Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania braziliensis

UniProt:

A4H8G0_LEIBR

TriTrypDb:

LbrM.16.0360 , LBRM2903_160009100

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	2

Expansion

Sequence features

A4H8G0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8G0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	12
GO:0051716	cellular response to stimulus	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006304	DNA modification	5	1
GO:0009451	RNA modification	5	1
GO:0016070	RNA metabolic process	5	1
GO:0035510	DNA dealkylation	6	1
GO:0035511	obsolete oxidative DNA demethylation	4	1
GO:0035513	oxidative RNA demethylation	4	1
GO:0035552	oxidative single-stranded DNA demethylation	5	1
GO:0043412	macromolecule modification	4	1
GO:0044728	obsolete DNA methylation or demethylation	6	1
GO:0070988	demethylation	2	1
GO:0070989	oxidative demethylation	3	1
GO:0080111	DNA demethylation	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0051213	dioxygenase activity	3	12
GO:0005488	binding	1	1
GO:0005506	iron ion binding	6	1
GO:0008198	ferrous iron binding	7	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	1
GO:0032451	demethylase activity	2	1
GO:0035514	DNA demethylase activity	3	1
GO:0035515	oxidative RNA demethylase activity	3	1
GO:0035516	oxidative DNA demethylase activity	4	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.502
CLV_C14_Caspase3-7	12	16	PF00656	0.364
CLV_C14_Caspase3-7	286	290	PF00656	0.488
CLV_NRD_NRD_1	13	15	PF00675	0.499
CLV_NRD_NRD_1	18	20	PF00675	0.544
CLV_NRD_NRD_1	44	46	PF00675	0.466
CLV_PCSK_KEX2_1	13	15	PF00082	0.466
CLV_PCSK_KEX2_1	17	19	PF00082	0.498
CLV_PCSK_KEX2_1	4	6	PF00082	0.445
CLV_PCSK_KEX2_1	44	46	PF00082	0.529
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.463
CLV_PCSK_PC7_1	13	19	PF00082	0.529
CLV_PCSK_SKI1_1	138	142	PF00082	0.247
CLV_PCSK_SKI1_1	263	267	PF00082	0.275
CLV_PCSK_SKI1_1	49	53	PF00082	0.572
DEG_APCC_DBOX_1	4	12	PF00400	0.465
DEG_SPOP_SBC_1	127	131	PF00917	0.527
DOC_CDC14_PxL_1	81	89	PF14671	0.352
DOC_MAPK_gen_1	166	175	PF00069	0.491
DOC_MAPK_gen_1	44	52	PF00069	0.538
DOC_PP2B_LxvP_1	280	283	PF13499	0.511
DOC_PP4_FxxP_1	258	261	PF00568	0.475
DOC_PP4_FxxP_1	352	355	PF00568	0.579
DOC_USP7_MATH_1	203	207	PF00917	0.503
DOC_USP7_MATH_1	222	226	PF00917	0.379
DOC_USP7_MATH_1	265	269	PF00917	0.476
DOC_USP7_MATH_1	290	294	PF00917	0.547
DOC_USP7_MATH_1	60	64	PF00917	0.616
DOC_WW_Pin1_4	266	271	PF00397	0.494
LIG_14-3-3_CanoR_1	125	135	PF00244	0.554
LIG_14-3-3_CanoR_1	138	143	PF00244	0.433
LIG_14-3-3_CanoR_1	157	162	PF00244	0.555
LIG_14-3-3_CanoR_1	38	46	PF00244	0.481
LIG_BIR_II_1	1	5	PF00653	0.523
LIG_BRCT_BRCA1_1	230	234	PF00533	0.450
LIG_EH1_1	201	209	PF00400	0.450
LIG_FHA_1	147	153	PF00498	0.511
LIG_FHA_1	194	200	PF00498	0.470
LIG_FHA_1	26	32	PF00498	0.471
LIG_FHA_1	267	273	PF00498	0.494
LIG_FHA_2	279	285	PF00498	0.501
LIG_FHA_2	286	292	PF00498	0.477
LIG_FHA_2	317	323	PF00498	0.432
LIG_LIR_Apic_2	130	136	PF02991	0.461
LIG_LIR_Gen_1	156	165	PF02991	0.475
LIG_LIR_Nem_3	156	161	PF02991	0.461
LIG_LIR_Nem_3	3	9	PF02991	0.453
LIG_LIR_Nem_3	324	329	PF02991	0.512
LIG_LIR_Nem_3	80	84	PF02991	0.355
LIG_PCNA_PIPBox_1	195	204	PF02747	0.450
LIG_PTB_Apo_2	304	311	PF02174	0.375
LIG_SH2_CRK	133	137	PF00017	0.536
LIG_SH2_SRC	133	136	PF00017	0.491
LIG_SH2_STAP1	144	148	PF00017	0.524
LIG_SH2_STAP1	301	305	PF00017	0.361
LIG_SH2_STAT3	192	195	PF00017	0.450
LIG_SH2_STAT3	344	347	PF00017	0.281
LIG_SH2_STAT5	279	282	PF00017	0.475
LIG_SH2_STAT5	79	82	PF00017	0.401
LIG_SH3_1	17	23	PF00018	0.624
LIG_SH3_3	17	23	PF00018	0.612
LIG_SH3_3	343	349	PF00018	0.268
LIG_SH3_3	47	53	PF00018	0.537
LIG_SUMO_SIM_anti_2	171	178	PF11976	0.522
LIG_TRAF2_1	319	322	PF00917	0.494
LIG_TYR_ITIM	199	204	PF00017	0.303
LIG_WW_2	20	23	PF00397	0.425
LIG_WW_3	52	56	PF00397	0.400
MOD_CDK_SPK_2	266	271	PF00069	0.364
MOD_CK1_1	215	221	PF00069	0.345
MOD_CK2_1	278	284	PF00069	0.373
MOD_CK2_1	285	291	PF00069	0.322
MOD_CK2_1	316	322	PF00069	0.277
MOD_CK2_1	92	98	PF00069	0.355
MOD_GlcNHglycan	162	165	PF01048	0.430
MOD_GlcNHglycan	230	233	PF01048	0.393
MOD_GlcNHglycan	251	254	PF01048	0.296
MOD_GlcNHglycan	64	67	PF01048	0.635
MOD_GSK3_1	138	145	PF00069	0.312
MOD_GSK3_1	156	163	PF00069	0.119
MOD_GSK3_1	224	231	PF00069	0.290
MOD_N-GLC_1	60	65	PF02516	0.666
MOD_NEK2_1	224	229	PF00069	0.300
MOD_NEK2_1	235	240	PF00069	0.268
MOD_PIKK_1	146	152	PF00454	0.333
MOD_PIKK_1	235	241	PF00454	0.423
MOD_PKA_2	156	162	PF00069	0.450
MOD_PKA_2	37	43	PF00069	0.534
MOD_PKB_1	155	163	PF00069	0.411
MOD_Plk_1	215	221	PF00069	0.337
MOD_Plk_1	290	296	PF00069	0.197
MOD_Plk_1	60	66	PF00069	0.665
MOD_Plk_2-3	285	291	PF00069	0.409
MOD_Plk_2-3	37	43	PF00069	0.560
MOD_Plk_4	171	177	PF00069	0.363
MOD_Plk_4	203	209	PF00069	0.326
MOD_ProDKin_1	266	272	PF00069	0.364
TRG_DiLeu_BaEn_1	42	47	PF01217	0.561
TRG_DiLeu_LyEn_5	42	47	PF01217	0.561
TRG_ENDOCYTIC_2	158	161	PF00928	0.360
TRG_ENDOCYTIC_2	201	204	PF00928	0.253
TRG_ENDOCYTIC_2	279	282	PF00928	0.391
TRG_ENDOCYTIC_2	326	329	PF00928	0.423
TRG_ER_diArg_1	165	168	PF00400	0.354
TRG_ER_diArg_1	17	19	PF00400	0.603
TRG_ER_diArg_1	292	295	PF00400	0.450
TRG_ER_diArg_1	44	46	PF00400	0.380
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAG0	Leptomonas seymouri	72%	86%
A0A0S4IYK4	Bodo saltans	47%	95%
A0A1X0PAI9	Trypanosomatidae	52%	100%
A0A3Q8IAB8	Leishmania donovani	82%	100%
A0A3R7NC97	Trypanosoma rangeli	50%	90%
A4HWT4	Leishmania infantum	82%	100%
C9ZLP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AQJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QEY5	Leishmania major	83%	100%
Q54N08	Dictyostelium discoideum	26%	93%
Q9SA98	Arabidopsis thaliana	26%	100%
V5BRD6	Trypanosoma cruzi	51%	98%