Ribosomal_L18e/L15P domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8C8_LEIBR

TriTrypDb:

LbrM.16.0020 , LBRM2903_160005300

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	11
GO:0032991	protein-containing complex	1	11
GO:0044391	ribosomal subunit	3	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005737	cytoplasm	2	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8C8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8C8

PDB structure(s): 7aih_G , 7am2_G , 7ane_G

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.532
CLV_MEL_PAP_1	153	159	PF00089	0.335
CLV_NRD_NRD_1	134	136	PF00675	0.346
CLV_NRD_NRD_1	144	146	PF00675	0.321
CLV_NRD_NRD_1	281	283	PF00675	0.485
CLV_NRD_NRD_1	292	294	PF00675	0.442
CLV_NRD_NRD_1	368	370	PF00675	0.567
CLV_NRD_NRD_1	53	55	PF00675	0.463
CLV_PCSK_KEX2_1	134	136	PF00082	0.339
CLV_PCSK_KEX2_1	294	296	PF00082	0.418
CLV_PCSK_KEX2_1	368	370	PF00082	0.495
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.407
CLV_PCSK_SKI1_1	145	149	PF00082	0.369
CLV_PCSK_SKI1_1	150	154	PF00082	0.384
CLV_PCSK_SKI1_1	201	205	PF00082	0.447
CLV_PCSK_SKI1_1	209	213	PF00082	0.447
CLV_PCSK_SKI1_1	54	58	PF00082	0.473
CLV_PCSK_SKI1_1	95	99	PF00082	0.381
DEG_APCC_DBOX_1	173	181	PF00400	0.378
DEG_Nend_Nbox_1	1	3	PF02207	0.588
DEG_SCF_FBW7_2	97	102	PF00400	0.396
DOC_CYCLIN_yClb5_NLxxxL_5	172	181	PF00134	0.266
DOC_MAPK_MEF2A_6	225	234	PF00069	0.378
DOC_PP1_RVXF_1	177	183	PF00149	0.366
DOC_PP1_RVXF_1	207	214	PF00149	0.378
DOC_PP1_RVXF_1	43	49	PF00149	0.593
DOC_USP7_MATH_1	155	159	PF00917	0.378
DOC_USP7_MATH_1	27	31	PF00917	0.465
DOC_USP7_MATH_1	309	313	PF00917	0.349
DOC_USP7_MATH_1	357	361	PF00917	0.492
DOC_USP7_MATH_1	367	371	PF00917	0.490
DOC_USP7_UBL2_3	340	344	PF12436	0.455
DOC_WW_Pin1_4	145	150	PF00397	0.330
DOC_WW_Pin1_4	95	100	PF00397	0.474
LIG_14-3-3_CanoR_1	12	18	PF00244	0.437
LIG_14-3-3_CanoR_1	156	162	PF00244	0.355
LIG_14-3-3_CanoR_1	315	323	PF00244	0.518
LIG_14-3-3_CanoR_1	368	374	PF00244	0.580
LIG_14-3-3_CanoR_1	45	49	PF00244	0.529
LIG_14-3-3_CanoR_1	73	82	PF00244	0.501
LIG_CaM_IQ_9	4	20	PF13499	0.379
LIG_FHA_1	184	190	PF00498	0.389
LIG_FHA_1	192	198	PF00498	0.362
LIG_FHA_1	2	8	PF00498	0.494
LIG_FHA_2	271	277	PF00498	0.591
LIG_FHA_2	323	329	PF00498	0.480
LIG_FHA_2	330	336	PF00498	0.468
LIG_LIR_Apic_2	100	106	PF02991	0.494
LIG_LIR_Apic_2	305	311	PF02991	0.459
LIG_LIR_Apic_2	317	323	PF02991	0.474
LIG_LIR_Apic_2	83	88	PF02991	0.450
LIG_LIR_Gen_1	171	180	PF02991	0.447
LIG_LIR_Gen_1	251	257	PF02991	0.439
LIG_LIR_Nem_3	171	175	PF02991	0.447
LIG_LIR_Nem_3	251	255	PF02991	0.418
LIG_LIR_Nem_3	269	274	PF02991	0.387
LIG_LIR_Nem_3	30	35	PF02991	0.419
LIG_LIR_Nem_3	47	51	PF02991	0.408
LIG_LIR_Nem_3	80	85	PF02991	0.479
LIG_LIR_Nem_3	91	97	PF02991	0.496
LIG_NRBOX	176	182	PF00104	0.355
LIG_SH2_GRB2like	36	39	PF00017	0.554
LIG_SH2_GRB2like	85	88	PF00017	0.463
LIG_SH2_NCK_1	308	312	PF00017	0.464
LIG_SH2_PTP2	103	106	PF00017	0.318
LIG_SH2_PTP2	320	323	PF00017	0.500
LIG_SH2_PTP2	85	88	PF00017	0.588
LIG_SH2_SRC	308	311	PF00017	0.468
LIG_SH2_SRC	85	88	PF00017	0.463
LIG_SH2_STAP1	126	130	PF00017	0.497
LIG_SH2_STAP1	36	40	PF00017	0.554
LIG_SH2_STAT5	103	106	PF00017	0.386
LIG_SH2_STAT5	320	323	PF00017	0.481
LIG_SH2_STAT5	85	88	PF00017	0.461
LIG_SH3_3	223	229	PF00018	0.281
LIG_SH3_3	318	324	PF00018	0.403
LIG_TRAF2_1	332	335	PF00917	0.501
LIG_TRFH_1	151	155	PF08558	0.335
LIG_WRC_WIRS_1	271	276	PF05994	0.594
MOD_CDK_SPK_2	145	150	PF00069	0.335
MOD_CK1_1	360	366	PF00069	0.475
MOD_CK2_1	270	276	PF00069	0.590
MOD_CK2_1	329	335	PF00069	0.479
MOD_CMANNOS	79	82	PF00535	0.467
MOD_Cter_Amidation	52	55	PF01082	0.469
MOD_GlcNHglycan	107	110	PF01048	0.475
MOD_GlcNHglycan	157	160	PF01048	0.392
MOD_GlcNHglycan	237	240	PF01048	0.373
MOD_GlcNHglycan	311	314	PF01048	0.500
MOD_GlcNHglycan	316	319	PF01048	0.461
MOD_GlcNHglycan	351	354	PF01048	0.519
MOD_GlcNHglycan	369	372	PF01048	0.391
MOD_GlcNHglycan	4	7	PF01048	0.673
MOD_GSK3_1	120	127	PF00069	0.470
MOD_GSK3_1	73	80	PF00069	0.577
MOD_N-GLC_1	175	180	PF02516	0.470
MOD_N-GLC_1	191	196	PF02516	0.437
MOD_N-GLC_1	235	240	PF02516	0.355
MOD_NEK2_1	1	6	PF00069	0.594
MOD_NEK2_1	13	18	PF00069	0.499
MOD_NEK2_1	175	180	PF00069	0.362
MOD_NEK2_2	27	32	PF00069	0.438
MOD_PIKK_1	88	94	PF00454	0.472
MOD_PKA_2	155	161	PF00069	0.355
MOD_PKA_2	314	320	PF00069	0.516
MOD_PKA_2	367	373	PF00069	0.540
MOD_PKA_2	44	50	PF00069	0.523
MOD_PKA_2	72	78	PF00069	0.511
MOD_Plk_1	191	197	PF00069	0.447
MOD_Plk_2-3	270	276	PF00069	0.623
MOD_Plk_4	27	33	PF00069	0.437
MOD_Plk_4	270	276	PF00069	0.590
MOD_Plk_4	351	357	PF00069	0.461
MOD_ProDKin_1	145	151	PF00069	0.330
MOD_ProDKin_1	95	101	PF00069	0.478
MOD_SUMO_rev_2	276	285	PF00179	0.501
TRG_DiLeu_BaEn_3	269	275	PF01217	0.584
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.409
TRG_ENDOCYTIC_2	263	266	PF00928	0.427
TRG_ER_diArg_1	162	165	PF00400	0.355
TRG_ER_diArg_1	292	295	PF00400	0.443
TRG_ER_diArg_1	9	12	PF00400	0.554
TRG_NLS_Bipartite_1	282	297	PF00514	0.538
TRG_NLS_MonoExtN_4	292	297	PF00514	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PET7	Leptomonas seymouri	89%	100%
A0A0S4JQJ9	Bodo saltans	59%	100%
A0A1X0NZG0	Trypanosomatidae	73%	100%
A0A3Q8IA98	Leishmania donovani	94%	100%
A4HWQ0	Leishmania infantum	94%	100%
C9ZPT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AQF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QF19	Leishmania major	92%	100%
V5BFU8	Trypanosoma cruzi	74%	100%