Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8G8_LEIBR

TriTrypDb:

LbrM.16.0440 , LBRM2903_160009900

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8G8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8G8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.635
CLV_NRD_NRD_1	133	135	PF00675	0.534
CLV_NRD_NRD_1	140	142	PF00675	0.572
CLV_NRD_NRD_1	72	74	PF00675	0.765
CLV_NRD_NRD_1	9	11	PF00675	0.793
CLV_PCSK_KEX2_1	133	135	PF00082	0.530
CLV_PCSK_KEX2_1	72	74	PF00082	0.633
CLV_PCSK_SKI1_1	11	15	PF00082	0.585
CLV_PCSK_SKI1_1	146	150	PF00082	0.683
DOC_MAPK_gen_1	15	23	PF00069	0.625
DOC_MAPK_gen_1	158	167	PF00069	0.594
DOC_USP7_MATH_1	27	31	PF00917	0.694
DOC_USP7_MATH_1	3	7	PF00917	0.529
DOC_USP7_MATH_1	39	43	PF00917	0.360
DOC_USP7_MATH_1	67	71	PF00917	0.668
DOC_USP7_MATH_1	82	86	PF00917	0.656
DOC_USP7_MATH_1	92	96	PF00917	0.563
DOC_USP7_UBL2_3	11	15	PF12436	0.635
DOC_WW_Pin1_4	80	85	PF00397	0.697
LIG_14-3-3_CanoR_1	31	37	PF00244	0.560
LIG_14-3-3_CanoR_1	40	47	PF00244	0.540
LIG_14-3-3_CanoR_1	72	81	PF00244	0.617
LIG_BRCT_BRCA1_1	29	33	PF00533	0.627
LIG_BRCT_BRCA1_1	86	90	PF00533	0.601
LIG_eIF4E_1	107	113	PF01652	0.384
LIG_FHA_1	33	39	PF00498	0.578
LIG_FHA_2	118	124	PF00498	0.674
LIG_LIR_Apic_2	105	111	PF02991	0.485
LIG_LIR_Gen_1	30	39	PF02991	0.619
LIG_LIR_Gen_1	96	107	PF02991	0.499
LIG_LIR_Nem_3	126	131	PF02991	0.606
LIG_LIR_Nem_3	30	36	PF02991	0.611
LIG_LIR_Nem_3	53	58	PF02991	0.628
LIG_LIR_Nem_3	87	93	PF02991	0.547
LIG_LIR_Nem_3	96	102	PF02991	0.447
LIG_RPA_C_Fungi	26	38	PF08784	0.664
LIG_SH3_3	149	155	PF00018	0.688
LIG_SH3_3	33	39	PF00018	0.533
LIG_SH3_3	41	47	PF00018	0.511
LIG_SH3_3	78	84	PF00018	0.591
LIG_SH3_3	86	92	PF00018	0.445
LIG_UBA3_1	112	119	PF00899	0.585
LIG_UBA3_1	98	106	PF00899	0.554
MOD_CK1_1	168	174	PF00069	0.703
MOD_CK1_1	63	69	PF00069	0.653
MOD_CK1_1	76	82	PF00069	0.727
MOD_CK1_1	83	89	PF00069	0.667
MOD_GlcNHglycan	69	72	PF01048	0.630
MOD_GlcNHglycan	75	78	PF01048	0.681
MOD_GSK3_1	165	172	PF00069	0.721
MOD_GSK3_1	27	34	PF00069	0.623
MOD_GSK3_1	63	70	PF00069	0.650
MOD_GSK3_1	76	83	PF00069	0.667
MOD_N-GLC_1	11	16	PF02516	0.657
MOD_PIKK_1	3	9	PF00454	0.530
MOD_PKA_1	16	22	PF00069	0.612
MOD_PKA_2	21	27	PF00069	0.557
MOD_PKA_2	39	45	PF00069	0.647
MOD_PKA_2	71	77	PF00069	0.725
MOD_Plk_4	160	166	PF00069	0.619
MOD_Plk_4	50	56	PF00069	0.613
MOD_Plk_4	84	90	PF00069	0.581
MOD_ProDKin_1	80	86	PF00069	0.694
MOD_SUMO_for_1	148	151	PF00179	0.704
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.383
TRG_ENDOCYTIC_2	55	58	PF00928	0.672
TRG_ER_diArg_1	20	23	PF00400	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8B0	Leptomonas seymouri	63%	100%
A0A0S4JAB3	Bodo saltans	38%	100%
A0A1X0P0C9	Trypanosomatidae	55%	100%
A0A3R7M9R7	Trypanosoma rangeli	56%	100%
A0A3S7WTU8	Leishmania donovani	74%	99%
A4HWU1	Leishmania infantum	74%	99%
C9ZW40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AQK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QEX7	Leishmania major	75%	100%