Rho-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8D4_LEIBR

TriTrypDb:

LbrM.16.0080 , LBRM2903_160005900

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8D4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.704
CLV_NRD_NRD_1	134	136	PF00675	0.510
CLV_NRD_NRD_1	20	22	PF00675	0.678
CLV_NRD_NRD_1	259	261	PF00675	0.566
CLV_NRD_NRD_1	330	332	PF00675	0.737
CLV_NRD_NRD_1	4	6	PF00675	0.739
CLV_PCSK_KEX2_1	11	13	PF00082	0.706
CLV_PCSK_KEX2_1	134	136	PF00082	0.556
CLV_PCSK_KEX2_1	20	22	PF00082	0.667
CLV_PCSK_KEX2_1	25	27	PF00082	0.675
CLV_PCSK_KEX2_1	330	332	PF00082	0.574
CLV_PCSK_KEX2_1	4	6	PF00082	0.743
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.675
CLV_PCSK_PC7_1	21	27	PF00082	0.780
CLV_PCSK_SKI1_1	255	259	PF00082	0.597
CLV_PCSK_SKI1_1	50	54	PF00082	0.517
CLV_Separin_Metazoa	158	162	PF03568	0.449
DOC_CKS1_1	319	324	PF01111	0.524
DOC_CYCLIN_RxL_1	186	195	PF00134	0.427
DOC_MAPK_gen_1	11	19	PF00069	0.791
DOC_MAPK_gen_1	25	33	PF00069	0.504
DOC_MAPK_MEF2A_6	11	19	PF00069	0.541
DOC_MAPK_MEF2A_6	281	289	PF00069	0.438
DOC_PP2B_LxvP_1	191	194	PF13499	0.705
DOC_PP2B_LxvP_1	204	207	PF13499	0.532
DOC_USP7_MATH_1	143	147	PF00917	0.615
DOC_USP7_MATH_1	173	177	PF00917	0.607
DOC_USP7_MATH_1	276	280	PF00917	0.574
DOC_USP7_MATH_1	48	52	PF00917	0.532
DOC_WW_Pin1_4	139	144	PF00397	0.660
DOC_WW_Pin1_4	318	323	PF00397	0.653
DOC_WW_Pin1_4	325	330	PF00397	0.789
DOC_WW_Pin1_4	50	55	PF00397	0.605
LIG_14-3-3_CanoR_1	11	16	PF00244	0.785
LIG_14-3-3_CanoR_1	197	202	PF00244	0.631
LIG_14-3-3_CanoR_1	253	258	PF00244	0.485
LIG_14-3-3_CanoR_1	273	280	PF00244	0.461
LIG_14-3-3_CanoR_1	4	8	PF00244	0.735
LIG_BIR_II_1	1	5	PF00653	0.576
LIG_BRCT_BRCA1_1	267	271	PF00533	0.446
LIG_CaM_NSCaTE_8	241	248	PF13499	0.702
LIG_CtBP_PxDLS_1	156	160	PF00389	0.447
LIG_CtBP_PxDLS_1	73	77	PF00389	0.779
LIG_FHA_2	139	145	PF00498	0.557
LIG_FHA_2	152	158	PF00498	0.521
LIG_GBD_Chelix_1	174	182	PF00786	0.645
LIG_LIR_Apic_2	85	91	PF02991	0.767
LIG_LIR_Gen_1	176	186	PF02991	0.651
LIG_LIR_Gen_1	265	274	PF02991	0.629
LIG_LIR_Gen_1	294	301	PF02991	0.456
LIG_LIR_Nem_3	176	182	PF02991	0.650
LIG_LIR_Nem_3	265	270	PF02991	0.623
LIG_LIR_Nem_3	294	298	PF02991	0.451
LIG_LIR_Nem_3	30	36	PF02991	0.777
LIG_LIR_Nem_3	311	315	PF02991	0.515
LIG_LIR_Nem_3	49	55	PF02991	0.468
LIG_LYPXL_SIV_4	262	270	PF13949	0.548
LIG_PCNA_yPIPBox_3	181	192	PF02747	0.402
LIG_SH2_CRK	179	183	PF00017	0.413
LIG_SH2_CRK	267	271	PF00017	0.709
LIG_SH2_CRK	88	92	PF00017	0.695
LIG_SH2_NCK_1	263	267	PF00017	0.543
LIG_SH2_STAP1	179	183	PF00017	0.546
LIG_SH2_STAP1	263	267	PF00017	0.665
LIG_SH2_STAT5	179	182	PF00017	0.549
LIG_SH2_STAT5	284	287	PF00017	0.595
LIG_SH2_STAT5	312	315	PF00017	0.556
LIG_SH2_STAT5	36	39	PF00017	0.562
LIG_SH3_1	88	94	PF00018	0.508
LIG_SH3_3	88	94	PF00018	0.511
LIG_SUMO_SIM_anti_2	14	19	PF11976	0.646
LIG_SUMO_SIM_anti_2	294	300	PF11976	0.455
LIG_SUMO_SIM_par_1	72	77	PF11976	0.709
MOD_CDC14_SPxK_1	328	331	PF00782	0.564
MOD_CDK_SPK_2	318	323	PF00069	0.521
MOD_CDK_SPK_2	325	330	PF00069	0.548
MOD_CDK_SPxK_1	325	331	PF00069	0.553
MOD_CDK_SPxK_1	50	56	PF00069	0.514
MOD_CK1_1	129	135	PF00069	0.648
MOD_CK1_1	138	144	PF00069	0.589
MOD_CK1_1	177	183	PF00069	0.383
MOD_CK1_1	275	281	PF00069	0.623
MOD_CK1_1	6	12	PF00069	0.748
MOD_CK2_1	138	144	PF00069	0.530
MOD_CK2_1	151	157	PF00069	0.385
MOD_CK2_1	74	80	PF00069	0.672
MOD_Cter_Amidation	2	5	PF01082	0.573
MOD_Cter_Amidation	23	26	PF01082	0.696
MOD_DYRK1A_RPxSP_1	50	54	PF00069	0.517
MOD_GlcNHglycan	1	4	PF01048	0.700
MOD_GlcNHglycan	128	131	PF01048	0.611
MOD_GlcNHglycan	274	277	PF01048	0.563
MOD_GlcNHglycan	7	11	PF01048	0.639
MOD_GlcNHglycan	76	79	PF01048	0.502
MOD_GSK3_1	135	142	PF00069	0.452
MOD_GSK3_1	173	180	PF00069	0.648
MOD_GSK3_1	214	221	PF00069	0.481
MOD_GSK3_1	245	252	PF00069	0.697
MOD_GSK3_1	272	279	PF00069	0.677
MOD_GSK3_1	35	42	PF00069	0.622
MOD_GSK3_1	46	53	PF00069	0.520
MOD_NEK2_1	112	117	PF00069	0.574
MOD_NEK2_1	126	131	PF00069	0.523
MOD_NEK2_1	151	156	PF00069	0.405
MOD_NEK2_1	214	219	PF00069	0.553
MOD_NEK2_1	245	250	PF00069	0.511
MOD_NEK2_1	315	320	PF00069	0.521
MOD_NEK2_1	60	65	PF00069	0.716
MOD_NEK2_2	276	281	PF00069	0.578
MOD_PIKK_1	265	271	PF00454	0.573
MOD_PIKK_1	39	45	PF00454	0.528
MOD_PK_1	11	17	PF00069	0.808
MOD_PK_1	135	141	PF00069	0.711
MOD_PK_1	197	203	PF00069	0.636
MOD_PKA_1	11	17	PF00069	0.804
MOD_PKA_2	11	17	PF00069	0.802
MOD_PKA_2	164	170	PF00069	0.697
MOD_PKA_2	272	278	PF00069	0.703
MOD_PKA_2	3	9	PF00069	0.733
MOD_PKA_2	315	321	PF00069	0.676
MOD_Plk_1	215	221	PF00069	0.683
MOD_Plk_4	174	180	PF00069	0.382
MOD_Plk_4	215	221	PF00069	0.464
MOD_ProDKin_1	139	145	PF00069	0.660
MOD_ProDKin_1	318	324	PF00069	0.655
MOD_ProDKin_1	325	331	PF00069	0.794
MOD_ProDKin_1	50	56	PF00069	0.605
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.396
TRG_ENDOCYTIC_2	179	182	PF00928	0.549
TRG_ENDOCYTIC_2	267	270	PF00928	0.623
TRG_ENDOCYTIC_2	284	287	PF00928	0.501
TRG_ENDOCYTIC_2	312	315	PF00928	0.556
TRG_ER_diArg_1	11	13	PF00400	0.708
TRG_ER_diArg_1	19	21	PF00400	0.669
TRG_ER_diArg_1	329	331	PF00400	0.571
TRG_Pf-PMV_PEXEL_1	161	166	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.700

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDJ0	Leishmania donovani	69%	83%
A4HWQ6	Leishmania infantum	69%	83%
E9AQG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	83%
Q4QF13	Leishmania major	66%	100%
Q8IS09	Leptomonas seymouri	34%	87%