Putative peroxisome assembly protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxisome assembly protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8D3_LEIBR

TriTrypDb:

LbrM.16.0070 , LBRM2903_160005800

Length:

959

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005778	peroxisomal membrane	6	1
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8D3

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006625	protein targeting to peroxisome	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007031	peroxisome organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0015919	peroxisomal membrane transport	5	1
GO:0016043	cellular component organization	3	1
GO:0016558	protein import into peroxisome matrix	5	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0043574	peroxisomal transport	4	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072662	protein localization to peroxisome	6	1
GO:0072663	establishment of protein localization to peroxisome	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	483	487	PF00656	0.411
CLV_C14_Caspase3-7	536	540	PF00656	0.397
CLV_C14_Caspase3-7	747	751	PF00656	0.271
CLV_C14_Caspase3-7	888	892	PF00656	0.494
CLV_NRD_NRD_1	318	320	PF00675	0.519
CLV_NRD_NRD_1	838	840	PF00675	0.422
CLV_PCSK_KEX2_1	166	168	PF00082	0.454
CLV_PCSK_KEX2_1	657	659	PF00082	0.388
CLV_PCSK_KEX2_1	680	682	PF00082	0.420
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.454
CLV_PCSK_PC1ET2_1	657	659	PF00082	0.407
CLV_PCSK_PC1ET2_1	680	682	PF00082	0.420
CLV_PCSK_SKI1_1	12	16	PF00082	0.414
CLV_PCSK_SKI1_1	123	127	PF00082	0.520
CLV_PCSK_SKI1_1	185	189	PF00082	0.558
CLV_PCSK_SKI1_1	236	240	PF00082	0.653
CLV_PCSK_SKI1_1	241	245	PF00082	0.598
CLV_PCSK_SKI1_1	333	337	PF00082	0.603
CLV_PCSK_SKI1_1	402	406	PF00082	0.487
CLV_PCSK_SKI1_1	463	467	PF00082	0.555
CLV_PCSK_SKI1_1	515	519	PF00082	0.348
CLV_PCSK_SKI1_1	552	556	PF00082	0.403
CLV_PCSK_SKI1_1	694	698	PF00082	0.271
CLV_PCSK_SKI1_1	730	734	PF00082	0.271
CLV_PCSK_SKI1_1	756	760	PF00082	0.300
CLV_PCSK_SKI1_1	835	839	PF00082	0.405
CLV_PCSK_SKI1_1	918	922	PF00082	0.561
DEG_APCC_DBOX_1	11	19	PF00400	0.430
DEG_APCC_DBOX_1	401	409	PF00400	0.445
DEG_APCC_KENBOX_2	425	429	PF00400	0.411
DEG_SCF_FBW7_2	408	414	PF00400	0.524
DOC_CDC14_PxL_1	554	562	PF14671	0.286
DOC_CDC14_PxL_1	663	671	PF14671	0.513
DOC_CKS1_1	408	413	PF01111	0.519
DOC_CYCLIN_yClb5_NLxxxL_5	182	188	PF00134	0.492
DOC_CYCLIN_yCln2_LP_2	804	810	PF00134	0.349
DOC_MAPK_gen_1	566	575	PF00069	0.448
DOC_MAPK_gen_1	657	668	PF00069	0.377
DOC_MAPK_gen_1	679	686	PF00069	0.368
DOC_MAPK_gen_1	814	823	PF00069	0.289
DOC_MAPK_HePTP_8	765	777	PF00069	0.404
DOC_MAPK_MEF2A_6	333	340	PF00069	0.498
DOC_MAPK_MEF2A_6	661	668	PF00069	0.368
DOC_MAPK_MEF2A_6	737	745	PF00069	0.271
DOC_MAPK_MEF2A_6	768	777	PF00069	0.271
DOC_MAPK_NFAT4_5	333	341	PF00069	0.446
DOC_MAPK_NFAT4_5	661	669	PF00069	0.373
DOC_PP1_RVXF_1	513	519	PF00149	0.358
DOC_PP1_RVXF_1	728	734	PF00149	0.271
DOC_PP2B_LxvP_1	821	824	PF13499	0.372
DOC_PP4_FxxP_1	441	444	PF00568	0.544
DOC_PP4_FxxP_1	555	558	PF00568	0.484
DOC_PP4_FxxP_1	686	689	PF00568	0.271
DOC_USP7_MATH_1	165	169	PF00917	0.593
DOC_USP7_MATH_1	271	275	PF00917	0.372
DOC_USP7_MATH_1	30	34	PF00917	0.414
DOC_USP7_MATH_1	393	397	PF00917	0.436
DOC_USP7_MATH_1	603	607	PF00917	0.410
DOC_USP7_MATH_1	615	619	PF00917	0.552
DOC_USP7_MATH_1	867	871	PF00917	0.320
DOC_USP7_MATH_1	90	94	PF00917	0.505
DOC_USP7_MATH_1	908	912	PF00917	0.726
DOC_USP7_MATH_1	96	100	PF00917	0.522
DOC_WW_Pin1_4	174	179	PF00397	0.406
DOC_WW_Pin1_4	378	383	PF00397	0.533
DOC_WW_Pin1_4	384	389	PF00397	0.469
DOC_WW_Pin1_4	407	412	PF00397	0.610
DOC_WW_Pin1_4	573	578	PF00397	0.550
DOC_WW_Pin1_4	737	742	PF00397	0.271
DOC_WW_Pin1_4	898	903	PF00397	0.672
LIG_14-3-3_CanoR_1	16	23	PF00244	0.466
LIG_14-3-3_CanoR_1	167	176	PF00244	0.679
LIG_14-3-3_CanoR_1	279	288	PF00244	0.540
LIG_14-3-3_CanoR_1	312	321	PF00244	0.604
LIG_14-3-3_CanoR_1	373	377	PF00244	0.625
LIG_14-3-3_CanoR_1	415	421	PF00244	0.312
LIG_14-3-3_CanoR_1	460	466	PF00244	0.394
LIG_14-3-3_CanoR_1	534	542	PF00244	0.609
LIG_14-3-3_CanoR_1	646	653	PF00244	0.397
LIG_14-3-3_CanoR_1	768	777	PF00244	0.404
LIG_Actin_WH2_2	107	125	PF00022	0.436
LIG_Actin_WH2_2	323	341	PF00022	0.519
LIG_Actin_WH2_2	388	404	PF00022	0.313
LIG_APCC_ABBA_1	841	846	PF00400	0.294
LIG_APCC_ABBAyCdc20_2	840	846	PF00400	0.300
LIG_BIR_II_1	1	5	PF00653	0.558
LIG_BIR_III_4	761	765	PF00653	0.271
LIG_BRCT_BRCA1_1	348	352	PF00533	0.444
LIG_CaM_NSCaTE_8	276	283	PF13499	0.605
LIG_Clathr_ClatBox_1	774	778	PF01394	0.289
LIG_deltaCOP1_diTrp_1	377	384	PF00928	0.444
LIG_FHA_1	238	244	PF00498	0.643
LIG_FHA_1	281	287	PF00498	0.540
LIG_FHA_1	362	368	PF00498	0.530
LIG_FHA_1	408	414	PF00498	0.595
LIG_FHA_1	417	423	PF00498	0.446
LIG_FHA_1	44	50	PF00498	0.564
LIG_FHA_1	472	478	PF00498	0.465
LIG_FHA_1	536	542	PF00498	0.481
LIG_FHA_1	582	588	PF00498	0.322
LIG_FHA_1	680	686	PF00498	0.455
LIG_FHA_1	80	86	PF00498	0.489
LIG_FHA_1	888	894	PF00498	0.715
LIG_FHA_1	9	15	PF00498	0.500
LIG_FHA_2	322	328	PF00498	0.724
LIG_FHA_2	339	345	PF00498	0.353
LIG_FHA_2	481	487	PF00498	0.588
LIG_FHA_2	534	540	PF00498	0.591
LIG_FHA_2	586	592	PF00498	0.469
LIG_FHA_2	824	830	PF00498	0.377
LIG_FHA_2	859	865	PF00498	0.323
LIG_FHA_2	886	892	PF00498	0.506
LIG_FHA_2	937	943	PF00498	0.483
LIG_GBD_Chelix_1	114	122	PF00786	0.651
LIG_GBD_Chelix_1	421	429	PF00786	0.280
LIG_LIR_Apic_2	439	444	PF02991	0.354
LIG_LIR_Gen_1	208	219	PF02991	0.497
LIG_LIR_Gen_1	396	405	PF02991	0.349
LIG_LIR_Gen_1	588	596	PF02991	0.417
LIG_LIR_Nem_3	179	184	PF02991	0.493
LIG_LIR_Nem_3	20	26	PF02991	0.430
LIG_LIR_Nem_3	208	214	PF02991	0.488
LIG_LIR_Nem_3	215	220	PF02991	0.514
LIG_LIR_Nem_3	254	260	PF02991	0.506
LIG_LIR_Nem_3	349	355	PF02991	0.613
LIG_LIR_Nem_3	396	401	PF02991	0.370
LIG_LIR_Nem_3	56	62	PF02991	0.480
LIG_LIR_Nem_3	588	592	PF02991	0.433
LIG_LIR_Nem_3	864	868	PF02991	0.430
LIG_LYPXL_yS_3	261	264	PF13949	0.554
LIG_LYPXL_yS_3	59	62	PF13949	0.497
LIG_MYND_1	667	671	PF01753	0.403
LIG_NRBOX	133	139	PF00104	0.496
LIG_NRP_CendR_1	958	959	PF00754	0.479
LIG_PCNA_PIPBox_1	253	262	PF02747	0.375
LIG_PCNA_TLS_4	921	928	PF02747	0.289
LIG_SH2_CRK	398	402	PF00017	0.423
LIG_SH2_CRK	687	691	PF00017	0.271
LIG_SH2_NCK_1	189	193	PF00017	0.602
LIG_SH2_SRC	589	592	PF00017	0.464
LIG_SH2_STAP1	205	209	PF00017	0.543
LIG_SH2_STAP1	34	38	PF00017	0.353
LIG_SH2_STAP1	589	593	PF00017	0.465
LIG_SH2_STAT3	34	37	PF00017	0.462
LIG_SH2_STAT5	211	214	PF00017	0.561
LIG_SH2_STAT5	288	291	PF00017	0.651
LIG_SH2_STAT5	629	632	PF00017	0.542
LIG_SH2_STAT5	7	10	PF00017	0.495
LIG_SH2_STAT5	721	724	PF00017	0.295
LIG_SH2_STAT5	820	823	PF00017	0.357
LIG_SH2_STAT5	860	863	PF00017	0.324
LIG_SH3_3	240	246	PF00018	0.480
LIG_SH3_3	345	351	PF00018	0.536
LIG_SH3_3	380	386	PF00018	0.487
LIG_SH3_3	405	411	PF00018	0.552
LIG_SH3_3	709	715	PF00018	0.271
LIG_SH3_3	81	87	PF00018	0.456
LIG_SH3_3	849	855	PF00018	0.479
LIG_SUMO_SIM_anti_2	302	309	PF11976	0.651
LIG_SUMO_SIM_anti_2	366	371	PF11976	0.626
LIG_SUMO_SIM_anti_2	474	479	PF11976	0.377
LIG_SUMO_SIM_anti_2	591	597	PF11976	0.378
LIG_SUMO_SIM_anti_2	612	619	PF11976	0.654
LIG_SUMO_SIM_anti_2	846	851	PF11976	0.274
LIG_SUMO_SIM_par_1	443	449	PF11976	0.349
LIG_SUMO_SIM_par_1	490	497	PF11976	0.424
LIG_SUMO_SIM_par_1	591	597	PF11976	0.492
LIG_SUMO_SIM_par_1	773	778	PF11976	0.289
LIG_SUMO_SIM_par_1	848	854	PF11976	0.387
LIG_TRAF2_1	880	883	PF00917	0.577
LIG_TRAF2_1	912	915	PF00917	0.724
LIG_TYR_ITIM	209	214	PF00017	0.433
LIG_TYR_ITIM	259	264	PF00017	0.581
LIG_TYR_ITIM	587	592	PF00017	0.463
LIG_TYR_ITIM	818	823	PF00017	0.271
LIG_UBA3_1	831	835	PF00899	0.421
LIG_WRC_WIRS_1	417	422	PF05994	0.468
MOD_CDK_SPK_2	573	578	PF00069	0.550
MOD_CK1_1	168	174	PF00069	0.424
MOD_CK1_1	190	196	PF00069	0.547
MOD_CK1_1	199	205	PF00069	0.521
MOD_CK1_1	407	413	PF00069	0.438
MOD_CK1_1	576	582	PF00069	0.413
MOD_CK1_1	618	624	PF00069	0.468
MOD_CK1_1	636	642	PF00069	0.363
MOD_CK1_1	74	80	PF00069	0.481
MOD_CK1_1	785	791	PF00069	0.314
MOD_CK2_1	271	277	PF00069	0.377
MOD_CK2_1	338	344	PF00069	0.455
MOD_CK2_1	502	508	PF00069	0.462
MOD_CK2_1	823	829	PF00069	0.386
MOD_CK2_1	908	914	PF00069	0.587
MOD_CK2_1	96	102	PF00069	0.505
MOD_GlcNHglycan	147	150	PF01048	0.555
MOD_GlcNHglycan	170	173	PF01048	0.532
MOD_GlcNHglycan	221	226	PF01048	0.561
MOD_GlcNHglycan	230	233	PF01048	0.582
MOD_GlcNHglycan	273	276	PF01048	0.607
MOD_GlcNHglycan	448	451	PF01048	0.387
MOD_GlcNHglycan	499	502	PF01048	0.606
MOD_GlcNHglycan	605	608	PF01048	0.458
MOD_GlcNHglycan	910	913	PF01048	0.556
MOD_GSK3_1	123	130	PF00069	0.538
MOD_GSK3_1	195	202	PF00069	0.535
MOD_GSK3_1	338	345	PF00069	0.663
MOD_GSK3_1	480	487	PF00069	0.427
MOD_GSK3_1	502	509	PF00069	0.496
MOD_GSK3_1	569	576	PF00069	0.455
MOD_GSK3_1	581	588	PF00069	0.316
MOD_GSK3_1	603	610	PF00069	0.386
MOD_GSK3_1	621	628	PF00069	0.450
MOD_GSK3_1	629	636	PF00069	0.542
MOD_GSK3_1	67	74	PF00069	0.577
MOD_GSK3_1	898	905	PF00069	0.637
MOD_N-GLC_1	118	123	PF02516	0.487
MOD_N-GLC_1	203	208	PF02516	0.513
MOD_N-GLC_1	953	958	PF02516	0.388
MOD_NEK2_1	118	123	PF00069	0.533
MOD_NEK2_1	196	201	PF00069	0.665
MOD_NEK2_1	228	233	PF00069	0.651
MOD_NEK2_1	338	343	PF00069	0.631
MOD_NEK2_1	461	466	PF00069	0.498
MOD_NEK2_1	858	863	PF00069	0.340
MOD_NEK2_1	893	898	PF00069	0.686
MOD_NEK2_1	953	958	PF00069	0.530
MOD_NEK2_2	393	398	PF00069	0.358
MOD_PIKK_1	190	196	PF00454	0.626
MOD_PIKK_1	342	348	PF00454	0.542
MOD_PIKK_1	768	774	PF00454	0.404
MOD_PKA_1	166	172	PF00069	0.439
MOD_PKA_1	679	685	PF00069	0.453
MOD_PKA_2	145	151	PF00069	0.631
MOD_PKA_2	166	172	PF00069	0.566
MOD_PKA_2	338	344	PF00069	0.559
MOD_PKA_2	372	378	PF00069	0.606
MOD_PKA_2	459	465	PF00069	0.423
MOD_PKA_2	533	539	PF00069	0.573
MOD_PKA_2	645	651	PF00069	0.393
MOD_Plk_1	118	124	PF00069	0.533
MOD_Plk_1	290	296	PF00069	0.480
MOD_Plk_4	205	211	PF00069	0.525
MOD_Plk_4	3	9	PF00069	0.424
MOD_Plk_4	321	327	PF00069	0.592
MOD_Plk_4	393	399	PF00069	0.347
MOD_Plk_4	416	422	PF00069	0.469
MOD_Plk_4	471	477	PF00069	0.496
MOD_Plk_4	490	496	PF00069	0.537
MOD_Plk_4	569	575	PF00069	0.484
MOD_Plk_4	621	627	PF00069	0.373
MOD_Plk_4	633	639	PF00069	0.451
MOD_Plk_4	692	698	PF00069	0.271
MOD_Plk_4	79	85	PF00069	0.472
MOD_ProDKin_1	174	180	PF00069	0.405
MOD_ProDKin_1	378	384	PF00069	0.524
MOD_ProDKin_1	407	413	PF00069	0.618
MOD_ProDKin_1	573	579	PF00069	0.543
MOD_ProDKin_1	737	743	PF00069	0.271
MOD_ProDKin_1	898	904	PF00069	0.676
MOD_SUMO_for_1	656	659	PF00179	0.354
TRG_DiLeu_BaEn_1	223	228	PF01217	0.435
TRG_DiLeu_BaEn_2	853	859	PF01217	0.482
TRG_DiLeu_BaLyEn_6	555	560	PF01217	0.510
TRG_DiLeu_BaLyEn_6	727	732	PF01217	0.271
TRG_ENDOCYTIC_2	211	214	PF00928	0.561
TRG_ENDOCYTIC_2	23	26	PF00928	0.330
TRG_ENDOCYTIC_2	261	264	PF00928	0.430
TRG_ENDOCYTIC_2	398	401	PF00928	0.502
TRG_ENDOCYTIC_2	589	592	PF00928	0.468
TRG_ENDOCYTIC_2	59	62	PF00928	0.497
TRG_ENDOCYTIC_2	7	10	PF00928	0.598
TRG_ENDOCYTIC_2	820	823	PF00928	0.335
TRG_ENDOCYTIC_2	946	949	PF00928	0.382
TRG_ER_diArg_1	566	569	PF00400	0.445
TRG_ER_diArg_1	928	931	PF00400	0.392
TRG_NES_CRM1_1	659	672	PF08389	0.519
TRG_NES_CRM1_1	842	854	PF08389	0.430
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	312	317	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	658	662	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	730	734	PF00026	0.271

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Z4	Leptomonas seymouri	66%	99%
A0A1X0NZ72	Trypanosomatidae	41%	100%
A0A3S5H6W4	Leishmania donovani	80%	100%
A0A422NAC8	Trypanosoma rangeli	47%	100%
A4HWQ5	Leishmania infantum	81%	100%
C9ZPS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	98%
E9AQG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QF14	Leishmania major	81%	100%
V5ARC8	Trypanosoma cruzi	42%	100%