Arginine N-methyltransferase, type I

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

arginine N-methyltransferase, type I

Species:

Leishmania braziliensis

UniProt:

A4H8D0_LEIBR

TriTrypDb:

LbrM.16.0040 , LBRM2903_160005500

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005840	ribosome	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4H8D0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8D0

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008213	protein alkylation	5	12
GO:0009987	cellular process	1	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018195	peptidyl-arginine modification	6	12
GO:0018216	peptidyl-arginine methylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0032259	methylation	2	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	8	1
GO:0034969	histone arginine methylation	6	1
GO:0035246	peptidyl-arginine N-methylation	6	1
GO:0035247	peptidyl-arginine omega-N-methylation	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016273	arginine N-methyltransferase activity	6	12
GO:0016274	protein-arginine N-methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0008169	C-methyltransferase activity	5	1
GO:0008469	histone arginine N-methyltransferase activity	5	1
GO:0035244	protein-arginine C-methyltransferase activity	4	1
GO:0042054	histone methyltransferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.517
CLV_PCSK_SKI1_1	158	162	PF00082	0.322
CLV_PCSK_SKI1_1	235	239	PF00082	0.437
CLV_PCSK_SKI1_1	28	32	PF00082	0.394
CLV_PCSK_SKI1_1	41	45	PF00082	0.351
DEG_MDM2_SWIB_1	198	205	PF02201	0.479
DEG_Nend_UBRbox_3	1	3	PF02207	0.720
DEG_ODPH_VHL_1	310	323	PF01847	0.519
DOC_ANK_TNKS_1	46	53	PF00023	0.473
DOC_CYCLIN_RxL_1	232	240	PF00134	0.468
DOC_CYCLIN_RxL_1	36	48	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	184	190	PF00134	0.465
DOC_MAPK_gen_1	32	39	PF00069	0.477
DOC_MAPK_gen_1	325	335	PF00069	0.458
DOC_MAPK_MEF2A_6	128	137	PF00069	0.401
DOC_PP1_RVXF_1	213	219	PF00149	0.478
DOC_PP1_RVXF_1	357	363	PF00149	0.497
DOC_PP2B_LxvP_1	184	187	PF13499	0.463
DOC_PP2B_LxvP_1	310	313	PF13499	0.530
DOC_USP7_MATH_1	167	171	PF00917	0.530
DOC_USP7_MATH_1	277	281	PF00917	0.520
DOC_USP7_MATH_1	69	73	PF00917	0.524
DOC_WW_Pin1_4	223	228	PF00397	0.454
DOC_WW_Pin1_4	305	310	PF00397	0.381
LIG_14-3-3_CanoR_1	101	105	PF00244	0.505
LIG_14-3-3_CanoR_1	347	353	PF00244	0.462
LIG_14-3-3_CanoR_1	90	98	PF00244	0.524
LIG_Actin_WH2_2	331	349	PF00022	0.468
LIG_APCC_ABBA_1	143	148	PF00400	0.424
LIG_deltaCOP1_diTrp_1	139	146	PF00928	0.325
LIG_FHA_1	223	229	PF00498	0.477
LIG_FHA_1	249	255	PF00498	0.491
LIG_FHA_1	305	311	PF00498	0.447
LIG_FHA_1	317	323	PF00498	0.294
LIG_FHA_2	106	112	PF00498	0.429
LIG_FHA_2	347	353	PF00498	0.501
LIG_Integrin_isoDGR_2	180	182	PF01839	0.279
LIG_LIR_Gen_1	19	29	PF02991	0.481
LIG_LIR_Gen_1	196	205	PF02991	0.407
LIG_LIR_Gen_1	246	257	PF02991	0.507
LIG_LIR_Gen_1	334	342	PF02991	0.456
LIG_LIR_Nem_3	138	143	PF02991	0.325
LIG_LIR_Nem_3	15	21	PF02991	0.466
LIG_LIR_Nem_3	196	201	PF02991	0.398
LIG_LIR_Nem_3	246	252	PF02991	0.499
LIG_LIR_Nem_3	293	298	PF02991	0.334
LIG_LIR_Nem_3	326	330	PF02991	0.455
LIG_LIR_Nem_3	334	338	PF02991	0.453
LIG_Pex14_1	140	144	PF04695	0.327
LIG_Pex14_1	245	249	PF04695	0.465
LIG_Pex14_2	198	202	PF04695	0.479
LIG_Pex14_2	292	296	PF04695	0.342
LIG_REV1ctd_RIR_1	158	166	PF16727	0.309
LIG_SH2_CRK	40	44	PF00017	0.483
LIG_SH2_STAP1	194	198	PF00017	0.417
LIG_SH2_STAP1	7	11	PF00017	0.660
LIG_SH2_STAT5	144	147	PF00017	0.341
LIG_SH2_STAT5	17	20	PF00017	0.475
LIG_SH3_3	228	234	PF00018	0.413
LIG_SH3_3	306	312	PF00018	0.383
LIG_SH3_3	318	324	PF00018	0.337
LIG_SUMO_SIM_par_1	250	256	PF11976	0.517
LIG_SUMO_SIM_par_1	54	60	PF11976	0.460
LIG_SUMO_SIM_par_1	76	81	PF11976	0.509
LIG_TRAF2_1	108	111	PF00917	0.342
LIG_WW_3	232	236	PF00397	0.457
MOD_CK1_1	248	254	PF00069	0.489
MOD_CK1_1	9	15	PF00069	0.581
MOD_CK2_1	105	111	PF00069	0.475
MOD_CK2_1	277	283	PF00069	0.550
MOD_CK2_1	45	51	PF00069	0.424
MOD_CK2_1	81	87	PF00069	0.472
MOD_CK2_1	9	15	PF00069	0.435
MOD_GlcNHglycan	275	278	PF01048	0.470
MOD_GlcNHglycan	59	62	PF01048	0.259
MOD_GlcNHglycan	71	74	PF01048	0.251
MOD_GSK3_1	262	269	PF00069	0.397
MOD_GSK3_1	273	280	PF00069	0.437
MOD_GSK3_1	281	288	PF00069	0.188
MOD_GSK3_1	342	349	PF00069	0.413
MOD_GSK3_1	59	66	PF00069	0.452
MOD_GSK3_1	76	83	PF00069	0.451
MOD_LATS_1	315	321	PF00433	0.396
MOD_NEK2_1	120	125	PF00069	0.404
MOD_NEK2_1	168	173	PF00069	0.501
MOD_NEK2_1	266	271	PF00069	0.437
MOD_NEK2_1	281	286	PF00069	0.403
MOD_NEK2_1	296	301	PF00069	0.268
MOD_NEK2_1	342	347	PF00069	0.398
MOD_NEK2_1	39	44	PF00069	0.425
MOD_NEK2_2	22	27	PF00069	0.547
MOD_PKA_2	100	106	PF00069	0.512
MOD_PKA_2	346	352	PF00069	0.505
MOD_Plk_1	22	28	PF00069	0.543
MOD_Plk_1	255	261	PF00069	0.366
MOD_Plk_1	342	348	PF00069	0.403
MOD_Plk_1	45	51	PF00069	0.360
MOD_Plk_1	80	86	PF00069	0.462
MOD_Plk_2-3	250	256	PF00069	0.299
MOD_Plk_2-3	81	87	PF00069	0.472
MOD_Plk_4	100	106	PF00069	0.499
MOD_Plk_4	150	156	PF00069	0.338
MOD_Plk_4	256	262	PF00069	0.512
MOD_Plk_4	277	283	PF00069	0.280
MOD_Plk_4	317	323	PF00069	0.390
MOD_Plk_4	39	45	PF00069	0.311
MOD_ProDKin_1	223	229	PF00069	0.449
MOD_ProDKin_1	305	311	PF00069	0.383
MOD_SUMO_rev_2	46	55	PF00179	0.539
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.480
TRG_ENDOCYTIC_2	21	24	PF00928	0.469
TRG_ENDOCYTIC_2	339	342	PF00928	0.272
TRG_ENDOCYTIC_2	40	43	PF00928	0.492
TRG_ER_diArg_1	155	158	PF00400	0.339
TRG_ER_diArg_1	34	37	PF00400	0.482
TRG_NES_CRM1_1	337	352	PF08389	0.256
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A7	Leptomonas seymouri	23%	91%
A0A0N0P6T9	Leptomonas seymouri	31%	100%
A0A0N0P7Z0	Leptomonas seymouri	64%	100%
A0A0S4JQD8	Bodo saltans	37%	98%
A0A0S4JWH9	Bodo saltans	31%	100%
A0A1X0NMC6	Trypanosomatidae	29%	100%
A0A1X0P0F1	Trypanosomatidae	45%	99%
A0A3R7MAM8	Trypanosoma rangeli	48%	99%
A0A3S5H6M7	Leishmania donovani	31%	100%
A0A3S7WTR5	Leishmania donovani	83%	100%
A0A422NV18	Trypanosoma rangeli	29%	100%
A0A422NZF0	Trypanosoma rangeli	26%	86%
A0A451EJR0	Leishmania donovani	23%	90%
A2XYY8	Oryza sativa subsp. indica	29%	96%
A2Y953	Oryza sativa subsp. indica	29%	96%
A2YPT7	Oryza sativa subsp. indica	33%	69%
A2Z0C0	Oryza sativa subsp. indica	28%	94%
A2Z8S0	Oryza sativa subsp. indica	27%	92%
A3KPF2	Arabidopsis thaliana	30%	69%
A4H8A2	Leishmania braziliensis	22%	90%
A4HWQ2	Leishmania infantum	82%	100%
A8IEF3	Chlamydomonas reinhardtii	30%	100%
B0JYW5	Xenopus tropicalis	30%	100%
B3DLB3	Xenopus tropicalis	30%	84%
B3M1E1	Drosophila ananassae	30%	69%
B3P4N5	Drosophila erecta	30%	69%
B4GZ20	Drosophila persimilis	30%	69%
B4HJC0	Drosophila sechellia	30%	69%
B4JXV2	Drosophila grimshawi	30%	67%
B4KA23	Drosophila mojavensis	30%	68%
B4LVS8	Drosophila virilis	30%	68%
B4NKI9	Drosophila willistoni	30%	68%
B4PVH6	Drosophila yakuba	30%	69%
B4QVW6	Drosophila simulans	30%	69%
C9ZI39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZPS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	99%
D9IVE5	Xenopus laevis	29%	84%
E9ACK5	Leishmania major	23%	90%
E9AG49	Leishmania infantum	23%	90%
E9AGI9	Leishmania infantum	31%	100%
E9AIN9	Leishmania braziliensis	31%	99%
E9AJU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	91%
E9AP27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AQF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O13648	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	67%
O60678	Homo sapiens	30%	69%
O70467	Rattus norvegicus	29%	69%
O82210	Arabidopsis thaliana	28%	100%
P38074	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
P55345	Homo sapiens	29%	84%
Q08A71	Arabidopsis thaliana	30%	84%
Q0J2C6	Oryza sativa subsp. japonica	28%	94%
Q28F07	Xenopus tropicalis	30%	100%
Q29B63	Drosophila pseudoobscura pseudoobscura	30%	69%
Q4QF17	Leishmania major	85%	100%
Q4QGG2	Leishmania major	31%	100%
Q54EF2	Dictyostelium discoideum	25%	100%
Q54HI0	Dictyostelium discoideum	30%	71%
Q5E9L5	Bos taurus	33%	97%
Q5RGQ2	Danio rerio	29%	87%
Q63009	Rattus norvegicus	29%	100%
Q68EZ3	Xenopus laevis	30%	100%
Q6NWG4	Danio rerio	29%	100%
Q6NZB1	Mus musculus	31%	97%
Q6PAK3	Mus musculus	30%	93%
Q6VRB0	Xenopus laevis	30%	100%
Q75G68	Oryza sativa subsp. japonica	27%	92%
Q7XI75	Oryza sativa subsp. japonica	33%	69%
Q7XKC0	Oryza sativa subsp. japonica	28%	93%
Q84W92	Arabidopsis thaliana	32%	68%
Q8AV13	Xenopus laevis	30%	99%
Q922H1	Mus musculus	29%	69%
Q96LA8	Homo sapiens	31%	97%
Q99873	Homo sapiens	29%	98%
Q9JIF0	Mus musculus	29%	98%
Q9NR22	Homo sapiens	30%	93%
Q9R144	Mus musculus	29%	81%
Q9SNQ2	Oryza sativa subsp. japonica	29%	96%
Q9SU94	Arabidopsis thaliana	29%	94%
Q9U2X0	Caenorhabditis elegans	31%	100%
Q9URX7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q9VH48	Drosophila melanogaster	30%	69%
V5ARC3	Trypanosoma cruzi	47%	93%
V5BF38	Trypanosoma cruzi	29%	100%