GINS complex subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8B9_LEIBR

TriTrypDb:

LbrM.15.1510 , LBRM2903_150022300

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000811	GINS complex	4	11
GO:0031261	DNA replication preinitiation complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0032993	protein-DNA complex	2	11
GO:0140513	nuclear protein-containing complex	2	11

Expansion

Sequence features

A4H8B9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8B9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006260	DNA replication	5	10
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0006271	DNA strand elongation involved in DNA replication	6	1
GO:0022402	cell cycle process	2	1
GO:0022616	DNA strand elongation	5	1
GO:1902296	DNA strand elongation involved in cell cycle DNA replication	3	1
GO:1902319	DNA strand elongation involved in nuclear cell cycle DNA replication	4	1
GO:1902983	DNA strand elongation involved in mitotic DNA replication	4	1
GO:1903047	mitotic cell cycle process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_FUR_1	77	81	PF00082	0.453
CLV_PCSK_KEX2_1	79	81	PF00082	0.465
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.468
CLV_PCSK_SKI1_1	80	84	PF00082	0.506
DEG_APCC_DBOX_1	79	87	PF00400	0.506
DOC_CYCLIN_yCln2_LP_2	59	65	PF00134	0.565
DOC_PP4_FxxP_1	131	134	PF00568	0.521
LIG_14-3-3_CanoR_1	161	165	PF00244	0.662
LIG_14-3-3_CanoR_1	17	26	PF00244	0.574
LIG_14-3-3_CanoR_1	80	86	PF00244	0.491
LIG_BIR_II_1	1	5	PF00653	0.581
LIG_CtBP_PxDLS_1	134	138	PF00389	0.531
LIG_FHA_1	166	172	PF00498	0.568
LIG_FHA_1	82	88	PF00498	0.573
LIG_FHA_2	121	127	PF00498	0.618
LIG_FHA_2	26	32	PF00498	0.647
LIG_IBAR_NPY_1	54	56	PF08397	0.504
LIG_LIR_Apic_2	129	134	PF02991	0.509
LIG_LIR_Gen_1	175	186	PF02991	0.628
LIG_LIR_Gen_1	43	52	PF02991	0.561
LIG_LIR_Gen_1	53	64	PF02991	0.585
LIG_LIR_Nem_3	175	181	PF02991	0.637
LIG_LIR_Nem_3	43	48	PF02991	0.468
LIG_LIR_Nem_3	53	59	PF02991	0.557
LIG_NRBOX	82	88	PF00104	0.606
LIG_PCNA_yPIPBox_3	115	128	PF02747	0.570
LIG_SH2_NCK_1	45	49	PF00017	0.552
LIG_SH2_STAT5	116	119	PF00017	0.593
LIG_SH2_STAT5	140	143	PF00017	0.656
LIG_SH2_STAT5	64	67	PF00017	0.569
LIG_SH2_STAT5	85	88	PF00017	0.530
LIG_SH3_3	49	55	PF00018	0.352
LIG_TRAF2_1	180	183	PF00917	0.589
LIG_TYR_ITAM	42	59	PF00017	0.485
LIG_WRC_WIRS_1	128	133	PF05994	0.501
LIG_WRC_WIRS_1	178	183	PF05994	0.636
MOD_CK1_1	162	168	PF00069	0.521
MOD_CK1_1	2	8	PF00069	0.447
MOD_CK1_1	22	28	PF00069	0.568
MOD_CK1_1	50	56	PF00069	0.581
MOD_CK2_1	107	113	PF00069	0.591
MOD_CK2_1	120	126	PF00069	0.604
MOD_CK2_1	177	183	PF00069	0.630
MOD_CK2_1	25	31	PF00069	0.579
MOD_CK2_1	33	39	PF00069	0.506
MOD_GlcNHglycan	109	112	PF01048	0.598
MOD_GlcNHglycan	164	167	PF01048	0.546
MOD_GlcNHglycan	21	24	PF01048	0.528
MOD_GlcNHglycan	7	11	PF01048	0.571
MOD_GSK3_1	18	25	PF00069	0.536
MOD_GSK3_1	2	9	PF00069	0.445
MOD_N-GLC_1	41	46	PF02516	0.561
MOD_NEK2_1	105	110	PF00069	0.593
MOD_NEK2_1	160	165	PF00069	0.575
MOD_NEK2_1	19	24	PF00069	0.443
MOD_PIKK_1	2	8	PF00454	0.447
MOD_PIKK_1	57	63	PF00454	0.551
MOD_PK_1	143	149	PF00069	0.611
MOD_PK_1	33	39	PF00069	0.585
MOD_PKA_2	160	166	PF00069	0.619
MOD_Plk_1	41	47	PF00069	0.590
MOD_Plk_4	120	126	PF00069	0.589
MOD_Plk_4	165	171	PF00069	0.584
MOD_Plk_4	47	53	PF00069	0.547
MOD_Plk_4	81	87	PF00069	0.521
MOD_SUMO_rev_2	110	117	PF00179	0.588
MOD_SUMO_rev_2	25	34	PF00179	0.553
TRG_DiLeu_BaEn_1	15	20	PF01217	0.430
TRG_DiLeu_LyEn_5	183	188	PF01217	0.573
TRG_ENDOCYTIC_2	45	48	PF00928	0.558
TRG_ENDOCYTIC_2	56	59	PF00928	0.561
TRG_ER_diArg_1	152	155	PF00400	0.694

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD99	Leptomonas seymouri	76%	100%
A0A0S4J8J8	Bodo saltans	46%	99%
A0A1X0NUK0	Trypanosomatidae	57%	100%
A0A3R7K2K3	Trypanosoma rangeli	57%	100%
A0A3S7WTQ1	Leishmania donovani	91%	100%
A4HWP0	Leishmania infantum	91%	100%
A4IFH4	Bos taurus	27%	100%
C9ZXP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AQE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q14691	Homo sapiens	26%	100%
Q4QF28	Leishmania major	91%	100%
Q54HR6	Dictyostelium discoideum	23%	100%
Q7ZT47	Xenopus laevis	27%	100%
Q9CZ15	Mus musculus	27%	100%