Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8G9_LEIBR

TriTrypDb:

LbrM.16.0450 , LBRM2903_160010000

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4H8G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8G9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	55	57	PF00675	0.347
CLV_PCSK_KEX2_1	145	147	PF00082	0.424
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.424
CLV_PCSK_SKI1_1	122	126	PF00082	0.374
CLV_PCSK_SKI1_1	17	21	PF00082	0.477
DEG_APCC_DBOX_1	154	162	PF00400	0.334
DEG_Nend_Nbox_1	1	3	PF02207	0.678
DEG_SCF_FBW7_1	94	101	PF00400	0.501
DOC_MAPK_MEF2A_6	155	163	PF00069	0.419
DOC_MAPK_MEF2A_6	4	13	PF00069	0.664
DOC_USP7_MATH_1	185	189	PF00917	0.327
DOC_USP7_MATH_1	25	29	PF00917	0.651
DOC_WW_Pin1_4	144	149	PF00397	0.472
DOC_WW_Pin1_4	94	99	PF00397	0.479
LIG_14-3-3_CanoR_1	32	40	PF00244	0.692
LIG_14-3-3_CanoR_1	86	91	PF00244	0.490
LIG_BRCT_BRCA1_1	36	40	PF00533	0.575
LIG_DLG_GKlike_1	86	94	PF00625	0.490
LIG_FHA_1	232	238	PF00498	0.314
LIG_FHA_1	8	14	PF00498	0.649
LIG_FHA_1	99	105	PF00498	0.425
LIG_FHA_2	114	120	PF00498	0.515
LIG_FHA_2	145	151	PF00498	0.441
LIG_FHA_2	228	234	PF00498	0.390
LIG_FHA_2	76	82	PF00498	0.592
LIG_LIR_Apic_2	42	47	PF02991	0.696
LIG_LIR_Gen_1	160	171	PF02991	0.307
LIG_LIR_Gen_1	223	231	PF02991	0.337
LIG_LIR_Gen_1	78	88	PF02991	0.573
LIG_LIR_Nem_3	109	114	PF02991	0.496
LIG_LIR_Nem_3	160	166	PF02991	0.420
LIG_LIR_Nem_3	193	198	PF02991	0.351
LIG_LIR_Nem_3	78	83	PF02991	0.595
LIG_PDZ_Class_2	253	258	PF00595	0.419
LIG_Pex14_2	40	44	PF04695	0.555
LIG_SH2_CRK	195	199	PF00017	0.327
LIG_SH2_STAP1	100	104	PF00017	0.561
LIG_SH2_STAT5	100	103	PF00017	0.479
LIG_SH2_STAT5	107	110	PF00017	0.454
LIG_SH3_3	161	167	PF00018	0.369
LIG_SH3_3	19	25	PF00018	0.656
LIG_SH3_3	234	240	PF00018	0.297
LIG_SUMO_SIM_anti_2	101	106	PF11976	0.434
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.432
LIG_SUMO_SIM_par_1	251	257	PF11976	0.195
LIG_TRFH_1	163	167	PF08558	0.195
LIG_TYR_ITIM	105	110	PF00017	0.567
LIG_TYR_ITIM	134	139	PF00017	0.523
LIG_UBA3_1	124	133	PF00899	0.485
LIG_UBA3_1	139	145	PF00899	0.493
LIG_WRC_WIRS_1	228	233	PF05994	0.226
MOD_CK1_1	200	206	PF00069	0.451
MOD_CK1_1	27	33	PF00069	0.691
MOD_CK1_1	35	41	PF00069	0.657
MOD_CK2_1	113	119	PF00069	0.508
MOD_CK2_1	144	150	PF00069	0.535
MOD_CK2_1	227	233	PF00069	0.359
MOD_CK2_1	86	92	PF00069	0.501
MOD_GlcNHglycan	200	203	PF01048	0.658
MOD_GlcNHglycan	27	30	PF01048	0.531
MOD_GlcNHglycan	37	40	PF01048	0.439
MOD_GlcNHglycan	4	7	PF01048	0.372
MOD_GlcNHglycan	41	44	PF01048	0.389
MOD_GSK3_1	180	187	PF00069	0.304
MOD_GSK3_1	196	203	PF00069	0.424
MOD_GSK3_1	227	234	PF00069	0.335
MOD_GSK3_1	23	30	PF00069	0.699
MOD_GSK3_1	35	42	PF00069	0.622
MOD_GSK3_1	94	101	PF00069	0.493
MOD_LATS_1	84	90	PF00433	0.495
MOD_N-GLC_1	33	38	PF02516	0.379
MOD_NEK2_1	13	18	PF00069	0.680
MOD_NEK2_1	170	175	PF00069	0.346
MOD_NEK2_1	198	203	PF00069	0.422
MOD_NEK2_1	231	236	PF00069	0.404
MOD_NEK2_1	62	67	PF00069	0.551
MOD_NEK2_2	227	232	PF00069	0.343
MOD_PIKK_1	231	237	PF00454	0.271
MOD_PKA_2	13	19	PF00069	0.768
MOD_Plk_4	49	55	PF00069	0.661
MOD_Plk_4	68	74	PF00069	0.460
MOD_ProDKin_1	144	150	PF00069	0.471
MOD_ProDKin_1	94	100	PF00069	0.484
TRG_ENDOCYTIC_2	107	110	PF00928	0.576
TRG_ENDOCYTIC_2	136	139	PF00928	0.531
TRG_ENDOCYTIC_2	195	198	PF00928	0.329
TRG_ENDOCYTIC_2	225	228	PF00928	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I779	Leptomonas seymouri	55%	100%
A0A0S4JEF8	Bodo saltans	39%	100%
A0A1X0NHP7	Trypanosomatidae	46%	100%
A0A3S7WTT8	Leishmania donovani	85%	100%
A0A422N958	Trypanosoma rangeli	45%	100%
A4HWU3	Leishmania infantum	85%	100%
C9ZW39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AQK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QEX5	Leishmania major	84%	100%
V5D515	Trypanosoma cruzi	42%	100%