LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase, putative
Species:
Leishmania braziliensis
UniProt:
A4H8F5_LEIBR
TriTrypDb:
LbrM.16.0300 , LBRM2903_160008600 *
Length:
626

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4H8F5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8F5

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 13
GO:0006793 phosphorus metabolic process 3 13
GO:0006796 phosphate-containing compound metabolic process 4 13
GO:0006807 nitrogen compound metabolic process 2 13
GO:0008152 metabolic process 1 13
GO:0009987 cellular process 1 13
GO:0016310 phosphorylation 5 13
GO:0019538 protein metabolic process 3 13
GO:0036211 protein modification process 4 13
GO:0043170 macromolecule metabolic process 3 13
GO:0043412 macromolecule modification 4 13
GO:0044237 cellular metabolic process 2 13
GO:0044238 primary metabolic process 2 13
GO:0071704 organic substance metabolic process 2 13
GO:1901564 organonitrogen compound metabolic process 3 13
GO:0007165 signal transduction 2 2
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0035556 intracellular signal transduction 3 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0065007 biological regulation 1 2
GO:0009966 regulation of signal transduction 4 1
GO:0010646 regulation of cell communication 4 1
GO:0023051 regulation of signaling 3 1
GO:0043408 regulation of MAPK cascade 6 1
GO:0048583 regulation of response to stimulus 3 1
GO:1902531 regulation of intracellular signal transduction 5 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 13
GO:0003824 catalytic activity 1 13
GO:0004672 protein kinase activity 3 13
GO:0005488 binding 1 13
GO:0005524 ATP binding 5 13
GO:0016301 kinase activity 4 13
GO:0016740 transferase activity 2 13
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 13
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 13
GO:0017076 purine nucleotide binding 4 13
GO:0030554 adenyl nucleotide binding 5 13
GO:0032553 ribonucleotide binding 3 13
GO:0032555 purine ribonucleotide binding 4 13
GO:0032559 adenyl ribonucleotide binding 5 13
GO:0035639 purine ribonucleoside triphosphate binding 4 13
GO:0036094 small molecule binding 2 13
GO:0043167 ion binding 2 13
GO:0043168 anion binding 3 13
GO:0097159 organic cyclic compound binding 2 13
GO:0097367 carbohydrate derivative binding 2 13
GO:0140096 catalytic activity, acting on a protein 2 13
GO:1901265 nucleoside phosphate binding 3 13
GO:1901363 heterocyclic compound binding 2 13
GO:0004674 protein serine/threonine kinase activity 4 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 303 307 PF00656 0.579
CLV_C14_Caspase3-7 308 312 PF00656 0.574
CLV_NRD_NRD_1 113 115 PF00675 0.368
CLV_NRD_NRD_1 175 177 PF00675 0.306
CLV_NRD_NRD_1 254 256 PF00675 0.317
CLV_NRD_NRD_1 298 300 PF00675 0.482
CLV_NRD_NRD_1 362 364 PF00675 0.713
CLV_PCSK_KEX2_1 113 115 PF00082 0.308
CLV_PCSK_KEX2_1 175 177 PF00082 0.266
CLV_PCSK_KEX2_1 254 256 PF00082 0.328
CLV_PCSK_KEX2_1 297 299 PF00082 0.500
CLV_PCSK_KEX2_1 361 363 PF00082 0.743
CLV_PCSK_SKI1_1 126 130 PF00082 0.389
CLV_PCSK_SKI1_1 143 147 PF00082 0.315
CLV_PCSK_SKI1_1 18 22 PF00082 0.434
CLV_PCSK_SKI1_1 226 230 PF00082 0.266
CLV_PCSK_SKI1_1 254 258 PF00082 0.329
CLV_PCSK_SKI1_1 396 400 PF00082 0.577
CLV_PCSK_SKI1_1 418 422 PF00082 0.623
CLV_PCSK_SKI1_1 536 540 PF00082 0.501
DEG_APCC_DBOX_1 125 133 PF00400 0.302
DEG_APCC_DBOX_1 395 403 PF00400 0.571
DEG_SPOP_SBC_1 437 441 PF00917 0.512
DOC_ANK_TNKS_1 298 305 PF00023 0.408
DOC_ANK_TNKS_1 469 476 PF00023 0.516
DOC_CDC14_PxL_1 397 405 PF14671 0.532
DOC_CYCLIN_RxL_1 250 260 PF00134 0.297
DOC_CYCLIN_RxL_1 415 425 PF00134 0.486
DOC_CYCLIN_yCln2_LP_2 116 122 PF00134 0.296
DOC_MAPK_DCC_7 396 405 PF00069 0.566
DOC_MAPK_gen_1 143 152 PF00069 0.315
DOC_MAPK_gen_1 261 271 PF00069 0.466
DOC_MAPK_HePTP_8 393 405 PF00069 0.570
DOC_MAPK_MEF2A_6 396 405 PF00069 0.566
DOC_MAPK_MEF2A_6 59 66 PF00069 0.204
DOC_PP1_RVXF_1 224 231 PF00149 0.298
DOC_PP4_FxxP_1 229 232 PF00568 0.266
DOC_PP4_FxxP_1 275 278 PF00568 0.489
DOC_PP4_FxxP_1 507 510 PF00568 0.504
DOC_USP7_MATH_1 437 441 PF00917 0.648
DOC_USP7_MATH_1 560 564 PF00917 0.416
DOC_WW_Pin1_4 243 248 PF00397 0.266
DOC_WW_Pin1_4 274 279 PF00397 0.312
DOC_WW_Pin1_4 356 361 PF00397 0.654
DOC_WW_Pin1_4 362 367 PF00397 0.765
DOC_WW_Pin1_4 519 524 PF00397 0.651
LIG_14-3-3_CanoR_1 113 119 PF00244 0.298
LIG_14-3-3_CanoR_1 175 180 PF00244 0.270
LIG_14-3-3_CanoR_1 501 510 PF00244 0.466
LIG_Actin_WH2_2 249 266 PF00022 0.298
LIG_Actin_WH2_2 561 577 PF00022 0.398
LIG_Actin_WH2_2 600 615 PF00022 0.518
LIG_AP2alpha_2 273 275 PF02296 0.266
LIG_APCC_ABBAyCdc20_2 138 144 PF00400 0.355
LIG_BRCT_BRCA1_1 561 565 PF00533 0.415
LIG_Clathr_ClatBox_1 402 406 PF01394 0.614
LIG_deltaCOP1_diTrp_1 243 252 PF00928 0.266
LIG_eIF4E_1 503 509 PF01652 0.516
LIG_FHA_1 207 213 PF00498 0.355
LIG_FHA_1 41 47 PF00498 0.315
LIG_FHA_1 426 432 PF00498 0.689
LIG_FHA_1 437 443 PF00498 0.491
LIG_FHA_1 548 554 PF00498 0.488
LIG_FHA_1 569 575 PF00498 0.692
LIG_FHA_1 588 594 PF00498 0.393
LIG_FHA_2 206 212 PF00498 0.225
LIG_FHA_2 55 61 PF00498 0.346
LIG_FHA_2 574 580 PF00498 0.506
LIG_LIR_Apic_2 182 188 PF02991 0.315
LIG_LIR_Apic_2 273 278 PF02991 0.488
LIG_LIR_Apic_2 505 510 PF02991 0.463
LIG_LIR_Gen_1 106 116 PF02991 0.419
LIG_LIR_Gen_1 19 29 PF02991 0.310
LIG_LIR_Gen_1 562 569 PF02991 0.418
LIG_LIR_Gen_1 86 95 PF02991 0.294
LIG_LIR_Nem_3 106 112 PF02991 0.296
LIG_LIR_Nem_3 19 24 PF02991 0.339
LIG_LIR_Nem_3 407 413 PF02991 0.564
LIG_LIR_Nem_3 521 527 PF02991 0.571
LIG_LIR_Nem_3 562 568 PF02991 0.422
LIG_LYPXL_yS_3 524 527 PF13949 0.474
LIG_NRBOX 128 134 PF00104 0.204
LIG_PCNA_PIPBox_1 496 505 PF02747 0.471
LIG_PCNA_yPIPBox_3 284 298 PF02747 0.404
LIG_Pex14_2 561 565 PF04695 0.415
LIG_SH2_CRK 109 113 PF00017 0.327
LIG_SH2_CRK 528 532 PF00017 0.563
LIG_SH2_STAP1 196 200 PF00017 0.283
LIG_SH2_STAP1 589 593 PF00017 0.565
LIG_SH2_STAT5 123 126 PF00017 0.296
LIG_SH2_STAT5 134 137 PF00017 0.328
LIG_SH2_STAT5 586 589 PF00017 0.561
LIG_SH2_STAT5 99 102 PF00017 0.299
LIG_SH3_3 395 401 PF00018 0.520
LIG_SH3_3 468 474 PF00018 0.590
LIG_SH3_3 517 523 PF00018 0.611
LIG_SH3_3 524 530 PF00018 0.659
LIG_SUMO_SIM_anti_2 60 66 PF11976 0.285
LIG_SUMO_SIM_anti_2 68 74 PF11976 0.306
LIG_SUMO_SIM_par_1 208 214 PF11976 0.294
LIG_TRAF2_1 282 285 PF00917 0.413
LIG_TRAF2_1 333 336 PF00917 0.628
LIG_TRAF2_1 576 579 PF00917 0.364
LIG_WW_1 525 528 PF00397 0.553
MOD_CDC14_SPxK_1 359 362 PF00782 0.508
MOD_CDK_SPK_2 356 361 PF00069 0.495
MOD_CDK_SPxK_1 356 362 PF00069 0.499
MOD_CDK_SPxxK_3 356 363 PF00069 0.571
MOD_CK1_1 312 318 PF00069 0.536
MOD_CK1_1 365 371 PF00069 0.574
MOD_CK1_1 424 430 PF00069 0.532
MOD_CK1_1 489 495 PF00069 0.518
MOD_CK2_1 205 211 PF00069 0.266
MOD_CK2_1 297 303 PF00069 0.447
MOD_CK2_1 54 60 PF00069 0.355
MOD_CK2_1 573 579 PF00069 0.626
MOD_CK2_1 591 597 PF00069 0.410
MOD_GlcNHglycan 265 268 PF01048 0.355
MOD_GlcNHglycan 314 317 PF01048 0.535
MOD_GlcNHglycan 4 7 PF01048 0.500
MOD_GlcNHglycan 413 416 PF01048 0.662
MOD_GlcNHglycan 456 459 PF01048 0.723
MOD_GlcNHglycan 461 464 PF01048 0.589
MOD_GlcNHglycan 511 514 PF01048 0.536
MOD_GlcNHglycan 621 624 PF01048 0.416
MOD_GSK3_1 171 178 PF00069 0.312
MOD_GSK3_1 201 208 PF00069 0.266
MOD_GSK3_1 305 312 PF00069 0.577
MOD_GSK3_1 318 325 PF00069 0.548
MOD_GSK3_1 421 428 PF00069 0.556
MOD_GSK3_1 486 493 PF00069 0.672
MOD_GSK3_1 569 576 PF00069 0.536
MOD_GSK3_1 587 594 PF00069 0.543
MOD_N-GLC_1 312 317 PF02516 0.587
MOD_N-GLC_1 489 494 PF02516 0.568
MOD_NEK2_1 150 155 PF00069 0.484
MOD_NEK2_1 163 168 PF00069 0.244
MOD_NEK2_1 169 174 PF00069 0.271
MOD_NEK2_1 179 184 PF00069 0.306
MOD_NEK2_1 205 210 PF00069 0.270
MOD_NEK2_1 421 426 PF00069 0.639
MOD_NEK2_1 486 491 PF00069 0.690
MOD_NEK2_1 495 500 PF00069 0.520
MOD_NEK2_1 547 552 PF00069 0.529
MOD_NEK2_1 568 573 PF00069 0.553
MOD_NEK2_1 607 612 PF00069 0.504
MOD_NEK2_1 83 88 PF00069 0.408
MOD_PIKK_1 474 480 PF00454 0.485
MOD_PIKK_1 560 566 PF00454 0.435
MOD_PK_1 297 303 PF00069 0.381
MOD_PK_1 322 328 PF00069 0.596
MOD_PKA_1 175 181 PF00069 0.266
MOD_PKA_1 297 303 PF00069 0.533
MOD_PKA_2 175 181 PF00069 0.268
MOD_PKA_2 263 269 PF00069 0.315
MOD_PKA_2 297 303 PF00069 0.533
MOD_PKA_2 40 46 PF00069 0.285
MOD_Plk_1 312 318 PF00069 0.617
MOD_Plk_1 406 412 PF00069 0.574
MOD_Plk_1 490 496 PF00069 0.524
MOD_Plk_1 569 575 PF00069 0.538
MOD_Plk_2-3 101 107 PF00069 0.298
MOD_Plk_2-3 406 412 PF00069 0.574
MOD_Plk_4 164 170 PF00069 0.204
MOD_Plk_4 175 181 PF00069 0.316
MOD_Plk_4 315 321 PF00069 0.508
MOD_Plk_4 322 328 PF00069 0.567
MOD_Plk_4 491 497 PF00069 0.546
MOD_Plk_4 503 509 PF00069 0.510
MOD_Plk_4 607 613 PF00069 0.432
MOD_ProDKin_1 243 249 PF00069 0.266
MOD_ProDKin_1 274 280 PF00069 0.314
MOD_ProDKin_1 356 362 PF00069 0.658
MOD_ProDKin_1 519 525 PF00069 0.646
MOD_SUMO_rev_2 14 20 PF00179 0.400
MOD_SUMO_rev_2 594 601 PF00179 0.538
TRG_DiLeu_BaEn_1 549 554 PF01217 0.574
TRG_DiLeu_BaLyEn_6 116 121 PF01217 0.355
TRG_DiLeu_BaLyEn_6 252 257 PF01217 0.350
TRG_DiLeu_BaLyEn_6 398 403 PF01217 0.562
TRG_DiLeu_BaLyEn_6 602 607 PF01217 0.373
TRG_ENDOCYTIC_2 109 112 PF00928 0.306
TRG_ENDOCYTIC_2 524 527 PF00928 0.474
TRG_ENDOCYTIC_2 87 90 PF00928 0.343
TRG_ER_diArg_1 112 114 PF00400 0.355
TRG_ER_diArg_1 253 255 PF00400 0.319
TRG_ER_diArg_1 297 299 PF00400 0.443
TRG_ER_diArg_1 360 363 PF00400 0.534
TRG_ER_diArg_1 39 42 PF00400 0.204
TRG_ER_diArg_1 603 606 PF00400 0.369
TRG_NES_CRM1_1 45 58 PF08389 0.267
TRG_NES_CRM1_1 60 74 PF08389 0.271
TRG_Pf-PMV_PEXEL_1 114 118 PF00026 0.296
TRG_Pf-PMV_PEXEL_1 255 260 PF00026 0.281
TRG_Pf-PMV_PEXEL_1 299 303 PF00026 0.661

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEW4 Leptomonas seymouri 60% 100%
A0A0S4IHW4 Bodo saltans 46% 100%
A0A1X0NFW4 Trypanosomatidae 49% 100%
A0A3S5H5U5 Leishmania donovani 23% 100%
A0A3S7WTT7 Leishmania donovani 80% 100%
A4HWS9 Leishmania infantum 80% 100%
E9AG71 Leishmania infantum 23% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9AQI7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 99%
Q4QEZ0 Leishmania major 82% 100%
Q4QIV8 Leishmania major 23% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS