Mitochondrial ornithine transporter 1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial ornithine transporter 1-like protein

Species:

Leishmania braziliensis

UniProt:

A4H8E7_LEIBR

TriTrypDb:

LbrM.16.0220 , LBRM2903_160007400

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14

Expansion

Sequence features

A4H8E7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8E7

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	1
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006820	monoatomic anion transport	5	1
GO:0006865	amino acid transport	5	1
GO:0009987	cellular process	1	2
GO:0015711	organic anion transport	5	1
GO:0015807	L-amino acid transport	5	1
GO:0015822	ornithine transport	6	1
GO:0015849	organic acid transport	5	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0046942	carboxylic acid transport	6	1
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098656	monoatomic anion transmembrane transport	4	1
GO:1902475	L-alpha-amino acid transmembrane transport	6	1
GO:1903352	L-ornithine transmembrane transport	5	1
GO:1903825	organic acid transmembrane transport	3	1
GO:1905039	carboxylic acid transmembrane transport	4	1
GO:1990542	mitochondrial transmembrane transport	3	1
GO:1990575	mitochondrial L-ornithine transmembrane transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000064	L-ornithine transmembrane transporter activity	5	1
GO:0005215	transporter activity	1	1
GO:0005342	organic acid transmembrane transporter activity	3	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0008509	monoatomic anion transmembrane transporter activity	4	1
GO:0008514	organic anion transmembrane transporter activity	5	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015171	amino acid transmembrane transporter activity	5	1
GO:0015179	L-amino acid transmembrane transporter activity	6	1
GO:0022857	transmembrane transporter activity	2	1
GO:0046943	carboxylic acid transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.495
CLV_NRD_NRD_1	135	137	PF00675	0.462
CLV_NRD_NRD_1	303	305	PF00675	0.283
CLV_PCSK_KEX2_1	134	136	PF00082	0.749
CLV_PCSK_KEX2_1	201	203	PF00082	0.374
CLV_PCSK_KEX2_1	303	305	PF00082	0.283
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.749
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.291
CLV_PCSK_PC7_1	130	136	PF00082	0.447
CLV_PCSK_PC7_1	197	203	PF00082	0.317
CLV_PCSK_SKI1_1	233	237	PF00082	0.368
CLV_PCSK_SKI1_1	333	337	PF00082	0.394
DEG_APCC_DBOX_1	232	240	PF00400	0.317
DEG_SPOP_SBC_1	367	371	PF00917	0.410
DOC_CKS1_1	180	185	PF01111	0.262
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.403
DOC_PP2B_LxvP_1	83	86	PF13499	0.355
DOC_PP4_FxxP_1	355	358	PF00568	0.385
DOC_USP7_MATH_1	142	146	PF00917	0.746
DOC_USP7_MATH_1	196	200	PF00917	0.237
DOC_USP7_MATH_1	363	367	PF00917	0.624
DOC_WW_Pin1_4	160	165	PF00397	0.610
DOC_WW_Pin1_4	179	184	PF00397	0.228
DOC_WW_Pin1_4	354	359	PF00397	0.612
DOC_WW_Pin1_4	56	61	PF00397	0.214
LIG_14-3-3_CanoR_1	135	139	PF00244	0.468
LIG_14-3-3_CanoR_1	202	208	PF00244	0.358
LIG_14-3-3_CanoR_1	309	315	PF00244	0.419
LIG_14-3-3_CanoR_1	31	41	PF00244	0.187
LIG_14-3-3_CanoR_1	333	342	PF00244	0.387
LIG_14-3-3_CanoR_1	347	353	PF00244	0.344
LIG_14-3-3_CanoR_1	45	52	PF00244	0.378
LIG_14-3-3_CanoR_1	81	86	PF00244	0.350
LIG_BRCT_BRCA1_1	277	281	PF00533	0.335
LIG_BRCT_BRCA1_1	338	342	PF00533	0.317
LIG_BRCT_MDC1_1	383	387	PF00533	0.588
LIG_deltaCOP1_diTrp_1	250	256	PF00928	0.294
LIG_EVH1_1	149	153	PF00568	0.477
LIG_FHA_1	15	21	PF00498	0.335
LIG_FHA_1	226	232	PF00498	0.319
LIG_FHA_1	306	312	PF00498	0.405
LIG_FHA_1	56	62	PF00498	0.459
LIG_FHA_2	180	186	PF00498	0.294
LIG_FHA_2	341	347	PF00498	0.403
LIG_Integrin_RGD_1	130	132	PF01839	0.495
LIG_LIR_Apic_2	159	164	PF02991	0.643
LIG_LIR_Gen_1	35	44	PF02991	0.420
LIG_LIR_Gen_1	356	367	PF02991	0.550
LIG_LIR_Nem_3	35	40	PF02991	0.331
LIG_LIR_Nem_3	356	362	PF02991	0.650
LIG_LIR_Nem_3	78	83	PF02991	0.260
LIG_PCNA_yPIPBox_3	102	111	PF02747	0.317
LIG_Pex14_1	283	287	PF04695	0.325
LIG_PTB_Apo_2	235	242	PF02174	0.403
LIG_PTB_Phospho_1	235	241	PF10480	0.403
LIG_SH2_CRK	224	228	PF00017	0.294
LIG_SH2_CRK	359	363	PF00017	0.545
LIG_SH2_CRK	37	41	PF00017	0.300
LIG_SH2_CRK	80	84	PF00017	0.324
LIG_SH2_NCK_1	37	41	PF00017	0.170
LIG_SH2_STAT3	376	379	PF00017	0.455
LIG_SH2_STAT5	224	227	PF00017	0.418
LIG_SH2_STAT5	241	244	PF00017	0.161
LIG_SH2_STAT5	359	362	PF00017	0.400
LIG_SH2_STAT5	37	40	PF00017	0.300
LIG_SH3_3	144	150	PF00018	0.657
LIG_SH3_3	151	157	PF00018	0.551
LIG_SUMO_SIM_par_1	156	163	PF11976	0.391
LIG_TRAF2_1	378	381	PF00917	0.518
LIG_WRC_WIRS_1	76	81	PF05994	0.322
MOD_CK1_1	159	165	PF00069	0.465
MOD_CK1_1	348	354	PF00069	0.414
MOD_CK1_1	35	41	PF00069	0.177
MOD_CK1_1	366	372	PF00069	0.672
MOD_CK1_1	56	62	PF00069	0.239
MOD_CK2_1	142	148	PF00069	0.737
MOD_CK2_1	179	185	PF00069	0.294
MOD_CK2_1	340	346	PF00069	0.355
MOD_GlcNHglycan	126	129	PF01048	0.561
MOD_GlcNHglycan	169	172	PF01048	0.451
MOD_GlcNHglycan	194	197	PF01048	0.442
MOD_GlcNHglycan	277	280	PF01048	0.311
MOD_GlcNHglycan	316	319	PF01048	0.412
MOD_GlcNHglycan	365	368	PF01048	0.611
MOD_GlcNHglycan	372	375	PF01048	0.673
MOD_GlcNHglycan	55	58	PF01048	0.294
MOD_GSK3_1	156	163	PF00069	0.615
MOD_GSK3_1	175	182	PF00069	0.271
MOD_GSK3_1	192	199	PF00069	0.324
MOD_GSK3_1	225	232	PF00069	0.370
MOD_GSK3_1	305	312	PF00069	0.454
MOD_GSK3_1	336	343	PF00069	0.415
MOD_GSK3_1	363	370	PF00069	0.643
MOD_GSK3_1	51	58	PF00069	0.405
MOD_GSK3_1	81	88	PF00069	0.291
MOD_LATS_1	345	351	PF00433	0.170
MOD_N-GLC_1	101	106	PF02516	0.428
MOD_NEK2_1	126	131	PF00069	0.440
MOD_NEK2_1	175	180	PF00069	0.403
MOD_NEK2_1	214	219	PF00069	0.415
MOD_NEK2_1	256	261	PF00069	0.520
MOD_NEK2_1	281	286	PF00069	0.319
MOD_NEK2_1	307	312	PF00069	0.379
MOD_NEK2_1	314	319	PF00069	0.377
MOD_NEK2_1	32	37	PF00069	0.430
MOD_NEK2_1	335	340	PF00069	0.377
MOD_NEK2_2	24	29	PF00069	0.294
MOD_NEK2_2	75	80	PF00069	0.307
MOD_PIKK_1	140	146	PF00454	0.491
MOD_PIKK_1	65	71	PF00454	0.415
MOD_PK_1	81	87	PF00069	0.291
MOD_PKA_1	134	140	PF00069	0.469
MOD_PKA_2	134	140	PF00069	0.766
MOD_PKA_2	196	202	PF00069	0.431
MOD_PKA_2	203	209	PF00069	0.410
MOD_PKA_2	346	352	PF00069	0.372
MOD_PKA_2	363	369	PF00069	0.654
MOD_PKA_2	44	50	PF00069	0.366
MOD_Plk_1	101	107	PF00069	0.428
MOD_Plk_4	175	181	PF00069	0.198
MOD_Plk_4	203	209	PF00069	0.224
MOD_Plk_4	268	274	PF00069	0.314
MOD_Plk_4	310	316	PF00069	0.413
MOD_Plk_4	327	333	PF00069	0.283
MOD_Plk_4	336	342	PF00069	0.388
MOD_Plk_4	59	65	PF00069	0.365
MOD_ProDKin_1	160	166	PF00069	0.601
MOD_ProDKin_1	179	185	PF00069	0.228
MOD_ProDKin_1	354	360	PF00069	0.611
MOD_ProDKin_1	56	62	PF00069	0.214
TRG_ENDOCYTIC_2	224	227	PF00928	0.363
TRG_ENDOCYTIC_2	282	285	PF00928	0.403
TRG_ENDOCYTIC_2	359	362	PF00928	0.680
TRG_ENDOCYTIC_2	37	40	PF00928	0.300
TRG_ENDOCYTIC_2	80	83	PF00928	0.324
TRG_ER_diArg_1	138	141	PF00400	0.519
TRG_NLS_MonoExtN_4	198	205	PF00514	0.170
TRG_Pf-PMV_PEXEL_1	107	112	PF00026	0.298

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0G2K309	Rattus norvegicus	29%	100%
A0A0N0P7X0	Leptomonas seymouri	27%	100%
A0A0N0P7Y4	Leptomonas seymouri	29%	100%
A0A0N1HX25	Leptomonas seymouri	23%	100%
A0A0N1I8T5	Leptomonas seymouri	23%	100%
A0A0N1IMA2	Leptomonas seymouri	50%	100%
A0A0S4IMF4	Bodo saltans	20%	100%
A0A0S4IV98	Bodo saltans	25%	100%
A0A0S4IZG7	Bodo saltans	21%	100%
A0A0S4JIA4	Bodo saltans	25%	91%
A0A0S4JM95	Bodo saltans	33%	100%
A0A0S4JQI3	Bodo saltans	23%	100%
A0A0S4JR63	Bodo saltans	22%	100%
A0A1X0NFT4	Trypanosomatidae	31%	100%
A0A1X0NIA3	Trypanosomatidae	24%	100%
A0A1X0NJD2	Trypanosomatidae	24%	100%
A0A1X0NLW7	Trypanosomatidae	23%	100%
A0A1X0NUT2	Trypanosomatidae	26%	100%
A0A1X0P4Q9	Trypanosomatidae	28%	100%
A0A1X0PA63	Trypanosomatidae	23%	100%
A0A3R7KGU8	Trypanosoma rangeli	28%	100%
A0A3R7N0M4	Trypanosoma rangeli	25%	100%
A0A3R7RT89	Trypanosoma rangeli	24%	100%
A0A3S5H6W7	Leishmania donovani	78%	100%
A0A3S7WTS6	Leishmania donovani	28%	100%
A0A3S7WYS1	Leishmania donovani	27%	100%
A0A422NF39	Trypanosoma rangeli	28%	100%
A0A422NVT9	Trypanosoma rangeli	21%	100%
A1CIF6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	25%	100%
A1CWA4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	25%	100%
A2Q9F0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	25%	100%
A4H8E6	Leishmania braziliensis	28%	85%
A4HDW8	Leishmania braziliensis	26%	100%
A4HWR9	Leishmania infantum	28%	100%
A4HWS0	Leishmania infantum	78%	100%
A4I163	Leishmania infantum	27%	100%
A4QNX2	Danio rerio	26%	100%
A6RAY2	Ajellomyces capsulatus (strain NAm1 / WU24)	25%	100%
B0Y4J4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	25%	100%
B2VSU4	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	24%	100%
C9ZM27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZW54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A5E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A9N0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9ALE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AQH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AQH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9AX97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
O43772	Homo sapiens	26%	100%
P32331	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P33303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P38087	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P38152	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P97521	Rattus norvegicus	25%	100%
Q01356	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	100%
Q03028	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q08DK4	Bos taurus	24%	100%
Q08DK7	Bos taurus	25%	100%
Q09461	Caenorhabditis elegans	22%	100%
Q0CT66	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	26%	100%
Q10248	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	20%	100%
Q12289	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q12375	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q1DRJ3	Coccidioides immitis (strain RS)	23%	100%
Q1ECW7	Danio rerio	22%	100%
Q1LZB3	Bos taurus	22%	100%
Q27257	Caenorhabditis elegans	23%	100%
Q2UU67	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	23%	100%
Q3MHI3	Bos taurus	25%	100%
Q3TZX3	Mus musculus	21%	100%
Q4QA75	Leishmania major	26%	87%
Q4QEZ9	Leishmania major	76%	99%
Q4QF00	Leishmania major	28%	85%
Q4WQC5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q54B67	Dictyostelium discoideum	23%	100%
Q54BM3	Dictyostelium discoideum	24%	100%
Q54FE6	Dictyostelium discoideum	26%	100%
Q54S10	Dictyostelium discoideum	22%	99%
Q54VS7	Dictyostelium discoideum	22%	100%
Q55DY8	Dictyostelium discoideum	23%	100%
Q5B717	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	23%	100%
Q5HZE0	Rattus norvegicus	23%	100%
Q5RFB7	Pongo abelii	22%	100%
Q5ZKP7	Gallus gallus	24%	100%
Q6DG32	Danio rerio	24%	100%
Q6DHS9	Danio rerio	23%	100%
Q6IS41	Mus musculus	25%	100%
Q6J329	Rattus norvegicus	24%	100%
Q6P036	Danio rerio	22%	100%
Q6Q0C1	Homo sapiens	24%	100%
Q6ZT89	Homo sapiens	26%	100%
Q84UC7	Arabidopsis thaliana	26%	100%
Q86AV5	Dictyostelium discoideum	26%	100%
Q86HN8	Dictyostelium discoideum	23%	89%
Q8BL03	Mus musculus	22%	100%
Q8BW66	Mus musculus	25%	100%
Q8CFJ7	Mus musculus	23%	100%
Q8HXY2	Macaca fascicularis	26%	100%
Q8N413	Homo sapiens	24%	100%
Q8N8R3	Homo sapiens	24%	100%
Q8RWA5	Arabidopsis thaliana	24%	100%
Q922G0	Mus musculus	24%	100%
Q93XM7	Arabidopsis thaliana	27%	100%
Q96CQ1	Homo sapiens	24%	100%
Q9BQT8	Homo sapiens	22%	100%
Q9BSK2	Homo sapiens	21%	100%
Q9BXI2	Homo sapiens	26%	100%
Q9CA93	Arabidopsis thaliana	25%	100%
Q9D6M3	Mus musculus	24%	100%
Q9VM51	Drosophila melanogaster	26%	100%
Q9VQ37	Drosophila melanogaster	22%	100%
Q9VQG4	Drosophila melanogaster	25%	100%
Q9WVD5	Mus musculus	27%	100%
Q9Y619	Homo sapiens	27%	100%
Q9Z2Z6	Mus musculus	25%	100%
V5BD15	Trypanosoma cruzi	22%	100%
V5BDR1	Trypanosoma cruzi	31%	100%
V5BI33	Trypanosoma cruzi	25%	100%
V5BKU8	Trypanosoma cruzi	23%	100%
V5BP20	Trypanosoma cruzi	27%	100%
V5BSW1	Trypanosoma cruzi	28%	100%
V5BVW0	Trypanosoma cruzi	22%	100%