FAT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8F6_LEIBR

TriTrypDb:

LbrM.16.0310 , LBRM2903_160008700

Length:

804

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8F6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	708	712	PF00656	0.457
CLV_NRD_NRD_1	306	308	PF00675	0.485
CLV_NRD_NRD_1	526	528	PF00675	0.373
CLV_NRD_NRD_1	559	561	PF00675	0.410
CLV_NRD_NRD_1	669	671	PF00675	0.460
CLV_NRD_NRD_1	67	69	PF00675	0.442
CLV_NRD_NRD_1	744	746	PF00675	0.599
CLV_NRD_NRD_1	756	758	PF00675	0.419
CLV_NRD_NRD_1	83	85	PF00675	0.445
CLV_PCSK_KEX2_1	306	308	PF00082	0.485
CLV_PCSK_KEX2_1	526	528	PF00082	0.373
CLV_PCSK_KEX2_1	559	561	PF00082	0.404
CLV_PCSK_KEX2_1	669	671	PF00082	0.460
CLV_PCSK_KEX2_1	67	69	PF00082	0.436
CLV_PCSK_KEX2_1	744	746	PF00082	0.599
CLV_PCSK_KEX2_1	756	758	PF00082	0.419
CLV_PCSK_KEX2_1	83	85	PF00082	0.460
CLV_PCSK_SKI1_1	111	115	PF00082	0.515
CLV_PCSK_SKI1_1	428	432	PF00082	0.320
CLV_PCSK_SKI1_1	624	628	PF00082	0.480
CLV_PCSK_SKI1_1	688	692	PF00082	0.430
CLV_PCSK_SKI1_1	718	722	PF00082	0.541
CLV_PCSK_SKI1_1	759	763	PF00082	0.474
CLV_Separin_Metazoa	22	26	PF03568	0.523
DEG_APCC_DBOX_1	153	161	PF00400	0.470
DEG_APCC_DBOX_1	427	435	PF00400	0.318
DEG_APCC_DBOX_1	717	725	PF00400	0.399
DOC_ANK_TNKS_1	123	130	PF00023	0.445
DOC_ANK_TNKS_1	525	532	PF00023	0.266
DOC_CYCLIN_RxL_1	425	432	PF00134	0.288
DOC_CYCLIN_RxL_1	81	92	PF00134	0.525
DOC_CYCLIN_yClb1_LxF_4	686	691	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	241	247	PF00134	0.402
DOC_CYCLIN_yCln2_LP_2	683	689	PF00134	0.357
DOC_MAPK_DCC_7	510	520	PF00069	0.411
DOC_MAPK_gen_1	306	315	PF00069	0.557
DOC_MAPK_gen_1	562	571	PF00069	0.658
DOC_MAPK_gen_1	744	752	PF00069	0.538
DOC_MAPK_MEF2A_6	354	363	PF00069	0.420
DOC_MAPK_MEF2A_6	464	473	PF00069	0.488
DOC_MAPK_MEF2A_6	684	691	PF00069	0.252
DOC_MAPK_MEF2A_6	744	752	PF00069	0.503
DOC_PP1_RVXF_1	686	692	PF00149	0.387
DOC_PP2B_LxvP_1	222	225	PF13499	0.398
DOC_PP2B_LxvP_1	683	686	PF13499	0.384
DOC_USP7_MATH_1	14	18	PF00917	0.406
DOC_USP7_MATH_1	3	7	PF00917	0.524
DOC_USP7_MATH_1	326	330	PF00917	0.380
DOC_USP7_MATH_1	44	48	PF00917	0.594
DOC_USP7_MATH_1	496	500	PF00917	0.497
DOC_USP7_MATH_1	594	598	PF00917	0.303
DOC_USP7_MATH_1	619	623	PF00917	0.650
DOC_USP7_MATH_1	651	655	PF00917	0.294
DOC_USP7_MATH_1	660	664	PF00917	0.419
DOC_USP7_MATH_1	8	12	PF00917	0.450
DOC_WW_Pin1_4	308	313	PF00397	0.473
DOC_WW_Pin1_4	329	334	PF00397	0.450
DOC_WW_Pin1_4	494	499	PF00397	0.425
DOC_WW_Pin1_4	569	574	PF00397	0.543
DOC_WW_Pin1_4	712	717	PF00397	0.709
DOC_WW_Pin1_4	92	97	PF00397	0.463
LIG_14-3-3_CanoR_1	19	26	PF00244	0.531
LIG_14-3-3_CanoR_1	318	327	PF00244	0.359
LIG_14-3-3_CanoR_1	441	450	PF00244	0.489
LIG_14-3-3_CanoR_1	52	62	PF00244	0.357
LIG_14-3-3_CanoR_1	562	571	PF00244	0.633
LIG_14-3-3_CanoR_1	624	634	PF00244	0.338
LIG_Actin_WH2_2	497	512	PF00022	0.478
LIG_APCC_ABBA_1	571	576	PF00400	0.494
LIG_BIR_II_1	1	4	PF00653	0.458
LIG_BIR_III_3	1	4	PF00653	0.458
LIG_Clathr_ClatBox_1	677	681	PF01394	0.312
LIG_deltaCOP1_diTrp_1	141	144	PF00928	0.481
LIG_eIF4E_1	798	804	PF01652	0.382
LIG_FHA_1	112	118	PF00498	0.302
LIG_FHA_1	18	24	PF00498	0.566
LIG_FHA_1	292	298	PF00498	0.532
LIG_FHA_1	309	315	PF00498	0.641
LIG_FHA_1	442	448	PF00498	0.398
LIG_FHA_1	454	460	PF00498	0.503
LIG_FHA_1	466	472	PF00498	0.496
LIG_FHA_1	576	582	PF00498	0.348
LIG_FHA_1	598	604	PF00498	0.263
LIG_FHA_1	798	804	PF00498	0.491
LIG_FHA_2	253	259	PF00498	0.607
LIG_GBD_Chelix_1	367	375	PF00786	0.361
LIG_LIR_Apic_2	513	517	PF02991	0.467
LIG_LIR_Gen_1	549	558	PF02991	0.322
LIG_LIR_Gen_1	572	582	PF02991	0.341
LIG_LIR_Nem_3	232	238	PF02991	0.392
LIG_LIR_Nem_3	348	352	PF02991	0.260
LIG_LIR_Nem_3	530	535	PF02991	0.458
LIG_LIR_Nem_3	549	555	PF02991	0.319
LIG_LIR_Nem_3	572	577	PF02991	0.358
LIG_NRBOX	237	243	PF00104	0.382
LIG_NRBOX	260	266	PF00104	0.435
LIG_NRBOX	673	679	PF00104	0.348
LIG_PCNA_PIPBox_1	714	723	PF02747	0.414
LIG_PCNA_yPIPBox_3	707	721	PF02747	0.428
LIG_Pex14_1	478	482	PF04695	0.340
LIG_SH2_PTP2	749	752	PF00017	0.547
LIG_SH2_SRC	487	490	PF00017	0.448
LIG_SH2_STAT5	395	398	PF00017	0.561
LIG_SH2_STAT5	487	490	PF00017	0.550
LIG_SH2_STAT5	535	538	PF00017	0.305
LIG_SH2_STAT5	749	752	PF00017	0.433
LIG_SH2_STAT5	798	801	PF00017	0.435
LIG_SH3_2	119	124	PF14604	0.529
LIG_SH3_3	116	122	PF00018	0.478
LIG_SH3_3	241	247	PF00018	0.402
LIG_SH3_3	292	298	PF00018	0.687
LIG_SH3_3	327	333	PF00018	0.440
LIG_SH3_3	358	364	PF00018	0.417
LIG_SH3_3	377	383	PF00018	0.360
LIG_SH3_3	4	10	PF00018	0.616
LIG_SH3_3	773	779	PF00018	0.285
LIG_SUMO_SIM_anti_2	201	206	PF11976	0.392
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.560
LIG_SUMO_SIM_par_1	311	317	PF11976	0.432
LIG_SUMO_SIM_par_1	566	572	PF11976	0.461
LIG_TRFH_1	243	247	PF08558	0.394
LIG_UBA3_1	469	474	PF00899	0.445
LIG_WRC_WIRS_1	346	351	PF05994	0.226
LIG_WRC_WIRS_1	595	600	PF05994	0.311
LIG_WRC_WIRS_1	652	657	PF05994	0.426
LIG_WW_1	155	158	PF00397	0.542
MOD_CDC14_SPxK_1	715	718	PF00782	0.468
MOD_CDK_SPxK_1	712	718	PF00069	0.478
MOD_CK1_1	17	23	PF00069	0.444
MOD_CK1_1	230	236	PF00069	0.389
MOD_CK1_1	329	335	PF00069	0.423
MOD_CK1_1	385	391	PF00069	0.520
MOD_CK1_1	597	603	PF00069	0.239
MOD_CK1_1	654	660	PF00069	0.266
MOD_CK2_1	252	258	PF00069	0.607
MOD_CK2_1	785	791	PF00069	0.447
MOD_GlcNHglycan	133	136	PF01048	0.735
MOD_GlcNHglycan	147	150	PF01048	0.527
MOD_GlcNHglycan	151	154	PF01048	0.441
MOD_GlcNHglycan	229	232	PF01048	0.269
MOD_GlcNHglycan	261	264	PF01048	0.500
MOD_GlcNHglycan	286	289	PF01048	0.761
MOD_GlcNHglycan	320	323	PF01048	0.280
MOD_GlcNHglycan	384	387	PF01048	0.706
MOD_GlcNHglycan	417	420	PF01048	0.470
MOD_GlcNHglycan	42	45	PF01048	0.472
MOD_GlcNHglycan	422	425	PF01048	0.241
MOD_GlcNHglycan	431	434	PF01048	0.277
MOD_GlcNHglycan	46	49	PF01048	0.494
MOD_GlcNHglycan	565	568	PF01048	0.581
MOD_GlcNHglycan	621	624	PF01048	0.561
MOD_GSK3_1	14	21	PF00069	0.378
MOD_GSK3_1	145	152	PF00069	0.670
MOD_GSK3_1	279	286	PF00069	0.580
MOD_GSK3_1	329	336	PF00069	0.460
MOD_GSK3_1	382	389	PF00069	0.533
MOD_GSK3_1	40	47	PF00069	0.633
MOD_GSK3_1	429	436	PF00069	0.373
MOD_GSK3_1	437	444	PF00069	0.396
MOD_NEK2_1	268	273	PF00069	0.480
MOD_NEK2_1	453	458	PF00069	0.413
MOD_NEK2_1	748	753	PF00069	0.483
MOD_NEK2_2	14	19	PF00069	0.346
MOD_PKA_2	18	24	PF00069	0.305
MOD_PKA_2	283	289	PF00069	0.622
MOD_PKA_2	415	421	PF00069	0.424
MOD_PKA_2	563	569	PF00069	0.601
MOD_Plk_1	462	468	PF00069	0.389
MOD_Plk_1	575	581	PF00069	0.356
MOD_Plk_4	465	471	PF00069	0.542
MOD_Plk_4	496	502	PF00069	0.492
MOD_Plk_4	510	516	PF00069	0.483
MOD_Plk_4	531	537	PF00069	0.321
MOD_Plk_4	651	657	PF00069	0.511
MOD_Plk_4	785	791	PF00069	0.493
MOD_ProDKin_1	308	314	PF00069	0.462
MOD_ProDKin_1	329	335	PF00069	0.453
MOD_ProDKin_1	494	500	PF00069	0.419
MOD_ProDKin_1	569	575	PF00069	0.533
MOD_ProDKin_1	712	718	PF00069	0.708
MOD_ProDKin_1	92	98	PF00069	0.463
TRG_AP2beta_CARGO_1	549	559	PF09066	0.327
TRG_DiLeu_BaEn_1	201	206	PF01217	0.317
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.535
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.454
TRG_DiLeu_BaLyEn_6	622	627	PF01217	0.518
TRG_ENDOCYTIC_2	574	577	PF00928	0.396
TRG_ENDOCYTIC_2	749	752	PF00928	0.589
TRG_ER_diArg_1	181	184	PF00400	0.274
TRG_ER_diArg_1	305	307	PF00400	0.473
TRG_ER_diArg_1	558	560	PF00400	0.401
TRG_ER_diArg_1	668	670	PF00400	0.462
TRG_NES_CRM1_1	576	588	PF08389	0.518
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.256
TRG_Pf-PMV_PEXEL_1	707	711	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ5	Leptomonas seymouri	48%	82%
A0A1X0NGG8	Trypanosomatidae	28%	91%
A0A3Q8IIY2	Leishmania donovani	70%	77%
A0A422N375	Trypanosoma rangeli	32%	100%
A4HWS6	Leishmania infantum	70%	77%
C9ZW48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	92%
E9AQI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	77%
Q4QEZ3	Leishmania major	70%	100%
V5D1D7	Trypanosoma cruzi	32%	93%