Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8G6_LEIBR

TriTrypDb:

LbrM.16.0420 , LBRM2903_160009700

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8G6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	453	457	PF00656	0.804
CLV_MEL_PAP_1	500	506	PF00089	0.593
CLV_NRD_NRD_1	229	231	PF00675	0.509
CLV_NRD_NRD_1	391	393	PF00675	0.450
CLV_NRD_NRD_1	45	47	PF00675	0.734
CLV_NRD_NRD_1	454	456	PF00675	0.529
CLV_NRD_NRD_1	515	517	PF00675	0.565
CLV_NRD_NRD_1	56	58	PF00675	0.666
CLV_PCSK_KEX2_1	228	230	PF00082	0.536
CLV_PCSK_KEX2_1	281	283	PF00082	0.444
CLV_PCSK_KEX2_1	391	393	PF00082	0.596
CLV_PCSK_KEX2_1	433	435	PF00082	0.649
CLV_PCSK_KEX2_1	440	442	PF00082	0.781
CLV_PCSK_KEX2_1	444	446	PF00082	0.822
CLV_PCSK_KEX2_1	454	456	PF00082	0.543
CLV_PCSK_KEX2_1	514	516	PF00082	0.586
CLV_PCSK_KEX2_1	56	58	PF00082	0.708
CLV_PCSK_KEX2_1	71	73	PF00082	0.445
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.536
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.451
CLV_PCSK_PC1ET2_1	433	435	PF00082	0.686
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.781
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.822
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.693
CLV_PCSK_SKI1_1	207	211	PF00082	0.383
CLV_PCSK_SKI1_1	355	359	PF00082	0.394
CLV_PCSK_SKI1_1	42	46	PF00082	0.634
CLV_PCSK_SKI1_1	430	434	PF00082	0.518
CLV_PCSK_SKI1_1	476	480	PF00082	0.651
DEG_APCC_DBOX_1	391	399	PF00400	0.317
DEG_SPOP_SBC_1	175	179	PF00917	0.526
DEG_SPOP_SBC_1	180	184	PF00917	0.508
DEG_SPOP_SBC_1	409	413	PF00917	0.566
DEG_SPOP_SBC_1	6	10	PF00917	0.602
DOC_CKS1_1	347	352	PF01111	0.541
DOC_CYCLIN_RxL_1	300	311	PF00134	0.523
DOC_CYCLIN_yCln2_LP_2	347	353	PF00134	0.599
DOC_MAPK_gen_1	314	323	PF00069	0.403
DOC_MAPK_MEF2A_6	141	150	PF00069	0.452
DOC_MAPK_MEF2A_6	25	32	PF00069	0.425
DOC_MAPK_MEF2A_6	261	268	PF00069	0.426
DOC_MAPK_MEF2A_6	316	325	PF00069	0.399
DOC_PP2B_LxvP_1	143	146	PF13499	0.234
DOC_PP2B_LxvP_1	216	219	PF13499	0.485
DOC_PP2B_LxvP_1	264	267	PF13499	0.336
DOC_PP2B_LxvP_1	305	308	PF13499	0.510
DOC_PP2B_PxIxI_1	145	151	PF00149	0.246
DOC_USP7_MATH_1	173	177	PF00917	0.740
DOC_USP7_MATH_1	24	28	PF00917	0.549
DOC_USP7_MATH_1	362	366	PF00917	0.518
DOC_USP7_MATH_1	410	414	PF00917	0.755
DOC_USP7_MATH_1	419	423	PF00917	0.578
DOC_USP7_MATH_1	499	503	PF00917	0.635
DOC_USP7_MATH_1	523	527	PF00917	0.685
DOC_USP7_MATH_1	7	11	PF00917	0.531
DOC_USP7_UBL2_3	440	444	PF12436	0.746
DOC_WW_Pin1_4	117	122	PF00397	0.577
DOC_WW_Pin1_4	133	138	PF00397	0.295
DOC_WW_Pin1_4	169	174	PF00397	0.758
DOC_WW_Pin1_4	346	351	PF00397	0.543
DOC_WW_Pin1_4	460	465	PF00397	0.518
LIG_14-3-3_CanoR_1	207	216	PF00244	0.365
LIG_14-3-3_CanoR_1	25	29	PF00244	0.572
LIG_14-3-3_CanoR_1	282	290	PF00244	0.481
LIG_14-3-3_CanoR_1	300	306	PF00244	0.570
LIG_14-3-3_CanoR_1	374	379	PF00244	0.440
LIG_14-3-3_CanoR_1	434	438	PF00244	0.522
LIG_14-3-3_CanoR_1	488	496	PF00244	0.404
LIG_14-3-3_CanoR_1	501	510	PF00244	0.508
LIG_14-3-3_CanoR_1	536	545	PF00244	0.533
LIG_14-3-3_CanoR_1	57	67	PF00244	0.564
LIG_14-3-3_CanoR_1	87	93	PF00244	0.686
LIG_Actin_WH2_2	493	510	PF00022	0.639
LIG_BRCT_BRCA1_1	318	322	PF00533	0.454
LIG_CaM_IQ_9	507	522	PF13499	0.449
LIG_deltaCOP1_diTrp_1	239	245	PF00928	0.441
LIG_eIF4E_1	336	342	PF01652	0.332
LIG_FHA_1	106	112	PF00498	0.442
LIG_FHA_1	134	140	PF00498	0.438
LIG_FHA_1	18	24	PF00498	0.490
LIG_FHA_1	213	219	PF00498	0.542
LIG_FHA_1	250	256	PF00498	0.363
LIG_FHA_1	310	316	PF00498	0.526
LIG_FHA_1	374	380	PF00498	0.492
LIG_FHA_1	61	67	PF00498	0.621
LIG_FHA_1	94	100	PF00498	0.593
LIG_FHA_2	118	124	PF00498	0.445
LIG_FHA_2	410	416	PF00498	0.642
LIG_FHA_2	488	494	PF00498	0.603
LIG_Integrin_isoDGR_2	298	300	PF01839	0.412
LIG_LIR_Gen_1	239	250	PF02991	0.364
LIG_LIR_Gen_1	333	344	PF02991	0.420
LIG_LIR_Nem_3	138	143	PF02991	0.327
LIG_LIR_Nem_3	239	245	PF02991	0.409
LIG_LIR_Nem_3	262	268	PF02991	0.482
LIG_LIR_Nem_3	31	35	PF02991	0.559
LIG_LIR_Nem_3	319	325	PF02991	0.346
LIG_LIR_Nem_3	333	339	PF02991	0.386
LIG_LIR_Nem_3	388	393	PF02991	0.419
LIG_LIR_Nem_3	473	478	PF02991	0.607
LIG_MAD2	129	137	PF02301	0.498
LIG_NRBOX	138	144	PF00104	0.386
LIG_NRP_CendR_1	543	546	PF00754	0.538
LIG_Pex14_1	386	390	PF04695	0.409
LIG_RPA_C_Fungi	225	237	PF08784	0.441
LIG_SH2_CRK	140	144	PF00017	0.441
LIG_SH2_PTP2	265	268	PF00017	0.445
LIG_SH2_STAT5	135	138	PF00017	0.388
LIG_SH2_STAT5	265	268	PF00017	0.455
LIG_SH2_STAT5	336	339	PF00017	0.338
LIG_SH2_STAT5	389	392	PF00017	0.437
LIG_SH2_STAT5	477	480	PF00017	0.517
LIG_SH3_3	195	201	PF00018	0.610
LIG_SUMO_SIM_anti_2	149	155	PF11976	0.372
LIG_SUMO_SIM_par_1	396	402	PF11976	0.603
LIG_TRAF2_1	115	118	PF00917	0.498
LIG_TRAF2_1	519	522	PF00917	0.605
LIG_TYR_ITIM	334	339	PF00017	0.349
LIG_WRC_WIRS_1	29	34	PF05994	0.440
MOD_CK1_1	133	139	PF00069	0.365
MOD_CK1_1	171	177	PF00069	0.648
MOD_CK1_1	178	184	PF00069	0.574
MOD_CK1_1	188	194	PF00069	0.520
MOD_CK1_1	413	419	PF00069	0.640
MOD_CK1_1	422	428	PF00069	0.673
MOD_CK1_1	502	508	PF00069	0.564
MOD_CK1_1	525	531	PF00069	0.609
MOD_CK2_1	117	123	PF00069	0.461
MOD_CK2_1	362	368	PF00069	0.490
MOD_CK2_1	409	415	PF00069	0.667
MOD_CK2_1	487	493	PF00069	0.477
MOD_CK2_1	516	522	PF00069	0.664
MOD_CK2_1	72	78	PF00069	0.452
MOD_CK2_1	94	100	PF00069	0.650
MOD_Cter_Amidation	226	229	PF01082	0.525
MOD_Cter_Amidation	442	445	PF01082	0.689
MOD_Cter_Amidation	69	72	PF01082	0.469
MOD_GlcNHglycan	132	135	PF01048	0.493
MOD_GlcNHglycan	173	176	PF01048	0.740
MOD_GlcNHglycan	187	190	PF01048	0.586
MOD_GlcNHglycan	283	286	PF01048	0.506
MOD_GlcNHglycan	32	35	PF01048	0.587
MOD_GlcNHglycan	351	354	PF01048	0.512
MOD_GlcNHglycan	415	418	PF01048	0.712
MOD_GlcNHglycan	430	433	PF01048	0.598
MOD_GlcNHglycan	469	473	PF01048	0.460
MOD_GlcNHglycan	525	528	PF01048	0.643
MOD_GlcNHglycan	529	532	PF01048	0.693
MOD_GlcNHglycan	9	12	PF01048	0.527
MOD_GSK3_1	119	126	PF00069	0.498
MOD_GSK3_1	167	174	PF00069	0.707
MOD_GSK3_1	175	182	PF00069	0.755
MOD_GSK3_1	188	195	PF00069	0.699
MOD_GSK3_1	24	31	PF00069	0.550
MOD_GSK3_1	277	284	PF00069	0.532
MOD_GSK3_1	345	352	PF00069	0.407
MOD_GSK3_1	362	369	PF00069	0.387
MOD_GSK3_1	409	416	PF00069	0.684
MOD_GSK3_1	419	426	PF00069	0.600
MOD_GSK3_1	443	450	PF00069	0.783
MOD_GSK3_1	460	467	PF00069	0.461
MOD_GSK3_1	522	529	PF00069	0.606
MOD_N-GLC_1	309	314	PF02516	0.318
MOD_N-GLC_1	345	350	PF02516	0.320
MOD_N-GLC_2	16	18	PF02516	0.463
MOD_NEK2_1	168	173	PF00069	0.690
MOD_NEK2_1	28	33	PF00069	0.480
MOD_NEK2_1	373	378	PF00069	0.443
MOD_NEK2_1	379	384	PF00069	0.415
MOD_PIKK_1	60	66	PF00454	0.543
MOD_PKA_1	281	287	PF00069	0.544
MOD_PKA_1	433	439	PF00069	0.739
MOD_PKA_1	516	522	PF00069	0.595
MOD_PKA_2	24	30	PF00069	0.563
MOD_PKA_2	281	287	PF00069	0.519
MOD_PKA_2	373	379	PF00069	0.434
MOD_PKA_2	433	439	PF00069	0.589
MOD_PKA_2	487	493	PF00069	0.410
MOD_PKA_2	502	508	PF00069	0.507
MOD_PKA_2	538	544	PF00069	0.763
MOD_PKA_2	88	94	PF00069	0.726
MOD_PKB_1	314	322	PF00069	0.405
MOD_PKB_1	40	48	PF00069	0.620
MOD_PKB_1	514	522	PF00069	0.621
MOD_Plk_1	484	490	PF00069	0.607
MOD_Plk_2-3	78	84	PF00069	0.567
MOD_Plk_4	135	141	PF00069	0.439
MOD_Plk_4	24	30	PF00069	0.535
MOD_Plk_4	374	380	PF00069	0.527
MOD_ProDKin_1	117	123	PF00069	0.574
MOD_ProDKin_1	133	139	PF00069	0.291
MOD_ProDKin_1	169	175	PF00069	0.759
MOD_ProDKin_1	346	352	PF00069	0.544
MOD_ProDKin_1	460	466	PF00069	0.512
TRG_DiLeu_BaEn_1	313	318	PF01217	0.420
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.440
TRG_ENDOCYTIC_2	140	143	PF00928	0.355
TRG_ENDOCYTIC_2	144	147	PF00928	0.345
TRG_ENDOCYTIC_2	265	268	PF00928	0.445
TRG_ENDOCYTIC_2	336	339	PF00928	0.338
TRG_ENDOCYTIC_2	38	41	PF00928	0.465
TRG_ENDOCYTIC_2	475	478	PF00928	0.674
TRG_ER_diArg_1	127	130	PF00400	0.531
TRG_ER_diArg_1	229	231	PF00400	0.509
TRG_ER_diArg_1	314	317	PF00400	0.414
TRG_ER_diArg_1	390	392	PF00400	0.314
TRG_ER_diArg_1	500	503	PF00400	0.463
TRG_ER_diArg_1	514	516	PF00400	0.437
TRG_ER_diArg_1	87	90	PF00400	0.572
TRG_NES_CRM1_1	262	278	PF08389	0.327
TRG_NLS_Bipartite_1	433	448	PF00514	0.684
TRG_NLS_MonoExtC_3	515	520	PF00514	0.617
TRG_NLS_MonoExtN_4	441	448	PF00514	0.530
TRG_NLS_MonoExtN_4	514	520	PF00514	0.633
TRG_Pf-PMV_PEXEL_1	270	275	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7X8	Leptomonas seymouri	59%	82%
A0A1X0NZC8	Trypanosomatidae	40%	90%
A0A3S7WTU1	Leishmania donovani	85%	95%
A0A422N971	Trypanosoma rangeli	40%	91%
A4HWT9	Leishmania infantum	85%	95%
C9ZPR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	95%
E9AQJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	95%
Q4QEX9	Leishmania major	83%	100%
V5B948	Trypanosoma cruzi	41%	97%