Anti-silencing protein a-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

anti-silencing protein a-like protein

Species:

Leishmania braziliensis

UniProt:

A4H8C7_LEIBR

TriTrypDb:

LbrM.16.0010 , LBRM2903_160005200

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	16
GO:0043226	organelle	2	16
GO:0043227	membrane-bounded organelle	3	16
GO:0043229	intracellular organelle	3	16
GO:0043231	intracellular membrane-bounded organelle	4	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A4H8C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8C7

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	16
GO:0009987	cellular process	1	16
GO:0016043	cellular component organization	3	16
GO:0071840	cellular component organization or biogenesis	2	16
GO:0006335	DNA replication-dependent chromatin assembly	5	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	16
GO:0030527	structural constituent of chromatin	2	16
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.717
CLV_NRD_NRD_1	7	9	PF00675	0.401
CLV_PCSK_FUR_1	176	180	PF00082	0.707
CLV_PCSK_KEX2_1	175	177	PF00082	0.585
CLV_PCSK_KEX2_1	178	180	PF00082	0.665
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.601
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.686
CLV_PCSK_SKI1_1	175	179	PF00082	0.617
DEG_APCC_DBOX_1	3	11	PF00400	0.326
DEG_SPOP_SBC_1	125	129	PF00917	0.182
DOC_MAPK_gen_1	101	110	PF00069	0.303
DOC_MAPK_gen_1	35	45	PF00069	0.424
DOC_MAPK_MEF2A_6	25	32	PF00069	0.387
DOC_MAPK_MEF2A_6	38	45	PF00069	0.176
DOC_MAPK_NFAT4_5	25	33	PF00069	0.435
DOC_PP1_RVXF_1	142	149	PF00149	0.424
DOC_PP4_FxxP_1	20	23	PF00568	0.326
DOC_PP4_FxxP_1	33	36	PF00568	0.326
DOC_USP7_MATH_1	15	19	PF00917	0.435
DOC_USP7_MATH_1	154	158	PF00917	0.696
DOC_USP7_MATH_1	166	170	PF00917	0.748
DOC_WW_Pin1_4	45	50	PF00397	0.348
LIG_14-3-3_CterR_2	181	185	PF00244	0.685
LIG_BRCT_BRCA1_1	16	20	PF00533	0.182
LIG_CSL_BTD_1	46	49	PF09270	0.376
LIG_FHA_1	127	133	PF00498	0.387
LIG_FHA_1	92	98	PF00498	0.296
LIG_FHA_2	1	7	PF00498	0.357
LIG_FHA_2	125	131	PF00498	0.415
LIG_LIR_Apic_2	17	23	PF02991	0.371
LIG_LIR_Apic_2	31	36	PF02991	0.254
LIG_LIR_Apic_2	48	54	PF02991	0.378
LIG_LIR_Gen_1	106	115	PF02991	0.290
LIG_LIR_Nem_3	106	110	PF02991	0.287
LIG_LIR_Nem_3	44	50	PF02991	0.333
LIG_LYPXL_yS_3	140	143	PF13949	0.424
LIG_SH2_CRK	112	116	PF00017	0.182
LIG_SH2_STAT3	102	105	PF00017	0.227
LIG_SH3_3	87	93	PF00018	0.334
LIG_SH3_3	9	15	PF00018	0.438
LIG_SUMO_SIM_par_1	28	34	PF11976	0.376
LIG_TYR_ITIM	110	115	PF00017	0.198
LIG_UBA3_1	96	103	PF00899	0.398
MOD_CK1_1	159	165	PF00069	0.695
MOD_CK2_1	124	130	PF00069	0.321
MOD_CK2_1	158	164	PF00069	0.584
MOD_GlcNHglycan	152	155	PF01048	0.635
MOD_GlcNHglycan	164	167	PF01048	0.693
MOD_GlcNHglycan	168	171	PF01048	0.709
MOD_GSK3_1	126	133	PF00069	0.232
MOD_GSK3_1	150	157	PF00069	0.621
MOD_GSK3_1	158	165	PF00069	0.647
MOD_GSK3_1	41	48	PF00069	0.424
MOD_NEK2_1	158	163	PF00069	0.485
MOD_NEK2_1	96	101	PF00069	0.299
MOD_Plk_1	41	47	PF00069	0.403
MOD_Plk_1	73	79	PF00069	0.332
MOD_ProDKin_1	45	51	PF00069	0.348
MOD_SUMO_for_1	177	180	PF00179	0.738
TRG_ENDOCYTIC_2	112	115	PF00928	0.184
TRG_ENDOCYTIC_2	140	143	PF00928	0.424
TRG_NLS_MonoExtC_3	174	179	PF00514	0.589
TRG_NLS_MonoExtN_4	173	179	PF00514	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0I1	Leptomonas seymouri	66%	100%
A0A0N1I2C8	Leptomonas seymouri	33%	100%
A0A0S4IIL8	Bodo saltans	28%	100%
A0A0S4JN61	Bodo saltans	47%	100%
A0A0S4JR86	Bodo saltans	49%	86%
A0A1X0NWK6	Trypanosomatidae	35%	100%
A0A1X0P1H0	Trypanosomatidae	62%	92%
A0A3Q8IAD9	Leishmania donovani	79%	100%
A0A3Q8IBF3	Leishmania donovani	32%	100%
A0A3R7M8V4	Trypanosoma rangeli	32%	100%
A0A422ND92	Trypanosoma rangeli	54%	91%
A4HBH4	Leishmania braziliensis	33%	100%
A4HWP9	Leishmania infantum	79%	100%
A4HYJ8	Leishmania infantum	32%	100%
C9ZHU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
C9ZW62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	83%
E9AQF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9AUE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
O74515	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	71%
P32447	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	66%
Q17QJ0	Bos taurus	31%	92%
Q1E0W9	Coccidioides immitis (strain RS)	31%	68%
Q2GQS2	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	30%	67%
Q2KIG1	Bos taurus	31%	91%
Q3C1E9	Gallus gallus	31%	91%
Q4IR08	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	33%	66%
Q4PBU8	Ustilago maydis (strain 521 / FGSC 9021)	28%	100%
Q4QF20	Leishmania major	79%	100%
Q59MV1	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	75%
Q5B3I9	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	30%	66%
Q69DB9	Xenopus laevis	31%	92%
Q6BYE5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	29%	70%
Q6CI62	Yarrowia lipolytica (strain CLIB 122 / E 150)	29%	70%
Q6CN69	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	29%	67%
Q6DIP1	Xenopus tropicalis	32%	92%
Q6NY34	Danio rerio	34%	94%
Q6NYY4	Danio rerio	32%	94%
Q759F6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	30%	67%
Q7S1X9	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	29%	68%
Q7T0M6	Xenopus laevis	33%	92%
Q9BJ46	Leishmania major	32%	100%
Q9CQE6	Mus musculus	31%	91%
Q9DAP7	Mus musculus	31%	92%
Q9NVP2	Homo sapiens	32%	92%
Q9V464	Drosophila melanogaster	33%	85%
Q9Y294	Homo sapiens	31%	91%
V5B915	Trypanosoma cruzi	54%	92%
V5C0E3	Trypanosoma cruzi	35%	100%