Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8H5_LEIBR

TriTrypDb:

LbrM.16.0510 , LBRM2903_160011100

Length:

200

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin: surface protein with roles in host adhesion, especially at the amastigote stage.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 19
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19

Expansion

Sequence features

A4H8H5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8H5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	28	30	PF00675	0.588
CLV_PCSK_KEX2_1	153	155	PF00082	0.476
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.476
DOC_MAPK_MEF2A_6	5	14	PF00069	0.475
DOC_PP1_RVXF_1	3	10	PF00149	0.434
DOC_USP7_MATH_1	19	23	PF00917	0.259
DOC_WW_Pin1_4	34	39	PF00397	0.313
LIG_14-3-3_CanoR_1	47	53	PF00244	0.487
LIG_14-3-3_CanoR_1	63	68	PF00244	0.351
LIG_BRCT_BRCA1_1	21	25	PF00533	0.395
LIG_BRCT_BRCA1_1	94	98	PF00533	0.219
LIG_DLG_GKlike_1	63	70	PF00625	0.267
LIG_eIF4E_1	106	112	PF01652	0.460
LIG_FHA_1	127	133	PF00498	0.357
LIG_FHA_1	136	142	PF00498	0.382
LIG_FHA_1	166	172	PF00498	0.389
LIG_FHA_1	37	43	PF00498	0.386
LIG_LIR_Gen_1	114	123	PF02991	0.404
LIG_LIR_Gen_1	173	181	PF02991	0.339
LIG_LIR_Nem_3	114	120	PF02991	0.379
LIG_LIR_Nem_3	161	166	PF02991	0.299
LIG_LIR_Nem_3	173	177	PF02991	0.323
LIG_LIR_Nem_3	22	28	PF02991	0.395
LIG_LIR_Nem_3	64	70	PF02991	0.332
LIG_PDZ_Class_3	195	200	PF00595	0.537
LIG_Pex14_1	102	106	PF04695	0.458
LIG_Pex14_2	177	181	PF04695	0.390
LIG_Pex14_2	98	102	PF04695	0.259
LIG_RPA_C_Fungi	58	70	PF08784	0.306
LIG_SH2_CRK	67	71	PF00017	0.512
LIG_SH2_NCK_1	157	161	PF00017	0.306
LIG_SH2_NCK_1	78	82	PF00017	0.413
LIG_SH2_STAP1	137	141	PF00017	0.497
LIG_SH2_STAP1	65	69	PF00017	0.492
LIG_SH2_STAP1	78	82	PF00017	0.408
LIG_SH2_STAT5	135	138	PF00017	0.397
LIG_SH2_STAT5	164	167	PF00017	0.295
LIG_SH2_STAT5	78	81	PF00017	0.304
LIG_SUMO_SIM_par_1	10	16	PF11976	0.329
LIG_TRAF2_1	143	146	PF00917	0.358
LIG_WRC_WIRS_1	117	122	PF05994	0.311
LIG_WRC_WIRS_1	171	176	PF05994	0.232
MOD_CK1_1	126	132	PF00069	0.385
MOD_CK1_1	33	39	PF00069	0.524
MOD_CK1_1	49	55	PF00069	0.375
MOD_GlcNHglycan	103	106	PF01048	0.382
MOD_GlcNHglycan	126	129	PF01048	0.261
MOD_GSK3_1	112	119	PF00069	0.355
MOD_GSK3_1	133	140	PF00069	0.456
MOD_GSK3_1	166	173	PF00069	0.253
MOD_GSK3_1	28	35	PF00069	0.338
MOD_GSK3_1	59	66	PF00069	0.383
MOD_N-GLC_1	33	38	PF02516	0.564
MOD_NEK2_1	111	116	PF00069	0.334
MOD_NEK2_1	121	126	PF00069	0.325
MOD_NEK2_1	13	18	PF00069	0.344
MOD_NEK2_1	133	138	PF00069	0.430
MOD_NEK2_1	165	170	PF00069	0.322
MOD_NEK2_1	183	188	PF00069	0.475
MOD_NEK2_1	28	33	PF00069	0.384
MOD_NEK2_1	61	66	PF00069	0.454
MOD_NEK2_2	38	43	PF00069	0.327
MOD_NEK2_2	93	98	PF00069	0.191
MOD_PIKK_1	144	150	PF00454	0.545
MOD_PKA_2	28	34	PF00069	0.320
MOD_PKA_2	46	52	PF00069	0.490
MOD_Plk_1	144	150	PF00069	0.527
MOD_Plk_4	113	119	PF00069	0.364
MOD_Plk_4	170	176	PF00069	0.313
MOD_Plk_4	183	189	PF00069	0.483
MOD_Plk_4	19	25	PF00069	0.412
MOD_Plk_4	87	93	PF00069	0.372
MOD_ProDKin_1	34	40	PF00069	0.356
TRG_DiLeu_BaEn_1	161	166	PF01217	0.345
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.296
TRG_ENDOCYTIC_2	67	70	PF00928	0.505
TRG_Pf-PMV_PEXEL_1	68	73	PF00026	0.294

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z4	Leptomonas seymouri	28%	100%
A0A0N0P3Z6	Leptomonas seymouri	35%	88%
A0A0N0P4D5	Leptomonas seymouri	32%	96%
A0A0N1PD13	Leptomonas seymouri	26%	85%
A0A1X0P9D7	Trypanosomatidae	27%	94%
A0A3Q8IIZ2	Leishmania donovani	31%	90%
A0A3R7KFR8	Trypanosoma rangeli	31%	100%
A0A3S5H6X1	Leishmania donovani	64%	100%
A0A3S7WTU4	Leishmania donovani	28%	100%
A4H8H3	Leishmania braziliensis	29%	100%
A4H8H6	Leishmania braziliensis	35%	90%
A4HWU5	Leishmania infantum	28%	100%
A4HWU7	Leishmania infantum	64%	100%
A4HWU8	Leishmania infantum	31%	90%
E9AQK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AQK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	97%
E9AQK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	93%
Q4QEX0	Leishmania major	31%	100%
Q4QEX1	Leishmania major	63%	100%
Q4QEX3	Leishmania major	28%	100%