Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8G5_LEIBR

TriTrypDb:

LbrM.16.0410 , LBRM2903_160009600

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H8G5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8G5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.447
CLV_NRD_NRD_1	13	15	PF00675	0.393
CLV_NRD_NRD_1	189	191	PF00675	0.685
CLV_PCSK_KEX2_1	13	15	PF00082	0.428
CLV_PCSK_KEX2_1	189	191	PF00082	0.736
CLV_PCSK_SKI1_1	155	159	PF00082	0.613
DEG_APCC_DBOX_1	154	162	PF00400	0.425
DEG_COP1_1	201	209	PF00400	0.422
DOC_CKS1_1	110	115	PF01111	0.355
DOC_CYCLIN_yCln2_LP_2	288	294	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	64	70	PF00134	0.453
DOC_MAPK_gen_1	13	21	PF00069	0.707
DOC_MAPK_gen_1	189	196	PF00069	0.437
DOC_PP1_RVXF_1	168	174	PF00149	0.504
DOC_PP2B_LxvP_1	174	177	PF13499	0.357
DOC_PP2B_LxvP_1	288	291	PF13499	0.482
DOC_PP4_FxxP_1	173	176	PF00568	0.349
DOC_PP4_FxxP_1	312	315	PF00568	0.369
DOC_PP4_MxPP_1	1	4	PF00568	0.579
DOC_USP7_MATH_1	129	133	PF00917	0.457
DOC_USP7_MATH_1	253	257	PF00917	0.578
DOC_USP7_MATH_1	31	35	PF00917	0.513
DOC_USP7_MATH_1	320	324	PF00917	0.284
DOC_WW_Pin1_4	109	114	PF00397	0.349
DOC_WW_Pin1_4	205	210	PF00397	0.609
DOC_WW_Pin1_4	45	50	PF00397	0.417
DOC_WW_Pin1_4	63	68	PF00397	0.403
LIG_14-3-3_CanoR_1	170	174	PF00244	0.435
LIG_14-3-3_CanoR_1	189	194	PF00244	0.468
LIG_14-3-3_CanoR_1	268	277	PF00244	0.552
LIG_14-3-3_CanoR_1	40	44	PF00244	0.548
LIG_AP2alpha_2	275	277	PF02296	0.537
LIG_BIR_II_1	1	5	PF00653	0.726
LIG_BIR_III_1	1	5	PF00653	0.573
LIG_BIR_III_2	148	152	PF00653	0.440
LIG_BIR_III_3	1	5	PF00653	0.573
LIG_BRCT_BRCA1_1	177	181	PF00533	0.431
LIG_CaMK_CASK_1	240	246	PF00069	0.586
LIG_EH1_1	20	28	PF00400	0.261
LIG_eIF4E_1	324	330	PF01652	0.513
LIG_EVH1_2	3	7	PF00568	0.549
LIG_FHA_1	110	116	PF00498	0.464
LIG_FHA_1	219	225	PF00498	0.481
LIG_FHA_1	46	52	PF00498	0.460
LIG_FHA_1	59	65	PF00498	0.413
LIG_FHA_2	226	232	PF00498	0.560
LIG_LIR_Apic_2	172	176	PF02991	0.343
LIG_LIR_Apic_2	293	298	PF02991	0.553
LIG_LIR_Apic_2	311	315	PF02991	0.370
LIG_LIR_Gen_1	178	188	PF02991	0.406
LIG_LIR_Gen_1	48	56	PF02991	0.613
LIG_LIR_Gen_1	5	15	PF02991	0.592
LIG_LIR_Nem_3	102	108	PF02991	0.462
LIG_LIR_Nem_3	178	184	PF02991	0.403
LIG_LIR_Nem_3	275	280	PF02991	0.453
LIG_LIR_Nem_3	33	39	PF02991	0.385
LIG_LIR_Nem_3	48	53	PF02991	0.454
LIG_LIR_Nem_3	5	10	PF02991	0.598
LIG_NRBOX	24	30	PF00104	0.261
LIG_Pex14_1	327	331	PF04695	0.411
LIG_PTB_Apo_2	95	102	PF02174	0.445
LIG_PTB_Phospho_1	95	101	PF10480	0.447
LIG_SH2_CRK	105	109	PF00017	0.445
LIG_SH2_CRK	17	21	PF00017	0.438
LIG_SH2_CRK	295	299	PF00017	0.554
LIG_SH2_CRK	338	342	PF00017	0.411
LIG_SH2_SRC	30	33	PF00017	0.261
LIG_SH2_STAP1	101	105	PF00017	0.543
LIG_SH2_STAP1	17	21	PF00017	0.438
LIG_SH2_STAT5	101	104	PF00017	0.552
LIG_SH2_STAT5	156	159	PF00017	0.411
LIG_SH2_STAT5	324	327	PF00017	0.459
LIG_SH2_STAT5	334	337	PF00017	0.353
LIG_SH2_STAT5	338	341	PF00017	0.328
LIG_SH2_STAT5	37	40	PF00017	0.576
LIG_SH3_3	104	110	PF00018	0.456
LIG_SH3_3	119	125	PF00018	0.418
LIG_SH3_3	203	209	PF00018	0.418
LIG_SH3_3	273	279	PF00018	0.482
LIG_SH3_3	57	63	PF00018	0.456
LIG_SH3_3	64	70	PF00018	0.434
LIG_Sin3_3	24	31	PF02671	0.261
LIG_SUMO_SIM_anti_2	22	27	PF11976	0.294
LIG_TRAF2_1	237	240	PF00917	0.414
LIG_TYR_ITIM	15	20	PF00017	0.529
LIG_TYR_ITIM	332	337	PF00017	0.404
LIG_WRC_WIRS_1	309	314	PF05994	0.366
LIG_WRC_WIRS_1	337	342	PF05994	0.261
MOD_CDK_SPK_2	205	210	PF00069	0.429
MOD_CDK_SPxxK_3	109	116	PF00069	0.357
MOD_CDK_SPxxK_3	205	212	PF00069	0.613
MOD_CK1_1	251	257	PF00069	0.496
MOD_CK1_1	72	78	PF00069	0.437
MOD_CK2_1	234	240	PF00069	0.509
MOD_CK2_1	77	83	PF00069	0.623
MOD_DYRK1A_RPxSP_1	109	113	PF00069	0.353
MOD_GlcNHglycan	138	141	PF01048	0.808
MOD_GlcNHglycan	253	256	PF01048	0.759
MOD_GlcNHglycan	342	345	PF01048	0.457
MOD_GSK3_1	249	256	PF00069	0.445
MOD_GSK3_1	336	343	PF00069	0.411
MOD_GSK3_1	54	61	PF00069	0.446
MOD_NEK2_1	163	168	PF00069	0.369
MOD_NEK2_1	258	263	PF00069	0.454
MOD_NEK2_1	340	345	PF00069	0.663
MOD_NEK2_2	31	36	PF00069	0.513
MOD_NEK2_2	85	90	PF00069	0.444
MOD_PIKK_1	58	64	PF00454	0.476
MOD_PK_1	189	195	PF00069	0.538
MOD_PK_1	286	292	PF00069	0.478
MOD_PKA_1	189	195	PF00069	0.538
MOD_PKA_2	169	175	PF00069	0.436
MOD_PKA_2	188	194	PF00069	0.464
MOD_PKA_2	39	45	PF00069	0.551
MOD_PKA_2	54	60	PF00069	0.438
MOD_PKB_1	210	218	PF00069	0.417
MOD_Plk_1	234	240	PF00069	0.516
MOD_Plk_1	258	264	PF00069	0.540
MOD_Plk_1	85	91	PF00069	0.444
MOD_Plk_4	163	169	PF00069	0.399
MOD_Plk_4	189	195	PF00069	0.366
MOD_Plk_4	3	9	PF00069	0.687
MOD_Plk_4	308	314	PF00069	0.455
MOD_Plk_4	31	37	PF00069	0.432
MOD_Plk_4	320	326	PF00069	0.228
MOD_Plk_4	336	342	PF00069	0.372
MOD_Plk_4	39	45	PF00069	0.473
MOD_ProDKin_1	109	115	PF00069	0.353
MOD_ProDKin_1	205	211	PF00069	0.609
MOD_ProDKin_1	45	51	PF00069	0.418
MOD_ProDKin_1	63	69	PF00069	0.403
TRG_DiLeu_BaEn_2	221	227	PF01217	0.360
TRG_ENDOCYTIC_2	101	104	PF00928	0.479
TRG_ENDOCYTIC_2	105	108	PF00928	0.430
TRG_ENDOCYTIC_2	17	20	PF00928	0.698
TRG_ENDOCYTIC_2	334	337	PF00928	0.404
TRG_ENDOCYTIC_2	338	341	PF00928	0.411
TRG_ENDOCYTIC_2	36	39	PF00928	0.368
TRG_ER_diArg_1	12	14	PF00400	0.620
TRG_ER_diArg_1	152	155	PF00400	0.416
TRG_ER_diArg_1	188	190	PF00400	0.528
TRG_ER_diArg_1	209	212	PF00400	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0F8	Leptomonas seymouri	38%	93%
A0A3S7WTU6	Leishmania donovani	65%	100%
E9AGN1	Leishmania infantum	65%	100%
E9AQJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	98%
Q4QEY0	Leishmania major	61%	100%