Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8G1_LEIBR

TriTrypDb:

LbrM.16.0370 , LBRM2903_160009200

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8G1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8G1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	411	415	PF00656	0.545
CLV_MEL_PAP_1	446	452	PF00089	0.547
CLV_NRD_NRD_1	123	125	PF00675	0.692
CLV_NRD_NRD_1	375	377	PF00675	0.537
CLV_NRD_NRD_1	535	537	PF00675	0.590
CLV_PCSK_KEX2_1	112	114	PF00082	0.673
CLV_PCSK_KEX2_1	123	125	PF00082	0.674
CLV_PCSK_KEX2_1	280	282	PF00082	0.460
CLV_PCSK_KEX2_1	375	377	PF00082	0.537
CLV_PCSK_KEX2_1	512	514	PF00082	0.524
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.607
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.460
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.524
CLV_PCSK_SKI1_1	26	30	PF00082	0.573
CLV_PCSK_SKI1_1	277	281	PF00082	0.613
CLV_PCSK_SKI1_1	306	310	PF00082	0.627
CLV_PCSK_SKI1_1	357	361	PF00082	0.658
CLV_PCSK_SKI1_1	467	471	PF00082	0.541
CLV_PCSK_SKI1_1	472	476	PF00082	0.538
CLV_PCSK_SKI1_1	78	82	PF00082	0.614
DEG_Nend_Nbox_1	1	3	PF02207	0.482
DEG_SPOP_SBC_1	385	389	PF00917	0.529
DEG_SPOP_SBC_1	434	438	PF00917	0.533
DEG_SPOP_SBC_1	542	546	PF00917	0.527
DEG_SPOP_SBC_1	79	83	PF00917	0.652
DOC_MAPK_gen_1	417	424	PF00069	0.455
DOC_MAPK_MEF2A_6	145	152	PF00069	0.500
DOC_USP7_MATH_1	19	23	PF00917	0.601
DOC_USP7_MATH_1	243	247	PF00917	0.659
DOC_USP7_MATH_1	252	256	PF00917	0.617
DOC_USP7_MATH_1	352	356	PF00917	0.538
DOC_USP7_MATH_1	36	40	PF00917	0.632
DOC_USP7_MATH_1	374	378	PF00917	0.583
DOC_USP7_MATH_1	385	389	PF00917	0.574
DOC_USP7_MATH_1	433	437	PF00917	0.627
DOC_USP7_MATH_1	497	501	PF00917	0.534
DOC_USP7_MATH_1	518	522	PF00917	0.523
DOC_USP7_MATH_1	541	545	PF00917	0.520
DOC_USP7_MATH_1	548	552	PF00917	0.526
DOC_USP7_MATH_1	79	83	PF00917	0.652
DOC_USP7_MATH_1	86	90	PF00917	0.581
DOC_USP7_UBL2_3	270	274	PF12436	0.468
DOC_WW_Pin1_4	116	121	PF00397	0.661
DOC_WW_Pin1_4	14	19	PF00397	0.627
DOC_WW_Pin1_4	165	170	PF00397	0.629
DOC_WW_Pin1_4	189	194	PF00397	0.390
DOC_WW_Pin1_4	311	316	PF00397	0.710
DOC_WW_Pin1_4	32	37	PF00397	0.596
DOC_WW_Pin1_4	368	373	PF00397	0.658
DOC_WW_Pin1_4	379	384	PF00397	0.631
DOC_WW_Pin1_4	423	428	PF00397	0.594
DOC_WW_Pin1_4	451	456	PF00397	0.673
DOC_WW_Pin1_4	457	462	PF00397	0.628
DOC_WW_Pin1_4	481	486	PF00397	0.613
DOC_WW_Pin1_4	500	505	PF00397	0.499
DOC_WW_Pin1_4	543	548	PF00397	0.559
DOC_WW_Pin1_4	591	596	PF00397	0.652
LIG_14-3-3_CanoR_1	145	151	PF00244	0.573
LIG_14-3-3_CanoR_1	153	161	PF00244	0.471
LIG_14-3-3_CanoR_1	265	273	PF00244	0.615
LIG_14-3-3_CanoR_1	293	302	PF00244	0.516
LIG_14-3-3_CanoR_1	367	372	PF00244	0.563
LIG_14-3-3_CanoR_1	375	383	PF00244	0.615
LIG_14-3-3_CanoR_1	409	413	PF00244	0.556
LIG_14-3-3_CanoR_1	449	455	PF00244	0.601
LIG_14-3-3_CanoR_1	78	87	PF00244	0.587
LIG_Actin_WH2_2	130	147	PF00022	0.455
LIG_BRCT_BRCA1_1	106	110	PF00533	0.535
LIG_BRCT_BRCA1_1	191	195	PF00533	0.376
LIG_BRCT_BRCA1_1	349	353	PF00533	0.498
LIG_BRCT_BRCA1_1	574	578	PF00533	0.628
LIG_BRCT_BRCA1_2	106	112	PF00533	0.527
LIG_Clathr_ClatBox_1	229	233	PF01394	0.477
LIG_EH1_1	201	209	PF00400	0.393
LIG_FHA_1	147	153	PF00498	0.476
LIG_FHA_1	199	205	PF00498	0.678
LIG_FHA_1	326	332	PF00498	0.643
LIG_FHA_1	503	509	PF00498	0.534
LIG_FHA_1	79	85	PF00498	0.653
LIG_FHA_2	397	403	PF00498	0.659
LIG_FHA_2	484	490	PF00498	0.596
LIG_FHA_2	491	497	PF00498	0.548
LIG_FHA_2	553	559	PF00498	0.534
LIG_LIR_Gen_1	52	61	PF02991	0.632
LIG_LIR_LC3C_4	228	232	PF02991	0.469
LIG_LIR_Nem_3	174	180	PF02991	0.440
LIG_LIR_Nem_3	192	198	PF02991	0.331
LIG_LIR_Nem_3	350	356	PF02991	0.647
LIG_LIR_Nem_3	416	421	PF02991	0.709
LIG_LIR_Nem_3	52	56	PF02991	0.626
LIG_PCNA_PIPBox_1	250	259	PF02747	0.748
LIG_RPA_C_Fungi	50	62	PF08784	0.508
LIG_RPA_C_Fungi	531	543	PF08784	0.510
LIG_SH2_CRK	356	360	PF00017	0.657
LIG_SH2_CRK	53	57	PF00017	0.629
LIG_SH2_NCK_1	523	527	PF00017	0.527
LIG_SH2_PTP2	8	11	PF00017	0.491
LIG_SH2_SRC	197	200	PF00017	0.382
LIG_SH2_SRC	523	526	PF00017	0.527
LIG_SH2_STAP1	584	588	PF00017	0.506
LIG_SH2_STAT5	197	200	PF00017	0.508
LIG_SH2_STAT5	266	269	PF00017	0.468
LIG_SH2_STAT5	584	587	PF00017	0.522
LIG_SH2_STAT5	8	11	PF00017	0.638
LIG_SH3_3	187	193	PF00018	0.515
LIG_SH3_3	328	334	PF00018	0.564
LIG_SH3_3	338	344	PF00018	0.548
LIG_SH3_3	391	397	PF00018	0.532
LIG_SH3_3	553	559	PF00018	0.534
LIG_SH3_3	71	77	PF00018	0.693
LIG_SUMO_SIM_anti_2	228	233	PF11976	0.565
LIG_SUMO_SIM_par_1	228	233	PF11976	0.474
LIG_SUMO_SIM_par_1	357	363	PF11976	0.515
LIG_SUMO_SIM_par_1	396	402	PF11976	0.597
LIG_SUMO_SIM_par_1	473	479	PF11976	0.512
LIG_UBA3_1	475	480	PF00899	0.517
MOD_CDK_SPK_2	462	467	PF00069	0.536
MOD_CDK_SPxK_1	311	317	PF00069	0.688
MOD_CDK_SPxK_1	457	463	PF00069	0.617
MOD_CDK_SPxxK_3	116	123	PF00069	0.653
MOD_CDK_SPxxK_3	14	21	PF00069	0.514
MOD_CDK_SPxxK_3	189	196	PF00069	0.373
MOD_CDK_SPxxK_3	368	375	PF00069	0.526
MOD_CK1_1	104	110	PF00069	0.626
MOD_CK1_1	165	171	PF00069	0.625
MOD_CK1_1	268	274	PF00069	0.575
MOD_CK1_1	332	338	PF00069	0.619
MOD_CK1_1	387	393	PF00069	0.604
MOD_CK1_1	423	429	PF00069	0.523
MOD_CK1_1	451	457	PF00069	0.578
MOD_CK1_1	500	506	PF00069	0.533
MOD_CK1_1	579	585	PF00069	0.490
MOD_CK2_1	19	25	PF00069	0.556
MOD_CK2_1	222	228	PF00069	0.495
MOD_CK2_1	483	489	PF00069	0.594
MOD_CK2_1	490	496	PF00069	0.551
MOD_CK2_1	552	558	PF00069	0.539
MOD_GlcNHglycan	154	157	PF01048	0.624
MOD_GlcNHglycan	169	172	PF01048	0.698
MOD_GlcNHglycan	236	239	PF01048	0.626
MOD_GlcNHglycan	245	248	PF01048	0.540
MOD_GlcNHglycan	331	334	PF01048	0.644
MOD_GlcNHglycan	337	340	PF01048	0.583
MOD_GlcNHglycan	38	41	PF01048	0.678
MOD_GlcNHglycan	437	440	PF01048	0.665
MOD_GlcNHglycan	451	454	PF01048	0.567
MOD_GlcNHglycan	471	475	PF01048	0.474
MOD_GlcNHglycan	514	517	PF01048	0.526
MOD_GlcNHglycan	520	523	PF01048	0.518
MOD_GlcNHglycan	57	60	PF01048	0.515
MOD_GlcNHglycan	88	91	PF01048	0.639
MOD_GSK3_1	104	111	PF00069	0.574
MOD_GSK3_1	163	170	PF00069	0.611
MOD_GSK3_1	198	205	PF00069	0.609
MOD_GSK3_1	218	225	PF00069	0.431
MOD_GSK3_1	307	314	PF00069	0.704
MOD_GSK3_1	316	323	PF00069	0.719
MOD_GSK3_1	32	39	PF00069	0.630
MOD_GSK3_1	325	332	PF00069	0.612
MOD_GSK3_1	343	350	PF00069	0.554
MOD_GSK3_1	374	381	PF00069	0.684
MOD_GSK3_1	383	390	PF00069	0.627
MOD_GSK3_1	444	451	PF00069	0.566
MOD_GSK3_1	492	499	PF00069	0.568
MOD_GSK3_1	548	555	PF00069	0.540
MOD_GSK3_1	572	579	PF00069	0.481
MOD_N-GLC_1	104	109	PF02516	0.641
MOD_N-GLC_1	319	324	PF02516	0.571
MOD_NEK2_1	146	151	PF00069	0.495
MOD_NEK2_1	152	157	PF00069	0.446
MOD_NEK2_1	163	168	PF00069	0.645
MOD_NEK2_1	198	203	PF00069	0.389
MOD_NEK2_1	222	227	PF00069	0.478
MOD_NEK2_1	309	314	PF00069	0.657
MOD_NEK2_1	316	321	PF00069	0.611
MOD_NEK2_1	347	352	PF00069	0.645
MOD_NEK2_1	360	365	PF00069	0.557
MOD_NEK2_1	470	475	PF00069	0.597
MOD_NEK2_1	476	481	PF00069	0.554
MOD_NEK2_1	80	85	PF00069	0.652
MOD_NEK2_2	218	223	PF00069	0.342
MOD_OGLYCOS	379	384	PF02709	0.524
MOD_PIKK_1	202	208	PF00454	0.607
MOD_PIKK_1	389	395	PF00454	0.538
MOD_PIKK_1	497	503	PF00454	0.537
MOD_PKA_1	512	518	PF00069	0.524
MOD_PKA_2	152	158	PF00069	0.524
MOD_PKA_2	222	228	PF00069	0.575
MOD_PKA_2	316	322	PF00069	0.696
MOD_PKA_2	366	372	PF00069	0.537
MOD_PKA_2	374	380	PF00069	0.550
MOD_PKA_2	408	414	PF00069	0.540
MOD_PKA_2	448	454	PF00069	0.626
MOD_PKA_2	512	518	PF00069	0.524
MOD_Plk_1	304	310	PF00069	0.512
MOD_Plk_1	470	476	PF00069	0.510
MOD_Plk_4	146	152	PF00069	0.489
MOD_Plk_4	252	258	PF00069	0.554
MOD_Plk_4	268	274	PF00069	0.511
MOD_Plk_4	420	426	PF00069	0.519
MOD_Plk_4	80	86	PF00069	0.664
MOD_ProDKin_1	116	122	PF00069	0.656
MOD_ProDKin_1	14	20	PF00069	0.628
MOD_ProDKin_1	165	171	PF00069	0.625
MOD_ProDKin_1	189	195	PF00069	0.381
MOD_ProDKin_1	311	317	PF00069	0.713
MOD_ProDKin_1	32	38	PF00069	0.596
MOD_ProDKin_1	368	374	PF00069	0.658
MOD_ProDKin_1	379	385	PF00069	0.630
MOD_ProDKin_1	423	429	PF00069	0.596
MOD_ProDKin_1	451	457	PF00069	0.673
MOD_ProDKin_1	462	468	PF00069	0.580
MOD_ProDKin_1	481	487	PF00069	0.578
MOD_ProDKin_1	500	506	PF00069	0.501
MOD_ProDKin_1	543	549	PF00069	0.561
MOD_ProDKin_1	591	597	PF00069	0.655
MOD_SUMO_rev_2	436	446	PF00179	0.556
TRG_DiLeu_BaEn_1	471	476	PF01217	0.509
TRG_DiLeu_BaEn_2	24	30	PF01217	0.548
TRG_DiLeu_BaLyEn_6	355	360	PF01217	0.652
TRG_ENDOCYTIC_2	197	200	PF00928	0.507
TRG_ENDOCYTIC_2	356	359	PF00928	0.773
TRG_ENDOCYTIC_2	418	421	PF00928	0.744
TRG_ENDOCYTIC_2	53	56	PF00928	0.630
TRG_ENDOCYTIC_2	8	11	PF00928	0.491
TRG_ER_diArg_1	114	117	PF00400	0.798
TRG_ER_diArg_1	122	124	PF00400	0.674
TRG_ER_diArg_1	566	569	PF00400	0.633
TRG_Pf-PMV_PEXEL_1	357	362	PF00026	0.763
TRG_Pf-PMV_PEXEL_1	444	448	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	467	471	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IA95	Leishmania donovani	57%	87%
A4HWT5	Leishmania infantum	57%	87%
E9AQJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	88%
Q4QEY4	Leishmania major	57%	100%