Adenylate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Adenylate kinase

Gene product:

AAA domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8C9_LEIBR

TriTrypDb:

LbrM.16.0030 , LBRM2903_160005400

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	6
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0005737	cytoplasm	2	2
GO:0005777	peroxisome	6	1
GO:0005829	cytosol	2	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1

Expansion

Sequence features

A4H8C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8C9

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	18
GO:0006796	phosphate-containing compound metabolic process	4	18
GO:0008152	metabolic process	1	19
GO:0009987	cellular process	1	19
GO:0016310	phosphorylation	5	18
GO:0044237	cellular metabolic process	2	19
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009117	nucleotide metabolic process	5	2
GO:0009132	nucleoside diphosphate metabolic process	5	2
GO:0009141	nucleoside triphosphate metabolic process	5	2
GO:0009142	nucleoside triphosphate biosynthetic process	6	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046939	obsolete nucleotide phosphorylation	6	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901293	nucleoside phosphate biosynthetic process	5	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0033554	cellular response to stress	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0090304	nucleic acid metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	19
GO:0003824	catalytic activity	1	19
GO:0004017	adenylate kinase activity	6	14
GO:0005488	binding	1	19
GO:0005524	ATP binding	5	19
GO:0016301	kinase activity	4	19
GO:0016740	transferase activity	2	19
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	19
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	14
GO:0017076	purine nucleotide binding	4	19
GO:0019205	nucleobase-containing compound kinase activity	5	19
GO:0030554	adenyl nucleotide binding	5	19
GO:0032553	ribonucleotide binding	3	19
GO:0032555	purine ribonucleotide binding	4	19
GO:0032559	adenyl ribonucleotide binding	5	19
GO:0035639	purine ribonucleoside triphosphate binding	4	19
GO:0036094	small molecule binding	2	19
GO:0043167	ion binding	2	19
GO:0043168	anion binding	3	19
GO:0050145	nucleoside monophosphate kinase activity	5	14
GO:0097159	organic cyclic compound binding	2	19
GO:0097367	carbohydrate derivative binding	2	19
GO:1901265	nucleoside phosphate binding	3	19
GO:1901363	heterocyclic compound binding	2	19
GO:0004127	cytidylate kinase activity	6	2
GO:0004550	nucleoside diphosphate kinase activity	5	2
GO:0004386	helicase activity	2	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:0140657	ATP-dependent activity	1	2
GO:0003678	DNA helicase activity	3	1
GO:0008094	ATP-dependent activity, acting on DNA	2	1
GO:0009378	four-way junction helicase activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.434
CLV_NRD_NRD_1	176	178	PF00675	0.379
CLV_NRD_NRD_1	47	49	PF00675	0.489
CLV_PCSK_KEX2_1	176	178	PF00082	0.453
CLV_PCSK_KEX2_1	47	49	PF00082	0.421
CLV_PCSK_SKI1_1	20	24	PF00082	0.335
DOC_MAPK_DCC_7	44	54	PF00069	0.337
DOC_MAPK_gen_1	44	54	PF00069	0.401
DOC_MAPK_MEF2A_6	47	56	PF00069	0.341
DOC_PP1_RVXF_1	15	22	PF00149	0.403
DOC_PP2B_LxvP_1	138	141	PF13499	0.324
DOC_PP2B_LxvP_1	32	35	PF13499	0.521
DOC_PP4_FxxP_1	46	49	PF00568	0.413
DOC_USP7_MATH_1	153	157	PF00917	0.694
DOC_USP7_MATH_1	59	63	PF00917	0.407
DOC_USP7_MATH_1	78	82	PF00917	0.441
DOC_WW_Pin1_4	128	133	PF00397	0.410
DOC_WW_Pin1_4	47	52	PF00397	0.556
LIG_14-3-3_CanoR_1	176	184	PF00244	0.310
LIG_BIR_II_1	1	5	PF00653	0.537
LIG_FHA_1	125	131	PF00498	0.410
LIG_FHA_1	176	182	PF00498	0.410
LIG_FHA_1	208	214	PF00498	0.445
LIG_FHA_2	116	122	PF00498	0.417
LIG_FHA_2	194	200	PF00498	0.493
LIG_FHA_2	81	87	PF00498	0.473
LIG_LIR_Apic_2	43	49	PF02991	0.403
LIG_LIR_Nem_3	169	173	PF02991	0.342
LIG_LIR_Nem_3	182	187	PF02991	0.371
LIG_SH2_SRC	13	16	PF00017	0.268
LIG_SH2_STAT5	13	16	PF00017	0.412
LIG_SH3_3	32	38	PF00018	0.411
LIG_SH3_3	87	93	PF00018	0.329
LIG_UBA3_1	96	101	PF00899	0.338
MOD_CK1_1	128	134	PF00069	0.279
MOD_CK1_1	157	163	PF00069	0.547
MOD_CK1_1	2	8	PF00069	0.560
MOD_CK1_1	62	68	PF00069	0.424
MOD_CK2_1	193	199	PF00069	0.465
MOD_GlcNHglycan	127	130	PF01048	0.475
MOD_GlcNHglycan	61	64	PF01048	0.366
MOD_GlcNHglycan	80	83	PF01048	0.420
MOD_GSK3_1	124	131	PF00069	0.410
MOD_GSK3_1	153	160	PF00069	0.602
MOD_GSK3_1	175	182	PF00069	0.319
MOD_GSK3_1	207	214	PF00069	0.417
MOD_GSK3_1	59	66	PF00069	0.425
MOD_NEK2_1	125	130	PF00069	0.489
MOD_NEK2_2	207	212	PF00069	0.473
MOD_PKA_2	147	153	PF00069	0.458
MOD_PKA_2	175	181	PF00069	0.328
MOD_Plk_1	191	197	PF00069	0.467
MOD_Plk_1	7	13	PF00069	0.522
MOD_ProDKin_1	128	134	PF00069	0.405
MOD_ProDKin_1	47	53	PF00069	0.546
MOD_SUMO_rev_2	95	103	PF00179	0.499
TRG_ENDOCYTIC_2	184	187	PF00928	0.348
TRG_ENDOCYTIC_2	188	191	PF00928	0.339
TRG_ER_diArg_1	175	177	PF00400	0.404
TRG_ER_diArg_1	46	48	PF00400	0.406
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7A0	Leptomonas seymouri	48%	100%
A0A0S4JIH6	Bodo saltans	27%	83%
A0A0S4JLR6	Bodo saltans	27%	83%
A0A1X0NZB3	Trypanosomatidae	28%	82%
A0A1X0P0N7	Trypanosomatidae	29%	82%
A0A3R7KVX5	Trypanosoma rangeli	29%	82%
A0A3S7WTR3	Leishmania donovani	71%	100%
A0A3S7WWN3	Leishmania donovani	29%	80%
A0A422MYT1	Trypanosoma rangeli	31%	82%
A0A422N279	Trypanosoma rangeli	28%	93%
A4HBY0	Leishmania braziliensis	30%	78%
A4HWQ1	Leishmania infantum	71%	100%
A4HZC2	Leishmania infantum	29%	80%
B1MGB3	Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)	24%	100%
B4SI37	Stenotrophomonas maltophilia (strain R551-3)	25%	100%
B8ZS96	Mycobacterium leprae (strain Br4923)	27%	100%
C9ZJR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	82%
C9ZPT0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	82%
D0A165	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	82%
E9AQF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
E9AVA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	80%
O33007	Mycobacterium leprae (strain TN)	27%	100%
O61069	Trypanosoma brucei rhodesiense	24%	100%
P12115	Cyprinus carpio	25%	100%
Q4QC71	Leishmania major	30%	100%
Q4QF18	Leishmania major	70%	100%
Q5LGH0	Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow)	23%	100%
Q64XA6	Bacteroides fragilis (strain YCH46)	23%	100%
Q89ZJ0	Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)	23%	100%
Q8DML4	Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)	27%	100%
Q9PGM3	Xylella fastidiosa (strain 9a5c)	25%	100%
V5B6T5	Trypanosoma cruzi	29%	68%
V5BH98	Trypanosoma cruzi	31%	82%