Las1 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Las1 family protein

Gene product:

Las1-like, putative

Species:

Leishmania braziliensis

UniProt:

A4H8E5_LEIBR

TriTrypDb:

LbrM.16.0200 , LBRM2903_160007200

Length:

357

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	11
GO:0090730	Las1 complex	4	11
GO:0140535	intracellular protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1902555	endoribonuclease complex	4	11
GO:1902911	protein kinase complex	5	11
GO:1905348	endonuclease complex	3	11
GO:1905354	exoribonuclease complex	3	11
GO:1990234	transferase complex	3	11
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H8E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8E5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000460	maturation of 5.8S rRNA	9	1
GO:0000470	maturation of LSU-rRNA	9	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0004519	endonuclease activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.567
CLV_C14_Caspase3-7	53	57	PF00656	0.514
CLV_NRD_NRD_1	11	13	PF00675	0.609
CLV_NRD_NRD_1	125	127	PF00675	0.369
CLV_NRD_NRD_1	18	20	PF00675	0.517
CLV_NRD_NRD_1	185	187	PF00675	0.306
CLV_NRD_NRD_1	2	4	PF00675	0.637
CLV_NRD_NRD_1	43	45	PF00675	0.673
CLV_PCSK_KEX2_1	10	12	PF00082	0.544
CLV_PCSK_KEX2_1	111	113	PF00082	0.150
CLV_PCSK_KEX2_1	18	20	PF00082	0.498
CLV_PCSK_KEX2_1	187	189	PF00082	0.336
CLV_PCSK_KEX2_1	2	4	PF00082	0.588
CLV_PCSK_KEX2_1	40	42	PF00082	0.584
CLV_PCSK_KEX2_1	98	100	PF00082	0.393
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.150
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.329
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.678
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.396
CLV_PCSK_SKI1_1	112	116	PF00082	0.280
CLV_PCSK_SKI1_1	12	16	PF00082	0.544
CLV_PCSK_SKI1_1	294	298	PF00082	0.516
CLV_PCSK_SKI1_1	98	102	PF00082	0.337
DEG_APCC_DBOX_1	111	119	PF00400	0.297
DEG_APCC_DBOX_1	25	33	PF00400	0.634
DEG_APCC_DBOX_1	293	301	PF00400	0.470
DEG_Nend_UBRbox_1	1	4	PF02207	0.580
DEG_SPOP_SBC_1	247	251	PF00917	0.374
DOC_CYCLIN_RxL_1	96	105	PF00134	0.340
DOC_MAPK_gen_1	186	194	PF00069	0.297
DOC_MAPK_MEF2A_6	217	226	PF00069	0.297
DOC_PP1_RVXF_1	96	103	PF00149	0.311
DOC_PP2B_LxvP_1	35	38	PF13499	0.666
DOC_USP7_MATH_1	110	114	PF00917	0.348
DOC_USP7_MATH_1	211	215	PF00917	0.369
DOC_USP7_MATH_1	245	249	PF00917	0.358
DOC_WW_Pin1_4	268	273	PF00397	0.741
DOC_WW_Pin1_4	324	329	PF00397	0.770
LIG_14-3-3_CanoR_1	186	195	PF00244	0.419
LIG_14-3-3_CanoR_1	257	261	PF00244	0.459
LIG_14-3-3_CanoR_1	262	272	PF00244	0.684
LIG_14-3-3_CanoR_1	340	349	PF00244	0.558
LIG_14-3-3_CanoR_1	62	69	PF00244	0.676
LIG_14-3-3_CterR_2	355	357	PF00244	0.661
LIG_Actin_WH2_2	138	156	PF00022	0.355
LIG_BRCT_BRCA1_1	83	87	PF00533	0.512
LIG_deltaCOP1_diTrp_1	89	94	PF00928	0.357
LIG_FHA_1	136	142	PF00498	0.279
LIG_FHA_1	211	217	PF00498	0.400
LIG_FHA_1	274	280	PF00498	0.700
LIG_FHA_1	46	52	PF00498	0.683
LIG_FHA_1	72	78	PF00498	0.660
LIG_FHA_2	287	293	PF00498	0.519
LIG_Integrin_RGD_1	317	319	PF01839	0.552
LIG_LIR_Gen_1	93	102	PF02991	0.360
LIG_LIR_Nem_3	93	97	PF02991	0.282
LIG_Pex14_2	228	232	PF04695	0.279
LIG_Pex14_2	83	87	PF04695	0.399
LIG_SH2_SRC	134	137	PF00017	0.279
LIG_SH2_STAT3	240	243	PF00017	0.491
LIG_SH2_STAT5	134	137	PF00017	0.297
LIG_SH2_STAT5	240	243	PF00017	0.515
LIG_SH3_3	325	331	PF00018	0.575
MOD_CDK_SPxxK_3	268	275	PF00069	0.477
MOD_CK1_1	176	182	PF00069	0.410
MOD_CK1_1	248	254	PF00069	0.468
MOD_CK1_1	268	274	PF00069	0.671
MOD_CK1_1	323	329	PF00069	0.615
MOD_CK1_1	344	350	PF00069	0.621
MOD_CK1_1	4	10	PF00069	0.555
MOD_CK1_1	57	63	PF00069	0.660
MOD_CK2_1	110	116	PF00069	0.454
MOD_CK2_1	55	61	PF00069	0.570
MOD_CMANNOS	91	94	PF00535	0.279
MOD_GlcNHglycan	103	107	PF01048	0.298
MOD_GlcNHglycan	112	115	PF01048	0.360
MOD_GlcNHglycan	178	181	PF01048	0.410
MOD_GlcNHglycan	250	253	PF01048	0.603
MOD_GlcNHglycan	26	29	PF01048	0.689
MOD_GlcNHglycan	265	268	PF01048	0.708
MOD_GlcNHglycan	276	279	PF01048	0.671
MOD_GlcNHglycan	322	325	PF01048	0.711
MOD_GSK3_1	261	268	PF00069	0.507
MOD_GSK3_1	320	327	PF00069	0.634
MOD_GSK3_1	341	348	PF00069	0.686
MOD_GSK3_1	45	52	PF00069	0.628
MOD_GSK3_1	57	64	PF00069	0.650
MOD_GSK3_1	67	74	PF00069	0.697
MOD_N-GLC_1	341	346	PF02516	0.498
MOD_NEK2_1	1	6	PF00069	0.648
MOD_NEK2_1	102	107	PF00069	0.291
MOD_NEK2_1	173	178	PF00069	0.322
MOD_NEK2_1	226	231	PF00069	0.403
MOD_NEK2_1	256	261	PF00069	0.540
MOD_NEK2_1	279	284	PF00069	0.627
MOD_NEK2_1	82	87	PF00069	0.386
MOD_PIKK_1	1	7	PF00454	0.498
MOD_PIKK_1	226	232	PF00454	0.355
MOD_PIKK_1	279	285	PF00454	0.486
MOD_PIKK_1	306	312	PF00454	0.516
MOD_PKA_1	187	193	PF00069	0.469
MOD_PKA_1	44	50	PF00069	0.550
MOD_PKA_2	1	7	PF00069	0.645
MOD_PKA_2	187	193	PF00069	0.469
MOD_PKA_2	256	262	PF00069	0.516
MOD_PKA_2	61	67	PF00069	0.761
MOD_Plk_1	55	61	PF00069	0.638
MOD_Plk_1	65	71	PF00069	0.443
MOD_Plk_2-3	299	305	PF00069	0.616
MOD_Plk_4	82	88	PF00069	0.388
MOD_ProDKin_1	268	274	PF00069	0.742
MOD_ProDKin_1	324	330	PF00069	0.771
MOD_SUMO_rev_2	90	100	PF00179	0.319
TRG_ER_diArg_1	1	3	PF00400	0.694
TRG_ER_diArg_1	10	12	PF00400	0.628
TRG_ER_diArg_1	121	124	PF00400	0.417
TRG_ER_diArg_1	18	20	PF00400	0.542
TRG_ER_diArg_1	185	188	PF00400	0.287
TRG_ER_diArg_1	201	204	PF00400	0.294
TRG_NES_CRM1_1	215	225	PF08389	0.279
TRG_NLS_MonoExtC_3	185	191	PF00514	0.322
TRG_Pf-PMV_PEXEL_1	294	299	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAG6	Leptomonas seymouri	57%	100%
A0A0S4JJ56	Bodo saltans	37%	100%
A0A1X0NFY0	Trypanosomatidae	44%	100%
A0A3Q8IA87	Leishmania donovani	72%	100%
A0A3R7K8F7	Trypanosoma rangeli	45%	100%
A4HWR8	Leishmania infantum	72%	100%
C9ZW55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	94%
E9AQH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QF01	Leishmania major	76%	100%