DUF4110 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Galactose oxidase, central domain/Domain of unknown function (DUF4110), putative

Species:

Leishmania braziliensis

UniProt:

A4H8D5_LEIBR

TriTrypDb:

LbrM.16.0090 , LBRM2903_160006000

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8D5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8D5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.330
CLV_C14_Caspase3-7	408	412	PF00656	0.553
CLV_NRD_NRD_1	372	374	PF00675	0.455
CLV_NRD_NRD_1	450	452	PF00675	0.279
CLV_NRD_NRD_1	549	551	PF00675	0.581
CLV_NRD_NRD_1	61	63	PF00675	0.310
CLV_NRD_NRD_1	699	701	PF00675	0.262
CLV_NRD_NRD_1	7	9	PF00675	0.538
CLV_NRD_NRD_1	715	717	PF00675	0.449
CLV_PCSK_FUR_1	5	9	PF00082	0.527
CLV_PCSK_FUR_1	697	701	PF00082	0.340
CLV_PCSK_KEX2_1	119	121	PF00082	0.280
CLV_PCSK_KEX2_1	19	21	PF00082	0.490
CLV_PCSK_KEX2_1	200	202	PF00082	0.329
CLV_PCSK_KEX2_1	330	332	PF00082	0.446
CLV_PCSK_KEX2_1	364	366	PF00082	0.369
CLV_PCSK_KEX2_1	372	374	PF00082	0.437
CLV_PCSK_KEX2_1	376	378	PF00082	0.529
CLV_PCSK_KEX2_1	383	385	PF00082	0.498
CLV_PCSK_KEX2_1	450	452	PF00082	0.272
CLV_PCSK_KEX2_1	549	551	PF00082	0.581
CLV_PCSK_KEX2_1	55	57	PF00082	0.513
CLV_PCSK_KEX2_1	699	701	PF00082	0.262
CLV_PCSK_KEX2_1	7	9	PF00082	0.537
CLV_PCSK_KEX2_1	715	717	PF00082	0.449
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.280
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.483
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.423
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.446
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.332
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.521
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.461
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.506
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.552
CLV_PCSK_PC7_1	372	378	PF00082	0.511
CLV_PCSK_SKI1_1	16	20	PF00082	0.507
CLV_PCSK_SKI1_1	182	186	PF00082	0.426
CLV_PCSK_SKI1_1	195	199	PF00082	0.336
CLV_PCSK_SKI1_1	23	27	PF00082	0.510
CLV_PCSK_SKI1_1	373	377	PF00082	0.514
CLV_PCSK_SKI1_1	475	479	PF00082	0.246
CLV_PCSK_SKI1_1	658	662	PF00082	0.342
CLV_PCSK_SKI1_1	676	680	PF00082	0.159
DEG_APCC_DBOX_1	675	683	PF00400	0.323
DEG_APCC_KENBOX_2	33	37	PF00400	0.591
DEG_SCF_FBW7_2	582	589	PF00400	0.501
DEG_SCF_FBW7_2	623	629	PF00400	0.389
DEG_SPOP_SBC_1	134	138	PF00917	0.310
DEG_SPOP_SBC_1	637	641	PF00917	0.323
DOC_ANK_TNKS_1	647	654	PF00023	0.323
DOC_CKS1_1	623	628	PF01111	0.246
DOC_CKS1_1	75	80	PF01111	0.433
DOC_MAPK_gen_1	19	28	PF00069	0.630
DOC_MAPK_gen_1	200	206	PF00069	0.285
DOC_MAPK_gen_1	364	371	PF00069	0.337
DOC_MAPK_gen_1	450	458	PF00069	0.280
DOC_MAPK_gen_1	600	608	PF00069	0.454
DOC_PP1_RVXF_1	193	200	PF00149	0.281
DOC_PP1_RVXF_1	548	555	PF00149	0.589
DOC_USP7_MATH_1	134	138	PF00917	0.295
DOC_USP7_MATH_1	428	432	PF00917	0.626
DOC_USP7_MATH_1	637	641	PF00917	0.321
DOC_USP7_MATH_1	647	651	PF00917	0.208
DOC_USP7_UBL2_3	3	7	PF12436	0.546
DOC_USP7_UBL2_3	30	34	PF12436	0.596
DOC_USP7_UBL2_3	55	59	PF12436	0.383
DOC_USP7_UBL2_3	690	694	PF12436	0.255
DOC_WW_Pin1_4	340	345	PF00397	0.377
DOC_WW_Pin1_4	582	587	PF00397	0.482
DOC_WW_Pin1_4	622	627	PF00397	0.246
DOC_WW_Pin1_4	74	79	PF00397	0.394
LIG_14-3-3_CanoR_1	120	124	PF00244	0.244
LIG_14-3-3_CanoR_1	125	134	PF00244	0.248
LIG_14-3-3_CanoR_1	135	143	PF00244	0.296
LIG_14-3-3_CanoR_1	174	181	PF00244	0.468
LIG_14-3-3_CanoR_1	249	255	PF00244	0.358
LIG_14-3-3_CanoR_1	274	282	PF00244	0.410
LIG_14-3-3_CanoR_1	638	643	PF00244	0.281
LIG_APCC_ABBA_1	254	259	PF00400	0.351
LIG_BRCT_BRCA1_1	323	327	PF00533	0.383
LIG_BRCT_BRCA1_1	479	483	PF00533	0.280
LIG_deltaCOP1_diTrp_1	167	171	PF00928	0.272
LIG_eIF4E_1	673	679	PF01652	0.323
LIG_FHA_1	460	466	PF00498	0.280
LIG_FHA_1	583	589	PF00498	0.497
LIG_FHA_1	75	81	PF00498	0.344
LIG_FHA_2	296	302	PF00498	0.475
LIG_FHA_2	476	482	PF00498	0.246
LIG_FHA_2	644	650	PF00498	0.367
LIG_LIR_Gen_1	122	130	PF02991	0.237
LIG_LIR_Gen_1	160	168	PF02991	0.320
LIG_LIR_Gen_1	176	184	PF02991	0.342
LIG_LIR_Gen_1	269	280	PF02991	0.405
LIG_LIR_Gen_1	350	361	PF02991	0.365
LIG_LIR_Gen_1	629	637	PF02991	0.327
LIG_LIR_Nem_3	122	126	PF02991	0.289
LIG_LIR_Nem_3	160	165	PF02991	0.340
LIG_LIR_Nem_3	176	181	PF02991	0.320
LIG_LIR_Nem_3	269	275	PF02991	0.409
LIG_LIR_Nem_3	350	356	PF02991	0.474
LIG_LIR_Nem_3	363	369	PF02991	0.187
LIG_LIR_Nem_3	491	496	PF02991	0.332
LIG_LIR_Nem_3	629	635	PF02991	0.362
LIG_LIR_Nem_3	704	710	PF02991	0.270
LIG_LYPXL_S_1	366	370	PF13949	0.312
LIG_LYPXL_yS_3	367	370	PF13949	0.320
LIG_Pex14_2	150	154	PF04695	0.328
LIG_Pex14_2	165	169	PF04695	0.219
LIG_Pex14_2	219	223	PF04695	0.293
LIG_Pex14_2	632	636	PF04695	0.389
LIG_Pex14_2	97	101	PF04695	0.389
LIG_PTB_Apo_2	351	358	PF02174	0.328
LIG_PTB_Apo_2	458	465	PF02174	0.261
LIG_PTB_Phospho_1	351	357	PF10480	0.374
LIG_PTB_Phospho_1	458	464	PF10480	0.261
LIG_REV1ctd_RIR_1	113	124	PF16727	0.389
LIG_REV1ctd_RIR_1	633	642	PF16727	0.261
LIG_REV1ctd_RIR_1	693	704	PF16727	0.246
LIG_SH2_CRK	493	497	PF00017	0.364
LIG_SH2_GRB2like	210	213	PF00017	0.318
LIG_SH2_NCK_1	710	714	PF00017	0.474
LIG_SH2_SRC	210	213	PF00017	0.318
LIG_SH2_SRC	464	467	PF00017	0.389
LIG_SH2_SRC	710	713	PF00017	0.471
LIG_SH2_STAP1	210	214	PF00017	0.242
LIG_SH2_STAP1	529	533	PF00017	0.550
LIG_SH2_STAT3	267	270	PF00017	0.456
LIG_SH2_STAT3	466	469	PF00017	0.389
LIG_SH2_STAT5	114	117	PF00017	0.286
LIG_SH2_STAT5	146	149	PF00017	0.385
LIG_SH2_STAT5	162	165	PF00017	0.398
LIG_SH2_STAT5	218	221	PF00017	0.298
LIG_SH2_STAT5	333	336	PF00017	0.307
LIG_SH2_STAT5	357	360	PF00017	0.389
LIG_SH2_STAT5	464	467	PF00017	0.261
LIG_SH3_3	127	133	PF00018	0.168
LIG_SH3_3	419	425	PF00018	0.476
LIG_SH3_3	620	626	PF00018	0.246
LIG_SH3_3	70	76	PF00018	0.387
LIG_SH3_3	82	88	PF00018	0.315
LIG_SUMO_SIM_par_1	337	343	PF11976	0.344
LIG_SUMO_SIM_par_1	81	86	PF11976	0.155
LIG_TRAF2_1	430	433	PF00917	0.664
LIG_TRAF2_1	66	69	PF00917	0.498
LIG_UBA3_1	288	295	PF00899	0.415
LIG_UBA3_1	482	489	PF00899	0.323
LIG_WRC_WIRS_1	349	354	PF05994	0.315
LIG_WW_3	132	136	PF00397	0.220
MOD_CDK_SPK_2	74	79	PF00069	0.387
MOD_CDK_SPxxK_3	340	347	PF00069	0.390
MOD_CK1_1	173	179	PF00069	0.363
MOD_CK1_1	189	195	PF00069	0.296
MOD_CK1_1	250	256	PF00069	0.318
MOD_CK1_1	278	284	PF00069	0.344
MOD_CK1_1	405	411	PF00069	0.556
MOD_CK1_1	414	420	PF00069	0.671
MOD_CK1_1	437	443	PF00069	0.518
MOD_CK1_1	517	523	PF00069	0.466
MOD_CK2_1	173	179	PF00069	0.458
MOD_CK2_1	295	301	PF00069	0.481
MOD_CK2_1	410	416	PF00069	0.565
MOD_CK2_1	470	476	PF00069	0.389
MOD_CK2_1	643	649	PF00069	0.362
MOD_CK2_1	83	89	PF00069	0.449
MOD_Cter_Amidation	381	384	PF01082	0.517
MOD_Cter_Amidation	547	550	PF01082	0.561
MOD_Cter_Amidation	601	604	PF01082	0.456
MOD_GlcNHglycan	127	130	PF01048	0.362
MOD_GlcNHglycan	191	194	PF01048	0.305
MOD_GlcNHglycan	249	252	PF01048	0.299
MOD_GlcNHglycan	380	383	PF01048	0.519
MOD_GlcNHglycan	394	397	PF01048	0.558
MOD_GlcNHglycan	453	456	PF01048	0.372
MOD_GlcNHglycan	500	504	PF01048	0.479
MOD_GlcNHglycan	519	522	PF01048	0.482
MOD_GlcNHglycan	525	528	PF01048	0.484
MOD_GlcNHglycan	619	622	PF01048	0.262
MOD_GSK3_1	153	160	PF00069	0.321
MOD_GSK3_1	232	239	PF00069	0.345
MOD_GSK3_1	405	412	PF00069	0.582
MOD_GSK3_1	495	502	PF00069	0.294
MOD_GSK3_1	508	515	PF00069	0.473
MOD_GSK3_1	519	526	PF00069	0.439
MOD_GSK3_1	643	650	PF00069	0.301
MOD_LATS_1	449	455	PF00433	0.389
MOD_N-GLC_1	110	115	PF02516	0.389
MOD_N-GLC_1	555	560	PF02516	0.603
MOD_NEK2_1	348	353	PF00069	0.383
MOD_NEK2_1	470	475	PF00069	0.377
MOD_NEK2_1	617	622	PF00069	0.336
MOD_NEK2_1	636	641	PF00069	0.136
MOD_PIKK_1	135	141	PF00454	0.304
MOD_PIKK_1	153	159	PF00454	0.237
MOD_PIKK_1	232	238	PF00454	0.444
MOD_PIKK_1	266	272	PF00454	0.390
MOD_PIKK_1	420	426	PF00454	0.696
MOD_PIKK_1	428	434	PF00454	0.689
MOD_PIKK_1	495	501	PF00454	0.373
MOD_PKA_1	119	125	PF00069	0.255
MOD_PKA_1	19	25	PF00069	0.509
MOD_PKA_2	119	125	PF00069	0.275
MOD_PKA_2	134	140	PF00069	0.265
MOD_PKA_2	173	179	PF00069	0.458
MOD_PKA_2	19	25	PF00069	0.447
MOD_PKA_2	434	440	PF00069	0.414
MOD_PKA_2	637	643	PF00069	0.271
MOD_PKA_2	647	653	PF00069	0.247
MOD_Plk_1	110	116	PF00069	0.321
MOD_Plk_1	278	284	PF00069	0.420
MOD_Plk_1	295	301	PF00069	0.554
MOD_Plk_1	475	481	PF00069	0.246
MOD_Plk_1	50	56	PF00069	0.365
MOD_Plk_1	628	634	PF00069	0.386
MOD_Plk_2-3	402	408	PF00069	0.654
MOD_Plk_2-3	411	417	PF00069	0.576
MOD_Plk_4	110	116	PF00069	0.362
MOD_Plk_4	348	354	PF00069	0.397
MOD_Plk_4	459	465	PF00069	0.274
MOD_Plk_4	638	644	PF00069	0.362
MOD_ProDKin_1	340	346	PF00069	0.385
MOD_ProDKin_1	582	588	PF00069	0.481
MOD_ProDKin_1	622	628	PF00069	0.246
MOD_ProDKin_1	74	80	PF00069	0.392
MOD_SUMO_for_1	660	663	PF00179	0.364
MOD_SUMO_rev_2	176	184	PF00179	0.335
MOD_SUMO_rev_2	649	656	PF00179	0.368
MOD_SUMO_rev_2	686	696	PF00179	0.389
TRG_DiLeu_BaEn_1	674	679	PF01217	0.246
TRG_DiLeu_BaEn_4	179	185	PF01217	0.401
TRG_DiLeu_BaLyEn_6	492	497	PF01217	0.474
TRG_ENDOCYTIC_2	146	149	PF00928	0.306
TRG_ENDOCYTIC_2	162	165	PF00928	0.404
TRG_ENDOCYTIC_2	353	356	PF00928	0.496
TRG_ENDOCYTIC_2	367	370	PF00928	0.186
TRG_ENDOCYTIC_2	493	496	PF00928	0.364
TRG_ER_diArg_1	371	373	PF00400	0.406
TRG_ER_diArg_1	450	452	PF00400	0.261
TRG_ER_diArg_1	699	701	PF00400	0.340
TRG_ER_diArg_1	715	717	PF00400	0.532
TRG_NES_CRM1_1	388	402	PF08389	0.479
TRG_Pf-PMV_PEXEL_1	658	663	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	676	681	PF00026	0.203
TRG_Pf-PMV_PEXEL_1	699	704	PF00026	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8R8	Leptomonas seymouri	74%	100%
A0A0S4JR73	Bodo saltans	49%	94%
A0A1X0NZQ9	Trypanosomatidae	59%	100%
A0A3Q8I9A1	Leishmania donovani	85%	99%
A0A422NAE1	Trypanosoma rangeli	59%	99%
A4HWQ7	Leishmania infantum	86%	99%
C9ZPS3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	98%
E9AQG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q08979	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q4QF12	Leishmania major	84%	100%
Q5R8W1	Pongo abelii	31%	100%
Q8TBB5	Homo sapiens	32%	100%
Q921I2	Mus musculus	32%	100%
V5BBA4	Trypanosoma cruzi	59%	100%