LeishMANIAdb
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Elongator complex protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongator complex protein 3
Gene product:
Elongator-like Protein 3a, putative
Species:
Leishmania braziliensis
UniProt:
A4H8F0_LEIBR
TriTrypDb:
LbrM.16.0250 , LBRM2903_160007700 *
Length:
760

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 3
GO:0005634 nucleus 5 2
GO:0005635 nuclear envelope 4 1
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 2
GO:0031967 organelle envelope 3 1
GO:0031975 envelope 2 1
GO:0032991 protein-containing complex 1 2
GO:0033588 elongator holoenzyme complex 3 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043228 non-membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0043232 intracellular non-membrane-bounded organelle 4 2
GO:0140535 intracellular protein-containing complex 2 2
GO:1902494 catalytic complex 2 2
GO:0005819 spindle 5 1

Expansion

Sequence features

A4H8F0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8F0

Function

Biological processes
Term Name Level Count
GO:0002097 tRNA wobble base modification 7 2
GO:0002098 tRNA wobble uridine modification 8 2
GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation 9 2
GO:0006139 nucleobase-containing compound metabolic process 3 2
GO:0006259 DNA metabolic process 4 1
GO:0006396 RNA processing 6 2
GO:0006399 tRNA metabolic process 7 2
GO:0006400 tRNA modification 6 2
GO:0006473 protein acetylation 6 1
GO:0006475 internal protein amino acid acetylation 7 1
GO:0006725 cellular aromatic compound metabolic process 3 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0006996 organelle organization 4 1
GO:0008033 tRNA processing 8 2
GO:0008152 metabolic process 1 2
GO:0009451 RNA modification 5 2
GO:0009987 cellular process 1 2
GO:0016043 cellular component organization 3 1
GO:0016070 RNA metabolic process 5 2
GO:0016570 histone modification 5 1
GO:0016573 histone acetylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018205 peptidyl-lysine modification 6 1
GO:0018393 internal peptidyl-lysine acetylation 8 1
GO:0018394 peptidyl-lysine acetylation 7 1
GO:0019538 protein metabolic process 3 1
GO:0034470 ncRNA processing 7 2
GO:0034641 cellular nitrogen compound metabolic process 3 2
GO:0034660 ncRNA metabolic process 6 2
GO:0036211 protein modification process 4 1
GO:0043007 maintenance of rDNA 6 1
GO:0043170 macromolecule metabolic process 3 2
GO:0043412 macromolecule modification 4 2
GO:0043543 protein acylation 5 1
GO:0043570 maintenance of DNA repeat elements 5 1
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0046483 heterocycle metabolic process 3 2
GO:0051276 chromosome organization 5 1
GO:0071704 organic substance metabolic process 2 2
GO:0071840 cellular component organization or biogenesis 2 1
GO:0090304 nucleic acid metabolic process 4 2
GO:1901360 organic cyclic compound metabolic process 3 2
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000049 tRNA binding 5 20
GO:0003676 nucleic acid binding 3 20
GO:0003723 RNA binding 4 20
GO:0003824 catalytic activity 1 20
GO:0005488 binding 1 20
GO:0016407 acetyltransferase activity 5 20
GO:0016740 transferase activity 2 20
GO:0016746 acyltransferase activity 3 20
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 20
GO:0043167 ion binding 2 20
GO:0043169 cation binding 3 20
GO:0046872 metal ion binding 4 20
GO:0051536 iron-sulfur cluster binding 3 20
GO:0051539 4 iron, 4 sulfur cluster binding 4 20
GO:0051540 metal cluster binding 2 20
GO:0097159 organic cyclic compound binding 2 20
GO:0106261 tRNA uridine(34) acetyltransferase activity 6 11
GO:1901363 heterocyclic compound binding 2 20

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 3 7 PF00656 0.493
CLV_C14_Caspase3-7 399 403 PF00656 0.282
CLV_C14_Caspase3-7 653 657 PF00656 0.530
CLV_NRD_NRD_1 222 224 PF00675 0.232
CLV_NRD_NRD_1 291 293 PF00675 0.266
CLV_NRD_NRD_1 332 334 PF00675 0.226
CLV_NRD_NRD_1 430 432 PF00675 0.248
CLV_NRD_NRD_1 520 522 PF00675 0.316
CLV_NRD_NRD_1 632 634 PF00675 0.272
CLV_NRD_NRD_1 683 685 PF00675 0.640
CLV_NRD_NRD_1 732 734 PF00675 0.559
CLV_NRD_NRD_1 77 79 PF00675 0.397
CLV_NRD_NRD_1 84 86 PF00675 0.411
CLV_PCSK_KEX2_1 222 224 PF00082 0.232
CLV_PCSK_KEX2_1 291 293 PF00082 0.263
CLV_PCSK_KEX2_1 332 334 PF00082 0.226
CLV_PCSK_KEX2_1 520 522 PF00082 0.334
CLV_PCSK_KEX2_1 605 607 PF00082 0.279
CLV_PCSK_KEX2_1 632 634 PF00082 0.271
CLV_PCSK_KEX2_1 683 685 PF00082 0.640
CLV_PCSK_KEX2_1 734 736 PF00082 0.527
CLV_PCSK_KEX2_1 77 79 PF00082 0.336
CLV_PCSK_KEX2_1 84 86 PF00082 0.567
CLV_PCSK_PC1ET2_1 605 607 PF00082 0.344
CLV_PCSK_PC1ET2_1 734 736 PF00082 0.480
CLV_PCSK_PC7_1 628 634 PF00082 0.252
CLV_PCSK_SKI1_1 226 230 PF00082 0.240
CLV_PCSK_SKI1_1 274 278 PF00082 0.203
CLV_PCSK_SKI1_1 349 353 PF00082 0.204
CLV_PCSK_SKI1_1 368 372 PF00082 0.184
CLV_PCSK_SKI1_1 394 398 PF00082 0.270
CLV_PCSK_SKI1_1 480 484 PF00082 0.214
CLV_PCSK_SKI1_1 500 504 PF00082 0.217
CLV_PCSK_SKI1_1 602 606 PF00082 0.332
CLV_PCSK_SKI1_1 84 88 PF00082 0.380
CLV_PCSK_SKI1_1 89 93 PF00082 0.316
DEG_APCC_DBOX_1 291 299 PF00400 0.445
DEG_COP1_1 134 143 PF00400 0.563
DEG_SCF_FBW7_1 143 150 PF00400 0.485
DOC_CDC14_PxL_1 28 36 PF14671 0.394
DOC_CKS1_1 417 422 PF01111 0.403
DOC_CKS1_1 556 561 PF01111 0.246
DOC_CYCLIN_RxL_1 84 97 PF00134 0.426
DOC_CYCLIN_yClb1_LxF_4 224 229 PF00134 0.403
DOC_CYCLIN_yClb5_NLxxxL_5 474 483 PF00134 0.414
DOC_MAPK_gen_1 171 181 PF00069 0.390
DOC_MAPK_gen_1 222 229 PF00069 0.432
DOC_MAPK_gen_1 238 245 PF00069 0.403
DOC_MAPK_gen_1 288 297 PF00069 0.364
DOC_MAPK_gen_1 449 458 PF00069 0.403
DOC_MAPK_gen_1 84 93 PF00069 0.367
DOC_MAPK_HePTP_8 446 458 PF00069 0.403
DOC_MAPK_MEF2A_6 288 297 PF00069 0.364
DOC_MAPK_MEF2A_6 449 458 PF00069 0.399
DOC_PP1_RVXF_1 164 171 PF00149 0.513
DOC_PP1_RVXF_1 224 230 PF00149 0.403
DOC_PP2B_PxIxI_1 453 459 PF00149 0.507
DOC_PP4_FxxP_1 170 173 PF00568 0.519
DOC_PP4_FxxP_1 284 287 PF00568 0.507
DOC_USP7_MATH_1 139 143 PF00917 0.681
DOC_USP7_MATH_1 386 390 PF00917 0.379
DOC_USP7_MATH_2 153 159 PF00917 0.401
DOC_WW_Pin1_4 143 148 PF00397 0.702
DOC_WW_Pin1_4 149 154 PF00397 0.685
DOC_WW_Pin1_4 400 405 PF00397 0.325
DOC_WW_Pin1_4 416 421 PF00397 0.403
DOC_WW_Pin1_4 431 436 PF00397 0.404
DOC_WW_Pin1_4 555 560 PF00397 0.243
LIG_14-3-3_CanoR_1 238 243 PF00244 0.403
LIG_14-3-3_CanoR_1 349 354 PF00244 0.420
LIG_14-3-3_CanoR_1 356 364 PF00244 0.411
LIG_14-3-3_CanoR_1 689 696 PF00244 0.620
LIG_14-3-3_CanoR_1 723 727 PF00244 0.459
LIG_Actin_RPEL_3 682 701 PF02755 0.393
LIG_Actin_WH2_2 668 685 PF00022 0.434
LIG_BIR_II_1 1 5 PF00653 0.611
LIG_BIR_III_2 138 142 PF00653 0.441
LIG_BIR_III_4 6 10 PF00653 0.476
LIG_BRCT_BRCA1_1 119 123 PF00533 0.450
LIG_EH1_1 645 653 PF00400 0.208
LIG_eIF4E_1 436 442 PF01652 0.431
LIG_FHA_1 155 161 PF00498 0.442
LIG_FHA_1 46 52 PF00498 0.446
LIG_FHA_1 691 697 PF00498 0.657
LIG_FHA_1 95 101 PF00498 0.244
LIG_FHA_2 280 286 PF00498 0.433
LIG_FHA_2 316 322 PF00498 0.407
LIG_FHA_2 357 363 PF00498 0.446
LIG_FHA_2 45 51 PF00498 0.350
LIG_FHA_2 505 511 PF00498 0.565
LIG_FHA_2 579 585 PF00498 0.287
LIG_LIR_Apic_2 282 287 PF02991 0.424
LIG_LIR_Gen_1 165 173 PF02991 0.550
LIG_LIR_Gen_1 20 29 PF02991 0.511
LIG_LIR_Gen_1 418 428 PF02991 0.440
LIG_LIR_Gen_1 528 537 PF02991 0.289
LIG_LIR_Gen_1 557 568 PF02991 0.239
LIG_LIR_Gen_1 613 622 PF02991 0.268
LIG_LIR_LC3C_4 177 182 PF02991 0.350
LIG_LIR_Nem_3 165 170 PF02991 0.534
LIG_LIR_Nem_3 196 202 PF02991 0.237
LIG_LIR_Nem_3 20 24 PF02991 0.511
LIG_LIR_Nem_3 230 235 PF02991 0.413
LIG_LIR_Nem_3 260 264 PF02991 0.439
LIG_LIR_Nem_3 409 414 PF02991 0.421
LIG_LIR_Nem_3 418 424 PF02991 0.440
LIG_LIR_Nem_3 430 436 PF02991 0.440
LIG_LIR_Nem_3 528 534 PF02991 0.268
LIG_LIR_Nem_3 557 563 PF02991 0.350
LIG_LIR_Nem_3 613 619 PF02991 0.239
LIG_MYND_3 31 35 PF01753 0.406
LIG_NRBOX 33 39 PF00104 0.391
LIG_NRBOX 478 484 PF00104 0.407
LIG_Pex14_1 199 203 PF04695 0.403
LIG_Pex14_1 556 560 PF04695 0.252
LIG_Pex14_2 195 199 PF04695 0.237
LIG_RPA_C_Fungi 684 696 PF08784 0.389
LIG_SH2_CRK 575 579 PF00017 0.282
LIG_SH2_CRK 636 640 PF00017 0.401
LIG_SH2_CRK 83 87 PF00017 0.410
LIG_SH2_CRK 96 100 PF00017 0.386
LIG_SH2_NCK_1 616 620 PF00017 0.290
LIG_SH2_STAP1 616 620 PF00017 0.290
LIG_SH2_STAP1 96 100 PF00017 0.348
LIG_SH2_STAT3 264 267 PF00017 0.147
LIG_SH2_STAT3 414 417 PF00017 0.237
LIG_SH2_STAT5 167 170 PF00017 0.357
LIG_SH2_STAT5 203 206 PF00017 0.261
LIG_SH2_STAT5 214 217 PF00017 0.261
LIG_SH2_STAT5 405 408 PF00017 0.359
LIG_SH2_STAT5 433 436 PF00017 0.388
LIG_SH2_STAT5 469 472 PF00017 0.261
LIG_SH2_STAT5 582 585 PF00017 0.374
LIG_SH2_STAT5 96 99 PF00017 0.231
LIG_SH3_1 202 208 PF00018 0.237
LIG_SH3_2 151 156 PF14604 0.449
LIG_SH3_2 287 292 PF14604 0.383
LIG_SH3_3 110 116 PF00018 0.599
LIG_SH3_3 121 127 PF00018 0.677
LIG_SH3_3 148 154 PF00018 0.717
LIG_SH3_3 156 162 PF00018 0.392
LIG_SH3_3 202 208 PF00018 0.261
LIG_SH3_3 284 290 PF00018 0.313
LIG_SH3_3 380 386 PF00018 0.292
LIG_SH3_3 531 537 PF00018 0.296
LIG_SUMO_SIM_anti_2 177 183 PF11976 0.338
LIG_SUMO_SIM_anti_2 250 256 PF11976 0.261
LIG_SUMO_SIM_anti_2 617 623 PF11976 0.265
LIG_SUMO_SIM_par_1 177 183 PF11976 0.338
LIG_SUMO_SIM_par_1 650 656 PF11976 0.302
LIG_TRAF2_1 116 119 PF00917 0.520
LIG_UBA3_1 441 449 PF00899 0.301
LIG_WW_3 285 289 PF00397 0.182
MOD_CDK_SPxxK_3 149 156 PF00069 0.546
MOD_CK1_1 142 148 PF00069 0.662
MOD_CK1_1 525 531 PF00069 0.269
MOD_CK1_1 694 700 PF00069 0.491
MOD_CK2_1 131 137 PF00069 0.430
MOD_CK2_1 149 155 PF00069 0.431
MOD_CK2_1 355 361 PF00069 0.273
MOD_CK2_1 419 425 PF00069 0.258
MOD_CK2_1 504 510 PF00069 0.520
MOD_CK2_1 578 584 PF00069 0.292
MOD_CK2_1 744 750 PF00069 0.552
MOD_GlcNHglycan 12 15 PF01048 0.725
MOD_GlcNHglycan 128 131 PF01048 0.487
MOD_GlcNHglycan 176 179 PF01048 0.372
MOD_GlcNHglycan 186 189 PF01048 0.315
MOD_GlcNHglycan 305 308 PF01048 0.299
MOD_GlcNHglycan 513 516 PF01048 0.430
MOD_GlcNHglycan 622 625 PF01048 0.237
MOD_GlcNHglycan 696 699 PF01048 0.534
MOD_GlcNHglycan 746 749 PF01048 0.601
MOD_GSK3_1 10 17 PF00069 0.697
MOD_GSK3_1 139 146 PF00069 0.695
MOD_GSK3_1 180 187 PF00069 0.302
MOD_GSK3_1 315 322 PF00069 0.260
MOD_GSK3_1 356 363 PF00069 0.297
MOD_GSK3_1 415 422 PF00069 0.261
MOD_GSK3_1 535 542 PF00069 0.459
MOD_GSK3_1 610 617 PF00069 0.250
MOD_GSK3_1 690 697 PF00069 0.517
MOD_GSK3_1 724 731 PF00069 0.498
MOD_N-GLC_1 107 112 PF02516 0.555
MOD_N-GLC_1 193 198 PF02516 0.345
MOD_N-GLC_1 303 308 PF02516 0.237
MOD_NEK2_1 180 185 PF00069 0.317
MOD_NEK2_1 303 308 PF00069 0.252
MOD_NEK2_1 334 339 PF00069 0.271
MOD_NEK2_1 370 375 PF00069 0.273
MOD_NEK2_1 38 43 PF00069 0.617
MOD_NEK2_1 639 644 PF00069 0.389
MOD_NEK2_1 722 727 PF00069 0.594
MOD_NEK2_1 87 92 PF00069 0.417
MOD_NEK2_2 279 284 PF00069 0.271
MOD_PIKK_1 172 178 PF00454 0.381
MOD_PIKK_1 61 67 PF00454 0.346
MOD_PIKK_1 663 669 PF00454 0.411
MOD_PIKK_1 724 730 PF00454 0.501
MOD_PIKK_1 94 100 PF00454 0.233
MOD_PKA_2 355 361 PF00069 0.252
MOD_PKA_2 722 728 PF00069 0.462
MOD_Plk_1 154 160 PF00069 0.381
MOD_Plk_1 360 366 PF00069 0.344
MOD_Plk_1 504 510 PF00069 0.516
MOD_Plk_1 539 545 PF00069 0.326
MOD_Plk_1 671 677 PF00069 0.568
MOD_Plk_2-3 535 541 PF00069 0.374
MOD_Plk_4 117 123 PF00069 0.724
MOD_Plk_4 155 161 PF00069 0.592
MOD_Plk_4 180 186 PF00069 0.322
MOD_Plk_4 279 285 PF00069 0.289
MOD_Plk_4 349 355 PF00069 0.314
MOD_Plk_4 539 545 PF00069 0.225
MOD_Plk_4 578 584 PF00069 0.339
MOD_Plk_4 691 697 PF00069 0.404
MOD_Plk_4 707 713 PF00069 0.471
MOD_Plk_4 87 93 PF00069 0.321
MOD_ProDKin_1 143 149 PF00069 0.703
MOD_ProDKin_1 400 406 PF00069 0.320
MOD_ProDKin_1 416 422 PF00069 0.237
MOD_ProDKin_1 431 437 PF00069 0.238
MOD_ProDKin_1 555 561 PF00069 0.243
MOD_SUMO_rev_2 20 29 PF00179 0.560
MOD_SUMO_rev_2 425 434 PF00179 0.272
TRG_DiLeu_BaLyEn_6 33 38 PF01217 0.415
TRG_DiLeu_BaLyEn_6 599 604 PF01217 0.331
TRG_DiLeu_BaLyEn_6 634 639 PF01217 0.309
TRG_ENDOCYTIC_2 167 170 PF00928 0.503
TRG_ENDOCYTIC_2 232 235 PF00928 0.252
TRG_ENDOCYTIC_2 575 578 PF00928 0.261
TRG_ENDOCYTIC_2 616 619 PF00928 0.287
TRG_ENDOCYTIC_2 636 639 PF00928 0.264
TRG_ENDOCYTIC_2 83 86 PF00928 0.416
TRG_ENDOCYTIC_2 96 99 PF00928 0.360
TRG_ER_diArg_1 221 223 PF00400 0.261
TRG_ER_diArg_1 290 292 PF00400 0.329
TRG_ER_diArg_1 331 333 PF00400 0.269
TRG_ER_diArg_1 497 500 PF00400 0.323
TRG_ER_diArg_1 520 522 PF00400 0.334
TRG_ER_diArg_1 547 550 PF00400 0.261
TRG_ER_diArg_1 631 633 PF00400 0.234
TRG_ER_diArg_1 682 684 PF00400 0.598
TRG_ER_diArg_1 77 79 PF00400 0.592
TRG_ER_diArg_1 83 85 PF00400 0.555
TRG_ER_FFAT_2 40 52 PF00635 0.319
TRG_NLS_MonoExtC_3 732 737 PF00514 0.604
TRG_Pf-PMV_PEXEL_1 271 275 PF00026 0.331
TRG_Pf-PMV_PEXEL_1 36 40 PF00026 0.406
TRG_Pf-PMV_PEXEL_1 460 464 PF00026 0.282

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PFU7 Leptomonas seymouri 69% 100%
A0A0S4KPU1 Bodo saltans 56% 100%
A0A1X0NG94 Trypanosomatidae 60% 100%
A0A1X0NX69 Trypanosomatidae 45% 100%
A0A3Q8ICG0 Leishmania donovani 85% 100%
A0A3S7WXV4 Leishmania donovani 45% 100%
A0A422NDG5 Trypanosoma rangeli 60% 100%
A4HD08 Leishmania braziliensis 44% 100%
A4HWS3 Leishmania infantum 85% 100%
A4I0J4 Leishmania infantum 45% 100%
C9ZVC1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
C9ZW50 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 70% 100%
D5VRB9 Methanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME) 37% 100%
E9AQI1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 99%
E9AWF5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
Q1ZXC6 Dictyostelium discoideum 33% 100%
Q2KJ61 Bos taurus 34% 100%
Q4QB17 Leishmania major 44% 100%
Q4QEZ6 Leishmania major 83% 100%
Q5HZM6 Xenopus laevis 35% 100%
Q5RIC0 Danio rerio 35% 100%
Q5ZHS1 Gallus gallus 35% 100%
Q6NVL5 Xenopus tropicalis 33% 100%
Q9CZX0 Mus musculus 33% 100%
Q9H9T3 Homo sapiens 33% 100%
V5B5L2 Trypanosoma cruzi 60% 100%
V5BNQ5 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS