Uridine/cytidine kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AAA domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8I1_LEIBR

TriTrypDb:

LbrM.16.0580 , LBRM2903_160011800

Length:

744

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8I1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.788
CLV_C14_Caspase3-7	459	463	PF00656	0.542
CLV_C14_Caspase3-7	51	55	PF00656	0.622
CLV_C14_Caspase3-7	514	518	PF00656	0.568
CLV_C14_Caspase3-7	548	552	PF00656	0.564
CLV_MEL_PAP_1	470	476	PF00089	0.505
CLV_NRD_NRD_1	160	162	PF00675	0.675
CLV_NRD_NRD_1	224	226	PF00675	0.725
CLV_NRD_NRD_1	302	304	PF00675	0.557
CLV_NRD_NRD_1	309	311	PF00675	0.608
CLV_NRD_NRD_1	425	427	PF00675	0.762
CLV_PCSK_FUR_1	158	162	PF00082	0.405
CLV_PCSK_FUR_1	221	225	PF00082	0.797
CLV_PCSK_KEX2_1	160	162	PF00082	0.675
CLV_PCSK_KEX2_1	221	223	PF00082	0.681
CLV_PCSK_KEX2_1	224	226	PF00082	0.716
CLV_PCSK_KEX2_1	302	304	PF00082	0.517
CLV_PCSK_KEX2_1	309	311	PF00082	0.581
CLV_PCSK_SKI1_1	302	306	PF00082	0.535
CLV_PCSK_SKI1_1	314	318	PF00082	0.653
CLV_PCSK_SKI1_1	582	586	PF00082	0.704
DEG_APCC_DBOX_1	149	157	PF00400	0.399
DEG_ODPH_VHL_1	642	655	PF01847	0.415
DEG_SCF_TRCP1_1	680	685	PF00400	0.532
DOC_CKS1_1	305	310	PF01111	0.693
DOC_CYCLIN_yCln2_LP_2	53	59	PF00134	0.510
DOC_CYCLIN_yCln2_LP_2	663	669	PF00134	0.382
DOC_MAPK_gen_1	363	372	PF00069	0.498
DOC_PP1_RVXF_1	669	675	PF00149	0.688
DOC_PP1_RVXF_1	708	714	PF00149	0.460
DOC_PP2B_LxvP_1	151	154	PF13499	0.628
DOC_PP2B_LxvP_1	561	564	PF13499	0.539
DOC_PP4_FxxP_1	305	308	PF00568	0.583
DOC_PP4_FxxP_1	417	420	PF00568	0.736
DOC_USP7_MATH_1	100	104	PF00917	0.539
DOC_USP7_MATH_1	169	173	PF00917	0.578
DOC_USP7_MATH_1	184	188	PF00917	0.777
DOC_USP7_MATH_1	463	467	PF00917	0.684
DOC_USP7_MATH_1	522	526	PF00917	0.650
DOC_USP7_MATH_1	631	635	PF00917	0.487
DOC_WW_Pin1_4	113	118	PF00397	0.725
DOC_WW_Pin1_4	170	175	PF00397	0.821
DOC_WW_Pin1_4	304	309	PF00397	0.590
DOC_WW_Pin1_4	410	415	PF00397	0.665
DOC_WW_Pin1_4	453	458	PF00397	0.701
DOC_WW_Pin1_4	52	57	PF00397	0.531
DOC_WW_Pin1_4	554	559	PF00397	0.802
DOC_WW_Pin1_4	597	602	PF00397	0.812
LIG_14-3-3_CanoR_1	120	125	PF00244	0.571
LIG_14-3-3_CanoR_1	280	286	PF00244	0.607
LIG_14-3-3_CanoR_1	673	678	PF00244	0.746
LIG_14-3-3_CanoR_1	90	95	PF00244	0.481
LIG_eIF4E_1	572	578	PF01652	0.451
LIG_eIF4E_1	580	586	PF01652	0.422
LIG_FHA_1	128	134	PF00498	0.541
LIG_FHA_1	264	270	PF00498	0.354
LIG_FHA_1	296	302	PF00498	0.547
LIG_FHA_1	560	566	PF00498	0.584
LIG_FHA_1	628	634	PF00498	0.619
LIG_FHA_2	372	378	PF00498	0.449
LIG_FHA_2	402	408	PF00498	0.694
LIG_FHA_2	457	463	PF00498	0.543
LIG_FHA_2	467	473	PF00498	0.475
LIG_FHA_2	512	518	PF00498	0.689
LIG_FHA_2	729	735	PF00498	0.721
LIG_FHA_2	74	80	PF00498	0.530
LIG_Integrin_isoDGR_2	717	719	PF01839	0.637
LIG_LIR_Apic_2	415	420	PF02991	0.643
LIG_LIR_Gen_1	143	154	PF02991	0.488
LIG_LIR_Gen_1	262	270	PF02991	0.393
LIG_LIR_Gen_1	489	500	PF02991	0.590
LIG_LIR_Gen_1	84	92	PF02991	0.379
LIG_LIR_Nem_3	157	162	PF02991	0.435
LIG_LIR_Nem_3	262	267	PF02991	0.478
LIG_LIR_Nem_3	284	288	PF02991	0.409
LIG_LIR_Nem_3	489	495	PF02991	0.594
LIG_LIR_Nem_3	648	654	PF02991	0.552
LIG_LIR_Nem_3	661	667	PF02991	0.538
LIG_LIR_Nem_3	76	80	PF02991	0.494
LIG_LIR_Nem_3	84	88	PF02991	0.446
LIG_LIR_Nem_3	89	94	PF02991	0.471
LIG_MYND_1	113	117	PF01753	0.557
LIG_NRP_CendR_1	741	744	PF00754	0.710
LIG_Pex14_1	496	500	PF04695	0.585
LIG_Pex14_2	492	496	PF04695	0.583
LIG_Pex14_2	645	649	PF04695	0.568
LIG_REV1ctd_RIR_1	302	307	PF16727	0.570
LIG_REV1ctd_RIR_1	492	502	PF16727	0.437
LIG_SH2_CRK	159	163	PF00017	0.417
LIG_SH2_CRK	580	584	PF00017	0.451
LIG_SH2_CRK	660	664	PF00017	0.497
LIG_SH2_CRK	85	89	PF00017	0.475
LIG_SH2_GRB2like	572	575	PF00017	0.711
LIG_SH2_NCK_1	85	89	PF00017	0.354
LIG_SH2_PTP2	264	267	PF00017	0.339
LIG_SH2_STAP1	647	651	PF00017	0.566
LIG_SH2_STAP1	660	664	PF00017	0.526
LIG_SH2_STAT3	572	575	PF00017	0.459
LIG_SH2_STAT5	264	267	PF00017	0.468
LIG_SH2_STAT5	268	271	PF00017	0.420
LIG_SH2_STAT5	285	288	PF00017	0.550
LIG_SH2_STAT5	315	318	PF00017	0.710
LIG_SH2_STAT5	572	575	PF00017	0.609
LIG_SH3_3	168	174	PF00018	0.587
LIG_SH3_3	223	229	PF00018	0.591
LIG_SH3_3	348	354	PF00018	0.715
LIG_SH3_3	416	422	PF00018	0.659
LIG_SH3_3	53	59	PF00018	0.510
LIG_SH3_3	592	598	PF00018	0.669
LIG_SH3_CIN85_PxpxPR_1	705	710	PF14604	0.709
LIG_SUMO_SIM_anti_2	272	278	PF11976	0.315
LIG_TRAF2_1	216	219	PF00917	0.767
LIG_TRAF2_1	564	567	PF00917	0.753
LIG_TRFH_1	242	246	PF08558	0.543
LIG_TYR_ITIM	658	663	PF00017	0.531
LIG_TYR_ITIM	83	88	PF00017	0.480
LIG_WW_3	418	422	PF00397	0.651
MOD_CDK_SPK_2	304	309	PF00069	0.590
MOD_CDK_SPxK_1	304	310	PF00069	0.590
MOD_CDK_SPxxK_3	113	120	PF00069	0.815
MOD_CK1_1	10	16	PF00069	0.599
MOD_CK1_1	116	122	PF00069	0.789
MOD_CK1_1	127	133	PF00069	0.558
MOD_CK1_1	172	178	PF00069	0.772
MOD_CK1_1	186	192	PF00069	0.722
MOD_CK1_1	207	213	PF00069	0.555
MOD_CK1_1	21	27	PF00069	0.374
MOD_CK1_1	361	367	PF00069	0.479
MOD_CK1_1	393	399	PF00069	0.657
MOD_CK1_1	40	46	PF00069	0.496
MOD_CK1_1	461	467	PF00069	0.745
MOD_CK1_1	554	560	PF00069	0.667
MOD_CK1_1	634	640	PF00069	0.627
MOD_CK1_1	693	699	PF00069	0.619
MOD_CK2_1	184	190	PF00069	0.815
MOD_CK2_1	371	377	PF00069	0.450
MOD_CK2_1	466	472	PF00069	0.514
MOD_CK2_1	526	532	PF00069	0.563
MOD_CK2_1	682	688	PF00069	0.746
MOD_CK2_1	722	728	PF00069	0.487
MOD_Cter_Amidation	219	222	PF01082	0.625
MOD_GlcNHglycan	125	129	PF01048	0.788
MOD_GlcNHglycan	167	170	PF01048	0.762
MOD_GlcNHglycan	174	177	PF01048	0.830
MOD_GlcNHglycan	247	250	PF01048	0.735
MOD_GlcNHglycan	319	322	PF01048	0.737
MOD_GlcNHglycan	37	40	PF01048	0.511
MOD_GlcNHglycan	462	466	PF01048	0.775
MOD_GlcNHglycan	478	481	PF01048	0.487
MOD_GlcNHglycan	553	556	PF01048	0.575
MOD_GlcNHglycan	633	636	PF01048	0.625
MOD_GlcNHglycan	639	642	PF01048	0.611
MOD_GlcNHglycan	680	683	PF01048	0.723
MOD_GlcNHglycan	684	687	PF01048	0.712
MOD_GlcNHglycan	692	695	PF01048	0.663
MOD_GlcNHglycan	724	727	PF01048	0.551
MOD_GlcNHglycan	736	739	PF01048	0.572
MOD_GlcNHglycan	8	12	PF01048	0.543
MOD_GSK3_1	116	123	PF00069	0.689
MOD_GSK3_1	165	172	PF00069	0.713
MOD_GSK3_1	19	26	PF00069	0.497
MOD_GSK3_1	200	207	PF00069	0.570
MOD_GSK3_1	236	243	PF00069	0.752
MOD_GSK3_1	259	266	PF00069	0.423
MOD_GSK3_1	310	317	PF00069	0.464
MOD_GSK3_1	37	44	PF00069	0.494
MOD_GSK3_1	384	391	PF00069	0.683
MOD_GSK3_1	476	483	PF00069	0.732
MOD_GSK3_1	48	55	PF00069	0.565
MOD_GSK3_1	507	514	PF00069	0.673
MOD_GSK3_1	522	529	PF00069	0.490
MOD_GSK3_1	627	634	PF00069	0.648
MOD_GSK3_1	678	685	PF00069	0.778
MOD_GSK3_1	86	93	PF00069	0.447
MOD_N-GLC_1	441	446	PF02516	0.560
MOD_N-GLC_1	476	481	PF02516	0.491
MOD_N-GLC_1	527	532	PF02516	0.501
MOD_N-GLC_2	476	478	PF02516	0.498
MOD_NEK2_1	281	286	PF00069	0.594
MOD_NEK2_1	526	531	PF00069	0.592
MOD_NEK2_1	585	590	PF00069	0.722
MOD_NEK2_2	240	245	PF00069	0.546
MOD_OFUCOSY	394	399	PF10250	0.493
MOD_PIKK_1	728	734	PF00454	0.626
MOD_PK_1	120	126	PF00069	0.570
MOD_PK_1	673	679	PF00069	0.748
MOD_PK_1	90	96	PF00069	0.573
MOD_PKA_2	119	125	PF00069	0.643
MOD_PKB_1	671	679	PF00069	0.725
MOD_Plk_1	16	22	PF00069	0.573
MOD_Plk_1	207	213	PF00069	0.705
MOD_Plk_1	240	246	PF00069	0.544
MOD_Plk_2-3	200	206	PF00069	0.735
MOD_Plk_4	281	287	PF00069	0.597
MOD_Plk_4	384	390	PF00069	0.542
MOD_Plk_4	522	528	PF00069	0.500
MOD_Plk_4	585	591	PF00069	0.482
MOD_Plk_4	90	96	PF00069	0.573
MOD_ProDKin_1	113	119	PF00069	0.728
MOD_ProDKin_1	170	176	PF00069	0.821
MOD_ProDKin_1	304	310	PF00069	0.590
MOD_ProDKin_1	410	416	PF00069	0.667
MOD_ProDKin_1	453	459	PF00069	0.700
MOD_ProDKin_1	52	58	PF00069	0.529
MOD_ProDKin_1	554	560	PF00069	0.796
MOD_ProDKin_1	597	603	PF00069	0.814
MOD_SUMO_rev_2	22	32	PF00179	0.338
TRG_DiLeu_BaEn_1	272	277	PF01217	0.410
TRG_ENDOCYTIC_2	159	162	PF00928	0.433
TRG_ENDOCYTIC_2	264	267	PF00928	0.339
TRG_ENDOCYTIC_2	580	583	PF00928	0.528
TRG_ENDOCYTIC_2	646	649	PF00928	0.566
TRG_ENDOCYTIC_2	651	654	PF00928	0.545
TRG_ENDOCYTIC_2	660	663	PF00928	0.531
TRG_ENDOCYTIC_2	80	83	PF00928	0.498
TRG_ENDOCYTIC_2	85	88	PF00928	0.477
TRG_ER_diArg_1	148	151	PF00400	0.493
TRG_ER_diArg_1	159	161	PF00400	0.587
TRG_ER_diArg_1	221	224	PF00400	0.689
TRG_ER_diArg_1	301	303	PF00400	0.551
TRG_ER_diArg_1	308	310	PF00400	0.599
TRG_ER_diArg_1	352	355	PF00400	0.657
TRG_ER_diArg_1	362	365	PF00400	0.569
TRG_ER_diArg_1	671	674	PF00400	0.598
TRG_NES_CRM1_1	371	386	PF08389	0.723
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVQ0	Leptomonas seymouri	34%	100%
A0A3S7WTV2	Leishmania donovani	64%	100%
A4HWV3	Leishmania infantum	64%	100%
E9AQL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4QEW4	Leishmania major	62%	100%