Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8D6_LEIBR

TriTrypDb:

LbrM.16.0100 , LBRM2903_160006200

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H8D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8D6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	227	229	PF00675	0.356
CLV_NRD_NRD_1	236	238	PF00675	0.434
CLV_NRD_NRD_1	296	298	PF00675	0.508
CLV_NRD_NRD_1	369	371	PF00675	0.573
CLV_NRD_NRD_1	62	64	PF00675	0.757
CLV_PCSK_KEX2_1	227	229	PF00082	0.428
CLV_PCSK_KEX2_1	236	238	PF00082	0.434
CLV_PCSK_KEX2_1	296	298	PF00082	0.488
CLV_PCSK_KEX2_1	369	371	PF00082	0.537
CLV_PCSK_KEX2_1	62	64	PF00082	0.658
CLV_PCSK_SKI1_1	194	198	PF00082	0.396
CLV_PCSK_SKI1_1	336	340	PF00082	0.392
CLV_PCSK_SKI1_1	390	394	PF00082	0.624
DEG_Nend_Nbox_1	1	3	PF02207	0.506
DEG_ODPH_VHL_1	348	361	PF01847	0.306
DOC_CKS1_1	249	254	PF01111	0.363
DOC_CYCLIN_RxL_1	268	282	PF00134	0.217
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	405	408	PF00134	0.416
DOC_MAPK_gen_1	336	344	PF00069	0.446
DOC_MAPK_gen_1	40	50	PF00069	0.481
DOC_MAPK_MEF2A_6	129	136	PF00069	0.499
DOC_MAPK_MEF2A_6	309	316	PF00069	0.513
DOC_MAPK_MEF2A_6	336	344	PF00069	0.519
DOC_MAPK_MEF2A_6	355	364	PF00069	0.434
DOC_PP2B_LxvP_1	404	407	PF13499	0.609
DOC_PP2B_LxvP_1	50	53	PF13499	0.487
DOC_PP2B_LxvP_1	70	73	PF13499	0.476
DOC_PP4_FxxP_1	169	172	PF00568	0.511
DOC_PP4_FxxP_1	307	310	PF00568	0.581
DOC_USP7_MATH_1	386	390	PF00917	0.463
DOC_USP7_MATH_1	53	57	PF00917	0.771
DOC_WW_Pin1_4	248	253	PF00397	0.253
DOC_WW_Pin1_4	354	359	PF00397	0.442
DOC_WW_Pin1_4	369	374	PF00397	0.650
LIG_14-3-3_CanoR_1	153	162	PF00244	0.461
LIG_14-3-3_CanoR_1	237	247	PF00244	0.441
LIG_14-3-3_CanoR_1	250	258	PF00244	0.443
LIG_14-3-3_CanoR_1	369	373	PF00244	0.631
LIG_ActinCP_TwfCPI_2	307	317	PF01115	0.550
LIG_BIR_III_2	206	210	PF00653	0.545
LIG_BRCT_BRCA1_1	165	169	PF00533	0.519
LIG_CSL_BTD_1	130	133	PF09270	0.378
LIG_deltaCOP1_diTrp_1	244	253	PF00928	0.484
LIG_EVH1_1	17	21	PF00568	0.426
LIG_FHA_1	125	131	PF00498	0.438
LIG_FHA_1	20	26	PF00498	0.401
LIG_FHA_1	355	361	PF00498	0.439
LIG_FHA_1	372	378	PF00498	0.569
LIG_FHA_1	95	101	PF00498	0.474
LIG_FHA_2	210	216	PF00498	0.363
LIG_FHA_2	239	245	PF00498	0.344
LIG_IRF3_LxIS_1	358	363	PF10401	0.276
LIG_LIR_Apic_2	166	172	PF02991	0.542
LIG_LIR_Gen_1	22	32	PF02991	0.606
LIG_LIR_Gen_1	328	338	PF02991	0.386
LIG_LIR_Nem_3	22	27	PF02991	0.600
LIG_LIR_Nem_3	328	334	PF02991	0.379
LIG_Pex14_2	20	24	PF04695	0.544
LIG_REV1ctd_RIR_1	351	357	PF16727	0.326
LIG_SH2_CRK	14	18	PF00017	0.424
LIG_SH2_CRK	249	253	PF00017	0.443
LIG_SH2_CRK	298	302	PF00017	0.384
LIG_SH2_CRK	323	327	PF00017	0.563
LIG_SH2_CRK	71	75	PF00017	0.476
LIG_SH2_NCK_1	298	302	PF00017	0.425
LIG_SH2_SRC	298	301	PF00017	0.432
LIG_SH2_STAT5	14	17	PF00017	0.525
LIG_SH2_STAT5	257	260	PF00017	0.313
LIG_SH3_3	127	133	PF00018	0.407
LIG_SH3_3	13	19	PF00018	0.504
LIG_SH3_3	39	45	PF00018	0.661
LIG_SUMO_SIM_anti_2	357	363	PF11976	0.286
LIG_SUMO_SIM_par_1	132	138	PF11976	0.316
LIG_SUMO_SIM_par_1	357	363	PF11976	0.286
LIG_TRAF2_1	220	223	PF00917	0.484
LIG_TRFH_1	142	146	PF08558	0.293
LIG_TYR_ITIM	321	326	PF00017	0.536
LIG_WRC_WIRS_1	139	144	PF05994	0.290
MOD_CK1_1	157	163	PF00069	0.507
MOD_CK1_1	201	207	PF00069	0.392
MOD_CK1_1	371	377	PF00069	0.688
MOD_CK1_1	7	13	PF00069	0.460
MOD_CK2_1	132	138	PF00069	0.358
MOD_CK2_1	209	215	PF00069	0.344
MOD_CK2_1	216	222	PF00069	0.344
MOD_CK2_1	238	244	PF00069	0.344
MOD_CK2_1	391	397	PF00069	0.489
MOD_GlcNHglycan	109	112	PF01048	0.493
MOD_GlcNHglycan	188	191	PF01048	0.393
MOD_GlcNHglycan	218	221	PF01048	0.477
MOD_GlcNHglycan	374	377	PF01048	0.695
MOD_GSK3_1	153	160	PF00069	0.574
MOD_GSK3_1	194	201	PF00069	0.481
MOD_GSK3_1	28	35	PF00069	0.561
MOD_GSK3_1	360	367	PF00069	0.541
MOD_GSK3_1	368	375	PF00069	0.596
MOD_GSK3_1	94	101	PF00069	0.464
MOD_N-GLC_1	157	162	PF02516	0.492
MOD_N-GLC_2	147	149	PF02516	0.323
MOD_NEK2_1	100	105	PF00069	0.341
MOD_NEK2_1	140	145	PF00069	0.398
MOD_NEK2_1	154	159	PF00069	0.558
MOD_NEK2_1	198	203	PF00069	0.645
MOD_NEK2_1	340	345	PF00069	0.468
MOD_NEK2_1	360	365	PF00069	0.459
MOD_NEK2_1	74	79	PF00069	0.474
MOD_PIKK_1	164	170	PF00454	0.412
MOD_PIKK_1	198	204	PF00454	0.524
MOD_PIKK_1	364	370	PF00454	0.530
MOD_PIKK_1	74	80	PF00454	0.474
MOD_PKA_2	288	294	PF00069	0.412
MOD_PKA_2	368	374	PF00069	0.654
MOD_PKB_1	122	130	PF00069	0.309
MOD_Plk_1	157	163	PF00069	0.422
MOD_Plk_1	194	200	PF00069	0.403
MOD_Plk_1	4	10	PF00069	0.574
MOD_Plk_1	400	406	PF00069	0.333
MOD_Plk_2-3	218	224	PF00069	0.443
MOD_Plk_2-3	391	397	PF00069	0.421
MOD_Plk_4	132	138	PF00069	0.355
MOD_Plk_4	157	163	PF00069	0.441
MOD_Plk_4	171	177	PF00069	0.301
MOD_Plk_4	19	25	PF00069	0.406
MOD_Plk_4	194	200	PF00069	0.403
MOD_Plk_4	340	346	PF00069	0.509
MOD_Plk_4	349	355	PF00069	0.478
MOD_Plk_4	400	406	PF00069	0.466
MOD_ProDKin_1	248	254	PF00069	0.253
MOD_ProDKin_1	354	360	PF00069	0.436
MOD_ProDKin_1	369	375	PF00069	0.658
MOD_SUMO_rev_2	56	61	PF00179	0.508
TRG_DiLeu_BaEn_1	112	117	PF01217	0.401
TRG_DiLeu_BaEn_1	401	406	PF01217	0.605
TRG_DiLeu_LyEn_5	112	117	PF01217	0.299
TRG_ENDOCYTIC_2	14	17	PF00928	0.422
TRG_ENDOCYTIC_2	298	301	PF00928	0.464
TRG_ENDOCYTIC_2	323	326	PF00928	0.452
TRG_ENDOCYTIC_2	71	74	PF00928	0.474
TRG_ER_diArg_1	226	228	PF00400	0.350
TRG_ER_diArg_1	236	238	PF00400	0.428
TRG_ER_diArg_1	296	298	PF00400	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA4	Leptomonas seymouri	50%	100%
A0A1X0P0E9	Trypanosomatidae	32%	100%
A0A3Q8ICF1	Leishmania donovani	69%	100%
A4HWQ8	Leishmania infantum	69%	100%
C9ZPS2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AQG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4QF11	Leishmania major	70%	100%
V5ARD2	Trypanosoma cruzi	34%	100%