Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8D9_LEIBR

TriTrypDb:

LbrM.16.0130 , LBRM2903_160006500

Length:

866

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8D9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8D9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	434	438	PF00656	0.551
CLV_C14_Caspase3-7	548	552	PF00656	0.572
CLV_C14_Caspase3-7	57	61	PF00656	0.456
CLV_C14_Caspase3-7	610	614	PF00656	0.518
CLV_NRD_NRD_1	197	199	PF00675	0.485
CLV_NRD_NRD_1	368	370	PF00675	0.492
CLV_NRD_NRD_1	397	399	PF00675	0.536
CLV_NRD_NRD_1	461	463	PF00675	0.433
CLV_NRD_NRD_1	575	577	PF00675	0.599
CLV_NRD_NRD_1	581	583	PF00675	0.516
CLV_NRD_NRD_1	624	626	PF00675	0.647
CLV_NRD_NRD_1	683	685	PF00675	0.473
CLV_NRD_NRD_1	83	85	PF00675	0.510
CLV_NRD_NRD_1	855	857	PF00675	0.564
CLV_PCSK_KEX2_1	163	165	PF00082	0.438
CLV_PCSK_KEX2_1	368	370	PF00082	0.485
CLV_PCSK_KEX2_1	397	399	PF00082	0.536
CLV_PCSK_KEX2_1	461	463	PF00082	0.529
CLV_PCSK_KEX2_1	581	583	PF00082	0.526
CLV_PCSK_KEX2_1	624	626	PF00082	0.510
CLV_PCSK_KEX2_1	683	685	PF00082	0.393
CLV_PCSK_KEX2_1	83	85	PF00082	0.517
CLV_PCSK_KEX2_1	855	857	PF00082	0.564
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.421
CLV_PCSK_PC7_1	851	857	PF00082	0.340
CLV_PCSK_SKI1_1	350	354	PF00082	0.458
CLV_PCSK_SKI1_1	368	372	PF00082	0.485
CLV_PCSK_SKI1_1	412	416	PF00082	0.427
CLV_PCSK_SKI1_1	493	497	PF00082	0.370
CLV_PCSK_SKI1_1	589	593	PF00082	0.468
CLV_PCSK_SKI1_1	639	643	PF00082	0.390
CLV_PCSK_SKI1_1	655	659	PF00082	0.414
CLV_PCSK_SKI1_1	660	664	PF00082	0.393
CLV_PCSK_SKI1_1	691	695	PF00082	0.456
CLV_PCSK_SKI1_1	773	777	PF00082	0.290
CLV_Separin_Metazoa	852	856	PF03568	0.588
DEG_APCC_DBOX_1	654	662	PF00400	0.411
DEG_APCC_DBOX_1	690	698	PF00400	0.496
DEG_SCF_FBW7_1	511	518	PF00400	0.545
DOC_ANK_TNKS_1	623	630	PF00023	0.499
DOC_ANK_TNKS_1	85	92	PF00023	0.678
DOC_CDC14_PxL_1	13	21	PF14671	0.460
DOC_CYCLIN_RxL_1	161	172	PF00134	0.579
DOC_CYCLIN_yClb5_NLxxxL_5	315	324	PF00134	0.274
DOC_MAPK_DCC_7	524	533	PF00069	0.632
DOC_MAPK_gen_1	161	170	PF00069	0.504
DOC_MAPK_gen_1	28	38	PF00069	0.479
DOC_MAPK_MEF2A_6	28	36	PF00069	0.481
DOC_MAPK_RevD_3	354	369	PF00069	0.295
DOC_PP1_RVXF_1	48	55	PF00149	0.434
DOC_PP2B_LxvP_1	697	700	PF13499	0.547
DOC_PP4_FxxP_1	5	8	PF00568	0.451
DOC_PP4_FxxP_1	758	761	PF00568	0.627
DOC_USP7_MATH_1	118	122	PF00917	0.386
DOC_USP7_MATH_1	231	235	PF00917	0.750
DOC_USP7_MATH_1	32	36	PF00917	0.751
DOC_USP7_MATH_1	373	377	PF00917	0.562
DOC_USP7_MATH_1	515	519	PF00917	0.683
DOC_USP7_MATH_1	546	550	PF00917	0.603
DOC_USP7_MATH_1	761	765	PF00917	0.691
DOC_USP7_MATH_1	777	781	PF00917	0.424
DOC_USP7_MATH_1	95	99	PF00917	0.683
DOC_USP7_MATH_2	515	521	PF00917	0.549
DOC_WW_Pin1_4	262	267	PF00397	0.496
DOC_WW_Pin1_4	302	307	PF00397	0.319
DOC_WW_Pin1_4	496	501	PF00397	0.607
DOC_WW_Pin1_4	511	516	PF00397	0.547
DOC_WW_Pin1_4	591	596	PF00397	0.463
DOC_WW_Pin1_4	757	762	PF00397	0.740
DOC_WW_Pin1_4	856	861	PF00397	0.405
LIG_14-3-3_CanoR_1	11	17	PF00244	0.677
LIG_14-3-3_CanoR_1	114	122	PF00244	0.434
LIG_14-3-3_CanoR_1	134	141	PF00244	0.485
LIG_14-3-3_CanoR_1	164	169	PF00244	0.496
LIG_14-3-3_CanoR_1	173	181	PF00244	0.465
LIG_14-3-3_CanoR_1	31	37	PF00244	0.704
LIG_14-3-3_CanoR_1	325	335	PF00244	0.349
LIG_14-3-3_CanoR_1	402	409	PF00244	0.469
LIG_14-3-3_CanoR_1	428	433	PF00244	0.499
LIG_14-3-3_CanoR_1	50	55	PF00244	0.392
LIG_14-3-3_CanoR_1	503	509	PF00244	0.515
LIG_14-3-3_CanoR_1	589	597	PF00244	0.488
LIG_14-3-3_CanoR_1	624	628	PF00244	0.641
LIG_14-3-3_CanoR_1	646	650	PF00244	0.470
LIG_14-3-3_CanoR_1	99	105	PF00244	0.575
LIG_Actin_WH2_2	281	298	PF00022	0.459
LIG_BRCT_BRCA1_1	410	414	PF00533	0.317
LIG_CaM_IQ_9	286	301	PF13499	0.304
LIG_Clathr_ClatBox_1	617	621	PF01394	0.639
LIG_deltaCOP1_diTrp_1	46	54	PF00928	0.435
LIG_eIF4E_1	16	22	PF01652	0.468
LIG_FHA_1	165	171	PF00498	0.622
LIG_FHA_1	315	321	PF00498	0.504
LIG_FHA_1	334	340	PF00498	0.390
LIG_FHA_1	39	45	PF00498	0.720
LIG_FHA_1	487	493	PF00498	0.424
LIG_FHA_1	503	509	PF00498	0.561
LIG_FHA_1	558	564	PF00498	0.482
LIG_FHA_1	570	576	PF00498	0.512
LIG_FHA_1	789	795	PF00498	0.549
LIG_FHA_2	373	379	PF00498	0.519
LIG_FHA_2	471	477	PF00498	0.331
LIG_FHA_2	512	518	PF00498	0.756
LIG_FHA_2	714	720	PF00498	0.419
LIG_FHA_2	818	824	PF00498	0.336
LIG_GBD_Chelix_1	808	816	PF00786	0.449
LIG_HP1_1	32	36	PF01393	0.479
LIG_LIR_Apic_2	3	8	PF02991	0.450
LIG_LIR_Apic_2	446	450	PF02991	0.510
LIG_LIR_Gen_1	152	162	PF02991	0.353
LIG_LIR_Gen_1	241	252	PF02991	0.653
LIG_LIR_Gen_1	351	361	PF02991	0.529
LIG_LIR_Gen_1	551	562	PF02991	0.488
LIG_LIR_Nem_3	15	19	PF02991	0.713
LIG_LIR_Nem_3	152	157	PF02991	0.348
LIG_LIR_Nem_3	241	247	PF02991	0.666
LIG_LIR_Nem_3	351	356	PF02991	0.503
LIG_LIR_Nem_3	411	417	PF02991	0.481
LIG_LIR_Nem_3	46	52	PF02991	0.556
LIG_LIR_Nem_3	551	557	PF02991	0.499
LIG_LIR_Nem_3	648	652	PF02991	0.531
LIG_LIR_Nem_3	681	685	PF02991	0.372
LIG_LIR_Nem_3	720	726	PF02991	0.398
LIG_LIR_Nem_3	741	746	PF02991	0.540
LIG_LIR_Nem_3	830	835	PF02991	0.540
LIG_LYPXL_yS_3	16	19	PF13949	0.462
LIG_MYND_3	699	703	PF01753	0.505
LIG_NRBOX	18	24	PF00104	0.475
LIG_NRBOX	258	264	PF00104	0.419
LIG_NRBOX	383	389	PF00104	0.355
LIG_NRBOX	637	643	PF00104	0.396
LIG_PDZ_Class_2	861	866	PF00595	0.698
LIG_RPA_C_Fungi	801	813	PF08784	0.529
LIG_RPA_C_Fungi	94	106	PF08784	0.459
LIG_SH2_CRK	585	589	PF00017	0.296
LIG_SH2_CRK	649	653	PF00017	0.557
LIG_SH2_CRK	726	730	PF00017	0.462
LIG_SH2_PTP2	554	557	PF00017	0.289
LIG_SH2_STAP1	122	126	PF00017	0.623
LIG_SH2_STAT3	487	490	PF00017	0.555
LIG_SH2_STAT5	111	114	PF00017	0.430
LIG_SH2_STAT5	417	420	PF00017	0.470
LIG_SH2_STAT5	487	490	PF00017	0.550
LIG_SH2_STAT5	554	557	PF00017	0.432
LIG_SH2_STAT5	72	75	PF00017	0.703
LIG_SH2_STAT5	785	788	PF00017	0.518
LIG_SH3_1	524	530	PF00018	0.456
LIG_SH3_3	137	143	PF00018	0.579
LIG_SH3_3	524	530	PF00018	0.534
LIG_SH3_3	539	545	PF00018	0.503
LIG_SH3_3	790	796	PF00018	0.560
LIG_SH3_3	816	822	PF00018	0.567
LIG_SH3_CIN85_PxpxPR_1	757	762	PF14604	0.503
LIG_SUMO_SIM_anti_2	167	172	PF11976	0.619
LIG_SUMO_SIM_anti_2	18	23	PF11976	0.575
LIG_SUMO_SIM_par_1	165	172	PF11976	0.621
LIG_SUMO_SIM_par_1	32	37	PF11976	0.477
LIG_SUMO_SIM_par_1	382	389	PF11976	0.463
LIG_SUMO_SIM_par_1	640	645	PF11976	0.369
LIG_TRAF2_1	204	207	PF00917	0.742
LIG_TRAF2_1	248	251	PF00917	0.507
LIG_TRAF2_1	443	446	PF00917	0.644
LIG_TRAF2_1	514	517	PF00917	0.549
LIG_TRAF2_1	787	790	PF00917	0.508
LIG_TRFH_1	597	601	PF08558	0.539
LIG_TYR_ITIM	583	588	PF00017	0.287
LIG_TYR_ITIM	647	652	PF00017	0.547
LIG_WRC_WIRS_1	51	56	PF05994	0.561
MOD_CDC14_SPxK_1	859	862	PF00782	0.434
MOD_CDK_SPK_2	262	267	PF00069	0.528
MOD_CDK_SPK_2	757	762	PF00069	0.711
MOD_CDK_SPxK_1	856	862	PF00069	0.411
MOD_CDK_SPxxK_3	496	503	PF00069	0.361
MOD_CK1_1	225	231	PF00069	0.686
MOD_CK1_1	234	240	PF00069	0.746
MOD_CK1_1	245	251	PF00069	0.447
MOD_CK1_1	337	343	PF00069	0.648
MOD_CK1_1	389	395	PF00069	0.522
MOD_CK1_1	472	478	PF00069	0.317
MOD_CK1_1	645	651	PF00069	0.499
MOD_CK1_1	711	717	PF00069	0.532
MOD_CK1_1	765	771	PF00069	0.537
MOD_CK1_1	780	786	PF00069	0.332
MOD_CK1_1	801	807	PF00069	0.477
MOD_CK1_1	817	823	PF00069	0.549
MOD_CK1_1	97	103	PF00069	0.628
MOD_CK2_1	166	172	PF00069	0.457
MOD_CK2_1	245	251	PF00069	0.622
MOD_CK2_1	34	40	PF00069	0.468
MOD_CK2_1	360	366	PF00069	0.458
MOD_CK2_1	372	378	PF00069	0.534
MOD_CK2_1	428	434	PF00069	0.538
MOD_CK2_1	472	478	PF00069	0.570
MOD_CK2_1	511	517	PF00069	0.666
MOD_CK2_1	713	719	PF00069	0.436
MOD_CK2_1	757	763	PF00069	0.578
MOD_CK2_1	835	841	PF00069	0.561
MOD_Cter_Amidation	196	199	PF01082	0.473
MOD_Cter_Amidation	366	369	PF01082	0.451
MOD_GlcNHglycan	101	104	PF01048	0.643
MOD_GlcNHglycan	116	119	PF01048	0.397
MOD_GlcNHglycan	135	138	PF01048	0.499
MOD_GlcNHglycan	206	210	PF01048	0.671
MOD_GlcNHglycan	233	236	PF01048	0.629
MOD_GlcNHglycan	237	240	PF01048	0.605
MOD_GlcNHglycan	243	247	PF01048	0.551
MOD_GlcNHglycan	328	331	PF01048	0.329
MOD_GlcNHglycan	375	378	PF01048	0.586
MOD_GlcNHglycan	421	424	PF01048	0.424
MOD_GlcNHglycan	440	444	PF01048	0.445
MOD_GlcNHglycan	548	551	PF01048	0.485
MOD_GlcNHglycan	56	59	PF01048	0.704
MOD_GlcNHglycan	578	581	PF01048	0.447
MOD_GlcNHglycan	632	635	PF01048	0.624
MOD_GlcNHglycan	763	767	PF01048	0.610
MOD_GlcNHglycan	827	830	PF01048	0.506
MOD_GSK3_1	114	121	PF00069	0.508
MOD_GSK3_1	145	152	PF00069	0.457
MOD_GSK3_1	162	169	PF00069	0.464
MOD_GSK3_1	219	226	PF00069	0.568
MOD_GSK3_1	231	238	PF00069	0.730
MOD_GSK3_1	32	39	PF00069	0.583
MOD_GSK3_1	333	340	PF00069	0.669
MOD_GSK3_1	369	376	PF00069	0.555
MOD_GSK3_1	50	57	PF00069	0.482
MOD_GSK3_1	502	509	PF00069	0.458
MOD_GSK3_1	511	518	PF00069	0.542
MOD_GSK3_1	565	572	PF00069	0.510
MOD_GSK3_1	713	720	PF00069	0.442
MOD_GSK3_1	757	764	PF00069	0.623
MOD_GSK3_1	794	801	PF00069	0.561
MOD_GSK3_1	817	824	PF00069	0.470
MOD_GSK3_1	835	842	PF00069	0.588
MOD_GSK3_1	858	865	PF00069	0.477
MOD_GSK3_1	94	101	PF00069	0.728
MOD_N-GLC_1	270	275	PF02516	0.579
MOD_N-GLC_1	337	342	PF02516	0.467
MOD_NEK2_1	133	138	PF00069	0.568
MOD_NEK2_1	205	210	PF00069	0.692
MOD_NEK2_1	219	224	PF00069	0.460
MOD_NEK2_1	284	289	PF00069	0.534
MOD_NEK2_1	300	305	PF00069	0.349
MOD_NEK2_1	314	319	PF00069	0.383
MOD_NEK2_1	323	328	PF00069	0.419
MOD_NEK2_1	38	43	PF00069	0.681
MOD_NEK2_1	491	496	PF00069	0.534
MOD_NEK2_1	52	57	PF00069	0.454
MOD_NEK2_1	533	538	PF00069	0.560
MOD_NEK2_1	565	570	PF00069	0.480
MOD_NEK2_1	623	628	PF00069	0.699
MOD_NEK2_1	642	647	PF00069	0.361
MOD_NEK2_1	835	840	PF00069	0.524
MOD_NEK2_1	845	850	PF00069	0.322
MOD_NEK2_2	270	275	PF00069	0.497
MOD_NEK2_2	456	461	PF00069	0.533
MOD_NEK2_2	58	63	PF00069	0.462
MOD_NEK2_2	738	743	PF00069	0.540
MOD_PIKK_1	120	126	PF00454	0.582
MOD_PIKK_1	486	492	PF00454	0.546
MOD_PIKK_1	517	523	PF00454	0.692
MOD_PK_1	428	434	PF00069	0.395
MOD_PKA_1	576	582	PF00069	0.336
MOD_PKA_2	133	139	PF00069	0.575
MOD_PKA_2	401	407	PF00069	0.515
MOD_PKA_2	502	508	PF00069	0.499
MOD_PKA_2	623	629	PF00069	0.635
MOD_PKA_2	645	651	PF00069	0.494
MOD_PKA_2	761	767	PF00069	0.615
MOD_PKA_2	98	104	PF00069	0.576
MOD_PKB_1	164	172	PF00069	0.369
MOD_PKB_1	426	434	PF00069	0.388
MOD_Plk_1	118	124	PF00069	0.594
MOD_Plk_1	242	248	PF00069	0.433
MOD_Plk_1	270	276	PF00069	0.591
MOD_Plk_1	300	306	PF00069	0.327
MOD_Plk_1	377	383	PF00069	0.500
MOD_Plk_1	439	445	PF00069	0.649
MOD_Plk_1	711	717	PF00069	0.585
MOD_Plk_2-3	401	407	PF00069	0.387
MOD_Plk_2-3	713	719	PF00069	0.578
MOD_Plk_4	166	172	PF00069	0.475
MOD_Plk_4	17	23	PF00069	0.630
MOD_Plk_4	284	290	PF00069	0.533
MOD_Plk_4	360	366	PF00069	0.495
MOD_Plk_4	410	416	PF00069	0.564
MOD_Plk_4	648	654	PF00069	0.525
MOD_Plk_4	713	719	PF00069	0.493
MOD_Plk_4	738	744	PF00069	0.538
MOD_Plk_4	798	804	PF00069	0.431
MOD_Plk_4	821	827	PF00069	0.428
MOD_ProDKin_1	262	268	PF00069	0.496
MOD_ProDKin_1	302	308	PF00069	0.316
MOD_ProDKin_1	496	502	PF00069	0.607
MOD_ProDKin_1	511	517	PF00069	0.550
MOD_ProDKin_1	591	597	PF00069	0.468
MOD_ProDKin_1	757	763	PF00069	0.741
MOD_ProDKin_1	856	862	PF00069	0.411
MOD_SUMO_rev_2	153	162	PF00179	0.496
MOD_SUMO_rev_2	768	778	PF00179	0.327
TRG_DiLeu_BaEn_4	789	795	PF01217	0.462
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.484
TRG_ENDOCYTIC_2	16	19	PF00928	0.716
TRG_ENDOCYTIC_2	292	295	PF00928	0.494
TRG_ENDOCYTIC_2	554	557	PF00928	0.487
TRG_ENDOCYTIC_2	585	588	PF00928	0.533
TRG_ENDOCYTIC_2	649	652	PF00928	0.548
TRG_ENDOCYTIC_2	726	729	PF00928	0.469
TRG_ER_diArg_1	274	277	PF00400	0.550
TRG_ER_diArg_1	368	370	PF00400	0.488
TRG_ER_diArg_1	396	398	PF00400	0.575
TRG_ER_diArg_1	460	462	PF00400	0.304
TRG_ER_diArg_1	510	513	PF00400	0.614
TRG_ER_diArg_1	581	583	PF00400	0.526
TRG_ER_diArg_1	623	625	PF00400	0.507
TRG_ER_diArg_1	682	684	PF00400	0.477
TRG_ER_diArg_1	82	84	PF00400	0.508
TRG_ER_diArg_1	854	856	PF00400	0.536
TRG_NLS_MonoExtN_4	161	167	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	198	203	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	806	810	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Y7	Leptomonas seymouri	43%	100%
A0A1X0NZ28	Trypanosomatidae	28%	100%
A0A3R7M3M3	Trypanosoma rangeli	28%	100%
A0A3S7WTS3	Leishmania donovani	72%	100%
A4HWR1	Leishmania infantum	72%	100%
C9ZPS0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AQG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QF08	Leishmania major	72%	99%