Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8F9_LEIBR

TriTrypDb:

LbrM.16.0340 , LBRM2903_160009000

Length:

393

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8F9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.557
CLV_NRD_NRD_1	222	224	PF00675	0.349
CLV_NRD_NRD_1	319	321	PF00675	0.440
CLV_NRD_NRD_1	354	356	PF00675	0.373
CLV_NRD_NRD_1	84	86	PF00675	0.304
CLV_PCSK_KEX2_1	195	197	PF00082	0.580
CLV_PCSK_KEX2_1	222	224	PF00082	0.349
CLV_PCSK_KEX2_1	354	356	PF00082	0.371
CLV_PCSK_KEX2_1	84	86	PF00082	0.461
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.508
CLV_PCSK_SKI1_1	203	207	PF00082	0.521
CLV_PCSK_SKI1_1	267	271	PF00082	0.298
CLV_PCSK_SKI1_1	320	324	PF00082	0.411
CLV_PCSK_SKI1_1	346	350	PF00082	0.399
CLV_PCSK_SKI1_1	355	359	PF00082	0.315
DEG_APCC_DBOX_1	222	230	PF00400	0.348
DEG_SPOP_SBC_1	152	156	PF00917	0.479
DEG_SPOP_SBC_1	47	51	PF00917	0.471
DOC_CKS1_1	184	189	PF01111	0.640
DOC_CYCLIN_RxL_1	351	359	PF00134	0.401
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.475
DOC_MAPK_gen_1	354	362	PF00069	0.413
DOC_PP1_RVXF_1	324	331	PF00149	0.341
DOC_PP1_RVXF_1	352	359	PF00149	0.397
DOC_PP2B_LxvP_1	272	275	PF13499	0.473
DOC_USP7_MATH_1	314	318	PF00917	0.509
DOC_USP7_MATH_1	47	51	PF00917	0.676
DOC_USP7_MATH_1	53	57	PF00917	0.562
DOC_WW_Pin1_4	153	158	PF00397	0.688
DOC_WW_Pin1_4	168	173	PF00397	0.612
DOC_WW_Pin1_4	179	184	PF00397	0.622
DOC_WW_Pin1_4	246	251	PF00397	0.513
DOC_WW_Pin1_4	378	383	PF00397	0.537
LIG_14-3-3_CanoR_1	151	157	PF00244	0.473
LIG_14-3-3_CanoR_1	166	170	PF00244	0.441
LIG_14-3-3_CanoR_1	209	217	PF00244	0.585
LIG_14-3-3_CanoR_1	267	276	PF00244	0.306
LIG_BRCT_BRCA1_1	108	112	PF00533	0.495
LIG_BRCT_BRCA1_1	181	185	PF00533	0.438
LIG_Clathr_ClatBox_1	332	336	PF01394	0.479
LIG_eIF4E_1	120	126	PF01652	0.520
LIG_FAT_LD_1	226	234	PF03623	0.454
LIG_FHA_1	106	112	PF00498	0.483
LIG_FHA_1	154	160	PF00498	0.753
LIG_FHA_1	209	215	PF00498	0.609
LIG_FHA_2	132	138	PF00498	0.637
LIG_FHA_2	290	296	PF00498	0.492
LIG_FHA_2	381	387	PF00498	0.391
LIG_LIR_Gen_1	295	306	PF02991	0.348
LIG_LIR_Nem_3	109	115	PF02991	0.508
LIG_LIR_Nem_3	200	205	PF02991	0.589
LIG_LIR_Nem_3	295	301	PF02991	0.353
LIG_LYPXL_S_1	272	276	PF13949	0.420
LIG_LYPXL_yS_3	273	276	PF13949	0.415
LIG_MAD2	267	275	PF02301	0.427
LIG_MYND_1	157	161	PF01753	0.459
LIG_NRBOX	110	116	PF00104	0.392
LIG_NRBOX	225	231	PF00104	0.501
LIG_Pex14_2	198	202	PF04695	0.517
LIG_Pex14_2	358	362	PF04695	0.427
LIG_Rb_LxCxE_1	331	350	PF01857	0.408
LIG_REV1ctd_RIR_1	321	330	PF16727	0.404
LIG_SH2_CRK	23	27	PF00017	0.426
LIG_SH2_CRK	298	302	PF00017	0.419
LIG_SH2_STAT5	117	120	PF00017	0.465
LIG_SH2_STAT5	204	207	PF00017	0.557
LIG_SH2_STAT5	232	235	PF00017	0.456
LIG_SH3_3	154	160	PF00018	0.512
LIG_SH3_3	167	173	PF00018	0.526
LIG_Sin3_3	112	119	PF02671	0.406
LIG_SUMO_SIM_par_1	171	177	PF11976	0.453
LIG_WW_2	157	160	PF00397	0.460
MOD_CK1_1	150	156	PF00069	0.748
MOD_CK1_1	96	102	PF00069	0.511
MOD_CK2_1	131	137	PF00069	0.636
MOD_CK2_1	289	295	PF00069	0.380
MOD_CK2_1	380	386	PF00069	0.496
MOD_CK2_1	53	59	PF00069	0.625
MOD_GlcNHglycan	191	194	PF01048	0.443
MOD_GlcNHglycan	276	279	PF01048	0.451
MOD_GlcNHglycan	32	35	PF01048	0.553
MOD_GSK3_1	147	154	PF00069	0.725
MOD_GSK3_1	168	175	PF00069	0.747
MOD_GSK3_1	179	186	PF00069	0.569
MOD_GSK3_1	203	210	PF00069	0.591
MOD_GSK3_1	26	33	PF00069	0.519
MOD_GSK3_1	263	270	PF00069	0.306
MOD_GSK3_1	55	62	PF00069	0.570
MOD_GSK3_1	96	103	PF00069	0.531
MOD_N-GLC_1	282	287	PF02516	0.443
MOD_N-GLC_1	96	101	PF02516	0.615
MOD_NEK2_1	1	6	PF00069	0.659
MOD_NEK2_1	115	120	PF00069	0.464
MOD_NEK2_1	26	31	PF00069	0.487
MOD_NEK2_1	347	352	PF00069	0.441
MOD_NEK2_1	48	53	PF00069	0.625
MOD_NEK2_1	63	68	PF00069	0.606
MOD_PIKK_1	267	273	PF00454	0.321
MOD_PIKK_1	282	288	PF00454	0.401
MOD_PKA_2	150	156	PF00069	0.490
MOD_PKA_2	165	171	PF00069	0.441
MOD_PKA_2	208	214	PF00069	0.586
MOD_PKA_2	26	32	PF00069	0.621
MOD_Plk_1	105	111	PF00069	0.314
MOD_Plk_1	96	102	PF00069	0.607
MOD_Plk_2-3	339	345	PF00069	0.423
MOD_Plk_4	1	7	PF00069	0.593
MOD_Plk_4	106	112	PF00069	0.516
MOD_Plk_4	197	203	PF00069	0.575
MOD_Plk_4	59	65	PF00069	0.520
MOD_ProDKin_1	153	159	PF00069	0.690
MOD_ProDKin_1	168	174	PF00069	0.611
MOD_ProDKin_1	179	185	PF00069	0.618
MOD_ProDKin_1	246	252	PF00069	0.516
MOD_ProDKin_1	378	384	PF00069	0.535
MOD_SUMO_rev_2	316	323	PF00179	0.454
MOD_SUMO_rev_2	339	348	PF00179	0.511
MOD_SUMO_rev_2	381	390	PF00179	0.454
TRG_DiLeu_BaEn_1	225	230	PF01217	0.458
TRG_DiLeu_BaEn_1	343	348	PF01217	0.409
TRG_DiLeu_BaEn_1	59	64	PF01217	0.676
TRG_DiLeu_BaEn_4	343	349	PF01217	0.408
TRG_ENDOCYTIC_2	23	26	PF00928	0.418
TRG_ENDOCYTIC_2	273	276	PF00928	0.415
TRG_ENDOCYTIC_2	298	301	PF00928	0.394
TRG_ER_diArg_1	221	223	PF00400	0.400
TRG_ER_diArg_1	353	355	PF00400	0.374
TRG_Pf-PMV_PEXEL_1	326	331	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	354	359	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Y6	Leptomonas seymouri	50%	92%
A0A0S4JDY7	Bodo saltans	43%	100%
A0A1X0NZ32	Trypanosomatidae	25%	92%
A0A3Q8IAF9	Leishmania donovani	82%	100%
A0A3R7KLW2	Trypanosoma rangeli	28%	89%
A0A422N3A0	Trypanosoma rangeli	47%	100%
A4HWT2	Leishmania infantum	82%	100%
C9ZW43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
C9ZXL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	91%
E9AQJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QEY7	Leishmania major	81%	98%
V5AX32	Trypanosoma cruzi	28%	74%
V5D513	Trypanosoma cruzi	27%	100%