LeishMANIAdb
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Protein tyrosine phosphatase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein tyrosine phosphatase-like protein
Gene product:
protein tyrosine phosphatase-like protein
Species:
Leishmania braziliensis
UniProt:
A4H8E9_LEIBR
TriTrypDb:
LbrM.16.0240 , LBRM2903_160007600 *
Length:
175

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 27
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 23
NetGPI no yes: 0, no: 23
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 2
GO:0005829 cytosol 2 1
GO:0018995 host cellular component 2 1
GO:0020023 kinetoplast 2 1
GO:0030430 host cell cytoplasm 5 1
GO:0031982 vesicle 4 1
GO:0033643 host cell part 3 1
GO:0033646 host intracellular part 4 1
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043230 extracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0065010 extracellular membrane-bounded organelle 4 1
GO:0070062 extracellular exosome 6 1
GO:0110165 cellular anatomical entity 1 2
GO:1903561 extracellular vesicle 5 1

Expansion

Sequence features

A4H8E9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8E9

PDB structure(s): 3s4o_A , 3s4o_B

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 24
GO:0006793 phosphorus metabolic process 3 24
GO:0006796 phosphate-containing compound metabolic process 4 24
GO:0006807 nitrogen compound metabolic process 2 24
GO:0008152 metabolic process 1 24
GO:0009987 cellular process 1 24
GO:0016311 dephosphorylation 5 24
GO:0019538 protein metabolic process 3 24
GO:0036211 protein modification process 4 24
GO:0043170 macromolecule metabolic process 3 24
GO:0043412 macromolecule modification 4 24
GO:0044237 cellular metabolic process 2 24
GO:0044238 primary metabolic process 2 24
GO:0071704 organic substance metabolic process 2 24
GO:1901564 organonitrogen compound metabolic process 3 24
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 24
GO:0004721 phosphoprotein phosphatase activity 3 24
GO:0004725 protein tyrosine phosphatase activity 4 17
GO:0008138 protein tyrosine/serine/threonine phosphatase activity 4 24
GO:0016787 hydrolase activity 2 24
GO:0016788 hydrolase activity, acting on ester bonds 3 24
GO:0016791 phosphatase activity 5 24
GO:0042578 phosphoric ester hydrolase activity 4 24
GO:0140096 catalytic activity, acting on a protein 2 24

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 136 140 PF00656 0.465
CLV_NRD_NRD_1 148 150 PF00675 0.423
CLV_NRD_NRD_1 165 167 PF00675 0.437
CLV_NRD_NRD_1 43 45 PF00675 0.305
CLV_PCSK_FUR_1 145 149 PF00082 0.416
CLV_PCSK_KEX2_1 147 149 PF00082 0.416
CLV_PCSK_KEX2_1 164 166 PF00082 0.430
CLV_PCSK_KEX2_1 43 45 PF00082 0.305
CLV_PCSK_PC1ET2_1 147 149 PF00082 0.421
CLV_PCSK_PC1ET2_1 164 166 PF00082 0.379
CLV_PCSK_SKI1_1 18 22 PF00082 0.391
CLV_PCSK_SKI1_1 82 86 PF00082 0.434
DEG_Nend_UBRbox_2 1 3 PF02207 0.492
DOC_CDC14_PxL_1 118 126 PF14671 0.340
DOC_MAPK_MEF2A_6 105 112 PF00069 0.399
DOC_MAPK_MEF2A_6 120 129 PF00069 0.326
DOC_PP1_RVXF_1 16 22 PF00149 0.454
DOC_PP2B_LxvP_1 26 29 PF13499 0.406
DOC_PP2B_PxIxI_1 107 113 PF00149 0.523
DOC_USP7_MATH_1 29 33 PF00917 0.407
DOC_WW_Pin1_4 27 32 PF00397 0.392
LIG_BRCT_BRCA1_1 70 74 PF00533 0.414
LIG_FHA_1 107 113 PF00498 0.411
LIG_FHA_1 79 85 PF00498 0.451
LIG_FHA_2 4 10 PF00498 0.398
LIG_LIR_Gen_1 86 96 PF02991 0.417
LIG_LIR_Nem_3 131 135 PF02991 0.373
LIG_LIR_Nem_3 86 91 PF02991 0.392
LIG_Pex14_1 159 163 PF04695 0.410
LIG_SH2_CRK 132 136 PF00017 0.428
LIG_SH2_STAP1 57 61 PF00017 0.418
LIG_SH2_STAT3 11 14 PF00017 0.291
LIG_SH2_STAT5 37 40 PF00017 0.404
LIG_SH3_2 13 18 PF14604 0.392
LIG_SH3_3 10 16 PF00018 0.377
LIG_SH3_3 100 106 PF00018 0.455
LIG_SH3_3 49 55 PF00018 0.374
LIG_SUMO_SIM_anti_2 139 146 PF11976 0.386
LIG_TYR_ITIM 130 135 PF00017 0.389
MOD_CAAXbox 172 175 PF01239 0.568
MOD_GlcNHglycan 135 138 PF01048 0.467
MOD_GSK3_1 29 36 PF00069 0.486
MOD_N-GLC_1 133 138 PF02516 0.559
MOD_N-GLC_1 152 157 PF02516 0.291
MOD_N-GLC_1 3 8 PF02516 0.391
MOD_PIKK_1 152 158 PF00454 0.420
MOD_Plk_1 133 139 PF00069 0.563
MOD_Plk_1 152 158 PF00069 0.296
MOD_Plk_1 3 9 PF00069 0.377
MOD_Plk_4 3 9 PF00069 0.398
MOD_Plk_4 33 39 PF00069 0.532
MOD_Plk_4 84 90 PF00069 0.391
MOD_ProDKin_1 27 33 PF00069 0.395
TRG_ENDOCYTIC_2 132 135 PF00928 0.371
TRG_NLS_Bipartite_1 147 168 PF00514 0.520
TRG_NLS_MonoExtN_4 162 168 PF00514 0.544

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7Y8 Leptomonas seymouri 78% 99%
A0A0N1IM31 Leptomonas seymouri 57% 99%
A0A0S4IS65 Bodo saltans 60% 97%
A0A1X0NFW2 Trypanosomatidae 69% 99%
A0A1X0NHQ7 Trypanosomatidae 59% 99%
A0A1X0NZ52 Trypanosomatidae 69% 99%
A0A3Q8I9A9 Leishmania donovani 91% 100%
A0A3S5IQZ9 Trypanosoma rangeli 55% 99%
A0A3S7WTS0 Leishmania donovani 61% 99%
A0A422N2F6 Trypanosoma rangeli 52% 100%
A0A422ND97 Trypanosoma rangeli 66% 99%
A2VDT1 Bos taurus 46% 100%
A4H8F1 Leishmania braziliensis 61% 99%
A4HWS2 Leishmania infantum 90% 100%
A4HWS4 Leishmania infantum 61% 99%
C9ZW52 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 70% 99%
E9AQI0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9AQI2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 61% 99%
O61722 Drosophila melanogaster 41% 99%
O70274 Mus musculus 45% 100%
O75365 Homo sapiens 45% 100%
Q12974 Homo sapiens 45% 100%
Q4CUJ8 Trypanosoma cruzi (strain CL Brener) 53% 99%
Q4QEZ5 Leishmania major 62% 100%
Q4QEZ7 Leishmania major 89% 100%
Q54DU9 Dictyostelium discoideum 48% 100%
Q5R7J8 Pongo abelii 48% 100%
Q63739 Mus musculus 47% 100%
Q6NT99 Mus musculus 31% 100%
Q6P9X4 Rattus norvegicus 45% 100%
Q78EG7 Rattus norvegicus 47% 100%
Q86IL4 Dictyostelium discoideum 34% 100%
Q93096 Homo sapiens 47% 100%
Q9BVJ7 Homo sapiens 30% 100%
Q9D658 Mus musculus 46% 100%
Q9TSM6 Macaca fascicularis 47% 100%
V5B959 Trypanosoma cruzi 67% 97%
V5BA64 Trypanosoma cruzi 54% 99%
V5BDR5 Trypanosoma cruzi 56% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS