEX2_1	300	302	PF00082	0.459
CLV_PCSK_KEX2_1	460	462	PF00082	0.591
CLV_PCSK_KEX2_1	508	510	PF00082	0.606
CLV_PCSK_KEX2_1	516	518	PF00082	0.579
CLV_PCSK_KEX2_1	53	55	PF00082	0.618
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.627
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.459
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.606
CLV_PCSK_SKI1_1	148	152	PF00082	0.646
CLV_PCSK_SKI1_1	490	494	PF00082	0.623
CLV_Separin_Metazoa	108	112	PF03568	0.580
DEG_APCC_DBOX_1	552	560	PF00400	0.645
DEG_Nend_UBRbox_1	1	4	PF02207	0.596
DOC_MAPK_gen_1	448	455	PF00069	0.455
DOC_MAPK_gen_1	485	495	PF00069	0.529
DOC_MAPK_gen_1	51	59	PF00069	0.547
DOC_MAPK_MEF2A_6	24	32	PF00069	0.499
DOC_MAPK_MEF2A_6	488	497	PF00069	0.435
DOC_PP2B_LxvP_1	11	14	PF13499	0.636
DOC_USP7_MATH_1	269	273	PF00917	0.746
DOC_USP7_MATH_1	345	349	PF00917	0.615
DOC_WW_Pin1_4	270	275	PF00397	0.668
LIG_14-3-3_CanoR_1	136	141	PF00244	0.610
LIG_14-3-3_CanoR_1	279	287	PF00244	0.594
LIG_14-3-3_CanoR_1	340	349	PF00244	0.546
LIG_14-3-3_CanoR_1	396	405	PF00244	0.614
LIG_14-3-3_CanoR_1	429	437	PF00244	0.533
LIG_Actin_WH2_2	196	214	PF00022	0.513
LIG_DLG_GKlike_1	136	144	PF00625	0.638
LIG_FHA_1	115	121	PF00498	0.559
LIG_FHA_1	175	181	PF00498	0.596
LIG_FHA_1	281	287	PF00498	0.522
LIG_FHA_1	306	312	PF00498	0.513
LIG_FHA_1	322	328	PF00498	0.541
LIG_FHA_1	54	60	PF00498	0.509
LIG_FHA_2	140	146	PF00498	0.603
LIG_FHA_2	182	188	PF00498	0.442
LIG_FHA_2	229	235	PF00498	0.507
LIG_FHA_2	59	65	PF00498	0.542
LIG_LIR_Gen_1	449	458	PF02991	0.555
LIG_LIR_Gen_1	535	544	PF02991	0.636
LIG_LIR_Nem_3	449	455	PF02991	0.560
LIG_LIR_Nem_3	535	539	PF02991	0.634
LIG_NRBOX	6	12	PF00104	0.662
LIG_PCNA_yPIPBox_3	2	11	PF02747	0.549
LIG_RPA_C_Fungi	153	165	PF08784	0.661
LIG_SH2_CRK	38	42	PF00017	0.571
LIG_SH2_PTP2	452	455	PF00017	0.356
LIG_SH2_SRC	452	455	PF00017	0.582
LIG_SH2_SRC	98	101	PF00017	0.606
LIG_SH2_STAP1	38	42	PF00017	0.466
LIG_SH2_STAT5	452	455	PF00017	0.356
LIG_SH2_STAT5	98	101	PF00017	0.579
LIG_SH3_1	256	262	PF00018	0.619
LIG_SH3_3	256	262	PF00018	0.559
LIG_SUMO_SIM_anti_2	184	190	PF11976	0.585
LIG_TRAF2_1	172	175	PF00917	0.666
LIG_TRAF2_1	364	367	PF00917	0.561
MOD_CK1_1	139	145	PF00069	0.614
MOD_CK1_1	273	279	PF00069	0.745
MOD_CK1_1	390	396	PF00069	0.573
MOD_CK1_1	535	541	PF00069	0.606
MOD_CK2_1	139	145	PF00069	0.601
MOD_CK2_1	149	155	PF00069	0.515
MOD_CK2_1	181	187	PF00069	0.568
MOD_CK2_1	228	234	PF00069	0.507
MOD_CK2_1	279	285	PF00069	0.597
MOD_CK2_1	345	351	PF00069	0.612
MOD_CK2_1	428	434	PF00069	0.524
MOD_CK2_1	443	449	PF00069	0.538
MOD_GlcNHglycan	262	265	PF01048	0.720
MOD_GlcNHglycan	343	346	PF01048	0.580
MOD_GlcNHglycan	389	392	PF01048	0.591
MOD_GlcNHglycan	399	402	PF01048	0.539
MOD_GlcNHglycan	412	415	PF01048	0.409
MOD_GlcNHglycan	420	423	PF01048	0.571
MOD_GlcNHglycan	445	448	PF01048	0.593
MOD_GSK3_1	235	242	PF00069	0.611
MOD_GSK3_1	269	276	PF00069	0.672
MOD_GSK3_1	341	348	PF00069	0.609
MOD_GSK3_1	362	369	PF00069	0.500
MOD_GSK3_1	428	435	PF00069	0.595
MOD_N-GLC_1	239	244	PF02516	0.605
MOD_NEK2_1	114	119	PF00069	0.498
MOD_NEK2_1	359	364	PF00069	0.594
MOD_NEK2_1	467	472	PF00069	0.623
MOD_NEK2_1	525	530	PF00069	0.547
MOD_NEK2_1	71	76	PF00069	0.548
MOD_PIKK_1	181	187	PF00454	0.585
MOD_PIKK_1	239	245	PF00454	0.487
MOD_PIKK_1	362	368	PF00454	0.501
MOD_PIKK_1	58	64	PF00454	0.573
MOD_PKA_1	148	154	PF00069	0.431
MOD_PKA_1	53	59	PF00069	0.511
MOD_PKA_2	148	154	PF00069	0.452
MOD_PKA_2	387	393	PF00069	0.595
MOD_PKA_2	410	416	PF00069	0.592
MOD_PKA_2	428	434	PF00069	0.495
MOD_PKA_2	53	59	PF00069	0.594
MOD_PKA_2	532	538	PF00069	0.584
MOD_PKB_1	51	59	PF00069	0.512
MOD_Plk_1	304	310	PF00069	0.476
MOD_Plk_1	366	372	PF00069	0.570
MOD_Plk_2-3	428	434	PF00069	0.618
MOD_Plk_4	176	182	PF00069	0.464
MOD_Plk_4	228	234	PF00069	0.372
MOD_Plk_4	532	538	PF00069	0.568
MOD_ProDKin_1	270	276	PF00069	0.670
MOD_SUMO_for_1	484	487	PF00179	0.540
MOD_SUMO_rev_2	159	165	PF00179	0.609
MOD_SUMO_rev_2	296	302	PF00179	0.478
MOD_SUMO_rev_2	357	365	PF00179	0.621
TRG_DiLeu_BaEn_4	47	53	PF01217	0.515
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.474
TRG_ENDOCYTIC_2	303	306	PF00928	0.342
TRG_ENDOCYTIC_2	38	41	PF00928	0.569
TRG_ENDOCYTIC_2	452	455	PF00928	0.574
TRG_ENDOCYTIC_2	462	465	PF00928	0.601
TRG_ER_diArg_1	110	113	PF00400	0.579
TRG_ER_diArg_1	21	24	PF00400	0.606
TRG_ER_diArg_1	352	355	PF00400	0.457
TRG_ER_diArg_1	460	462	PF00400	0.591
TRG_ER_diArg_1	509	511	PF00400	0.572
TRG_ER_diArg_1	51	54	PF00400	0.606
TRG_ER_diArg_1	516	518	PF00400	0.595
TRG_NES_CRM1_1	104	115	PF08389	0.580
TRG_NLS_MonoExtC_3	507	513	PF00514	0.510
TRG_Pf-PMV_PEXEL_1	118	123	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	490	494	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	509	513	PF00026	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBD3	Leptomonas seymouri	67%	91%
A0A0S4JEJ6	Bodo saltans	34%	95%
A0A1X0NNU4	Trypanosomatidae	38%	98%
A0A3S7WTX4	Leishmania donovani	83%	100%
A0A422MW68	Trypanosoma rangeli	38%	98%
A4HWW5	Leishmania infantum	83%	100%
C9ZPQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AQM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QEV3	Leishmania major	83%	100%
V5AX96	Trypanosoma cruzi	38%	98%