AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (many copies)/Alpha/beta hydrolase family, putative

Species:

Leishmania braziliensis

UniProt:

A4H8F2_LEIBR

TriTrypDb:

LbrM.16.0270 , LBRM2903_160008200

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4H8F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8F2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0019538	protein metabolic process	3	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044238	primary metabolic process	2	4
GO:0071704	organic substance metabolic process	2	4
GO:1901564	organonitrogen compound metabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	6
GO:0008233	peptidase activity	3	4
GO:0008236	serine-type peptidase activity	4	4
GO:0017171	serine hydrolase activity	3	4
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.377
CLV_NRD_NRD_1	260	262	PF00675	0.321
CLV_PCSK_FUR_1	258	262	PF00082	0.276
CLV_PCSK_KEX2_1	213	215	PF00082	0.323
CLV_PCSK_KEX2_1	260	262	PF00082	0.297
CLV_PCSK_KEX2_1	29	31	PF00082	0.363
CLV_PCSK_KEX2_1	319	321	PF00082	0.358
CLV_PCSK_KEX2_1	35	37	PF00082	0.364
CLV_PCSK_KEX2_1	374	376	PF00082	0.404
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.354
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.381
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.358
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.310
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.430
CLV_PCSK_SKI1_1	293	297	PF00082	0.285
CLV_PCSK_SKI1_1	416	420	PF00082	0.292
CLV_PCSK_SKI1_1	42	46	PF00082	0.219
CLV_PCSK_SKI1_1	76	80	PF00082	0.366
CLV_PCSK_SKI1_1	91	95	PF00082	0.322
DEG_SPOP_SBC_1	351	355	PF00917	0.583
DEG_SPOP_SBC_1	479	483	PF00917	0.544
DOC_ANK_TNKS_1	35	42	PF00023	0.400
DOC_CKS1_1	80	85	PF01111	0.650
DOC_CYCLIN_yCln2_LP_2	142	148	PF00134	0.363
DOC_MAPK_DCC_7	412	420	PF00069	0.506
DOC_MAPK_gen_1	136	144	PF00069	0.475
DOC_MAPK_gen_1	244	253	PF00069	0.547
DOC_MAPK_gen_1	374	381	PF00069	0.627
DOC_MAPK_gen_1	73	81	PF00069	0.530
DOC_MAPK_MEF2A_6	136	144	PF00069	0.479
DOC_MAPK_MEF2A_6	244	252	PF00069	0.573
DOC_MAPK_MEF2A_6	412	421	PF00069	0.506
DOC_MAPK_MEF2A_6	87	94	PF00069	0.581
DOC_MAPK_NFAT4_5	87	95	PF00069	0.602
DOC_MAPK_RevD_3	21	36	PF00069	0.571
DOC_PP1_RVXF_1	89	95	PF00149	0.614
DOC_PP2B_LxvP_1	142	145	PF13499	0.363
DOC_SPAK_OSR1_1	302	306	PF12202	0.476
DOC_USP7_MATH_1	191	195	PF00917	0.669
DOC_USP7_MATH_1	480	484	PF00917	0.668
DOC_USP7_MATH_2	463	469	PF00917	0.451
DOC_USP7_UBL2_3	25	29	PF12436	0.562
DOC_USP7_UBL2_3	315	319	PF12436	0.558
DOC_USP7_UBL2_3	491	495	PF12436	0.630
DOC_WW_Pin1_4	128	133	PF00397	0.703
DOC_WW_Pin1_4	411	416	PF00397	0.559
DOC_WW_Pin1_4	481	486	PF00397	0.758
DOC_WW_Pin1_4	79	84	PF00397	0.624
LIG_14-3-3_CanoR_1	260	264	PF00244	0.562
LIG_14-3-3_CanoR_1	293	298	PF00244	0.487
LIG_14-3-3_CanoR_1	375	379	PF00244	0.590
LIG_14-3-3_CanoR_1	385	391	PF00244	0.550
LIG_14-3-3_CanoR_1	432	438	PF00244	0.544
LIG_14-3-3_CanoR_1	54	60	PF00244	0.493
LIG_14-3-3_CanoR_1	91	100	PF00244	0.570
LIG_BIR_II_1	1	5	PF00653	0.572
LIG_BIR_III_4	38	42	PF00653	0.515
LIG_BRCT_BRCA1_1	367	371	PF00533	0.617
LIG_deltaCOP1_diTrp_1	203	208	PF00928	0.651
LIG_FHA_1	294	300	PF00498	0.553
LIG_FHA_1	387	393	PF00498	0.578
LIG_FHA_2	355	361	PF00498	0.569
LIG_FHA_2	459	465	PF00498	0.560
LIG_FHA_2	80	86	PF00498	0.506
LIG_Integrin_RGD_1	63	65	PF01839	0.362
LIG_LIR_Gen_1	219	226	PF02991	0.571
LIG_LIR_Gen_1	301	311	PF02991	0.476
LIG_LIR_Nem_3	165	171	PF02991	0.340
LIG_LIR_Nem_3	219	223	PF02991	0.579
LIG_LIR_Nem_3	301	306	PF02991	0.476
LIG_MLH1_MIPbox_1	367	371	PF16413	0.617
LIG_PCNA_yPIPBox_3	53	63	PF02747	0.537
LIG_Pex14_1	386	390	PF04695	0.589
LIG_Pex14_2	157	161	PF04695	0.358
LIG_Pex14_2	390	394	PF04695	0.574
LIG_PTB_Apo_2	269	276	PF02174	0.562
LIG_PTB_Phospho_1	269	275	PF10480	0.562
LIG_RPA_C_Fungi	49	61	PF08784	0.358
LIG_SH2_CRK	152	156	PF00017	0.468
LIG_SH2_CRK	275	279	PF00017	0.328
LIG_SH2_CRK	318	322	PF00017	0.413
LIG_SH2_CRK	376	380	PF00017	0.480
LIG_SH2_NCK_1	220	224	PF00017	0.422
LIG_SH2_PTP2	237	240	PF00017	0.435
LIG_SH2_SRC	220	223	PF00017	0.417
LIG_SH2_SRC	237	240	PF00017	0.393
LIG_SH2_STAP1	376	380	PF00017	0.466
LIG_SH2_STAP1	466	470	PF00017	0.410
LIG_SH2_STAT3	370	373	PF00017	0.616
LIG_SH2_STAT5	170	173	PF00017	0.338
LIG_SH2_STAT5	175	178	PF00017	0.342
LIG_SH2_STAT5	231	234	PF00017	0.368
LIG_SH2_STAT5	237	240	PF00017	0.393
LIG_SH2_STAT5	370	373	PF00017	0.506
LIG_SH2_STAT5	448	451	PF00017	0.416
LIG_SH2_STAT5	59	62	PF00017	0.395
LIG_SH3_2	239	244	PF14604	0.567
LIG_SH3_3	206	212	PF00018	0.447
LIG_SH3_3	220	226	PF00018	0.412
LIG_SH3_3	235	241	PF00018	0.373
LIG_SH3_3	484	490	PF00018	0.745
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.357
LIG_SUMO_SIM_par_1	362	368	PF11976	0.569
LIG_TYR_ITIM	150	155	PF00017	0.439
LIG_TYR_ITIM	218	223	PF00017	0.414
LIG_WW_1	184	187	PF00397	0.415
MOD_CDC14_SPxK_1	488	491	PF00782	0.533
MOD_CDK_SPK_2	411	416	PF00069	0.445
MOD_CDK_SPxK_1	485	491	PF00069	0.528
MOD_CK1_1	131	137	PF00069	0.606
MOD_CK1_1	15	21	PF00069	0.619
MOD_CK1_1	194	200	PF00069	0.592
MOD_CK1_1	481	487	PF00069	0.646
MOD_CK2_1	3	9	PF00069	0.663
MOD_CK2_1	79	85	PF00069	0.403
MOD_CMANNOS	205	208	PF00535	0.563
MOD_CMANNOS	391	394	PF00535	0.510
MOD_Cter_Amidation	492	495	PF01082	0.544
MOD_GlcNHglycan	193	196	PF01048	0.590
MOD_GlcNHglycan	288	291	PF01048	0.435
MOD_GlcNHglycan	354	357	PF01048	0.502
MOD_GlcNHglycan	367	370	PF01048	0.597
MOD_GlcNHglycan	5	8	PF01048	0.523
MOD_GSK3_1	124	131	PF00069	0.685
MOD_GSK3_1	15	22	PF00069	0.574
MOD_GSK3_1	225	232	PF00069	0.326
MOD_GSK3_1	324	331	PF00069	0.328
MOD_GSK3_1	350	357	PF00069	0.518
MOD_GSK3_1	479	486	PF00069	0.705
MOD_GSK3_1	55	62	PF00069	0.381
MOD_N-GLC_1	424	429	PF02516	0.322
MOD_NEK2_1	311	316	PF00069	0.357
MOD_NEK2_1	324	329	PF00069	0.306
MOD_NEK2_1	424	429	PF00069	0.575
MOD_NEK2_1	458	463	PF00069	0.432
MOD_PIKK_1	106	112	PF00454	0.501
MOD_PK_1	374	380	PF00069	0.513
MOD_PKA_1	374	380	PF00069	0.573
MOD_PKA_2	105	111	PF00069	0.495
MOD_PKA_2	124	130	PF00069	0.695
MOD_PKA_2	259	265	PF00069	0.437
MOD_PKA_2	374	380	PF00069	0.514
MOD_PKA_2	431	437	PF00069	0.425
MOD_PKB_1	10	18	PF00069	0.604
MOD_PKB_1	104	112	PF00069	0.648
MOD_PKB_1	291	299	PF00069	0.339
MOD_Plk_1	12	18	PF00069	0.608
MOD_Plk_1	424	430	PF00069	0.319
MOD_Plk_1	466	472	PF00069	0.466
MOD_Plk_2-3	259	265	PF00069	0.449
MOD_Plk_4	12	18	PF00069	0.586
MOD_Plk_4	19	25	PF00069	0.445
MOD_Plk_4	329	335	PF00069	0.363
MOD_Plk_4	354	360	PF00069	0.544
MOD_Plk_4	362	368	PF00069	0.522
MOD_Plk_4	374	380	PF00069	0.280
MOD_Plk_4	386	392	PF00069	0.418
MOD_Plk_4	424	430	PF00069	0.543
MOD_Plk_4	466	472	PF00069	0.501
MOD_Plk_4	55	61	PF00069	0.358
MOD_ProDKin_1	128	134	PF00069	0.639
MOD_ProDKin_1	411	417	PF00069	0.440
MOD_ProDKin_1	481	487	PF00069	0.728
MOD_ProDKin_1	79	85	PF00069	0.542
MOD_SUMO_rev_2	439	447	PF00179	0.401
MOD_SUMO_rev_2	69	78	PF00179	0.475
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.391
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.512
TRG_ENDOCYTIC_2	152	155	PF00928	0.399
TRG_ENDOCYTIC_2	170	173	PF00928	0.227
TRG_ENDOCYTIC_2	220	223	PF00928	0.413
TRG_ENDOCYTIC_2	275	278	PF00928	0.328
TRG_ENDOCYTIC_2	318	321	PF00928	0.344
TRG_ENDOCYTIC_2	376	379	PF00928	0.350
TRG_ENDOCYTIC_2	47	50	PF00928	0.449
TRG_ER_diLys_1	494	497	PF00400	0.747
TRG_NES_CRM1_1	89	102	PF08389	0.425
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0G5	Leptomonas seymouri	74%	98%
A0A0S4IJD1	Bodo saltans	48%	99%
A0A1X0NHG0	Trypanosomatidae	57%	100%
A0A3S5H6W8	Leishmania donovani	86%	100%
A0A422N2H5	Trypanosoma rangeli	57%	100%
A4HWS5	Leishmania infantum	86%	100%
C9ZW49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AQI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QEZ4	Leishmania major	85%	100%
V5B955	Trypanosoma cruzi	57%	100%