Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8H8_LEIBR

TriTrypDb:

LbrM.16.0540 , LBRM2903_160011400

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8H8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8H8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.440
CLV_NRD_NRD_1	3	5	PF00675	0.582
CLV_PCSK_KEX2_1	166	168	PF00082	0.423
CLV_PCSK_KEX2_1	3	5	PF00082	0.582
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.432
CLV_PCSK_SKI1_1	128	132	PF00082	0.486
CLV_PCSK_SKI1_1	162	166	PF00082	0.531
CLV_PCSK_SKI1_1	195	199	PF00082	0.480
CLV_PCSK_SKI1_1	230	234	PF00082	0.546
DEG_APCC_DBOX_1	229	237	PF00400	0.469
DEG_Nend_Nbox_1	1	3	PF02207	0.712
DEG_SPOP_SBC_1	248	252	PF00917	0.335
DOC_MAPK_gen_1	128	136	PF00069	0.464
DOC_PP1_RVXF_1	1	8	PF00149	0.479
DOC_PP1_RVXF_1	65	72	PF00149	0.500
DOC_USP7_MATH_1	21	25	PF00917	0.551
DOC_USP7_UBL2_3	162	166	PF12436	0.420
DOC_WW_Pin1_4	13	18	PF00397	0.583
DOC_WW_Pin1_4	264	269	PF00397	0.599
DOC_WW_Pin1_4	29	34	PF00397	0.453
DOC_WW_Pin1_4	303	308	PF00397	0.539
DOC_WW_Pin1_4	313	318	PF00397	0.472
DOC_WW_Pin1_4	323	328	PF00397	0.628
LIG_14-3-3_CanoR_1	167	176	PF00244	0.563
LIG_14-3-3_CanoR_1	20	26	PF00244	0.430
LIG_14-3-3_CanoR_1	80	85	PF00244	0.460
LIG_Actin_WH2_2	285	300	PF00022	0.554
LIG_FHA_1	17	23	PF00498	0.614
LIG_FHA_1	248	254	PF00498	0.441
LIG_FHA_1	284	290	PF00498	0.626
LIG_FHA_1	87	93	PF00498	0.588
LIG_FHA_2	256	262	PF00498	0.554
LIG_FHA_2	304	310	PF00498	0.548
LIG_FHA_2	33	39	PF00498	0.476
LIG_FHA_2	70	76	PF00498	0.438
LIG_FHA_2	85	91	PF00498	0.418
LIG_LIR_Gen_1	79	88	PF02991	0.425
LIG_LIR_Nem_3	124	130	PF02991	0.449
LIG_LIR_Nem_3	79	84	PF02991	0.418
LIG_LIR_Nem_3	91	97	PF02991	0.435
LIG_Rb_LxCxE_1	272	290	PF01857	0.720
LIG_SH2_NCK_1	246	250	PF00017	0.561
LIG_SH2_STAP1	137	141	PF00017	0.368
LIG_SH2_STAT3	176	179	PF00017	0.549
LIG_SH2_STAT5	176	179	PF00017	0.510
LIG_SUMO_SIM_anti_2	24	29	PF11976	0.616
LIG_SUMO_SIM_par_1	55	61	PF11976	0.370
LIG_TYR_ITIM	92	97	PF00017	0.568
LIG_WRC_WIRS_1	133	138	PF05994	0.368
LIG_WRC_WIRS_1	156	161	PF05994	0.467
MOD_CDK_SPxxK_3	13	20	PF00069	0.479
MOD_CK1_1	132	138	PF00069	0.486
MOD_CK1_1	16	22	PF00069	0.554
MOD_CK1_1	316	322	PF00069	0.679
MOD_CK1_1	42	48	PF00069	0.506
MOD_CK2_1	132	138	PF00069	0.407
MOD_CK2_1	32	38	PF00069	0.584
MOD_GlcNHglycan	105	108	PF01048	0.415
MOD_GlcNHglycan	169	172	PF01048	0.461
MOD_GlcNHglycan	198	201	PF01048	0.306
MOD_GlcNHglycan	41	44	PF01048	0.578
MOD_GSK3_1	28	35	PF00069	0.596
MOD_GSK3_1	76	83	PF00069	0.384
MOD_N-GLC_1	29	34	PF02516	0.444
MOD_N-GLC_1	290	295	PF02516	0.409
MOD_NEK2_1	122	127	PF00069	0.442
MOD_NEK2_1	254	259	PF00069	0.364
MOD_NEK2_1	28	33	PF00069	0.613
MOD_NEK2_1	76	81	PF00069	0.414
MOD_NEK2_1	84	89	PF00069	0.389
MOD_NEK2_2	137	142	PF00069	0.483
MOD_PKA_2	122	128	PF00069	0.542
MOD_PKB_1	78	86	PF00069	0.295
MOD_Plk_1	137	143	PF00069	0.448
MOD_Plk_1	154	160	PF00069	0.475
MOD_Plk_2-3	93	99	PF00069	0.575
MOD_Plk_4	129	135	PF00069	0.390
MOD_Plk_4	137	143	PF00069	0.432
MOD_Plk_4	249	255	PF00069	0.374
MOD_Plk_4	80	86	PF00069	0.299
MOD_ProDKin_1	13	19	PF00069	0.581
MOD_ProDKin_1	264	270	PF00069	0.605
MOD_ProDKin_1	29	35	PF00069	0.457
MOD_ProDKin_1	303	309	PF00069	0.543
MOD_ProDKin_1	313	319	PF00069	0.470
MOD_SUMO_rev_2	124	133	PF00179	0.565
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.604
TRG_ENDOCYTIC_2	94	97	PF00928	0.542
TRG_ER_diArg_1	2	4	PF00400	0.581
TRG_ER_diArg_1	78	81	PF00400	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY5	Leptomonas seymouri	70%	100%
A0A1X0NZ39	Trypanosomatidae	53%	100%
A0A3R7MGA8	Trypanosoma rangeli	50%	99%
A0A3S5H6X2	Leishmania donovani	83%	100%
A4HWV0	Leishmania infantum	83%	100%
C9ZW37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	98%
E9AQL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QEW8	Leishmania major	81%	100%
V5B947	Trypanosoma cruzi	50%	100%