Putative tubulin tyrosine ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin tyrosine ligase, putative

Species:

Leishmania braziliensis

UniProt:

A4H8G3_LEIBR

TriTrypDb:

LbrM.16.0390 , LBRM2903_160009400

Length:

734

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005874	microtubule	6	7
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0099080	supramolecular complex	2	7
GO:0099081	supramolecular polymer	3	7
GO:0099512	supramolecular fiber	4	7
GO:0099513	polymeric cytoskeletal fiber	5	7

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Expansion

Sequence features

A4H8G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8G3

Function

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Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0018095	protein polyglutamylation	7	8
GO:0018193	peptidyl-amino acid modification	5	8

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	11
GO:0004835	tubulin-tyrosine ligase activity	3	8
GO:0005488	binding	1	8
GO:0005515	protein binding	2	2
GO:0005524	ATP binding	5	7
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0016874	ligase activity	2	11
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.592
CLV_NRD_NRD_1	11	13	PF00675	0.717
CLV_NRD_NRD_1	15	17	PF00675	0.587
CLV_NRD_NRD_1	19	21	PF00675	0.562
CLV_NRD_NRD_1	250	252	PF00675	0.579
CLV_NRD_NRD_1	283	285	PF00675	0.419
CLV_NRD_NRD_1	312	314	PF00675	0.289
CLV_NRD_NRD_1	405	407	PF00675	0.275
CLV_PCSK_FUR_1	248	252	PF00082	0.562
CLV_PCSK_KEX2_1	11	13	PF00082	0.676

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDX5	Leptomonas seymouri	58%	90%
A0A3Q8IDL7	Leishmania donovani	24%	100%
A0A3S5H6X0	Leishmania donovani	72%	90%
A4HWT7	Leishmania infantum	72%	90%
A4HYN9	Leishmania infantum	24%	100%
E9AID0	Leishmania braziliensis	25%	100%
E9AQJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	90%
E9AUL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4QCW7	Leishmania major	24%	100%
Q4QEY2	Leishmania major	71%	100%

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