Putative proteasome 26S non-ATPase subunit 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome 26S non-ATPase subunit 9, putative

Species:

Leishmania braziliensis

UniProt:

A4H8F4_LEIBR

TriTrypDb:

LbrM.16.0290 , LBRM2903_160008500

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1905368	peptidase complex	3	12
GO:1905369	endopeptidase complex	4	12
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8F4

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0043248	proteasome assembly	6	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0070682	proteasome regulatory particle assembly	7	12
GO:0071840	cellular component organization or biogenesis	2	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.426
CLV_NRD_NRD_1	15	17	PF00675	0.391
CLV_NRD_NRD_1	215	217	PF00675	0.395
CLV_NRD_NRD_1	37	39	PF00675	0.311
CLV_PCSK_KEX2_1	131	133	PF00082	0.427
CLV_PCSK_KEX2_1	140	142	PF00082	0.340
CLV_PCSK_KEX2_1	15	17	PF00082	0.391
CLV_PCSK_KEX2_1	37	39	PF00082	0.309
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.470
CLV_PCSK_PC7_1	33	39	PF00082	0.382
CLV_PCSK_SKI1_1	29	33	PF00082	0.420
CLV_PCSK_SKI1_1	43	47	PF00082	0.195
DEG_APCC_DBOX_1	32	40	PF00400	0.279
DEG_APCC_DBOX_1	94	102	PF00400	0.319
DEG_SPOP_SBC_1	19	23	PF00917	0.377
DOC_WW_Pin1_4	14	19	PF00397	0.488
DOC_WW_Pin1_4	164	169	PF00397	0.365
DOC_WW_Pin1_4	57	62	PF00397	0.245
LIG_14-3-3_CanoR_1	114	122	PF00244	0.588
LIG_14-3-3_CanoR_1	99	108	PF00244	0.285
LIG_AP2alpha_2	224	226	PF02296	0.282
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_FHA_1	19	25	PF00498	0.409
LIG_FHA_1	236	242	PF00498	0.267
LIG_FHA_1	49	55	PF00498	0.301
LIG_FHA_2	114	120	PF00498	0.504
LIG_FHA_2	15	21	PF00498	0.655
LIG_FHA_2	185	191	PF00498	0.433
LIG_FHA_2	92	98	PF00498	0.340
LIG_LIR_Gen_1	103	112	PF02991	0.390
LIG_LIR_Gen_1	223	232	PF02991	0.271
LIG_LIR_Nem_3	103	109	PF02991	0.390
LIG_LIR_Nem_3	223	229	PF02991	0.285
LIG_PDZ_Class_3	248	253	PF00595	0.465
LIG_PTB_Apo_2	68	75	PF02174	0.168
LIG_SH2_CRK	106	110	PF00017	0.390
LIG_SH2_CRK	183	187	PF00017	0.480
LIG_SH2_STAT5	56	59	PF00017	0.390
LIG_SH3_3	212	218	PF00018	0.431
LIG_SH3_3	226	232	PF00018	0.437
LIG_SUMO_SIM_anti_2	227	232	PF11976	0.436
LIG_SUMO_SIM_par_1	7	14	PF11976	0.572
LIG_TRAF2_1	116	119	PF00917	0.527
LIG_TRAF2_1	168	171	PF00917	0.494
LIG_TYR_ITIM	181	186	PF00017	0.343
MOD_CK1_1	107	113	PF00069	0.311
MOD_CK2_1	113	119	PF00069	0.493
MOD_CK2_1	164	170	PF00069	0.564
MOD_CK2_1	184	190	PF00069	0.228
MOD_CK2_1	216	222	PF00069	0.499
MOD_GlcNHglycan	1	4	PF01048	0.711
MOD_GlcNHglycan	109	112	PF01048	0.402
MOD_GSK3_1	14	21	PF00069	0.492
MOD_GSK3_1	83	90	PF00069	0.470
MOD_PIKK_1	113	119	PF00454	0.491
MOD_PIKK_1	38	44	PF00454	0.288
MOD_PKA_1	216	222	PF00069	0.429
MOD_PKA_2	113	119	PF00069	0.423
MOD_PKA_2	200	206	PF00069	0.397
MOD_PKA_2	87	93	PF00069	0.304
MOD_Plk_1	19	25	PF00069	0.593
MOD_Plk_2-3	20	26	PF00069	0.586
MOD_Plk_4	104	110	PF00069	0.310
MOD_ProDKin_1	14	20	PF00069	0.489
MOD_ProDKin_1	164	170	PF00069	0.369
MOD_ProDKin_1	57	63	PF00069	0.245
MOD_SUMO_rev_2	41	51	PF00179	0.305
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.390
TRG_ENDOCYTIC_2	106	109	PF00928	0.390
TRG_ENDOCYTIC_2	183	186	PF00928	0.352
TRG_ER_diArg_1	131	134	PF00400	0.529
TRG_ER_diArg_1	36	38	PF00400	0.382
TRG_Pf-PMV_PEXEL_1	37	42	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I787	Leptomonas seymouri	72%	96%
A0A0S4ITV9	Bodo saltans	39%	100%
A0A1X0NG23	Trypanosomatidae	37%	100%
A0A3R7M5T2	Trypanosoma rangeli	40%	100%
A0A3S5H6W9	Leishmania donovani	82%	98%
A4HWS8	Leishmania infantum	82%	98%
C9ZW47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AQI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
O00233	Homo sapiens	29%	100%
O94393	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P40555	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q10920	Caenorhabditis elegans	28%	100%
Q3SZ19	Bos taurus	31%	100%
Q4QEZ1	Leishmania major	82%	100%
Q552Y8	Dictyostelium discoideum	21%	97%
Q9CR00	Mus musculus	31%	100%
Q9VFS8	Drosophila melanogaster	31%	100%
Q9WTV5	Rattus norvegicus	31%	100%
V5AKS5	Trypanosoma cruzi	45%	100%