TP6A_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

meiotic recombination protein SPO11, putative

Species:

Leishmania braziliensis

UniProt:

A4H8I5_LEIBR

TriTrypDb:

LbrM.16.0620 , LBRM2903_160012500

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005694	chromosome	5	6
GO:0043226	organelle	2	6
GO:0043228	non-membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043232	intracellular non-membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6
GO:0000228	nuclear chromosome	6	1

Expansion

Sequence features

A4H8I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8I5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006259	DNA metabolic process	4	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:0000706	meiotic DNA double-strand break processing	3	1
GO:0000729	DNA double-strand break processing	5	1
GO:0006310	DNA recombination	5	1
GO:0007131	reciprocal meiotic recombination	3	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0035825	homologous recombination	6	1
GO:0042138	meiotic DNA double-strand break formation	4	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0140527	reciprocal homologous recombination	7	1
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003676	nucleic acid binding	3	6
GO:0003677	DNA binding	4	6
GO:0003824	catalytic activity	1	6
GO:0003916	DNA topoisomerase activity	3	6
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0008094	ATP-dependent activity, acting on DNA	2	6
GO:0016853	isomerase activity	2	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140097	catalytic activity, acting on DNA	3	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6
GO:0140657	ATP-dependent activity	1	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.479
CLV_C14_Caspase3-7	381	385	PF00656	0.414
CLV_C14_Caspase3-7	420	424	PF00656	0.556
CLV_C14_Caspase3-7	502	506	PF00656	0.436
CLV_NRD_NRD_1	27	29	PF00675	0.357
CLV_NRD_NRD_1	503	505	PF00675	0.454
CLV_NRD_NRD_1	599	601	PF00675	0.346
CLV_NRD_NRD_1	629	631	PF00675	0.612
CLV_NRD_NRD_1	649	651	PF00675	0.269
CLV_NRD_NRD_1	67	69	PF00675	0.607
CLV_NRD_NRD_1	83	85	PF00675	0.508
CLV_PCSK_KEX2_1	27	29	PF00082	0.357
CLV_PCSK_KEX2_1	503	505	PF00082	0.465
CLV_PCSK_KEX2_1	554	556	PF00082	0.703
CLV_PCSK_KEX2_1	599	601	PF00082	0.346
CLV_PCSK_KEX2_1	629	631	PF00082	0.606
CLV_PCSK_KEX2_1	649	651	PF00082	0.389
CLV_PCSK_KEX2_1	67	69	PF00082	0.613
CLV_PCSK_KEX2_1	83	85	PF00082	0.605
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.677
CLV_PCSK_PC7_1	550	556	PF00082	0.510
CLV_PCSK_PC7_1	595	601	PF00082	0.317
CLV_PCSK_SKI1_1	174	178	PF00082	0.227
CLV_PCSK_SKI1_1	284	288	PF00082	0.586
CLV_PCSK_SKI1_1	345	349	PF00082	0.420
CLV_PCSK_SKI1_1	378	382	PF00082	0.325
CLV_PCSK_SKI1_1	600	604	PF00082	0.301
DEG_APCC_DBOX_1	133	141	PF00400	0.293
DEG_APCC_DBOX_1	321	329	PF00400	0.351
DEG_APCC_DBOX_1	344	352	PF00400	0.421
DOC_ANK_TNKS_1	356	363	PF00023	0.292
DOC_CDC14_PxL_1	397	405	PF14671	0.418
DOC_CYCLIN_yCln2_LP_2	258	264	PF00134	0.491
DOC_MAPK_gen_1	132	140	PF00069	0.307
DOC_MAPK_gen_1	184	192	PF00069	0.293
DOC_MAPK_gen_1	27	33	PF00069	0.360
DOC_MAPK_gen_1	554	563	PF00069	0.570
DOC_MAPK_MEF2A_6	134	142	PF00069	0.318
DOC_MAPK_MEF2A_6	327	334	PF00069	0.341
DOC_MAPK_MEF2A_6	554	563	PF00069	0.495
DOC_PP2B_LxvP_1	183	186	PF13499	0.293
DOC_PP2B_LxvP_1	41	44	PF13499	0.480
DOC_USP7_MATH_1	123	127	PF00917	0.568
DOC_USP7_MATH_1	270	274	PF00917	0.536
DOC_USP7_MATH_1	380	384	PF00917	0.510
DOC_USP7_MATH_1	411	415	PF00917	0.329
DOC_USP7_MATH_1	468	472	PF00917	0.669
DOC_USP7_MATH_1	491	495	PF00917	0.645
DOC_USP7_MATH_1	634	638	PF00917	0.426
DOC_WW_Pin1_4	257	262	PF00397	0.526
DOC_WW_Pin1_4	266	271	PF00397	0.479
DOC_WW_Pin1_4	299	304	PF00397	0.299
DOC_WW_Pin1_4	439	444	PF00397	0.794
DOC_WW_Pin1_4	487	492	PF00397	0.567
DOC_WW_Pin1_4	522	527	PF00397	0.572
DOC_WW_Pin1_4	6	11	PF00397	0.444
LIG_14-3-3_CanoR_1	207	212	PF00244	0.375
LIG_14-3-3_CanoR_1	378	386	PF00244	0.466
LIG_14-3-3_CanoR_1	558	562	PF00244	0.534
LIG_14-3-3_CanoR_1	572	576	PF00244	0.530
LIG_14-3-3_CanoR_1	584	588	PF00244	0.430
LIG_14-3-3_CanoR_1	599	603	PF00244	0.508
LIG_14-3-3_CanoR_1	67	75	PF00244	0.533
LIG_BRCT_BRCA1_1	335	339	PF00533	0.283
LIG_BRCT_BRCA1_1	614	618	PF00533	0.338
LIG_CSL_BTD_1	41	44	PF09270	0.359
LIG_eIF4E_1	342	348	PF01652	0.355
LIG_FHA_1	166	172	PF00498	0.348
LIG_FHA_1	229	235	PF00498	0.359
LIG_FHA_1	408	414	PF00498	0.396
LIG_FHA_1	508	514	PF00498	0.322
LIG_FHA_1	51	57	PF00498	0.486
LIG_FHA_2	152	158	PF00498	0.293
LIG_FHA_2	2	8	PF00498	0.375
LIG_FHA_2	242	248	PF00498	0.494
LIG_FHA_2	379	385	PF00498	0.448
LIG_FHA_2	418	424	PF00498	0.492
LIG_FHA_2	500	506	PF00498	0.413
LIG_FHA_2	533	539	PF00498	0.542
LIG_FHA_2	80	86	PF00498	0.580
LIG_Integrin_RGD_1	149	151	PF01839	0.312
LIG_LIR_Apic_2	607	613	PF02991	0.456
LIG_LIR_Gen_1	157	167	PF02991	0.348
LIG_LIR_Gen_1	2	13	PF02991	0.446
LIG_LIR_Gen_1	251	262	PF02991	0.636
LIG_LIR_LC3C_4	230	235	PF02991	0.402
LIG_LIR_Nem_3	141	147	PF02991	0.454
LIG_LIR_Nem_3	157	163	PF02991	0.299
LIG_LIR_Nem_3	2	8	PF02991	0.443
LIG_LIR_Nem_3	205	209	PF02991	0.537
LIG_LIR_Nem_3	251	257	PF02991	0.640
LIG_LIR_Nem_3	336	342	PF02991	0.376
LIG_LIR_Nem_3	39	45	PF02991	0.357
LIG_LIR_Nem_3	394	400	PF02991	0.449
LIG_MYND_1	326	330	PF01753	0.348
LIG_NRBOX	36	42	PF00104	0.443
LIG_NRBOX	515	521	PF00104	0.456
LIG_SH2_CRK	160	164	PF00017	0.293
LIG_SH2_CRK	206	210	PF00017	0.395
LIG_SH2_CRK	570	574	PF00017	0.443
LIG_SH2_CRK	610	614	PF00017	0.476
LIG_SH2_NCK_1	441	445	PF00017	0.557
LIG_SH2_NCK_1	610	614	PF00017	0.476
LIG_SH2_PTP2	398	401	PF00017	0.308
LIG_SH2_SRC	478	481	PF00017	0.516
LIG_SH2_STAP1	614	618	PF00017	0.427
LIG_SH2_STAT5	199	202	PF00017	0.468
LIG_SH2_STAT5	32	35	PF00017	0.354
LIG_SH2_STAT5	398	401	PF00017	0.308
LIG_SH2_STAT5	441	444	PF00017	0.526
LIG_SH2_STAT5	610	613	PF00017	0.458
LIG_SH3_3	112	118	PF00018	0.526
LIG_SH3_3	353	359	PF00018	0.312
LIG_SH3_3	545	551	PF00018	0.525
LIG_SH3_3	91	97	PF00018	0.644
LIG_SUMO_SIM_par_1	11	17	PF11976	0.470
LIG_SUMO_SIM_par_1	136	141	PF11976	0.348
LIG_SUMO_SIM_par_1	230	239	PF11976	0.319
LIG_SUMO_SIM_par_1	307	312	PF11976	0.307
LIG_SUMO_SIM_par_1	92	100	PF11976	0.527
LIG_TRAF2_1	219	222	PF00917	0.497
LIG_TRAF2_1	236	239	PF00917	0.317
LIG_TRAF2_1	97	100	PF00917	0.524
LIG_TYR_ITIM	158	163	PF00017	0.348
LIG_TYR_ITIM	204	209	PF00017	0.371
LIG_UBA3_1	40	46	PF00899	0.463
MOD_CK1_1	260	266	PF00069	0.591
MOD_CK1_1	273	279	PF00069	0.577
MOD_CK1_1	471	477	PF00069	0.672
MOD_CK1_1	490	496	PF00069	0.591
MOD_CK1_1	51	57	PF00069	0.477
MOD_CK1_1	95	101	PF00069	0.554
MOD_CK2_1	1	7	PF00069	0.462
MOD_CK2_1	233	239	PF00069	0.316
MOD_CK2_1	241	247	PF00069	0.483
MOD_CK2_1	532	538	PF00069	0.542
MOD_CK2_1	79	85	PF00069	0.577
MOD_DYRK1A_RPxSP_1	266	270	PF00069	0.516
MOD_GlcNHglycan	272	275	PF01048	0.609
MOD_GlcNHglycan	289	292	PF01048	0.478
MOD_GlcNHglycan	389	392	PF01048	0.565
MOD_GlcNHglycan	470	473	PF01048	0.593
MOD_GlcNHglycan	50	53	PF01048	0.466
MOD_GlcNHglycan	620	623	PF01048	0.424
MOD_GlcNHglycan	89	92	PF01048	0.583
MOD_GSK3_1	252	259	PF00069	0.699
MOD_GSK3_1	260	267	PF00069	0.551
MOD_GSK3_1	272	279	PF00069	0.686
MOD_GSK3_1	285	292	PF00069	0.523
MOD_GSK3_1	380	387	PF00069	0.420
MOD_GSK3_1	407	414	PF00069	0.498
MOD_GSK3_1	419	426	PF00069	0.559
MOD_GSK3_1	453	460	PF00069	0.757
MOD_GSK3_1	46	53	PF00069	0.609
MOD_GSK3_1	470	477	PF00069	0.689
MOD_GSK3_1	487	494	PF00069	0.509
MOD_GSK3_1	608	615	PF00069	0.331
MOD_N-GLC_1	172	177	PF02516	0.293
MOD_N-GLC_1	423	428	PF02516	0.486
MOD_NEK2_1	1	6	PF00069	0.529
MOD_NEK2_1	138	143	PF00069	0.321
MOD_NEK2_1	190	195	PF00069	0.343
MOD_NEK2_1	233	238	PF00069	0.500
MOD_NEK2_1	264	269	PF00069	0.643
MOD_NEK2_1	333	338	PF00069	0.264
MOD_NEK2_1	36	41	PF00069	0.436
MOD_NEK2_1	417	422	PF00069	0.542
MOD_NEK2_1	446	451	PF00069	0.657
MOD_NEK2_1	50	55	PF00069	0.472
MOD_NEK2_1	520	525	PF00069	0.459
MOD_NEK2_1	618	623	PF00069	0.563
MOD_NEK2_1	78	83	PF00069	0.626
MOD_NEK2_2	123	128	PF00069	0.501
MOD_PIKK_1	151	157	PF00454	0.395
MOD_PIKK_1	165	171	PF00454	0.224
MOD_PIKK_1	333	339	PF00454	0.272
MOD_PIKK_1	634	640	PF00454	0.486
MOD_PIKK_1	67	73	PF00454	0.498
MOD_PKA_1	67	73	PF00069	0.498
MOD_PKA_2	276	282	PF00069	0.665
MOD_PKA_2	557	563	PF00069	0.585
MOD_PKA_2	571	577	PF00069	0.428
MOD_PKA_2	583	589	PF00069	0.549
MOD_PKA_2	598	604	PF00069	0.502
MOD_PKA_2	67	73	PF00069	0.516
MOD_Plk_1	172	178	PF00069	0.293
MOD_Plk_4	1	7	PF00069	0.396
MOD_Plk_4	138	144	PF00069	0.252
MOD_Plk_4	36	42	PF00069	0.443
MOD_Plk_4	51	57	PF00069	0.477
MOD_Plk_4	583	589	PF00069	0.407
MOD_Plk_4	620	626	PF00069	0.530
MOD_ProDKin_1	257	263	PF00069	0.526
MOD_ProDKin_1	266	272	PF00069	0.482
MOD_ProDKin_1	299	305	PF00069	0.295
MOD_ProDKin_1	439	445	PF00069	0.791
MOD_ProDKin_1	487	493	PF00069	0.563
MOD_ProDKin_1	522	528	PF00069	0.579
MOD_ProDKin_1	6	12	PF00069	0.444
MOD_SUMO_for_1	602	605	PF00179	0.367
TRG_DiLeu_BaEn_4	221	227	PF01217	0.447
TRG_DiLeu_BaLyEn_6	224	229	PF01217	0.387
TRG_DiLeu_BaLyEn_6	324	329	PF01217	0.403
TRG_ENDOCYTIC_2	159	162	PF00928	0.346
TRG_ENDOCYTIC_2	206	209	PF00928	0.534
TRG_ENDOCYTIC_2	397	400	PF00928	0.425
TRG_ENDOCYTIC_2	570	573	PF00928	0.456
TRG_ER_diArg_1	26	28	PF00400	0.369
TRG_ER_diArg_1	265	268	PF00400	0.513
TRG_ER_diArg_1	648	650	PF00400	0.445
TRG_ER_diArg_1	66	68	PF00400	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C1	Leptomonas seymouri	37%	98%
A0A3S7WTW1	Leishmania donovani	68%	100%
E9AQM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QEV6	Leishmania major	69%	99%