Putative orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4H8I0_LEIBR

TriTrypDb:

LbrM.16.0570 , LBRM2903_160011700

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H8I0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8I0

PDB structure(s): 3qw3_A , 3qw3_B

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006206	pyrimidine nucleobase metabolic process	5	11
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	7	11
GO:0006220	pyrimidine nucleotide metabolic process	5	11
GO:0006221	pyrimidine nucleotide biosynthetic process	6	11
GO:0006222	UMP biosynthetic process	8	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006753	nucleoside phosphate metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009112	nucleobase metabolic process	4	11
GO:0009117	nucleotide metabolic process	5	11
GO:0009123	nucleoside monophosphate metabolic process	5	11
GO:0009124	nucleoside monophosphate biosynthetic process	6	11
GO:0009129	pyrimidine nucleoside monophosphate metabolic process	6	11
GO:0009130	pyrimidine nucleoside monophosphate biosynthetic process	7	11
GO:0009156	ribonucleoside monophosphate biosynthetic process	7	11
GO:0009161	ribonucleoside monophosphate metabolic process	6	11
GO:0009165	nucleotide biosynthetic process	6	11
GO:0009173	pyrimidine ribonucleoside monophosphate metabolic process	7	11
GO:0009174	pyrimidine ribonucleoside monophosphate biosynthetic process	8	11
GO:0009218	pyrimidine ribonucleotide metabolic process	6	11
GO:0009220	pyrimidine ribonucleotide biosynthetic process	7	11
GO:0009259	ribonucleotide metabolic process	5	11
GO:0009260	ribonucleotide biosynthetic process	6	11
GO:0009987	cellular process	1	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019693	ribose phosphate metabolic process	4	11
GO:0019856	pyrimidine nucleobase biosynthetic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0044205	'de novo' UMP biosynthetic process	9	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0046049	UMP metabolic process	7	11
GO:0046112	nucleobase biosynthetic process	5	11
GO:0046390	ribose phosphate biosynthetic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0072527	pyrimidine-containing compound metabolic process	4	11
GO:0072528	pyrimidine-containing compound biosynthetic process	5	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901137	carbohydrate derivative biosynthetic process	4	11
GO:1901293	nucleoside phosphate biosynthetic process	5	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004588	orotate phosphoribosyltransferase activity	5	11
GO:0004590	orotidine-5'-phosphate decarboxylase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016757	glycosyltransferase activity	3	11
GO:0016763	pentosyltransferase activity	4	11
GO:0016829	lyase activity	2	11
GO:0016830	carbon-carbon lyase activity	3	11
GO:0016831	carboxy-lyase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	90	94	PF00656	0.314
CLV_NRD_NRD_1	345	347	PF00675	0.201
CLV_PCSK_KEX2_1	345	347	PF00082	0.201
CLV_PCSK_KEX2_1	84	86	PF00082	0.235
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.235
CLV_PCSK_SKI1_1	101	105	PF00082	0.233
CLV_PCSK_SKI1_1	128	132	PF00082	0.257
CLV_PCSK_SKI1_1	252	256	PF00082	0.534
CLV_PCSK_SKI1_1	346	350	PF00082	0.214
CLV_PCSK_SKI1_1	408	412	PF00082	0.334
CLV_PCSK_SKI1_1	446	450	PF00082	0.379
DOC_MAPK_gen_1	10	18	PF00069	0.280
DOC_MAPK_gen_1	188	196	PF00069	0.278
DOC_MAPK_gen_1	252	261	PF00069	0.385
DOC_MAPK_gen_1	279	288	PF00069	0.316
DOC_MAPK_gen_1	362	370	PF00069	0.457
DOC_MAPK_gen_1	386	394	PF00069	0.404
DOC_MAPK_MEF2A_6	12	20	PF00069	0.235
DOC_MAPK_MEF2A_6	188	196	PF00069	0.235
DOC_MAPK_MEF2A_6	282	290	PF00069	0.283
DOC_PP4_FxxP_1	196	199	PF00568	0.254
DOC_USP7_MATH_1	11	15	PF00917	0.355
DOC_USP7_MATH_1	218	222	PF00917	0.278
DOC_USP7_MATH_1	328	332	PF00917	0.496
DOC_USP7_MATH_1	436	440	PF00917	0.394
DOC_USP7_UBL2_3	135	139	PF12436	0.245
DOC_WW_Pin1_4	108	113	PF00397	0.254
DOC_WW_Pin1_4	281	286	PF00397	0.302
LIG_14-3-3_CanoR_1	10	16	PF00244	0.284
LIG_14-3-3_CanoR_1	209	213	PF00244	0.161
LIG_14-3-3_CanoR_1	229	237	PF00244	0.214
LIG_14-3-3_CanoR_1	23	31	PF00244	0.235
LIG_14-3-3_CanoR_1	291	297	PF00244	0.300
LIG_BIR_II_1	1	5	PF00653	0.342
LIG_eIF4E_1	287	293	PF01652	0.201
LIG_FHA_1	177	183	PF00498	0.291
LIG_FHA_2	377	383	PF00498	0.408
LIG_GBD_Chelix_1	329	337	PF00786	0.214
LIG_Integrin_RGD_1	85	87	PF01839	0.235
LIG_LIR_Apic_2	193	199	PF02991	0.254
LIG_LIR_Gen_1	2	11	PF02991	0.278
LIG_LIR_Gen_1	284	294	PF02991	0.278
LIG_LIR_Gen_1	306	314	PF02991	0.411
LIG_LIR_Gen_1	417	425	PF02991	0.355
LIG_LIR_Gen_1	61	70	PF02991	0.278
LIG_LIR_Nem_3	121	125	PF02991	0.176
LIG_LIR_Nem_3	193	198	PF02991	0.235
LIG_LIR_Nem_3	2	7	PF02991	0.270
LIG_LIR_Nem_3	284	290	PF02991	0.270
LIG_LIR_Nem_3	295	299	PF02991	0.235
LIG_LIR_Nem_3	306	310	PF02991	0.376
LIG_LIR_Nem_3	417	421	PF02991	0.362
LIG_LIR_Nem_3	61	66	PF02991	0.255
LIG_LIR_Nem_3	97	103	PF02991	0.238
LIG_LYPXL_yS_3	296	299	PF13949	0.368
LIG_PDZ_Class_1	452	457	PF00595	0.446
LIG_Pex14_2	448	452	PF04695	0.467
LIG_Pex14_2	54	58	PF04695	0.235
LIG_SH2_CRK	307	311	PF00017	0.401
LIG_SH2_CRK	324	328	PF00017	0.401
LIG_SH2_CRK	425	429	PF00017	0.308
LIG_SH2_NCK_1	155	159	PF00017	0.254
LIG_SH2_NCK_1	44	48	PF00017	0.235
LIG_SH2_PTP2	287	290	PF00017	0.317
LIG_SH2_STAP1	155	159	PF00017	0.269
LIG_SH2_STAP1	307	311	PF00017	0.401
LIG_SH2_STAP1	416	420	PF00017	0.332
LIG_SH2_STAP1	44	48	PF00017	0.235
LIG_SH2_STAP1	95	99	PF00017	0.235
LIG_SH2_STAT5	153	156	PF00017	0.300
LIG_SH2_STAT5	287	290	PF00017	0.274
LIG_SH3_3	291	297	PF00018	0.332
LIG_SUMO_SIM_anti_2	365	372	PF11976	0.401
LIG_SUMO_SIM_anti_2	393	399	PF11976	0.438
LIG_SUMO_SIM_par_1	365	372	PF11976	0.401
LIG_SUMO_SIM_par_1	396	402	PF11976	0.401
LIG_SUMO_SIM_par_1	77	82	PF11976	0.236
LIG_TRAF2_1	439	442	PF00917	0.466
LIG_TRFH_1	425	429	PF08558	0.308
LIG_TYR_ITIM	294	299	PF00017	0.440
LIG_TYR_ITIM	322	327	PF00017	0.235
LIG_WRC_WIRS_1	119	124	PF05994	0.326
MOD_CK1_1	118	124	PF00069	0.342
MOD_CK1_1	280	286	PF00069	0.415
MOD_CK1_1	331	337	PF00069	0.368
MOD_CK1_1	350	356	PF00069	0.368
MOD_CK2_1	372	378	PF00069	0.235
MOD_CK2_1	436	442	PF00069	0.389
MOD_GlcNHglycan	219	223	PF01048	0.262
MOD_GlcNHglycan	232	235	PF01048	0.302
MOD_GlcNHglycan	279	282	PF01048	0.403
MOD_GlcNHglycan	330	333	PF01048	0.310
MOD_GlcNHglycan	388	391	PF01048	0.278
MOD_GlcNHglycan	97	100	PF01048	0.235
MOD_GSK3_1	134	141	PF00069	0.262
MOD_GSK3_1	204	211	PF00069	0.368
MOD_GSK3_1	277	284	PF00069	0.355
MOD_GSK3_1	372	379	PF00069	0.235
MOD_GSK3_1	431	438	PF00069	0.401
MOD_N-GLC_1	225	230	PF02516	0.246
MOD_NEK2_1	133	138	PF00069	0.271
MOD_NEK2_1	265	270	PF00069	0.301
MOD_NEK2_1	277	282	PF00069	0.373
MOD_NEK2_1	292	297	PF00069	0.383
MOD_PIKK_1	436	442	PF00454	0.489
MOD_PK_1	255	261	PF00069	0.387
MOD_PKA_2	208	214	PF00069	0.158
MOD_PKA_2	431	437	PF00069	0.397
MOD_PKB_1	188	196	PF00069	0.278
MOD_Plk_4	11	17	PF00069	0.217
MOD_Plk_4	118	124	PF00069	0.249
MOD_Plk_4	190	196	PF00069	0.282
MOD_Plk_4	295	301	PF00069	0.218
MOD_Plk_4	393	399	PF00069	0.278
MOD_ProDKin_1	108	114	PF00069	0.254
MOD_ProDKin_1	281	287	PF00069	0.302
MOD_SUMO_rev_2	372	381	PF00179	0.235
TRG_DiLeu_BaEn_1	33	38	PF01217	0.254
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.318
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.254
TRG_ENDOCYTIC_2	155	158	PF00928	0.269
TRG_ENDOCYTIC_2	287	290	PF00928	0.274
TRG_ENDOCYTIC_2	296	299	PF00928	0.235
TRG_ENDOCYTIC_2	307	310	PF00928	0.114
TRG_ENDOCYTIC_2	324	327	PF00928	0.235
TRG_ENDOCYTIC_2	425	428	PF00928	0.382
TRG_ER_diArg_1	187	190	PF00400	0.280
TRG_ER_diArg_1	344	346	PF00400	0.235
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.278
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.368
TRG_PTS1	454	457	PF00515	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2D6	Leptomonas seymouri	85%	100%
A0A0S4KG32	Bodo saltans	68%	100%
A0A1X0NZ36	Trypanosomatidae	78%	100%
A0A3Q8IAC7	Leishmania donovani	94%	100%
A0A3R7RG15	Trypanosoma rangeli	75%	100%
A4HWV2	Leishmania infantum	93%	100%
C9ZPR2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AQL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QEW5	Leishmania major	92%	100%
Q8YSY4	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	35%	96%