LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H8C3_LEIBR
TriTrypDb:
LbrM.15.1550 , LBRM2903_150022600 *
Length:
298

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8C3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8C3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 285 287 PF00675 0.602
CLV_NRD_NRD_1 39 41 PF00675 0.446
CLV_PCSK_FUR_1 37 41 PF00082 0.444
CLV_PCSK_KEX2_1 123 125 PF00082 0.560
CLV_PCSK_KEX2_1 285 287 PF00082 0.650
CLV_PCSK_KEX2_1 39 41 PF00082 0.446
CLV_PCSK_PC1ET2_1 123 125 PF00082 0.567
CLV_PCSK_SKI1_1 123 127 PF00082 0.598
CLV_PCSK_SKI1_1 13 17 PF00082 0.433
CLV_PCSK_SKI1_1 42 46 PF00082 0.452
DEG_Nend_Nbox_1 1 3 PF02207 0.443
DEG_SCF_FBW7_1 246 253 PF00400 0.439
DEG_SPOP_SBC_1 43 47 PF00917 0.454
DOC_CKS1_1 14 19 PF01111 0.431
DOC_MAPK_gen_1 218 226 PF00069 0.580
DOC_MAPK_gen_1 285 291 PF00069 0.617
DOC_PP1_RVXF_1 89 95 PF00149 0.461
DOC_PP1_RVXF_1 98 104 PF00149 0.488
DOC_PP2B_LxvP_1 266 269 PF13499 0.694
DOC_SPAK_OSR1_1 8 12 PF12202 0.432
DOC_USP7_MATH_1 131 135 PF00917 0.687
DOC_USP7_MATH_1 150 154 PF00917 0.421
DOC_USP7_MATH_1 199 203 PF00917 0.666
DOC_USP7_MATH_1 208 212 PF00917 0.617
DOC_USP7_MATH_1 250 254 PF00917 0.548
DOC_USP7_MATH_1 278 282 PF00917 0.597
DOC_USP7_MATH_1 50 54 PF00917 0.420
DOC_USP7_UBL2_3 87 91 PF12436 0.381
DOC_WW_Pin1_4 13 18 PF00397 0.401
DOC_WW_Pin1_4 141 146 PF00397 0.511
DOC_WW_Pin1_4 2 7 PF00397 0.419
DOC_WW_Pin1_4 227 232 PF00397 0.545
DOC_WW_Pin1_4 246 251 PF00397 0.630
DOC_WW_Pin1_4 51 56 PF00397 0.412
LIG_14-3-3_CanoR_1 171 175 PF00244 0.734
LIG_14-3-3_CanoR_1 234 242 PF00244 0.638
LIG_14-3-3_CanoR_1 259 269 PF00244 0.663
LIG_14-3-3_CanoR_1 26 32 PF00244 0.378
LIG_14-3-3_CanoR_1 285 290 PF00244 0.732
LIG_14-3-3_CanoR_1 65 74 PF00244 0.398
LIG_14-3-3_CanoR_1 8 12 PF00244 0.432
LIG_BRCT_BRCA1_1 68 72 PF00533 0.389
LIG_FHA_1 14 20 PF00498 0.429
LIG_FHA_1 141 147 PF00498 0.588
LIG_FHA_1 238 244 PF00498 0.593
LIG_FHA_1 28 34 PF00498 0.387
LIG_GBD_Chelix_1 19 27 PF00786 0.430
LIG_LIR_Apic_2 193 197 PF02991 0.616
LIG_LIR_Gen_1 153 159 PF02991 0.614
LIG_LIR_Gen_1 206 215 PF02991 0.688
LIG_LIR_Gen_1 7 17 PF02991 0.431
LIG_LIR_Nem_3 133 139 PF02991 0.559
LIG_LIR_Nem_3 153 158 PF02991 0.378
LIG_LIR_Nem_3 7 12 PF02991 0.428
LIG_Pex14_2 136 140 PF04695 0.610
LIG_SH2_GRB2like 66 69 PF00017 0.397
LIG_SH2_PTP2 155 158 PF00017 0.729
LIG_SH2_STAT3 174 177 PF00017 0.594
LIG_SH2_STAT5 155 158 PF00017 0.679
LIG_SH2_STAT5 225 228 PF00017 0.498
LIG_SH2_STAT5 66 69 PF00017 0.397
LIG_SH3_3 193 199 PF00018 0.628
LIG_SH3_3 268 274 PF00018 0.699
LIG_SH3_3 49 55 PF00018 0.423
LIG_SH3_3 74 80 PF00018 0.391
LIG_SUMO_SIM_par_1 143 149 PF11976 0.654
LIG_TRAF2_1 230 233 PF00917 0.519
MOD_CDC14_SPxK_1 5 8 PF00782 0.413
MOD_CDK_SPxK_1 2 8 PF00069 0.420
MOD_CDK_SPxxK_3 227 234 PF00069 0.546
MOD_CK1_1 166 172 PF00069 0.682
MOD_CK2_1 203 209 PF00069 0.507
MOD_CK2_1 227 233 PF00069 0.493
MOD_GlcNHglycan 266 269 PF01048 0.715
MOD_GlcNHglycan 280 283 PF01048 0.590
MOD_GlcNHglycan 69 72 PF01048 0.592
MOD_GSK3_1 159 166 PF00069 0.649
MOD_GSK3_1 179 186 PF00069 0.558
MOD_GSK3_1 199 206 PF00069 0.594
MOD_GSK3_1 233 240 PF00069 0.596
MOD_GSK3_1 246 253 PF00069 0.558
MOD_GSK3_1 260 267 PF00069 0.602
MOD_GSK3_1 42 49 PF00069 0.457
MOD_N-GLC_1 67 72 PF02516 0.652
MOD_NEK2_1 148 153 PF00069 0.629
MOD_NEK2_1 190 195 PF00069 0.582
MOD_NEK2_1 27 32 PF00069 0.430
MOD_NEK2_1 67 72 PF00069 0.392
MOD_PIKK_1 199 205 PF00454 0.619
MOD_PIKK_1 261 267 PF00454 0.550
MOD_PK_1 285 291 PF00069 0.732
MOD_PKA_1 285 291 PF00069 0.626
MOD_PKA_2 166 172 PF00069 0.738
MOD_PKA_2 233 239 PF00069 0.609
MOD_PKA_2 285 291 PF00069 0.613
MOD_PKA_2 7 13 PF00069 0.429
MOD_Plk_1 250 256 PF00069 0.524
MOD_Plk_1 67 73 PF00069 0.611
MOD_Plk_1 85 91 PF00069 0.469
MOD_ProDKin_1 13 19 PF00069 0.400
MOD_ProDKin_1 141 147 PF00069 0.510
MOD_ProDKin_1 2 8 PF00069 0.420
MOD_ProDKin_1 227 233 PF00069 0.546
MOD_ProDKin_1 246 252 PF00069 0.622
MOD_ProDKin_1 51 57 PF00069 0.408
TRG_ENDOCYTIC_2 155 158 PF00928 0.617
TRG_ENDOCYTIC_2 207 210 PF00928 0.521
TRG_ER_diArg_1 36 39 PF00400 0.435
TRG_NLS_Bipartite_1 113 127 PF00514 0.648
TRG_Pf-PMV_PEXEL_1 128 133 PF00026 0.539

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7M0 Leptomonas seymouri 59% 100%
A0A0S4J706 Bodo saltans 34% 100%
A0A1X0NU63 Trypanosomatidae 37% 100%
A0A3R7MDP5 Trypanosoma rangeli 35% 100%
A0A3S7WTQ3 Leishmania donovani 81% 100%
A4HWP4 Leishmania infantum 81% 100%
C9ZXP2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9AQF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
Q4QF24 Leishmania major 81% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS