Pyridoxal-dependent decarboxylase conserved domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pyridoxal-dependent decarboxylase conserved domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8G7_LEIBR

TriTrypDb:

LbrM.16.0430 , LBRM2903_160009800

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8G7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8G7

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0019752	carboxylic acid metabolic process	5	10
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044281	small molecule metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0016829	lyase activity	2	10
GO:0016830	carbon-carbon lyase activity	3	10
GO:0019842	vitamin binding	3	10
GO:0030170	pyridoxal phosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0070279	vitamin B6 binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0016831	carboxy-lyase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.401
CLV_MEL_PAP_1	373	379	PF00089	0.551
CLV_NRD_NRD_1	296	298	PF00675	0.471
CLV_NRD_NRD_1	492	494	PF00675	0.480
CLV_PCSK_KEX2_1	137	139	PF00082	0.487
CLV_PCSK_KEX2_1	445	447	PF00082	0.816
CLV_PCSK_KEX2_1	492	494	PF00082	0.480
CLV_PCSK_KEX2_1	543	545	PF00082	0.456
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.487
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.816
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.399
CLV_PCSK_SKI1_1	103	107	PF00082	0.325
CLV_PCSK_SKI1_1	11	15	PF00082	0.513
CLV_PCSK_SKI1_1	385	389	PF00082	0.666
CLV_PCSK_SKI1_1	412	416	PF00082	0.436
DEG_APCC_DBOX_1	384	392	PF00400	0.525
DEG_COP1_1	255	266	PF00400	0.427
DEG_Nend_UBRbox_1	1	4	PF02207	0.526
DEG_SPOP_SBC_1	12	16	PF00917	0.637
DEG_SPOP_SBC_1	530	534	PF00917	0.427
DOC_CKS1_1	317	322	PF01111	0.561
DOC_CKS1_1	439	444	PF01111	0.513
DOC_CYCLIN_yCln2_LP_2	552	558	PF00134	0.438
DOC_MAPK_DCC_7	475	483	PF00069	0.493
DOC_MAPK_gen_1	492	500	PF00069	0.448
DOC_MAPK_MEF2A_6	475	483	PF00069	0.565
DOC_MAPK_MEF2A_6	492	500	PF00069	0.375
DOC_MAPK_RevD_3	123	138	PF00069	0.411
DOC_PP1_RVXF_1	295	302	PF00149	0.377
DOC_PP2B_LxvP_1	140	143	PF13499	0.597
DOC_USP7_MATH_1	12	16	PF00917	0.660
DOC_USP7_MATH_1	252	256	PF00917	0.520
DOC_USP7_MATH_1	352	356	PF00917	0.624
DOC_USP7_MATH_1	368	372	PF00917	0.503
DOC_USP7_MATH_1	41	45	PF00917	0.684
DOC_USP7_MATH_1	520	524	PF00917	0.572
DOC_USP7_MATH_1	530	534	PF00917	0.623
DOC_WW_Pin1_4	275	280	PF00397	0.580
DOC_WW_Pin1_4	316	321	PF00397	0.565
DOC_WW_Pin1_4	328	333	PF00397	0.502
DOC_WW_Pin1_4	438	443	PF00397	0.633
DOC_WW_Pin1_4	447	452	PF00397	0.751
LIG_14-3-3_CanoR_1	11	21	PF00244	0.713
LIG_14-3-3_CanoR_1	129	135	PF00244	0.399
LIG_14-3-3_CanoR_1	2	10	PF00244	0.667
LIG_14-3-3_CanoR_1	310	315	PF00244	0.594
LIG_14-3-3_CanoR_1	364	373	PF00244	0.609
LIG_14-3-3_CanoR_1	446	451	PF00244	0.797
LIG_14-3-3_CanoR_1	475	479	PF00244	0.539
LIG_14-3-3_CanoR_1	554	563	PF00244	0.495
LIG_CaM_IQ_9	75	90	PF13499	0.355
LIG_FHA_1	131	137	PF00498	0.555
LIG_FHA_1	22	28	PF00498	0.553
LIG_FHA_1	317	323	PF00498	0.560
LIG_FHA_1	344	350	PF00498	0.548
LIG_FHA_1	419	425	PF00498	0.473
LIG_FHA_1	534	540	PF00498	0.531
LIG_FHA_1	68	74	PF00498	0.423
LIG_FHA_1	76	82	PF00498	0.373
LIG_FHA_2	151	157	PF00498	0.491
LIG_FHA_2	33	39	PF00498	0.582
LIG_FHA_2	413	419	PF00498	0.467
LIG_FHA_2	439	445	PF00498	0.518
LIG_FHA_2	467	473	PF00498	0.502
LIG_FHA_2	62	68	PF00498	0.494
LIG_Integrin_RGD_1	392	394	PF01839	0.555
LIG_LIR_Gen_1	455	466	PF02991	0.516
LIG_LIR_Gen_1	67	76	PF02991	0.477
LIG_LIR_Nem_3	404	409	PF02991	0.384
LIG_LIR_Nem_3	455	461	PF02991	0.519
LIG_LIR_Nem_3	499	503	PF02991	0.588
LIG_LIR_Nem_3	67	72	PF02991	0.487
LIG_LYPXL_S_1	182	186	PF13949	0.278
LIG_LYPXL_yS_3	183	186	PF13949	0.278
LIG_SH2_CRK	272	276	PF00017	0.570
LIG_SH2_CRK	458	462	PF00017	0.523
LIG_SH2_CRK	69	73	PF00017	0.470
LIG_SH2_NCK_1	251	255	PF00017	0.432
LIG_SH2_STAP1	163	167	PF00017	0.345
LIG_SH2_STAP1	62	66	PF00017	0.494
LIG_SH2_STAP1	69	73	PF00017	0.354
LIG_SH2_STAT5	107	110	PF00017	0.392
LIG_SH2_STAT5	541	544	PF00017	0.655
LIG_SH2_STAT5	69	72	PF00017	0.526
LIG_SH3_3	232	238	PF00018	0.586
LIG_SH3_3	257	263	PF00018	0.446
LIG_SH3_3	273	279	PF00018	0.385
LIG_SH3_3	359	365	PF00018	0.702
LIG_SH3_3	436	442	PF00018	0.498
LIG_SH3_3	45	51	PF00018	0.471
LIG_SH3_3	557	563	PF00018	0.452
LIG_SUMO_SIM_par_1	69	75	PF11976	0.384
LIG_TYR_ITIM	270	275	PF00017	0.611
LIG_WRC_WIRS_1	188	193	PF05994	0.394
MOD_CDK_SPxxK_3	438	445	PF00069	0.515
MOD_CK1_1	147	153	PF00069	0.629
MOD_CK1_1	16	22	PF00069	0.567
MOD_CK1_1	193	199	PF00069	0.400
MOD_CK1_1	278	284	PF00069	0.593
MOD_CK1_1	331	337	PF00069	0.522
MOD_CK1_1	367	373	PF00069	0.507
MOD_CK1_1	449	455	PF00069	0.758
MOD_CK1_1	456	462	PF00069	0.647
MOD_CK1_1	464	470	PF00069	0.573
MOD_CK1_1	513	519	PF00069	0.497
MOD_CK1_1	533	539	PF00069	0.640
MOD_CK2_1	150	156	PF00069	0.441
MOD_CK2_1	32	38	PF00069	0.590
MOD_CK2_1	466	472	PF00069	0.504
MOD_CK2_1	61	67	PF00069	0.472
MOD_GlcNHglycan	192	195	PF01048	0.425
MOD_GlcNHglycan	366	369	PF01048	0.584
MOD_GlcNHglycan	4	7	PF01048	0.765
MOD_GlcNHglycan	43	46	PF01048	0.539
MOD_GlcNHglycan	463	466	PF01048	0.546
MOD_GlcNHglycan	522	525	PF01048	0.676
MOD_GlcNHglycan	556	559	PF01048	0.518
MOD_GlcNHglycan	84	87	PF01048	0.475
MOD_GlcNHglycan	95	98	PF01048	0.505
MOD_GSK3_1	12	19	PF00069	0.575
MOD_GSK3_1	141	148	PF00069	0.464
MOD_GSK3_1	150	157	PF00069	0.619
MOD_GSK3_1	21	28	PF00069	0.552
MOD_GSK3_1	252	259	PF00069	0.400
MOD_GSK3_1	261	268	PF00069	0.425
MOD_GSK3_1	278	285	PF00069	0.645
MOD_GSK3_1	348	355	PF00069	0.714
MOD_GSK3_1	364	371	PF00069	0.589
MOD_GSK3_1	397	404	PF00069	0.457
MOD_GSK3_1	426	433	PF00069	0.512
MOD_GSK3_1	449	456	PF00069	0.644
MOD_GSK3_1	457	464	PF00069	0.777
MOD_GSK3_1	529	536	PF00069	0.533
MOD_GSK3_1	75	82	PF00069	0.438
MOD_N-GLC_1	461	466	PF02516	0.513
MOD_NEK2_1	1	6	PF00069	0.601
MOD_NEK2_1	13	18	PF00069	0.618
MOD_NEK2_1	256	261	PF00069	0.370
MOD_NEK2_1	461	466	PF00069	0.513
MOD_NEK2_1	61	66	PF00069	0.442
MOD_NEK2_1	72	77	PF00069	0.369
MOD_PIKK_1	75	81	PF00454	0.468
MOD_PKA_2	1	7	PF00069	0.626
MOD_PKA_2	474	480	PF00069	0.556
MOD_PKA_2	82	88	PF00069	0.491
MOD_Plk_1	397	403	PF00069	0.485
MOD_Plk_1	418	424	PF00069	0.597
MOD_Plk_4	156	162	PF00069	0.533
MOD_Plk_4	256	262	PF00069	0.374
MOD_Plk_4	368	374	PF00069	0.447
MOD_Plk_4	401	407	PF00069	0.500
MOD_Plk_4	548	554	PF00069	0.610
MOD_Plk_4	67	73	PF00069	0.402
MOD_ProDKin_1	275	281	PF00069	0.574
MOD_ProDKin_1	316	322	PF00069	0.564
MOD_ProDKin_1	328	334	PF00069	0.504
MOD_ProDKin_1	438	444	PF00069	0.636
MOD_ProDKin_1	447	453	PF00069	0.748
TRG_DiLeu_BaLyEn_6	499	504	PF01217	0.540
TRG_ENDOCYTIC_2	183	186	PF00928	0.278
TRG_ENDOCYTIC_2	272	275	PF00928	0.639
TRG_ENDOCYTIC_2	458	461	PF00928	0.524
TRG_ENDOCYTIC_2	69	72	PF00928	0.476
TRG_ER_diArg_1	492	494	PF00400	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL2	Leptomonas seymouri	47%	76%
A0A1X0P0L1	Trypanosomatidae	30%	82%
A0A3Q8IDL2	Leishmania donovani	76%	99%
A0A3R7K963	Trypanosoma rangeli	34%	100%
A4HWU0	Leishmania infantum	76%	99%
C9ZW41	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	93%
E9AQJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4QEX8	Leishmania major	76%	100%