Amastin surface glycofamily protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H8H6_LEIBR

TriTrypDb:

LbrM.16.0520 , LBRM2903_160011200

Length:

222

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin: surface protein with roles in host adhesion, especially at the amastigote stage.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 20
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	21
GO:0110165	cellular anatomical entity	1	21

Expansion

Sequence features

A4H8H6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8H6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	28	30	PF00675	0.588
CLV_PCSK_SKI1_1	29	33	PF00082	0.461
DEG_Nend_Nbox_1	1	3	PF02207	0.599
DOC_MAPK_MEF2A_6	5	13	PF00069	0.507
DOC_USP7_MATH_1	124	128	PF00917	0.233
DOC_USP7_MATH_1	199	203	PF00917	0.694
DOC_USP7_MATH_1	207	211	PF00917	0.671
DOC_WW_Pin1_4	151	156	PF00397	0.268
DOC_WW_Pin1_4	203	208	PF00397	0.651
LIG_14-3-3_CanoR_1	29	35	PF00244	0.365
LIG_14-3-3_CanoR_1	39	43	PF00244	0.302
LIG_BRCT_BRCA1_1	21	25	PF00533	0.378
LIG_EH1_1	3	11	PF00400	0.467
LIG_eIF4E_1	4	10	PF01652	0.458
LIG_FHA_1	115	121	PF00498	0.359
LIG_FHA_1	133	139	PF00498	0.351
LIG_FHA_1	18	24	PF00498	0.449
LIG_FHA_1	66	72	PF00498	0.407
LIG_FHA_2	147	153	PF00498	0.391
LIG_LIR_Gen_1	163	173	PF02991	0.286
LIG_LIR_Nem_3	163	169	PF02991	0.307
LIG_LIR_Nem_3	22	28	PF02991	0.343
LIG_LIR_Nem_3	3	7	PF02991	0.486
LIG_SH2_CRK	4	8	PF00017	0.406
LIG_SH2_PTP2	80	83	PF00017	0.183
LIG_SH2_STAP1	139	143	PF00017	0.365
LIG_SH2_STAP1	67	71	PF00017	0.400
LIG_SH2_STAT5	137	140	PF00017	0.310
LIG_SH2_STAT5	67	70	PF00017	0.393
LIG_SH2_STAT5	80	83	PF00017	0.276
LIG_SH3_3	142	148	PF00018	0.350
LIG_SH3_3	201	207	PF00018	0.786
LIG_SUMO_SIM_anti_2	127	133	PF11976	0.326
LIG_SUMO_SIM_par_1	116	122	PF11976	0.241
LIG_SUMO_SIM_par_1	8	14	PF11976	0.375
LIG_TYR_ITIM	2	7	PF00017	0.450
LIG_TYR_ITIM	78	83	PF00017	0.228
LIG_UBA3_1	23	30	PF00899	0.456
LIG_WRC_WIRS_1	12	17	PF05994	0.191
LIG_WRC_WIRS_1	120	125	PF05994	0.318
MOD_CDC14_SPxK_1	154	157	PF00782	0.266
MOD_CDK_SPxK_1	151	157	PF00069	0.272
MOD_CK1_1	210	216	PF00069	0.633
MOD_CK1_1	49	55	PF00069	0.392
MOD_CK1_1	84	90	PF00069	0.324
MOD_CK2_1	146	152	PF00069	0.290
MOD_CK2_1	55	61	PF00069	0.497
MOD_GlcNHglycan	126	129	PF01048	0.294
MOD_GlcNHglycan	209	212	PF01048	0.599
MOD_GlcNHglycan	58	61	PF01048	0.651
MOD_GlcNHglycan	83	86	PF01048	0.386
MOD_GlcNHglycan	93	96	PF01048	0.432
MOD_GSK3_1	114	121	PF00069	0.360
MOD_GSK3_1	13	20	PF00069	0.371
MOD_GSK3_1	133	140	PF00069	0.353
MOD_GSK3_1	199	206	PF00069	0.701
MOD_GSK3_1	215	222	PF00069	0.672
MOD_GSK3_1	46	53	PF00069	0.366
MOD_N-GLC_1	109	114	PF02516	0.394
MOD_N-GLC_1	50	55	PF02516	0.620
MOD_NEK2_1	11	16	PF00069	0.358
MOD_NEK2_1	118	123	PF00069	0.344
MOD_NEK2_1	19	24	PF00069	0.317
MOD_NEK2_1	217	222	PF00069	0.712
MOD_NEK2_2	38	43	PF00069	0.285
MOD_PKA_1	29	35	PF00069	0.338
MOD_PKA_2	38	44	PF00069	0.428
MOD_Plk_1	109	115	PF00069	0.593
MOD_Plk_1	215	221	PF00069	0.583
MOD_Plk_4	114	120	PF00069	0.405
MOD_Plk_4	133	139	PF00069	0.264
MOD_Plk_4	19	25	PF00069	0.400
MOD_ProDKin_1	151	157	PF00069	0.272
MOD_ProDKin_1	203	209	PF00069	0.652
TRG_DiLeu_BaEn_1	164	169	PF01217	0.310
TRG_ENDOCYTIC_2	4	7	PF00928	0.463
TRG_ENDOCYTIC_2	80	83	PF00928	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z4	Leptomonas seymouri	31%	100%
A0A0N0P3Z6	Leptomonas seymouri	39%	98%
A0A0N0P4D5	Leptomonas seymouri	40%	100%
A0A0N1HU04	Leptomonas seymouri	28%	71%
A0A0N1PD13	Leptomonas seymouri	26%	95%
A0A1X0P9D7	Trypanosomatidae	24%	100%
A0A3Q8IIZ2	Leishmania donovani	46%	100%
A0A3R7KFR8	Trypanosoma rangeli	31%	100%
A0A3S5H6X1	Leishmania donovani	37%	100%
A0A3S7WTU4	Leishmania donovani	31%	100%
A4H8H3	Leishmania braziliensis	31%	98%
A4H8H5	Leishmania braziliensis	35%	100%
A4HWU5	Leishmania infantum	31%	100%
A4HWU7	Leishmania infantum	37%	100%
A4HWU8	Leishmania infantum	46%	100%
C9ZMZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AQK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AQK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AQK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
Q4QEX0	Leishmania major	44%	100%
Q4QEX1	Leishmania major	38%	100%
Q4QEX3	Leishmania major	32%	99%