APH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphotransferase enzyme family, putative

Species:

Leishmania braziliensis

UniProt:

A4H8D8_LEIBR

TriTrypDb:

LbrM.16.0120 , LBRM2903_160006400

Length:

826

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8D8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006635	fatty acid beta-oxidation	6	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009062	fatty acid catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0016042	lipid catabolic process	4	1
GO:0016054	organic acid catabolic process	4	1
GO:0019395	fatty acid oxidation	5	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030258	lipid modification	4	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	7	1
GO:0034440	lipid oxidation	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046395	carboxylic acid catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072329	monocarboxylic acid catabolic process	6	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0003995	acyl-CoA dehydrogenase activity	5	1
GO:0016491	oxidoreductase activity	2	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0052890	oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor	4	1
GO:0016740	transferase activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.388
CLV_C14_Caspase3-7	208	212	PF00656	0.673
CLV_C14_Caspase3-7	358	362	PF00656	0.594
CLV_NRD_NRD_1	124	126	PF00675	0.473
CLV_NRD_NRD_1	164	166	PF00675	0.509
CLV_NRD_NRD_1	199	201	PF00675	0.671
CLV_NRD_NRD_1	24	26	PF00675	0.482
CLV_NRD_NRD_1	253	255	PF00675	0.581
CLV_NRD_NRD_1	491	493	PF00675	0.442
CLV_NRD_NRD_1	524	526	PF00675	0.369
CLV_NRD_NRD_1	529	531	PF00675	0.327
CLV_NRD_NRD_1	549	551	PF00675	0.150
CLV_NRD_NRD_1	596	598	PF00675	0.447
CLV_NRD_NRD_1	760	762	PF00675	0.467
CLV_PCSK_FUR_1	547	551	PF00082	0.493
CLV_PCSK_FUR_1	597	601	PF00082	0.480
CLV_PCSK_KEX2_1	132	134	PF00082	0.482
CLV_PCSK_KEX2_1	199	201	PF00082	0.671
CLV_PCSK_KEX2_1	24	26	PF00082	0.482
CLV_PCSK_KEX2_1	253	255	PF00082	0.581
CLV_PCSK_KEX2_1	45	47	PF00082	0.655
CLV_PCSK_KEX2_1	491	493	PF00082	0.408
CLV_PCSK_KEX2_1	524	526	PF00082	0.369
CLV_PCSK_KEX2_1	529	531	PF00082	0.327
CLV_PCSK_KEX2_1	549	551	PF00082	0.150
CLV_PCSK_KEX2_1	596	598	PF00082	0.447
CLV_PCSK_KEX2_1	599	601	PF00082	0.447
CLV_PCSK_KEX2_1	617	619	PF00082	0.349
CLV_PCSK_KEX2_1	760	762	PF00082	0.429
CLV_PCSK_KEX2_1	796	798	PF00082	0.718
CLV_PCSK_KEX2_1	812	814	PF00082	0.537
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.482
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.581
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.655
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.449
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.227
CLV_PCSK_PC1ET2_1	796	798	PF00082	0.713
CLV_PCSK_PC1ET2_1	812	814	PF00082	0.536
CLV_PCSK_PC7_1	525	531	PF00082	0.355
CLV_PCSK_SKI1_1	102	106	PF00082	0.400
CLV_PCSK_SKI1_1	166	170	PF00082	0.394
CLV_PCSK_SKI1_1	200	204	PF00082	0.667
CLV_PCSK_SKI1_1	32	36	PF00082	0.319
CLV_PCSK_SKI1_1	327	331	PF00082	0.599
CLV_PCSK_SKI1_1	410	414	PF00082	0.463
CLV_PCSK_SKI1_1	524	528	PF00082	0.415
CLV_PCSK_SKI1_1	617	621	PF00082	0.447
CLV_PCSK_SKI1_1	643	647	PF00082	0.377
CLV_PCSK_SKI1_1	664	668	PF00082	0.314
CLV_PCSK_SKI1_1	735	739	PF00082	0.334
CLV_PCSK_SKI1_1	74	78	PF00082	0.491
CLV_Separin_Metazoa	310	314	PF03568	0.374
DEG_APCC_DBOX_1	101	109	PF00400	0.200
DEG_APCC_DBOX_1	81	89	PF00400	0.539
DEG_SPOP_SBC_1	14	18	PF00917	0.545
DOC_ANK_TNKS_1	183	190	PF00023	0.657
DOC_CKS1_1	509	514	PF01111	0.480
DOC_CKS1_1	728	733	PF01111	0.412
DOC_CYCLIN_yClb1_LxF_4	88	93	PF00134	0.593
DOC_CYCLIN_yCln2_LP_2	425	431	PF00134	0.360
DOC_MAPK_gen_1	165	171	PF00069	0.515
DOC_MAPK_gen_1	176	185	PF00069	0.516
DOC_MAPK_HePTP_8	250	262	PF00069	0.651
DOC_MAPK_MEF2A_6	253	262	PF00069	0.605
DOC_MAPK_MEF2A_6	556	563	PF00069	0.357
DOC_MAPK_MEF2A_6	599	608	PF00069	0.411
DOC_MAPK_MEF2A_6	704	712	PF00069	0.440
DOC_PP1_RVXF_1	408	414	PF00149	0.466
DOC_PP1_RVXF_1	733	739	PF00149	0.321
DOC_PP1_RVXF_1	88	94	PF00149	0.516
DOC_PP2B_LxvP_1	425	428	PF13499	0.491
DOC_PP2B_LxvP_1	507	510	PF13499	0.385
DOC_PP4_FxxP_1	381	384	PF00568	0.637
DOC_PP4_FxxP_1	738	741	PF00568	0.389
DOC_SPAK_OSR1_1	628	632	PF12202	0.447
DOC_USP7_MATH_1	484	488	PF00917	0.451
DOC_USP7_MATH_1	739	743	PF00917	0.489
DOC_USP7_MATH_2	386	392	PF00917	0.559
DOC_USP7_UBL2_3	566	570	PF12436	0.480
DOC_WW_Pin1_4	15	20	PF00397	0.542
DOC_WW_Pin1_4	160	165	PF00397	0.494
DOC_WW_Pin1_4	303	308	PF00397	0.412
DOC_WW_Pin1_4	356	361	PF00397	0.642
DOC_WW_Pin1_4	480	485	PF00397	0.408
DOC_WW_Pin1_4	501	506	PF00397	0.447
DOC_WW_Pin1_4	508	513	PF00397	0.447
DOC_WW_Pin1_4	579	584	PF00397	0.480
DOC_WW_Pin1_4	727	732	PF00397	0.436
DOC_WW_Pin1_4	737	742	PF00397	0.398
DOC_WW_Pin1_4	789	794	PF00397	0.701
LIG_14-3-3_CanoR_1	176	185	PF00244	0.497
LIG_14-3-3_CanoR_1	206	210	PF00244	0.628
LIG_14-3-3_CanoR_1	327	333	PF00244	0.429
LIG_14-3-3_CanoR_1	355	360	PF00244	0.443
LIG_14-3-3_CanoR_1	37	44	PF00244	0.586
LIG_14-3-3_CanoR_1	465	469	PF00244	0.335
LIG_14-3-3_CanoR_1	549	555	PF00244	0.358
LIG_14-3-3_CanoR_1	664	669	PF00244	0.227
LIG_14-3-3_CanoR_1	74	83	PF00244	0.477
LIG_14-3-3_CanoR_1	778	782	PF00244	0.404
LIG_14-3-3_CanoR_1	797	804	PF00244	0.627
LIG_AP2alpha_2	336	338	PF02296	0.493
LIG_BRCT_BRCA1_1	457	461	PF00533	0.578
LIG_BRCT_BRCA1_1	59	63	PF00533	0.378
LIG_BRCT_BRCA1_1	625	629	PF00533	0.301
LIG_BRCT_BRCA1_1	675	679	PF00533	0.442
LIG_Clathr_ClatBox_1	149	153	PF01394	0.532
LIG_eIF4E_1	375	381	PF01652	0.603
LIG_EVH1_2	583	587	PF00568	0.289
LIG_FHA_1	208	214	PF00498	0.671
LIG_FHA_1	307	313	PF00498	0.594
LIG_FHA_1	363	369	PF00498	0.592
LIG_FHA_1	509	515	PF00498	0.461
LIG_FHA_1	71	77	PF00498	0.446
LIG_FHA_1	778	784	PF00498	0.506
LIG_FHA_2	329	335	PF00498	0.562
LIG_FHA_2	356	362	PF00498	0.663
LIG_FHA_2	728	734	PF00498	0.525
LIG_LIR_Apic_2	725	731	PF02991	0.406
LIG_LIR_Gen_1	100	108	PF02991	0.473
LIG_LIR_Gen_1	306	314	PF02991	0.372
LIG_LIR_Gen_1	336	346	PF02991	0.502
LIG_LIR_Gen_1	493	500	PF02991	0.334
LIG_LIR_Gen_1	78	88	PF02991	0.575
LIG_LIR_Nem_3	100	106	PF02991	0.459
LIG_LIR_Nem_3	214	220	PF02991	0.574
LIG_LIR_Nem_3	239	245	PF02991	0.629
LIG_LIR_Nem_3	306	311	PF02991	0.419
LIG_LIR_Nem_3	320	325	PF02991	0.529
LIG_LIR_Nem_3	336	342	PF02991	0.403
LIG_LIR_Nem_3	458	464	PF02991	0.546
LIG_LIR_Nem_3	483	488	PF02991	0.292
LIG_LIR_Nem_3	60	66	PF02991	0.379
LIG_LIR_Nem_3	614	619	PF02991	0.301
LIG_LIR_Nem_3	765	770	PF02991	0.356
LIG_LIR_Nem_3	78	83	PF02991	0.449
LIG_LYPXL_yS_3	217	220	PF13949	0.714
LIG_LYPXL_yS_3	257	260	PF13949	0.645
LIG_MLH1_MIPbox_1	457	461	PF16413	0.578
LIG_MLH1_MIPbox_1	59	63	PF16413	0.421
LIG_MYND_1	420	424	PF01753	0.448
LIG_MYND_2	691	695	PF01753	0.441
LIG_PCNA_yPIPBox_3	664	678	PF02747	0.480
LIG_Pex14_2	93	97	PF04695	0.454
LIG_PTB_Apo_2	58	65	PF02174	0.496
LIG_Rb_pABgroove_1	236	244	PF01858	0.561
LIG_REV1ctd_RIR_1	524	534	PF16727	0.411
LIG_SH2_CRK	322	326	PF00017	0.336
LIG_SH2_CRK	616	620	PF00017	0.237
LIG_SH2_CRK	728	732	PF00017	0.372
LIG_SH2_GRB2like	232	235	PF00017	0.689
LIG_SH2_GRB2like	59	62	PF00017	0.398
LIG_SH2_SRC	232	235	PF00017	0.689
LIG_SH2_SRC	454	457	PF00017	0.599
LIG_SH2_STAP1	494	498	PF00017	0.447
LIG_SH2_STAP1	59	63	PF00017	0.377
LIG_SH2_STAT3	194	197	PF00017	0.441
LIG_SH2_STAT3	281	284	PF00017	0.387
LIG_SH2_STAT3	414	417	PF00017	0.409
LIG_SH2_STAT3	552	555	PF00017	0.227
LIG_SH2_STAT5	174	177	PF00017	0.520
LIG_SH2_STAT5	245	248	PF00017	0.566
LIG_SH2_STAT5	249	252	PF00017	0.562
LIG_SH2_STAT5	289	292	PF00017	0.588
LIG_SH2_STAT5	414	417	PF00017	0.401
LIG_SH2_STAT5	454	457	PF00017	0.599
LIG_SH2_STAT5	515	518	PF00017	0.381
LIG_SH2_STAT5	748	751	PF00017	0.384
LIG_SH2_STAT5	770	773	PF00017	0.353
LIG_SH3_1	301	307	PF00018	0.523
LIG_SH3_1	476	482	PF00018	0.355
LIG_SH3_3	216	222	PF00018	0.683
LIG_SH3_3	301	307	PF00018	0.523
LIG_SH3_3	425	431	PF00018	0.549
LIG_SH3_3	476	482	PF00018	0.355
LIG_SH3_3	580	586	PF00018	0.410
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.494
LIG_SUMO_SIM_par_1	104	109	PF11976	0.496
LIG_SUMO_SIM_par_1	148	153	PF11976	0.544
LIG_SUMO_SIM_par_1	707	714	PF11976	0.348
LIG_TRAF2_1	179	182	PF00917	0.487
LIG_TRAF2_1	264	267	PF00917	0.556
LIG_UBA3_1	104	110	PF00899	0.407
LIG_UBA3_1	171	178	PF00899	0.497
LIG_UBA3_1	422	426	PF00899	0.575
LIG_UBA3_1	694	701	PF00899	0.419
LIG_UBA3_1	717	722	PF00899	0.276
MOD_CDC14_SPxK_1	163	166	PF00782	0.543
MOD_CDK_SPK_2	160	165	PF00069	0.513
MOD_CDK_SPxK_1	160	166	PF00069	0.516
MOD_CDK_SPxxK_3	356	363	PF00069	0.660
MOD_CDK_SPxxK_3	789	796	PF00069	0.701
MOD_CK1_1	212	218	PF00069	0.573
MOD_CK1_1	248	254	PF00069	0.627
MOD_CK1_1	306	312	PF00069	0.497
MOD_CK1_1	328	334	PF00069	0.476
MOD_CK1_1	366	372	PF00069	0.668
MOD_CK1_1	392	398	PF00069	0.751
MOD_CK1_1	623	629	PF00069	0.227
MOD_CK2_1	176	182	PF00069	0.493
MOD_CK2_1	328	334	PF00069	0.553
MOD_CK2_1	618	624	PF00069	0.428
MOD_CK2_1	727	733	PF00069	0.452
MOD_CK2_1	75	81	PF00069	0.473
MOD_Cter_Amidation	522	525	PF01082	0.447
MOD_Cter_Amidation	794	797	PF01082	0.459
MOD_GlcNHglycan	214	217	PF01048	0.594
MOD_GlcNHglycan	445	448	PF01048	0.551
MOD_GlcNHglycan	576	579	PF01048	0.391
MOD_GlcNHglycan	624	628	PF01048	0.389
MOD_GlcNHglycan	634	637	PF01048	0.348
MOD_GlcNHglycan	713	716	PF01048	0.471
MOD_GlcNHglycan	749	752	PF01048	0.533
MOD_GlcNHglycan	77	80	PF01048	0.325
MOD_GlcNHglycan	787	790	PF01048	0.434
MOD_GSK3_1	205	212	PF00069	0.614
MOD_GSK3_1	228	235	PF00069	0.631
MOD_GSK3_1	321	328	PF00069	0.424
MOD_GSK3_1	362	369	PF00069	0.679
MOD_GSK3_1	388	395	PF00069	0.711
MOD_GSK3_1	460	467	PF00069	0.335
MOD_GSK3_1	480	487	PF00069	0.408
MOD_GSK3_1	618	625	PF00069	0.378
MOD_GSK3_1	673	680	PF00069	0.459
MOD_GSK3_1	777	784	PF00069	0.504
MOD_GSK3_1	785	792	PF00069	0.576
MOD_GSK3_1	796	803	PF00069	0.601
MOD_LATS_1	794	800	PF00433	0.698
MOD_N-GLC_1	538	543	PF02516	0.349
MOD_N-GLC_1	67	72	PF02516	0.472
MOD_N-GLC_1	672	677	PF02516	0.490
MOD_N-GLC_2	394	396	PF02516	0.499
MOD_NEK2_1	106	111	PF00069	0.464
MOD_NEK2_1	205	210	PF00069	0.598
MOD_NEK2_1	236	241	PF00069	0.610
MOD_NEK2_1	389	394	PF00069	0.454
MOD_NEK2_1	443	448	PF00069	0.547
MOD_NEK2_1	460	465	PF00069	0.319
MOD_NEK2_1	595	600	PF00069	0.420
MOD_NEK2_1	62	67	PF00069	0.445
MOD_NEK2_1	649	654	PF00069	0.351
MOD_NEK2_1	672	677	PF00069	0.359
MOD_NEK2_1	700	705	PF00069	0.384
MOD_NEK2_1	747	752	PF00069	0.480
MOD_NEK2_2	464	469	PF00069	0.335
MOD_OFUCOSY	390	396	PF10250	0.473
MOD_PIKK_1	176	182	PF00454	0.512
MOD_PIKK_1	436	442	PF00454	0.589
MOD_PIKK_1	538	544	PF00454	0.430
MOD_PIKK_1	649	655	PF00454	0.392
MOD_PKA_1	57	63	PF00069	0.469
MOD_PKA_1	796	802	PF00069	0.649
MOD_PKA_2	205	211	PF00069	0.522
MOD_PKA_2	354	360	PF00069	0.686
MOD_PKA_2	464	470	PF00069	0.335
MOD_PKA_2	555	561	PF00069	0.480
MOD_PKA_2	595	601	PF00069	0.428
MOD_PKA_2	777	783	PF00069	0.403
MOD_PKA_2	796	802	PF00069	0.649
MOD_Plk_1	538	544	PF00069	0.227
MOD_Plk_1	649	655	PF00069	0.355
MOD_Plk_1	672	678	PF00069	0.447
MOD_Plk_4	245	251	PF00069	0.591
MOD_Plk_4	363	369	PF00069	0.575
MOD_Plk_4	469	475	PF00069	0.319
MOD_Plk_4	673	679	PF00069	0.447
MOD_Plk_4	777	783	PF00069	0.501
MOD_ProDKin_1	15	21	PF00069	0.542
MOD_ProDKin_1	160	166	PF00069	0.497
MOD_ProDKin_1	303	309	PF00069	0.415
MOD_ProDKin_1	356	362	PF00069	0.643
MOD_ProDKin_1	480	486	PF00069	0.408
MOD_ProDKin_1	501	507	PF00069	0.447
MOD_ProDKin_1	508	514	PF00069	0.447
MOD_ProDKin_1	579	585	PF00069	0.480
MOD_ProDKin_1	727	733	PF00069	0.445
MOD_ProDKin_1	737	743	PF00069	0.400
MOD_ProDKin_1	789	795	PF00069	0.699
MOD_SUMO_rev_2	357	365	PF00179	0.453
MOD_SUMO_rev_2	432	437	PF00179	0.378
MOD_SUMO_rev_2	729	737	PF00179	0.418
TRG_DiLeu_BaEn_2	98	104	PF01217	0.535
TRG_DiLeu_BaEn_3	99	105	PF01217	0.525
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.450
TRG_DiLeu_BaLyEn_6	509	514	PF01217	0.480
TRG_DiLeu_BaLyEn_6	601	606	PF01217	0.408
TRG_ENDOCYTIC_2	198	201	PF00928	0.576
TRG_ENDOCYTIC_2	217	220	PF00928	0.589
TRG_ENDOCYTIC_2	257	260	PF00928	0.615
TRG_ENDOCYTIC_2	322	325	PF00928	0.469
TRG_ENDOCYTIC_2	485	488	PF00928	0.354
TRG_ENDOCYTIC_2	494	497	PF00928	0.335
TRG_ENDOCYTIC_2	59	62	PF00928	0.379
TRG_ENDOCYTIC_2	616	619	PF00928	0.229
TRG_ENDOCYTIC_2	764	767	PF00928	0.379
TRG_ER_diArg_1	198	200	PF00400	0.670
TRG_ER_diArg_1	24	26	PF00400	0.483
TRG_ER_diArg_1	490	492	PF00400	0.447
TRG_ER_diArg_1	524	526	PF00400	0.366
TRG_ER_diArg_1	528	530	PF00400	0.333
TRG_ER_diArg_1	546	549	PF00400	0.262
TRG_ER_diArg_1	595	597	PF00400	0.417
TRG_ER_diArg_1	760	763	PF00400	0.480
TRG_ER_diArg_1	818	821	PF00400	0.307
TRG_ER_FFAT_2	87	99	PF00635	0.596
TRG_NLS_MonoExtC_3	130	135	PF00514	0.486
TRG_NLS_MonoExtN_4	596	603	PF00514	0.447
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	802	806	PF00026	0.583
TRG_PTS1	823	826	PF00515	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM33	Leptomonas seymouri	75%	100%
A0A0S4JJA9	Bodo saltans	36%	94%
A0A1X0NZ43	Trypanosomatidae	49%	100%
A0A3S5H6W5	Leishmania donovani	89%	100%
A0A422MZZ3	Trypanosoma rangeli	49%	100%
A4HWR0	Leishmania infantum	89%	100%
E9AQG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QF09	Leishmania major	88%	100%
V5BFW1	Trypanosoma cruzi	49%	100%