Peptidyl-prolyl cis-trans isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4H8I6_LEIBR

TriTrypDb:

LbrM.16.0630 , LBRM2903_160012600

Length:

637

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4H8I6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8I6

Function

Biological processes
Term	Name	Level	Count
GO:0001932	regulation of protein phosphorylation	7	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031399	regulation of protein modification process	6	1
GO:0042325	regulation of phosphorylation	7	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901407	obsolete regulation of phosphorylation of RNA polymerase II C-terminal domain	8	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1
GO:0000413	protein peptidyl-prolyl isomerization	7	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0018193	peptidyl-amino acid modification	5	3
GO:0018208	peptidyl-proline modification	6	3
GO:0019538	protein metabolic process	3	3
GO:0036211	protein modification process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0016853	isomerase activity	2	10
GO:0016859	cis-trans isomerase activity	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	408	412	PF00656	0.740
CLV_C14_Caspase3-7	441	445	PF00656	0.748
CLV_NRD_NRD_1	116	118	PF00675	0.554
CLV_NRD_NRD_1	172	174	PF00675	0.586
CLV_NRD_NRD_1	272	274	PF00675	0.721
CLV_NRD_NRD_1	275	277	PF00675	0.681
CLV_NRD_NRD_1	320	322	PF00675	0.515
CLV_NRD_NRD_1	500	502	PF00675	0.566
CLV_NRD_NRD_1	628	630	PF00675	0.529
CLV_PCSK_FUR_1	273	277	PF00082	0.734
CLV_PCSK_FUR_1	318	322	PF00082	0.718
CLV_PCSK_KEX2_1	170	172	PF00082	0.605
CLV_PCSK_KEX2_1	272	274	PF00082	0.667
CLV_PCSK_KEX2_1	275	277	PF00082	0.641
CLV_PCSK_KEX2_1	320	322	PF00082	0.721
CLV_PCSK_KEX2_1	500	502	PF00082	0.592
CLV_PCSK_KEX2_1	630	632	PF00082	0.534
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.705
CLV_PCSK_PC1ET2_1	630	632	PF00082	0.558
CLV_PCSK_PC7_1	167	173	PF00082	0.696
CLV_PCSK_PC7_1	626	632	PF00082	0.524
CLV_PCSK_SKI1_1	320	324	PF00082	0.549
CLV_PCSK_SKI1_1	633	637	PF00082	0.709
CLV_PCSK_SKI1_1	86	90	PF00082	0.616
CLV_PCSK_SKI1_1	91	95	PF00082	0.610
DEG_Nend_UBRbox_3	1	3	PF02207	0.719
DEG_SPOP_SBC_1	144	148	PF00917	0.789
DEG_SPOP_SBC_1	215	219	PF00917	0.536
DEG_SPOP_SBC_1	439	443	PF00917	0.538
DOC_CYCLIN_RxL_1	83	90	PF00134	0.692
DOC_MAPK_gen_1	626	636	PF00069	0.683
DOC_MAPK_MEF2A_6	227	235	PF00069	0.448
DOC_MAPK_MEF2A_6	256	263	PF00069	0.697
DOC_MAPK_MEF2A_6	425	434	PF00069	0.768
DOC_MAPK_MEF2A_6	511	520	PF00069	0.652
DOC_MAPK_RevD_3	306	321	PF00069	0.750
DOC_PP2B_PxIxI_1	429	435	PF00149	0.779
DOC_USP7_MATH_1	127	131	PF00917	0.744
DOC_USP7_MATH_1	140	144	PF00917	0.753
DOC_USP7_MATH_1	179	183	PF00917	0.701
DOC_USP7_MATH_1	211	215	PF00917	0.774
DOC_USP7_MATH_1	306	310	PF00917	0.486
DOC_USP7_MATH_1	410	414	PF00917	0.650
DOC_USP7_MATH_1	43	47	PF00917	0.697
DOC_USP7_MATH_1	439	443	PF00917	0.607
DOC_USP7_MATH_1	484	488	PF00917	0.718
DOC_WW_Pin1_4	100	105	PF00397	0.667
DOC_WW_Pin1_4	218	223	PF00397	0.734
DOC_WW_Pin1_4	291	296	PF00397	0.506
LIG_14-3-3_CanoR_1	139	145	PF00244	0.560
LIG_14-3-3_CanoR_1	181	191	PF00244	0.539
LIG_14-3-3_CanoR_1	241	247	PF00244	0.616
LIG_14-3-3_CanoR_1	305	311	PF00244	0.684
LIG_14-3-3_CanoR_1	320	325	PF00244	0.600
LIG_14-3-3_CanoR_1	405	415	PF00244	0.604
LIG_14-3-3_CanoR_1	500	505	PF00244	0.719
LIG_14-3-3_CanoR_1	563	571	PF00244	0.507
LIG_14-3-3_CanoR_1	576	580	PF00244	0.530
LIG_Actin_WH2_2	257	274	PF00022	0.637
LIG_BIR_III_2	124	128	PF00653	0.685
LIG_BRCT_BRCA1_1	31	35	PF00533	0.698
LIG_FHA_1	131	137	PF00498	0.702
LIG_FHA_1	146	152	PF00498	0.677
LIG_FHA_1	22	28	PF00498	0.600
LIG_FHA_1	35	41	PF00498	0.561
LIG_FHA_1	513	519	PF00498	0.552
LIG_FHA_1	65	71	PF00498	0.644
LIG_FHA_2	243	249	PF00498	0.722
LIG_FHA_2	439	445	PF00498	0.790
LIG_FHA_2	547	553	PF00498	0.481
LIG_Integrin_RGD_1	530	532	PF01839	0.699
LIG_LIR_Apic_2	309	313	PF02991	0.689
LIG_LIR_Apic_2	339	345	PF02991	0.481
LIG_LIR_Apic_2	413	418	PF02991	0.512
LIG_LIR_Gen_1	255	264	PF02991	0.572
LIG_LIR_Gen_1	32	43	PF02991	0.698
LIG_LIR_Gen_1	49	60	PF02991	0.614
LIG_LIR_Gen_1	585	593	PF02991	0.508
LIG_LIR_Nem_3	190	194	PF02991	0.661
LIG_LIR_Nem_3	255	261	PF02991	0.578
LIG_LIR_Nem_3	32	38	PF02991	0.706
LIG_LIR_Nem_3	330	336	PF02991	0.618
LIG_LIR_Nem_3	339	344	PF02991	0.727
LIG_LIR_Nem_3	49	55	PF02991	0.609
LIG_LIR_Nem_3	559	564	PF02991	0.536
LIG_LIR_Nem_3	578	584	PF02991	0.490
LIG_LIR_Nem_3	585	589	PF02991	0.490
LIG_LIR_Nem_3	82	88	PF02991	0.550
LIG_PTB_Apo_2	456	463	PF02174	0.613
LIG_PTB_Phospho_1	456	462	PF10480	0.669
LIG_SH2_CRK	191	195	PF00017	0.755
LIG_SH2_CRK	400	404	PF00017	0.497
LIG_SH2_NCK_1	400	404	PF00017	0.497
LIG_SH2_PTP2	195	198	PF00017	0.533
LIG_SH2_PTP2	258	261	PF00017	0.671
LIG_SH2_PTP2	333	336	PF00017	0.729
LIG_SH2_SRC	195	198	PF00017	0.745
LIG_SH2_SRC	333	336	PF00017	0.482
LIG_SH2_STAT5	195	198	PF00017	0.780
LIG_SH2_STAT5	258	261	PF00017	0.589
LIG_SH2_STAT5	333	336	PF00017	0.729
LIG_SH2_STAT5	415	418	PF00017	0.749
LIG_SH2_STAT5	462	465	PF00017	0.628
LIG_SH2_STAT5	466	469	PF00017	0.625
LIG_SH3_1	332	338	PF00018	0.484
LIG_SH3_3	139	145	PF00018	0.545
LIG_SH3_3	191	197	PF00018	0.704
LIG_SH3_3	305	311	PF00018	0.489
LIG_SH3_3	331	337	PF00018	0.734
LIG_SUMO_SIM_anti_2	452	458	PF11976	0.656
LIG_SUMO_SIM_anti_2	514	520	PF11976	0.653
LIG_SUMO_SIM_par_1	230	236	PF11976	0.453
LIG_TYR_ITIM	579	584	PF00017	0.344
MOD_CK1_1	130	136	PF00069	0.769
MOD_CK1_1	143	149	PF00069	0.618
MOD_CK1_1	15	21	PF00069	0.604
MOD_CK1_1	182	188	PF00069	0.590
MOD_CK1_1	199	205	PF00069	0.716
MOD_CK1_1	214	220	PF00069	0.764
MOD_CK1_1	221	227	PF00069	0.672
MOD_CK1_1	247	253	PF00069	0.583
MOD_CK1_1	447	453	PF00069	0.622
MOD_CK1_1	46	52	PF00069	0.670
MOD_CK2_1	440	446	PF00069	0.777
MOD_CK2_1	447	453	PF00069	0.781
MOD_CK2_1	546	552	PF00069	0.369
MOD_GlcNHglycan	13	17	PF01048	0.594
MOD_GlcNHglycan	142	145	PF01048	0.690
MOD_GlcNHglycan	181	184	PF01048	0.559
MOD_GlcNHglycan	185	188	PF01048	0.593
MOD_GlcNHglycan	198	201	PF01048	0.718
MOD_GlcNHglycan	213	216	PF01048	0.738
MOD_GlcNHglycan	234	238	PF01048	0.592
MOD_GlcNHglycan	285	288	PF01048	0.530
MOD_GlcNHglycan	338	341	PF01048	0.665
MOD_GlcNHglycan	349	352	PF01048	0.597
MOD_GlcNHglycan	375	378	PF01048	0.544
MOD_GlcNHglycan	4	7	PF01048	0.770
MOD_GlcNHglycan	44	48	PF01048	0.662
MOD_GlcNHglycan	446	450	PF01048	0.618
MOD_GlcNHglycan	486	489	PF01048	0.749
MOD_GlcNHglycan	492	495	PF01048	0.649
MOD_GlcNHglycan	565	568	PF01048	0.353
MOD_GlcNHglycan	96	99	PF01048	0.684
MOD_GSK3_1	12	19	PF00069	0.627
MOD_GSK3_1	128	135	PF00069	0.751
MOD_GSK3_1	140	147	PF00069	0.715
MOD_GSK3_1	177	184	PF00069	0.557
MOD_GSK3_1	211	218	PF00069	0.782
MOD_GSK3_1	283	290	PF00069	0.552
MOD_GSK3_1	320	327	PF00069	0.641
MOD_GSK3_1	343	350	PF00069	0.659
MOD_GSK3_1	401	408	PF00069	0.658
MOD_GSK3_1	440	447	PF00069	0.600
MOD_GSK3_1	611	618	PF00069	0.435
MOD_GSK3_1	96	103	PF00069	0.616
MOD_N-GLC_1	512	517	PF02516	0.550
MOD_N-GLC_2	54	56	PF02516	0.523
MOD_NEK2_1	1	6	PF00069	0.601
MOD_NEK2_1	242	247	PF00069	0.595
MOD_NEK2_1	28	33	PF00069	0.589
MOD_NEK2_1	556	561	PF00069	0.344
MOD_NEK2_1	613	618	PF00069	0.468
MOD_NEK2_1	94	99	PF00069	0.543
MOD_NEK2_2	410	415	PF00069	0.712
MOD_PIKK_1	556	562	PF00454	0.369
MOD_PIKK_1	611	617	PF00454	0.441
MOD_PKA_1	320	326	PF00069	0.757
MOD_PKA_1	500	506	PF00069	0.718
MOD_PKA_2	320	326	PF00069	0.687
MOD_PKA_2	406	412	PF00069	0.590
MOD_PKA_2	484	490	PF00069	0.658
MOD_PKA_2	500	506	PF00069	0.602
MOD_PKA_2	575	581	PF00069	0.299
MOD_PKB_1	318	326	PF00069	0.616
MOD_Plk_1	247	253	PF00069	0.616
MOD_Plk_1	29	35	PF00069	0.602
MOD_Plk_1	410	416	PF00069	0.696
MOD_Plk_1	43	49	PF00069	0.571
MOD_Plk_1	512	518	PF00069	0.649
MOD_Plk_4	227	233	PF00069	0.678
MOD_Plk_4	320	326	PF00069	0.642
MOD_Plk_4	410	416	PF00069	0.644
MOD_Plk_4	500	506	PF00069	0.663
MOD_Plk_4	514	520	PF00069	0.546
MOD_ProDKin_1	100	106	PF00069	0.669
MOD_ProDKin_1	218	224	PF00069	0.730
MOD_ProDKin_1	291	297	PF00069	0.503
MOD_SUMO_rev_2	528	536	PF00179	0.562
MOD_SUMO_rev_2	566	575	PF00179	0.344
TRG_DiLeu_BaEn_1	514	519	PF01217	0.578
TRG_ENDOCYTIC_2	191	194	PF00928	0.755
TRG_ENDOCYTIC_2	195	198	PF00928	0.739
TRG_ENDOCYTIC_2	258	261	PF00928	0.671
TRG_ENDOCYTIC_2	333	336	PF00928	0.713
TRG_ENDOCYTIC_2	400	403	PF00928	0.743
TRG_ENDOCYTIC_2	581	584	PF00928	0.344
TRG_ENDOCYTIC_2	85	88	PF00928	0.580
TRG_ER_diArg_1	171	173	PF00400	0.659
TRG_ER_diArg_1	271	273	PF00400	0.709
TRG_ER_diArg_1	274	276	PF00400	0.719
TRG_ER_diArg_1	317	320	PF00400	0.618
TRG_ER_diArg_1	628	631	PF00400	0.511
TRG_NLS_MonoCore_2	169	174	PF00514	0.702
TRG_NLS_MonoExtC_3	116	122	PF00514	0.638
TRG_NLS_MonoExtC_3	628	633	PF00514	0.479
TRG_NLS_MonoExtN_4	116	121	PF00514	0.509
TRG_NLS_MonoExtN_4	167	174	PF00514	0.696
TRG_NLS_MonoExtN_4	626	633	PF00514	0.471
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.690
TRG_Pf-PMV_PEXEL_1	495	499	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	601	605	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB00	Leptomonas seymouri	55%	100%
A0A3Q8ICH7	Leishmania donovani	81%	91%
A0A422MVZ8	Trypanosoma rangeli	35%	100%
A4HWW3	Leishmania infantum	80%	91%
C9ZPQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AQM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QEV5	Leishmania major	78%	100%
V5DDE8	Trypanosoma cruzi	35%	100%