Presenilin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Presenilin

Gene product:

presenilin-like aspartic peptidase, putative

Species:

Leishmania braziliensis

UniProt:

A4H8C1_LEIBR

TriTrypDb:

LbrM.15.1530 , LBRM2903_150022400

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	12
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0098588	bounding membrane of organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005634	nucleus	5	1
GO:0005886	plasma membrane	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H8C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8C1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0007165	signal transduction	2	12
GO:0007166	cell surface receptor signaling pathway	3	12
GO:0007219	Notch signaling pathway	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016485	protein processing	5	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051604	protein maturation	4	12
GO:0065007	biological regulation	1	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004190	aspartic-type endopeptidase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0016787	hydrolase activity	2	12
GO:0070001	aspartic-type peptidase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	209	213	PF00082	0.258
DEG_APCC_DBOX_1	310	318	PF00400	0.422
DEG_MDM2_SWIB_1	115	122	PF02201	0.235
DOC_CDC14_PxL_1	314	322	PF14671	0.432
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.299
DOC_MAPK_DCC_7	19	29	PF00069	0.413
DOC_MAPK_gen_1	11	20	PF00069	0.528
DOC_MAPK_MEF2A_6	11	20	PF00069	0.505
DOC_PP2B_LxvP_1	23	26	PF13499	0.235
DOC_PP4_FxxP_1	129	132	PF00568	0.201
DOC_WW_Pin1_4	39	44	PF00397	0.264
LIG_14-3-3_CanoR_1	19	24	PF00244	0.515
LIG_14-3-3_CanoR_1	247	256	PF00244	0.553
LIG_14-3-3_CanoR_1	280	284	PF00244	0.312
LIG_14-3-3_CanoR_1	311	315	PF00244	0.501
LIG_BIR_II_1	1	5	PF00653	0.589
LIG_BRCT_BRCA1_1	287	291	PF00533	0.312
LIG_deltaCOP1_diTrp_1	182	186	PF00928	0.201
LIG_EH1_1	290	298	PF00400	0.264
LIG_FHA_1	135	141	PF00498	0.183
LIG_FHA_1	183	189	PF00498	0.252
LIG_FHA_1	192	198	PF00498	0.342
LIG_FHA_1	85	91	PF00498	0.234
LIG_GBD_Chelix_1	329	337	PF00786	0.258
LIG_LIR_Apic_2	127	132	PF02991	0.192
LIG_LIR_Apic_2	37	43	PF02991	0.157
LIG_LIR_Gen_1	162	172	PF02991	0.375
LIG_LIR_Gen_1	184	193	PF02991	0.285
LIG_LIR_Gen_1	194	201	PF02991	0.285
LIG_LIR_Gen_1	288	298	PF02991	0.276
LIG_LIR_Gen_1	323	333	PF02991	0.221
LIG_LIR_Gen_1	37	46	PF02991	0.257
LIG_LIR_Gen_1	87	96	PF02991	0.247
LIG_LIR_LC3C_4	22	25	PF02991	0.264
LIG_LIR_Nem_3	123	128	PF02991	0.287
LIG_LIR_Nem_3	162	168	PF02991	0.375
LIG_LIR_Nem_3	184	189	PF02991	0.285
LIG_LIR_Nem_3	194	198	PF02991	0.285
LIG_LIR_Nem_3	270	276	PF02991	0.227
LIG_LIR_Nem_3	288	294	PF02991	0.275
LIG_LIR_Nem_3	323	328	PF02991	0.169
LIG_LIR_Nem_3	37	41	PF02991	0.281
LIG_LIR_Nem_3	87	91	PF02991	0.247
LIG_NRBOX	303	309	PF00104	0.243
LIG_NRBOX	332	338	PF00104	0.258
LIG_PCNA_yPIPBox_3	204	217	PF02747	0.497
LIG_PDZ_Class_2	347	352	PF00595	0.306
LIG_Pex14_1	121	125	PF04695	0.312
LIG_Pex14_1	36	40	PF04695	0.157
LIG_Pex14_2	115	119	PF04695	0.239
LIG_Pex14_2	125	129	PF04695	0.243
LIG_Pex14_2	141	145	PF04695	0.159
LIG_Pex14_2	96	100	PF04695	0.520
LIG_Pex3_1	333	344	PF04882	0.258
LIG_SH2_CRK	133	137	PF00017	0.231
LIG_SH2_CRK	195	199	PF00017	0.221
LIG_SH2_CRK	274	278	PF00017	0.235
LIG_SH2_CRK	71	75	PF00017	0.297
LIG_SH2_GRB2like	45	48	PF00017	0.297
LIG_SH2_NCK_1	133	137	PF00017	0.257
LIG_SH2_NCK_1	156	160	PF00017	0.457
LIG_SH2_NCK_1	195	199	PF00017	0.159
LIG_SH2_SRC	195	198	PF00017	0.206
LIG_SH2_STAP1	195	199	PF00017	0.221
LIG_SH2_STAP1	274	278	PF00017	0.312
LIG_SH2_STAP1	71	75	PF00017	0.222
LIG_SH2_STAT5	128	131	PF00017	0.297
LIG_SH2_STAT5	165	168	PF00017	0.255
LIG_SH2_STAT5	40	43	PF00017	0.301
LIG_SH2_STAT5	45	48	PF00017	0.293
LIG_SH3_1	315	321	PF00018	0.457
LIG_SH3_3	315	321	PF00018	0.396
LIG_SUMO_SIM_anti_2	196	202	PF11976	0.221
LIG_SUMO_SIM_anti_2	30	37	PF11976	0.324
LIG_SUMO_SIM_anti_2	303	309	PF11976	0.361
LIG_SUMO_SIM_par_1	25	30	PF11976	0.247
LIG_TYR_ITIM	101	106	PF00017	0.340
LIG_TYR_ITIM	131	136	PF00017	0.192
LIG_TYR_ITIM	272	277	PF00017	0.235
LIG_WRC_WIRS_1	341	346	PF05994	0.412
LIG_WRC_WIRS_1	35	40	PF05994	0.157
MOD_CK1_1	157	163	PF00069	0.497
MOD_CK1_1	170	176	PF00069	0.244
MOD_CK1_1	250	256	PF00069	0.396
MOD_CK1_1	279	285	PF00069	0.198
MOD_CK1_1	340	346	PF00069	0.375
MOD_CK1_1	39	45	PF00069	0.278
MOD_CK2_1	176	182	PF00069	0.288
MOD_CMANNOS	183	186	PF00535	0.392
MOD_GlcNHglycan	108	111	PF01048	0.281
MOD_GlcNHglycan	2	5	PF01048	0.338
MOD_GlcNHglycan	227	230	PF01048	0.320
MOD_GlcNHglycan	241	245	PF01048	0.526
MOD_GlcNHglycan	249	252	PF01048	0.159
MOD_GlcNHglycan	283	286	PF01048	0.478
MOD_GSK3_1	233	240	PF00069	0.493
MOD_GSK3_1	250	257	PF00069	0.385
MOD_GSK3_1	272	279	PF00069	0.303
MOD_GSK3_1	281	288	PF00069	0.429
MOD_GSK3_1	320	327	PF00069	0.300
MOD_GSK3_1	339	346	PF00069	0.225
MOD_LATS_1	245	251	PF00433	0.535
MOD_NEK2_1	106	111	PF00069	0.253
MOD_NEK2_1	124	129	PF00069	0.192
MOD_NEK2_1	154	159	PF00069	0.423
MOD_NEK2_1	254	259	PF00069	0.527
MOD_NEK2_1	276	281	PF00069	0.174
MOD_NEK2_1	300	305	PF00069	0.221
MOD_NEK2_1	310	315	PF00069	0.392
MOD_NEK2_1	337	342	PF00069	0.293
MOD_NEK2_1	69	74	PF00069	0.277
MOD_NEK2_1	84	89	PF00069	0.196
MOD_NEK2_2	149	154	PF00069	0.153
MOD_PIKK_1	159	165	PF00454	0.497
MOD_PIKK_1	233	239	PF00454	0.422
MOD_PKA_2	10	16	PF00069	0.576
MOD_PKA_2	279	285	PF00069	0.368
MOD_PKA_2	310	316	PF00069	0.518
MOD_Plk_1	181	187	PF00069	0.201
MOD_Plk_4	124	130	PF00069	0.298
MOD_Plk_4	149	155	PF00069	0.314
MOD_Plk_4	167	173	PF00069	0.291
MOD_Plk_4	19	25	PF00069	0.513
MOD_Plk_4	250	256	PF00069	0.420
MOD_Plk_4	27	33	PF00069	0.349
MOD_Plk_4	272	278	PF00069	0.240
MOD_Plk_4	292	298	PF00069	0.332
MOD_Plk_4	300	306	PF00069	0.160
MOD_Plk_4	320	326	PF00069	0.118
MOD_Plk_4	69	75	PF00069	0.200
MOD_ProDKin_1	39	45	PF00069	0.264
TRG_AP2beta_CARGO_1	270	280	PF09066	0.312
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.542
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.434
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.264
TRG_ENDOCYTIC_2	103	106	PF00928	0.340
TRG_ENDOCYTIC_2	128	131	PF00928	0.252
TRG_ENDOCYTIC_2	133	136	PF00928	0.222
TRG_ENDOCYTIC_2	165	168	PF00928	0.249
TRG_ENDOCYTIC_2	195	198	PF00928	0.261
TRG_ENDOCYTIC_2	274	277	PF00928	0.232
TRG_ENDOCYTIC_2	71	74	PF00928	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILY0	Leptomonas seymouri	67%	97%
A0A0S4J6N6	Bodo saltans	46%	92%
A0A1X0NVS4	Trypanosomatidae	41%	93%
A0A3R7LP35	Trypanosoma rangeli	43%	93%
A0A3S5H6W2	Leishmania donovani	84%	100%
A4HWP2	Leishmania infantum	84%	100%
C9ZXP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	96%
E9AQF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O12976	Xenopus laevis	31%	81%
O12977	Xenopus laevis	32%	78%
O64668	Arabidopsis thaliana	32%	78%
O88777	Rattus norvegicus	33%	79%
P49768	Homo sapiens	30%	75%
P49769	Mus musculus	30%	75%
P49810	Homo sapiens	32%	79%
P52166	Caenorhabditis elegans	27%	79%
P79801	Microcebus murinus	33%	79%
P79802	Microcebus murinus	30%	75%
P97887	Rattus norvegicus	30%	75%
Q0MS45	Sus scrofa	32%	79%
Q4JIM4	Gallus gallus	31%	75%
Q4QF26	Leishmania major	84%	100%
Q54DE8	Dictyostelium discoideum	35%	74%
Q5R780	Pongo abelii	30%	75%
Q5RCN9	Pongo abelii	32%	79%
Q61144	Mus musculus	33%	79%
Q6RH31	Canis lupus familiaris	31%	76%
Q8HXW5	Macaca fascicularis	30%	75%
Q90X07	Gallus gallus	30%	78%
Q90ZE4	Danio rerio	32%	80%
Q9SIK7	Arabidopsis thaliana	33%	89%
Q9W6T7	Danio rerio	30%	77%
Q9XT96	Bos taurus	32%	78%
Q9XT97	Bos taurus	29%	74%
V5AR19	Trypanosoma cruzi	43%	100%