MORN_repeat_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MORN repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4H8D7_LEIBR

TriTrypDb:

LbrM.16.0110 , LBRM2903_160006300

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4H8D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8D7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.408
CLV_C14_Caspase3-7	183	187	PF00656	0.537
CLV_C14_Caspase3-7	225	229	PF00656	0.573
CLV_C14_Caspase3-7	391	395	PF00656	0.660
CLV_C14_Caspase3-7	656	660	PF00656	0.700
CLV_NRD_NRD_1	379	381	PF00675	0.451
CLV_NRD_NRD_1	501	503	PF00675	0.459
CLV_NRD_NRD_1	552	554	PF00675	0.405
CLV_NRD_NRD_1	580	582	PF00675	0.534
CLV_NRD_NRD_1	618	620	PF00675	0.479
CLV_PCSK_FUR_1	550	554	PF00082	0.319
CLV_PCSK_KEX2_1	121	123	PF00082	0.566
CLV_PCSK_KEX2_1	379	381	PF00082	0.451
CLV_PCSK_KEX2_1	501	503	PF00082	0.459
CLV_PCSK_KEX2_1	552	554	PF00082	0.405
CLV_PCSK_KEX2_1	580	582	PF00082	0.706
CLV_PCSK_KEX2_1	618	620	PF00082	0.479
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.591
CLV_PCSK_SKI1_1	138	142	PF00082	0.640
CLV_PCSK_SKI1_1	162	166	PF00082	0.771
CLV_PCSK_SKI1_1	172	176	PF00082	0.727
CLV_PCSK_SKI1_1	231	235	PF00082	0.628
CLV_PCSK_SKI1_1	379	383	PF00082	0.454
CLV_PCSK_SKI1_1	420	424	PF00082	0.349
DEG_APCC_DBOX_1	330	338	PF00400	0.498
DEG_APCC_DBOX_1	340	348	PF00400	0.444
DEG_APCC_DBOX_1	419	427	PF00400	0.581
DEG_APCC_DBOX_1	486	494	PF00400	0.655
DEG_APCC_DBOX_1	621	629	PF00400	0.500
DEG_SCF_FBW7_1	381	386	PF00400	0.667
DOC_CKS1_1	199	204	PF01111	0.392
DOC_CYCLIN_yCln2_LP_2	174	177	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.475
DOC_MAPK_DCC_7	172	180	PF00069	0.390
DOC_MAPK_FxFP_2	267	270	PF00069	0.363
DOC_MAPK_FxFP_2	368	371	PF00069	0.721
DOC_MAPK_gen_1	415	424	PF00069	0.665
DOC_MAPK_gen_1	484	492	PF00069	0.714
DOC_MAPK_gen_1	550	558	PF00069	0.679
DOC_MAPK_gen_1	618	627	PF00069	0.562
DOC_MAPK_MEF2A_6	172	180	PF00069	0.484
DOC_MAPK_RevD_3	566	581	PF00069	0.223
DOC_PP1_RVXF_1	418	425	PF00149	0.562
DOC_PP2B_LxvP_1	174	177	PF13499	0.529
DOC_PP2B_LxvP_1	272	275	PF13499	0.344
DOC_PP2B_LxvP_1	342	345	PF13499	0.452
DOC_PP2B_LxvP_1	434	437	PF13499	0.390
DOC_PP4_FxxP_1	267	270	PF00568	0.338
DOC_PP4_FxxP_1	304	307	PF00568	0.658
DOC_PP4_FxxP_1	368	371	PF00568	0.702
DOC_USP7_MATH_1	191	195	PF00917	0.485
DOC_USP7_MATH_1	299	303	PF00917	0.753
DOC_USP7_MATH_1	395	399	PF00917	0.721
DOC_WW_Pin1_4	165	170	PF00397	0.488
DOC_WW_Pin1_4	198	203	PF00397	0.445
DOC_WW_Pin1_4	236	241	PF00397	0.504
DOC_WW_Pin1_4	247	252	PF00397	0.455
DOC_WW_Pin1_4	379	384	PF00397	0.662
DOC_WW_Pin1_4	503	508	PF00397	0.723
DOC_WW_Pin1_4	580	585	PF00397	0.473
LIG_14-3-3_CanoR_1	231	240	PF00244	0.403
LIG_14-3-3_CanoR_1	259	267	PF00244	0.366
LIG_14-3-3_CanoR_1	283	288	PF00244	0.659
LIG_14-3-3_CanoR_1	341	345	PF00244	0.429
LIG_14-3-3_CanoR_1	550	560	PF00244	0.601
LIG_14-3-3_CanoR_1	587	597	PF00244	0.403
LIG_Actin_WH2_2	267	285	PF00022	0.449
LIG_Actin_WH2_2	465	480	PF00022	0.330
LIG_Actin_WH2_2	678	695	PF00022	0.223
LIG_BIR_II_1	1	5	PF00653	0.547
LIG_BIR_III_2	659	663	PF00653	0.677
LIG_BRCT_BRCA1_1	449	453	PF00533	0.500
LIG_BRCT_BRCA1_1	92	96	PF00533	0.380
LIG_BRCT_BRCA1_2	449	455	PF00533	0.388
LIG_CSL_BTD_1	275	278	PF09270	0.475
LIG_eIF4E_1	417	423	PF01652	0.643
LIG_eIF4E_1	534	540	PF01652	0.683
LIG_FHA_1	159	165	PF00498	0.575
LIG_FHA_1	225	231	PF00498	0.513
LIG_FHA_1	321	327	PF00498	0.288
LIG_FHA_1	380	386	PF00498	0.658
LIG_FHA_1	471	477	PF00498	0.402
LIG_FHA_1	675	681	PF00498	0.441
LIG_FHA_2	114	120	PF00498	0.396
LIG_FHA_2	142	148	PF00498	0.479
LIG_FHA_2	23	29	PF00498	0.483
LIG_FHA_2	341	347	PF00498	0.415
LIG_FHA_2	401	407	PF00498	0.619
LIG_FHA_2	615	621	PF00498	0.565
LIG_Integrin_isoDGR_2	407	409	PF01839	0.354
LIG_Integrin_RGD_1	109	111	PF01839	0.533
LIG_LIR_Apic_2	186	191	PF02991	0.388
LIG_LIR_Apic_2	234	240	PF02991	0.557
LIG_LIR_Apic_2	302	307	PF02991	0.667
LIG_LIR_Apic_2	366	371	PF02991	0.669
LIG_LIR_Apic_2	573	579	PF02991	0.223
LIG_LIR_Gen_1	22	29	PF02991	0.522
LIG_LIR_Gen_1	363	371	PF02991	0.344
LIG_LIR_Gen_1	471	482	PF02991	0.584
LIG_LIR_Gen_1	594	602	PF02991	0.301
LIG_LIR_Nem_3	12	17	PF02991	0.530
LIG_LIR_Nem_3	22	26	PF02991	0.516
LIG_LIR_Nem_3	273	279	PF02991	0.428
LIG_LIR_Nem_3	363	367	PF02991	0.369
LIG_LIR_Nem_3	471	477	PF02991	0.386
LIG_LIR_Nem_3	524	530	PF02991	0.592
LIG_LIR_Nem_3	594	598	PF02991	0.292
LIG_LIR_Nem_3	663	668	PF02991	0.664
LIG_LIR_Nem_3	99	105	PF02991	0.428
LIG_NRBOX	675	681	PF00104	0.223
LIG_Pex14_2	256	260	PF04695	0.444
LIG_Pex14_2	265	269	PF04695	0.340
LIG_Pex14_2	462	466	PF04695	0.413
LIG_Pex14_2	598	602	PF04695	0.475
LIG_Pex14_2	69	73	PF04695	0.341
LIG_Pex14_2	92	96	PF04695	0.343
LIG_PTB_Apo_2	411	418	PF02174	0.608
LIG_PTB_Apo_2	492	499	PF02174	0.685
LIG_PTB_Phospho_1	411	417	PF10480	0.607
LIG_REV1ctd_RIR_1	253	263	PF16727	0.340
LIG_REV1ctd_RIR_1	365	370	PF16727	0.642
LIG_SH2_CRK	102	106	PF00017	0.406
LIG_SH2_CRK	188	192	PF00017	0.388
LIG_SH2_CRK	237	241	PF00017	0.569
LIG_SH2_CRK	634	638	PF00017	0.620
LIG_SH2_CRK	670	674	PF00017	0.475
LIG_SH2_GRB2like	40	43	PF00017	0.465
LIG_SH2_NCK_1	17	21	PF00017	0.364
LIG_SH2_NCK_1	188	192	PF00017	0.388
LIG_SH2_PTP2	576	579	PF00017	0.507
LIG_SH2_PTP2	612	615	PF00017	0.508
LIG_SH2_SRC	610	613	PF00017	0.399
LIG_SH2_STAT3	152	155	PF00017	0.357
LIG_SH2_STAT3	443	446	PF00017	0.351
LIG_SH2_STAT5	152	155	PF00017	0.500
LIG_SH2_STAT5	364	367	PF00017	0.416
LIG_SH2_STAT5	576	579	PF00017	0.507
LIG_SH2_STAT5	610	613	PF00017	0.330
LIG_SH2_STAT5	626	629	PF00017	0.573
LIG_SH3_1	576	582	PF00018	0.388
LIG_SH3_2	278	283	PF14604	0.519
LIG_SH3_3	163	169	PF00018	0.413
LIG_SH3_3	196	202	PF00018	0.452
LIG_SH3_3	272	278	PF00018	0.344
LIG_SH3_3	576	582	PF00018	0.388
LIG_SUMO_SIM_anti_2	323	330	PF11976	0.300
LIG_SUMO_SIM_par_1	176	183	PF11976	0.529
LIG_SUMO_SIM_par_1	323	330	PF11976	0.447
LIG_SUMO_SIM_par_1	672	677	PF11976	0.370
LIG_TRFH_1	17	21	PF08558	0.364
LIG_TYR_ITIM	668	673	PF00017	0.262
LIG_WRC_WIRS_1	364	369	PF05994	0.475
LIG_WRC_WIRS_1	463	468	PF05994	0.425
LIG_WRC_WIRS_1	597	602	PF05994	0.449
MOD_CDC14_SPxK_1	506	509	PF00782	0.722
MOD_CDK_SPK_2	379	384	PF00069	0.678
MOD_CDK_SPxK_1	503	509	PF00069	0.723
MOD_CDK_SPxxK_3	165	172	PF00069	0.393
MOD_CDK_SPxxK_3	198	205	PF00069	0.392
MOD_CDK_SPxxK_3	580	587	PF00069	0.343
MOD_CK1_1	158	164	PF00069	0.523
MOD_CK1_1	210	216	PF00069	0.507
MOD_CK1_1	239	245	PF00069	0.529
MOD_CK1_1	30	36	PF00069	0.469
MOD_CK1_1	363	369	PF00069	0.475
MOD_CK1_1	430	436	PF00069	0.223
MOD_CK1_1	535	541	PF00069	0.673
MOD_CK1_1	642	648	PF00069	0.541
MOD_CK1_1	652	658	PF00069	0.596
MOD_CK2_1	141	147	PF00069	0.478
MOD_CK2_1	217	223	PF00069	0.406
MOD_CK2_1	22	28	PF00069	0.479
MOD_CK2_1	247	253	PF00069	0.360
MOD_CK2_1	283	289	PF00069	0.663
MOD_CK2_1	340	346	PF00069	0.431
MOD_CK2_1	614	620	PF00069	0.566
MOD_Cter_Amidation	119	122	PF01082	0.633
MOD_GlcNHglycan	295	298	PF01048	0.439
MOD_GlcNHglycan	385	388	PF01048	0.438
MOD_GlcNHglycan	434	437	PF01048	0.421
MOD_GlcNHglycan	527	530	PF01048	0.490
MOD_GlcNHglycan	543	546	PF01048	0.362
MOD_GlcNHglycan	64	67	PF01048	0.480
MOD_GlcNHglycan	74	77	PF01048	0.484
MOD_GlcNHglycan	92	95	PF01048	0.442
MOD_GSK3_1	121	128	PF00069	0.504
MOD_GSK3_1	207	214	PF00069	0.484
MOD_GSK3_1	232	239	PF00069	0.542
MOD_GSK3_1	379	386	PF00069	0.675
MOD_GSK3_1	432	439	PF00069	0.439
MOD_GSK3_1	462	469	PF00069	0.482
MOD_GSK3_1	521	528	PF00069	0.699
MOD_GSK3_1	587	594	PF00069	0.449
MOD_N-GLC_1	217	222	PF02516	0.787
MOD_NEK2_1	141	146	PF00069	0.491
MOD_NEK2_1	211	216	PF00069	0.476
MOD_NEK2_1	282	287	PF00069	0.622
MOD_NEK2_1	293	298	PF00069	0.595
MOD_NEK2_1	38	43	PF00069	0.462
MOD_NEK2_1	388	393	PF00069	0.662
MOD_NEK2_1	432	437	PF00069	0.393
MOD_NEK2_1	462	467	PF00069	0.305
MOD_NEK2_1	468	473	PF00069	0.269
MOD_NEK2_1	521	526	PF00069	0.723
MOD_NEK2_1	541	546	PF00069	0.600
MOD_NEK2_1	7	12	PF00069	0.446
MOD_NEK2_1	96	101	PF00069	0.339
MOD_NEK2_2	104	109	PF00069	0.234
MOD_NEK2_2	532	537	PF00069	0.697
MOD_NEK2_2	80	85	PF00069	0.297
MOD_NEK2_2	97	102	PF00069	0.373
MOD_PIKK_1	258	264	PF00454	0.331
MOD_PKA_1	121	127	PF00069	0.402
MOD_PKA_2	121	127	PF00069	0.452
MOD_PKA_2	258	264	PF00069	0.511
MOD_PKA_2	282	288	PF00069	0.683
MOD_PKA_2	340	346	PF00069	0.427
MOD_PKA_2	551	557	PF00069	0.575
MOD_PKA_2	652	658	PF00069	0.615
MOD_Plk_1	217	223	PF00069	0.589
MOD_Plk_2-3	22	28	PF00069	0.521
MOD_Plk_4	141	147	PF00069	0.485
MOD_Plk_4	207	213	PF00069	0.494
MOD_Plk_4	22	28	PF00069	0.454
MOD_Plk_4	239	245	PF00069	0.551
MOD_Plk_4	321	327	PF00069	0.298
MOD_Plk_4	360	366	PF00069	0.355
MOD_Plk_4	388	394	PF00069	0.680
MOD_Plk_4	427	433	PF00069	0.264
MOD_Plk_4	462	468	PF00069	0.356
MOD_Plk_4	470	476	PF00069	0.341
MOD_Plk_4	674	680	PF00069	0.437
MOD_Plk_4	80	86	PF00069	0.337
MOD_Plk_4	97	103	PF00069	0.413
MOD_ProDKin_1	165	171	PF00069	0.488
MOD_ProDKin_1	198	204	PF00069	0.447
MOD_ProDKin_1	236	242	PF00069	0.503
MOD_ProDKin_1	247	253	PF00069	0.452
MOD_ProDKin_1	379	385	PF00069	0.662
MOD_ProDKin_1	503	509	PF00069	0.723
MOD_ProDKin_1	580	586	PF00069	0.474
MOD_SUMO_rev_2	168	174	PF00179	0.462
MOD_SUMO_rev_2	391	398	PF00179	0.679
TRG_DiLeu_BaEn_1	170	175	PF01217	0.510
TRG_DiLeu_BaEn_1	500	505	PF01217	0.687
TRG_DiLeu_BaEn_2	288	294	PF01217	0.708
TRG_ENDOCYTIC_2	102	105	PF00928	0.405
TRG_ENDOCYTIC_2	364	367	PF00928	0.340
TRG_ENDOCYTIC_2	419	422	PF00928	0.600
TRG_ENDOCYTIC_2	595	598	PF00928	0.350
TRG_ENDOCYTIC_2	610	613	PF00928	0.344
TRG_ENDOCYTIC_2	634	637	PF00928	0.585
TRG_ENDOCYTIC_2	670	673	PF00928	0.434
TRG_ER_diArg_1	379	381	PF00400	0.651
TRG_ER_diArg_1	550	553	PF00400	0.620
TRG_ER_diArg_1	579	581	PF00400	0.329
TRG_NES_CRM1_1	629	643	PF08389	0.665
TRG_Pf-PMV_PEXEL_1	619	623	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD79	Leptomonas seymouri	63%	98%
A0A0S4JPR5	Bodo saltans	37%	75%
A0A1X0NZJ8	Trypanosomatidae	37%	99%
A0A3S7WTR7	Leishmania donovani	76%	100%
A0A422N036	Trypanosoma rangeli	36%	96%
A4HWQ9	Leishmania infantum	76%	100%
C9ZPS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	94%
E9AQG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QF10	Leishmania major	75%	100%
V5D792	Trypanosoma cruzi	37%	97%