Amastin surface glycofamily protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8H3_LEIBR

TriTrypDb:

LbrM.16.0490 , LBRM2903_160010200

Length:

184

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin: surface protein with roles in host adhesion, especially at the amastigote stage.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 2, no: 18
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	18
GO:0110165	cellular anatomical entity	1	18

Expansion

Sequence features

A4H8H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8H3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	42	46	PF00082	0.578
DEG_Nend_Nbox_1	1	3	PF02207	0.610
DOC_MAPK_HePTP_8	2	14	PF00069	0.315
DOC_MAPK_MEF2A_6	5	14	PF00069	0.480
DOC_PP1_RVXF_1	40	46	PF00149	0.309
DOC_USP7_MATH_1	78	82	PF00917	0.250
LIG_14-3-3_CanoR_1	67	74	PF00244	0.464
LIG_APCC_ABBA_1	176	181	PF00400	0.334
LIG_FHA_1	146	152	PF00498	0.525
LIG_FHA_1	2	8	PF00498	0.547
LIG_FHA_1	74	80	PF00498	0.484
LIG_LIR_Gen_1	132	143	PF02991	0.465
LIG_LIR_Gen_1	155	166	PF02991	0.361
LIG_LIR_Nem_3	132	138	PF02991	0.430
LIG_LIR_Nem_3	155	161	PF02991	0.405
LIG_LIR_Nem_3	162	167	PF02991	0.380
LIG_Pex14_2	179	183	PF04695	0.586
LIG_SH2_STAP1	61	65	PF00017	0.451
LIG_SH2_STAT5	61	64	PF00017	0.485
LIG_SUMO_SIM_anti_2	114	119	PF11976	0.395
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.395
LIG_SUMO_SIM_par_1	148	155	PF11976	0.296
LIG_UBA3_1	24	31	PF00899	0.459
LIG_WRC_WIRS_1	134	139	PF05994	0.507
MOD_CK1_1	129	135	PF00069	0.448
MOD_GlcNHglycan	80	83	PF01048	0.477
MOD_GSK3_1	107	114	PF00069	0.618
MOD_GSK3_1	129	136	PF00069	0.426
MOD_N-GLC_1	145	150	PF02516	0.682
MOD_N-GLC_1	67	72	PF02516	0.540
MOD_NEK2_1	1	6	PF00069	0.530
MOD_NEK2_1	107	112	PF00069	0.608
MOD_NEK2_1	126	131	PF00069	0.412
MOD_NEK2_1	138	143	PF00069	0.425
MOD_NEK2_1	27	32	PF00069	0.393
MOD_PKA_2	66	72	PF00069	0.445
MOD_Plk_1	145	151	PF00069	0.469
MOD_Plk_4	111	117	PF00069	0.517
MOD_Plk_4	129	135	PF00069	0.480
MOD_SUMO_rev_2	49	54	PF00179	0.354
TRG_DiLeu_BaEn_2	161	167	PF01217	0.243
TRG_DiLeu_BaEn_2	40	46	PF01217	0.272
TRG_ENDOCYTIC_2	104	107	PF00928	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z4	Leptomonas seymouri	46%	100%
A0A0N0P3Z6	Leptomonas seymouri	35%	81%
A0A0N0P4D5	Leptomonas seymouri	30%	88%
A0A1X0P9D7	Trypanosomatidae	28%	86%
A0A3Q8IIZ2	Leishmania donovani	34%	83%
A0A3R7KFR8	Trypanosoma rangeli	27%	100%
A0A3S5H6X1	Leishmania donovani	28%	92%
A0A3S7WTU4	Leishmania donovani	68%	100%
A4H8H5	Leishmania braziliensis	29%	92%
A4H8H6	Leishmania braziliensis	31%	83%
A4HWU5	Leishmania infantum	67%	100%
A4HWU7	Leishmania infantum	28%	92%
A4HWU8	Leishmania infantum	34%	83%
E9AQK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
E9AQK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	89%
E9AQK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	85%
Q4QEX0	Leishmania major	34%	100%
Q4QEX1	Leishmania major	29%	100%
Q4QEX3	Leishmania major	67%	100%