Elongator complex protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Elongator-like Protein 3a, putative

Species:

Leishmania braziliensis

UniProt:

A4H8F0_LEIBR

TriTrypDb:

LbrM.16.0250 , LBRM2903_160007700

Length:

760

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005634	nucleus	5	2
GO:0005635	nuclear envelope	4	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	2
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	2
GO:0033588	elongator holoenzyme complex	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:0005819	spindle	5	1

Expansion

Sequence features

A4H8F0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8F0

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	2
GO:0002098	tRNA wobble uridine modification	8	2
GO:0002926	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	1
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006400	tRNA modification	6	2
GO:0006473	protein acetylation	6	1
GO:0006475	internal protein amino acid acetylation	7	1
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006996	organelle organization	4	1
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	2
GO:0016570	histone modification	5	1
GO:0016573	histone acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0018393	internal peptidyl-lysine acetylation	8	1
GO:0018394	peptidyl-lysine acetylation	7	1
GO:0019538	protein metabolic process	3	1
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0036211	protein modification process	4	1
GO:0043007	maintenance of rDNA	6	1
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	1
GO:0043570	maintenance of DNA repeat elements	5	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	2
GO:0051276	chromosome organization	5	1
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	20
GO:0003676	nucleic acid binding	3	20
GO:0003723	RNA binding	4	20
GO:0003824	catalytic activity	1	20
GO:0005488	binding	1	20
GO:0016407	acetyltransferase activity	5	20
GO:0016740	transferase activity	2	20
GO:0016746	acyltransferase activity	3	20
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	20
GO:0043167	ion binding	2	20
GO:0043169	cation binding	3	20
GO:0046872	metal ion binding	4	20
GO:0051536	iron-sulfur cluster binding	3	20
GO:0051539	4 iron, 4 sulfur cluster binding	4	20
GO:0051540	metal cluster binding	2	20
GO:0097159	organic cyclic compound binding	2	20
GO:0106261	tRNA uridine(34) acetyltransferase activity	6	11
GO:1901363	heterocyclic compound binding	2	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.493
CLV_C14_Caspase3-7	399	403	PF00656	0.282
CLV_C14_Caspase3-7	653	657	PF00656	0.530
CLV_NRD_NRD_1	222	224	PF00675	0.232
CLV_NRD_NRD_1	291	293	PF00675	0.266
CLV_NRD_NRD_1	332	334	PF00675	0.226
CLV_NRD_NRD_1	430	432	PF00675	0.248
CLV_NRD_NRD_1	520	522	PF00675	0.316
CLV_NRD_NRD_1	632	634	PF00675	0.272
CLV_NRD_NRD_1	683	685	PF00675	0.640
CLV_NRD_NRD_1	732	734	PF00675	0.559
CLV_NRD_NRD_1	77	79	PF00675	0.397
CLV_NRD_NRD_1	84	86	PF00675	0.411
CLV_PCSK_KEX2_1	222	224	PF00082	0.232
CLV_PCSK_KEX2_1	291	293	PF00082	0.263
CLV_PCSK_KEX2_1	332	334	PF00082	0.226
CLV_PCSK_KEX2_1	520	522	PF00082	0.334
CLV_PCSK_KEX2_1	605	607	PF00082	0.279
CLV_PCSK_KEX2_1	632	634	PF00082	0.271
CLV_PCSK_KEX2_1	683	685	PF00082	0.640
CLV_PCSK_KEX2_1	734	736	PF00082	0.527
CLV_PCSK_KEX2_1	77	79	PF00082	0.336
CLV_PCSK_KEX2_1	84	86	PF00082	0.567
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.344
CLV_PCSK_PC1ET2_1	734	736	PF00082	0.480
CLV_PCSK_PC7_1	628	634	PF00082	0.252
CLV_PCSK_SKI1_1	226	230	PF00082	0.240
CLV_PCSK_SKI1_1	274	278	PF00082	0.203
CLV_PCSK_SKI1_1	349	353	PF00082	0.204
CLV_PCSK_SKI1_1	368	372	PF00082	0.184
CLV_PCSK_SKI1_1	394	398	PF00082	0.270
CLV_PCSK_SKI1_1	480	484	PF00082	0.214
CLV_PCSK_SKI1_1	500	504	PF00082	0.217
CLV_PCSK_SKI1_1	602	606	PF00082	0.332
CLV_PCSK_SKI1_1	84	88	PF00082	0.380
CLV_PCSK_SKI1_1	89	93	PF00082	0.316
DEG_APCC_DBOX_1	291	299	PF00400	0.445
DEG_COP1_1	134	143	PF00400	0.563
DEG_SCF_FBW7_1	143	150	PF00400	0.485
DOC_CDC14_PxL_1	28	36	PF14671	0.394
DOC_CKS1_1	417	422	PF01111	0.403
DOC_CKS1_1	556	561	PF01111	0.246
DOC_CYCLIN_RxL_1	84	97	PF00134	0.426
DOC_CYCLIN_yClb1_LxF_4	224	229	PF00134	0.403
DOC_CYCLIN_yClb5_NLxxxL_5	474	483	PF00134	0.414
DOC_MAPK_gen_1	171	181	PF00069	0.390
DOC_MAPK_gen_1	222	229	PF00069	0.432
DOC_MAPK_gen_1	238	245	PF00069	0.403
DOC_MAPK_gen_1	288	297	PF00069	0.364
DOC_MAPK_gen_1	449	458	PF00069	0.403
DOC_MAPK_gen_1	84	93	PF00069	0.367
DOC_MAPK_HePTP_8	446	458	PF00069	0.403
DOC_MAPK_MEF2A_6	288	297	PF00069	0.364
DOC_MAPK_MEF2A_6	449	458	PF00069	0.399
DOC_PP1_RVXF_1	164	171	PF00149	0.513
DOC_PP1_RVXF_1	224	230	PF00149	0.403
DOC_PP2B_PxIxI_1	453	459	PF00149	0.507
DOC_PP4_FxxP_1	170	173	PF00568	0.519
DOC_PP4_FxxP_1	284	287	PF00568	0.507
DOC_USP7_MATH_1	139	143	PF00917	0.681
DOC_USP7_MATH_1	386	390	PF00917	0.379
DOC_USP7_MATH_2	153	159	PF00917	0.401
DOC_WW_Pin1_4	143	148	PF00397	0.702
DOC_WW_Pin1_4	149	154	PF00397	0.685
DOC_WW_Pin1_4	400	405	PF00397	0.325
DOC_WW_Pin1_4	416	421	PF00397	0.403
DOC_WW_Pin1_4	431	436	PF00397	0.404
DOC_WW_Pin1_4	555	560	PF00397	0.243
LIG_14-3-3_CanoR_1	238	243	PF00244	0.403
LIG_14-3-3_CanoR_1	349	354	PF00244	0.420
LIG_14-3-3_CanoR_1	356	364	PF00244	0.411
LIG_14-3-3_CanoR_1	689	696	PF00244	0.620
LIG_14-3-3_CanoR_1	723	727	PF00244	0.459
LIG_Actin_RPEL_3	682	701	PF02755	0.393
LIG_Actin_WH2_2	668	685	PF00022	0.434
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BIR_III_2	138	142	PF00653	0.441
LIG_BIR_III_4	6	10	PF00653	0.476
LIG_BRCT_BRCA1_1	119	123	PF00533	0.450
LIG_EH1_1	645	653	PF00400	0.208
LIG_eIF4E_1	436	442	PF01652	0.431
LIG_FHA_1	155	161	PF00498	0.442
LIG_FHA_1	46	52	PF00498	0.446
LIG_FHA_1	691	697	PF00498	0.657
LIG_FHA_1	95	101	PF00498	0.244
LIG_FHA_2	280	286	PF00498	0.433
LIG_FHA_2	316	322	PF00498	0.407
LIG_FHA_2	357	363	PF00498	0.446
LIG_FHA_2	45	51	PF00498	0.350
LIG_FHA_2	505	511	PF00498	0.565
LIG_FHA_2	579	585	PF00498	0.287
LIG_LIR_Apic_2	282	287	PF02991	0.424
LIG_LIR_Gen_1	165	173	PF02991	0.550
LIG_LIR_Gen_1	20	29	PF02991	0.511
LIG_LIR_Gen_1	418	428	PF02991	0.440
LIG_LIR_Gen_1	528	537	PF02991	0.289
LIG_LIR_Gen_1	557	568	PF02991	0.239
LIG_LIR_Gen_1	613	622	PF02991	0.268
LIG_LIR_LC3C_4	177	182	PF02991	0.350
LIG_LIR_Nem_3	165	170	PF02991	0.534
LIG_LIR_Nem_3	196	202	PF02991	0.237
LIG_LIR_Nem_3	20	24	PF02991	0.511
LIG_LIR_Nem_3	230	235	PF02991	0.413
LIG_LIR_Nem_3	260	264	PF02991	0.439
LIG_LIR_Nem_3	409	414	PF02991	0.421
LIG_LIR_Nem_3	418	424	PF02991	0.440
LIG_LIR_Nem_3	430	436	PF02991	0.440
LIG_LIR_Nem_3	528	534	PF02991	0.268
LIG_LIR_Nem_3	557	563	PF02991	0.350
LIG_LIR_Nem_3	613	619	PF02991	0.239
LIG_MYND_3	31	35	PF01753	0.406
LIG_NRBOX	33	39	PF00104	0.391
LIG_NRBOX	478	484	PF00104	0.407
LIG_Pex14_1	199	203	PF04695	0.403
LIG_Pex14_1	556	560	PF04695	0.252
LIG_Pex14_2	195	199	PF04695	0.237
LIG_RPA_C_Fungi	684	696	PF08784	0.389
LIG_SH2_CRK	575	579	PF00017	0.282
LIG_SH2_CRK	636	640	PF00017	0.401
LIG_SH2_CRK	83	87	PF00017	0.410
LIG_SH2_CRK	96	100	PF00017	0.386
LIG_SH2_NCK_1	616	620	PF00017	0.290
LIG_SH2_STAP1	616	620	PF00017	0.290
LIG_SH2_STAP1	96	100	PF00017	0.348
LIG_SH2_STAT3	264	267	PF00017	0.147
LIG_SH2_STAT3	414	417	PF00017	0.237
LIG_SH2_STAT5	167	170	PF00017	0.357
LIG_SH2_STAT5	203	206	PF00017	0.261
LIG_SH2_STAT5	214	217	PF00017	0.261
LIG_SH2_STAT5	405	408	PF00017	0.359
LIG_SH2_STAT5	433	436	PF00017	0.388
LIG_SH2_STAT5	469	472	PF00017	0.261
LIG_SH2_STAT5	582	585	PF00017	0.374
LIG_SH2_STAT5	96	99	PF00017	0.231
LIG_SH3_1	202	208	PF00018	0.237
LIG_SH3_2	151	156	PF14604	0.449
LIG_SH3_2	287	292	PF14604	0.383
LIG_SH3_3	110	116	PF00018	0.599
LIG_SH3_3	121	127	PF00018	0.677
LIG_SH3_3	148	154	PF00018	0.717
LIG_SH3_3	156	162	PF00018	0.392
LIG_SH3_3	202	208	PF00018	0.261
LIG_SH3_3	284	290	PF00018	0.313
LIG_SH3_3	380	386	PF00018	0.292
LIG_SH3_3	531	537	PF00018	0.296
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.338
LIG_SUMO_SIM_anti_2	250	256	PF11976	0.261
LIG_SUMO_SIM_anti_2	617	623	PF11976	0.265
LIG_SUMO_SIM_par_1	177	183	PF11976	0.338
LIG_SUMO_SIM_par_1	650	656	PF11976	0.302
LIG_TRAF2_1	116	119	PF00917	0.520
LIG_UBA3_1	441	449	PF00899	0.301
LIG_WW_3	285	289	PF00397	0.182
MOD_CDK_SPxxK_3	149	156	PF00069	0.546
MOD_CK1_1	142	148	PF00069	0.662
MOD_CK1_1	525	531	PF00069	0.269
MOD_CK1_1	694	700	PF00069	0.491
MOD_CK2_1	131	137	PF00069	0.430
MOD_CK2_1	149	155	PF00069	0.431
MOD_CK2_1	355	361	PF00069	0.273
MOD_CK2_1	419	425	PF00069	0.258
MOD_CK2_1	504	510	PF00069	0.520
MOD_CK2_1	578	584	PF00069	0.292
MOD_CK2_1	744	750	PF00069	0.552
MOD_GlcNHglycan	12	15	PF01048	0.725
MOD_GlcNHglycan	128	131	PF01048	0.487
MOD_GlcNHglycan	176	179	PF01048	0.372
MOD_GlcNHglycan	186	189	PF01048	0.315
MOD_GlcNHglycan	305	308	PF01048	0.299
MOD_GlcNHglycan	513	516	PF01048	0.430
MOD_GlcNHglycan	622	625	PF01048	0.237
MOD_GlcNHglycan	696	699	PF01048	0.534
MOD_GlcNHglycan	746	749	PF01048	0.601
MOD_GSK3_1	10	17	PF00069	0.697
MOD_GSK3_1	139	146	PF00069	0.695
MOD_GSK3_1	180	187	PF00069	0.302
MOD_GSK3_1	315	322	PF00069	0.260
MOD_GSK3_1	356	363	PF00069	0.297
MOD_GSK3_1	415	422	PF00069	0.261
MOD_GSK3_1	535	542	PF00069	0.459
MOD_GSK3_1	610	617	PF00069	0.250
MOD_GSK3_1	690	697	PF00069	0.517
MOD_GSK3_1	724	731	PF00069	0.498
MOD_N-GLC_1	107	112	PF02516	0.555
MOD_N-GLC_1	193	198	PF02516	0.345
MOD_N-GLC_1	303	308	PF02516	0.237
MOD_NEK2_1	180	185	PF00069	0.317
MOD_NEK2_1	303	308	PF00069	0.252
MOD_NEK2_1	334	339	PF00069	0.271
MOD_NEK2_1	370	375	PF00069	0.273
MOD_NEK2_1	38	43	PF00069	0.617
MOD_NEK2_1	639	644	PF00069	0.389
MOD_NEK2_1	722	727	PF00069	0.594
MOD_NEK2_1	87	92	PF00069	0.417
MOD_NEK2_2	279	284	PF00069	0.271
MOD_PIKK_1	172	178	PF00454	0.381
MOD_PIKK_1	61	67	PF00454	0.346
MOD_PIKK_1	663	669	PF00454	0.411
MOD_PIKK_1	724	730	PF00454	0.501
MOD_PIKK_1	94	100	PF00454	0.233
MOD_PKA_2	355	361	PF00069	0.252
MOD_PKA_2	722	728	PF00069	0.462
MOD_Plk_1	154	160	PF00069	0.381
MOD_Plk_1	360	366	PF00069	0.344
MOD_Plk_1	504	510	PF00069	0.516
MOD_Plk_1	539	545	PF00069	0.326
MOD_Plk_1	671	677	PF00069	0.568
MOD_Plk_2-3	535	541	PF00069	0.374
MOD_Plk_4	117	123	PF00069	0.724
MOD_Plk_4	155	161	PF00069	0.592
MOD_Plk_4	180	186	PF00069	0.322
MOD_Plk_4	279	285	PF00069	0.289
MOD_Plk_4	349	355	PF00069	0.314
MOD_Plk_4	539	545	PF00069	0.225
MOD_Plk_4	578	584	PF00069	0.339
MOD_Plk_4	691	697	PF00069	0.404
MOD_Plk_4	707	713	PF00069	0.471
MOD_Plk_4	87	93	PF00069	0.321
MOD_ProDKin_1	143	149	PF00069	0.703
MOD_ProDKin_1	400	406	PF00069	0.320
MOD_ProDKin_1	416	422	PF00069	0.237
MOD_ProDKin_1	431	437	PF00069	0.238
MOD_ProDKin_1	555	561	PF00069	0.243
MOD_SUMO_rev_2	20	29	PF00179	0.560
MOD_SUMO_rev_2	425	434	PF00179	0.272
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.415
TRG_DiLeu_BaLyEn_6	599	604	PF01217	0.331
TRG_DiLeu_BaLyEn_6	634	639	PF01217	0.309
TRG_ENDOCYTIC_2	167	170	PF00928	0.503
TRG_ENDOCYTIC_2	232	235	PF00928	0.252
TRG_ENDOCYTIC_2	575	578	PF00928	0.261
TRG_ENDOCYTIC_2	616	619	PF00928	0.287
TRG_ENDOCYTIC_2	636	639	PF00928	0.264
TRG_ENDOCYTIC_2	83	86	PF00928	0.416
TRG_ENDOCYTIC_2	96	99	PF00928	0.360
TRG_ER_diArg_1	221	223	PF00400	0.261
TRG_ER_diArg_1	290	292	PF00400	0.329
TRG_ER_diArg_1	331	333	PF00400	0.269
TRG_ER_diArg_1	497	500	PF00400	0.323
TRG_ER_diArg_1	520	522	PF00400	0.334
TRG_ER_diArg_1	547	550	PF00400	0.261
TRG_ER_diArg_1	631	633	PF00400	0.234
TRG_ER_diArg_1	682	684	PF00400	0.598
TRG_ER_diArg_1	77	79	PF00400	0.592
TRG_ER_diArg_1	83	85	PF00400	0.555
TRG_ER_FFAT_2	40	52	PF00635	0.319
TRG_NLS_MonoExtC_3	732	737	PF00514	0.604
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.282

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFU7	Leptomonas seymouri	69%	100%
A0A0S4KPU1	Bodo saltans	56%	100%
A0A1X0NG94	Trypanosomatidae	60%	100%
A0A1X0NX69	Trypanosomatidae	45%	100%
A0A3Q8ICG0	Leishmania donovani	85%	100%
A0A3S7WXV4	Leishmania donovani	45%	100%
A0A422NDG5	Trypanosoma rangeli	60%	100%
A4HD08	Leishmania braziliensis	44%	100%
A4HWS3	Leishmania infantum	85%	100%
A4I0J4	Leishmania infantum	45%	100%
C9ZVC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZW50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
D5VRB9	Methanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)	37%	100%
E9AQI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
E9AWF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
Q1ZXC6	Dictyostelium discoideum	33%	100%
Q2KJ61	Bos taurus	34%	100%
Q4QB17	Leishmania major	44%	100%
Q4QEZ6	Leishmania major	83%	100%
Q5HZM6	Xenopus laevis	35%	100%
Q5RIC0	Danio rerio	35%	100%
Q5ZHS1	Gallus gallus	35%	100%
Q6NVL5	Xenopus tropicalis	33%	100%
Q9CZX0	Mus musculus	33%	100%
Q9H9T3	Homo sapiens	33%	100%
V5B5L2	Trypanosoma cruzi	60%	100%
V5BNQ5	Trypanosoma cruzi	46%	100%