RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RING-H2 zinc finger, putative

Species:

Leishmania braziliensis

UniProt:

A4H8I7_LEIBR

TriTrypDb:

LbrM.16.0640 , LBRM2903_160012700

Length:

105

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	7
GO:0000152	nuclear ubiquitin ligase complex	3	7
GO:0005634	nucleus	5	2
GO:0005680	anaphase-promoting complex	4	7
GO:0031461	cullin-RING ubiquitin ligase complex	4	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	7
GO:0140535	intracellular protein-containing complex	2	7
GO:1902494	catalytic complex	2	7
GO:1990234	transferase complex	3	7

Expansion

Sequence features

A4H8I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8I7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	7
GO:0006511	ubiquitin-dependent protein catabolic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0007088	regulation of mitotic nuclear division	6	2
GO:0007346	regulation of mitotic cell cycle	5	2
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009057	macromolecule catabolic process	4	7
GO:0009987	cellular process	1	7
GO:0010498	proteasomal protein catabolic process	5	6
GO:0010564	regulation of cell cycle process	5	2
GO:0010638	positive regulation of organelle organization	6	2
GO:0010965	regulation of mitotic sister chromatid separation	6	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	7
GO:0019941	modification-dependent protein catabolic process	6	7
GO:0030071	regulation of mitotic metaphase/anaphase transition	7	2
GO:0030163	protein catabolic process	4	6
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	6
GO:0032446	protein modification by small protein conjugation	6	2
GO:0033043	regulation of organelle organization	5	2
GO:0033044	regulation of chromosome organization	6	2
GO:0033045	regulation of sister chromatid segregation	5	2
GO:0036211	protein modification process	4	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	6
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	2
GO:0043632	modification-dependent macromolecule catabolic process	5	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044248	cellular catabolic process	3	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0044265	obsolete cellular macromolecule catabolic process	4	7
GO:0045787	positive regulation of cell cycle	5	2
GO:0045840	positive regulation of mitotic nuclear division	7	2
GO:0045842	positive regulation of mitotic metaphase/anaphase transition	8	2
GO:0045931	positive regulation of mitotic cell cycle	6	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051130	positive regulation of cellular component organization	5	2
GO:0051301	cell division	2	5
GO:0051603	proteolysis involved in protein catabolic process	5	7
GO:0051726	regulation of cell cycle	4	2
GO:0051783	regulation of nuclear division	6	2
GO:0051785	positive regulation of nuclear division	7	2
GO:0051983	regulation of chromosome segregation	4	2
GO:0065007	biological regulation	1	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	7
GO:0090068	positive regulation of cell cycle process	6	2
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901565	organonitrogen compound catabolic process	4	6
GO:1901575	organic substance catabolic process	3	7
GO:1901970	positive regulation of mitotic sister chromatid separation	7	2
GO:1901987	regulation of cell cycle phase transition	6	2
GO:1901989	positive regulation of cell cycle phase transition	7	2
GO:1901990	regulation of mitotic cell cycle phase transition	6	2
GO:1901992	positive regulation of mitotic cell cycle phase transition	7	2
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	6	2
GO:1902101	positive regulation of metaphase/anaphase transition of cell cycle	7	2
GO:1905818	regulation of chromosome separation	5	2
GO:1905820	positive regulation of chromosome separation	6	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	18
GO:0008270	zinc ion binding	6	18
GO:0043167	ion binding	2	18
GO:0043169	cation binding	3	18
GO:0046872	metal ion binding	4	18
GO:0046914	transition metal ion binding	5	18
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0005515	protein binding	2	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0061630	ubiquitin protein ligase activity	5	7
GO:0061659	ubiquitin-like protein ligase activity	4	7
GO:0097602	cullin family protein binding	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.529
CLV_PCSK_SKI1_1	35	39	PF00082	0.327
CLV_PCSK_SKI1_1	48	52	PF00082	0.194
DOC_PP4_FxxP_1	17	20	PF00568	0.377
LIG_FHA_1	21	27	PF00498	0.355
LIG_FHA_1	86	92	PF00498	0.496
LIG_LIR_Apic_2	14	20	PF02991	0.393
LIG_LIR_Gen_1	22	33	PF02991	0.465
LIG_LIR_Nem_3	22	28	PF02991	0.458
LIG_SH2_PTP2	25	28	PF00017	0.317
LIG_SH2_SRC	25	28	PF00017	0.544
LIG_SH2_STAT5	25	28	PF00017	0.551
LIG_TYR_ITSM	21	28	PF00017	0.489
LIG_UBA3_1	18	24	PF00899	0.294
MOD_CK1_1	3	9	PF00069	0.576
MOD_CK2_1	58	64	PF00069	0.520
MOD_GlcNHglycan	10	13	PF01048	0.525
MOD_GlcNHglycan	48	51	PF01048	0.379
MOD_GSK3_1	1	8	PF00069	0.686
MOD_NEK2_1	1	6	PF00069	0.585
MOD_NEK2_1	85	90	PF00069	0.409
MOD_SUMO_rev_2	16	26	PF00179	0.373
TRG_ENDOCYTIC_2	25	28	PF00928	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V1	Leptomonas seymouri	37%	90%
A0A0N0P965	Leptomonas seymouri	39%	100%
A0A0N1I1Q1	Leptomonas seymouri	59%	100%
A0A0S4IYF9	Bodo saltans	27%	76%
A0A0S4KL27	Bodo saltans	33%	96%
A0A3S7WTW3	Leishmania donovani	88%	100%
A0A3S7X9W9	Leishmania donovani	39%	100%
A0A422MW18	Trypanosoma rangeli	35%	100%
A4HDM1	Leishmania braziliensis	36%	88%
A4HNB7	Leishmania braziliensis	39%	100%
A4HWW4	Leishmania infantum	88%	100%
A4IBZ0	Leishmania infantum	39%	100%
C9ZPQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	99%
E9AFS7	Leishmania major	39%	100%
E9AQM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9B6X9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
Q4QEV4	Leishmania major	91%	100%
Q9NHX0	Drosophila melanogaster	30%	86%
V5BCN0	Trypanosoma cruzi	32%	100%